Cancer epigenetics

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To elucidate the functional role of DNA methylation on colon cancer formation, we are using integrative epigenome sequencing approaches on mouse models and patient samples. For example, we have discovered stable DNA methylation signatures that are maintained from the cancer cell-of-origin through colorectal adenoma and carcinoma formation, which provides new possibilities for the development of risk stratification biomarkers. We are also investigating the epigenetic changes that are induced by intestinal inflammation, which represents a major risk factor in colon cancer formation. Furthermore, the group also has a longstanding interest in epigenetic changes associated with skin aging and skin cancer. Similar to our findings in colon cancer, we have discovered stable DNA methylation signatures that are conserved from the cancer cell-of-origin. Most recently, we have published our first studies based on single-cell sequencing, which represents a critically importantapproach for the identification and characterization of tumor cells-of-origin.

 

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