Stellenangebote

Stellenangebot

Abteilung:

NCT Molecular Pathology Core

Bezeichnung:

Bioinformatician

Kennziffer:

349/2017

Ihre Aufgaben:

Further development of the experimental morphologic and molecular pathology core at the NCT (National Center for Tumor Diseases) is essential for the translation of discoveries from large-scale experimental programs of the NCT, DKFZ, and DKTK (German Cancer Consortium) into diagnostic and therapeutic application. The core comprises a unit for translational morphology as well as a large molecular analysis platform for translation of -omics findings into high throughput human tissue studies and molecular diagnostic setting. The core will function as a pathology knowledge hub between experimental programs, translational pathology and oncology.

The position offers the prospect of leading the bioinformatics unit that is currently being built up at the Institute of Pathology at the University Hospital Heidelberg. Applicants must have a strong record of research in applied bioinformatics and computational biology, including the ability to integrate multiple types of large scale data. The appropriate person will coordinate the bioinformatics aspects of individual and collaborative projects involving large scale datasets. Candidates must bring a demonstrated ability to pursue active and viable research in a multi-disciplinary manner.

• Analysis of multidimensional and large data sets which are either already available or will be generated using state-of-the-art techniques
• Statistical correlation analysis (e.g. phenotype-genotype correlations) with additional, case-specific clinical, pathological and molecular data sets
• Analysis of next generation sequencing (NGS) data, including variant calling (SNV, In/Del), structural variants (SV), copy number variations (CNV), expression profiles, differentially expressed genes, fusion genes, enrichment profiles, gene ontology, gene set analysis and pathway analysis. Experience with Illumina-derived data sets is particularly advantageous
• Roll-out and advancement of databases, which includes improving the effectiveness and the technology used, building up new databases, monitoring data entry procedures and troubleshooting

Ihr Profil:

• PhD with documented strong performance in applied bioinformatics, computational biology, or computer science (or equivalent experience)
• Excellent oral and written communication skills in German and English
• Good understanding of molecular and cancer biology
• Solid knowledge in statistics and R programming
• Experience in the analysis of next generation sequencing data
• Experience with programming and/or scripting languages
• Experience with unix compute systems and system administration
• Strong communication skills

Wir bieten:

  • Interessanten, vielseitigen Arbeitsplatz
  • Internationales Umfeld
  • Vergütung nach TV-L
  • Möglichkeiten zur Teilzeitarbeit
  • Flexible Arbeitszeiten
  • Gute Fort- und Weiterbildung

Beginn:

as soon as possible

Befristung:

The position is limited to 2 years. The position can in principle be part-time.

Bewerbungsschluss:

January 22, 2018

Weitere Informationen:

Project coordination: Dr. rer. nat. Amelie Lier
Project leader: Dr. med. Albrecht Stenzinger
phone +49 6221 56-38175


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