Radiotherapy Optimization

Group leader: Dr. Niklas Wahl


matRad, our open-source software for dose calculation and optimiztiation, keeps growing.

Niklas' ICCR presentation on confidence constraints for probabilistic treatment planning has been selected as Highlight Presentation and Hans-Peter's presentation on biological uncertainy modeling in carbon therapy won 3rd place in the rising stars competition

Rosario's AAPM presentation about the role anatomical variations for xerostomia prediction has been selected as Science Highlight 

Niklas' and Hans-Peter's papers on analytical probabilistic modeling and on its application for C12 have been published

Hubert's work on using machine learning methods in combination with dosiomics features for xerostomia brediction has been published in Frontiers in Oncology.


Our work revolves around the development and implementation of physical, biological and mathematical models into the treatment planning process for radiation therapy. Thereby, we maintain the open source dose calculation and treatment planning toolkit "matRad" (

Currently, we focus on three topics:

  • Numerical optimization techniques for the quantification and minimization of uncertainties in radiation therapy
  • Machine Learning to infer predictive models for the outcome of radiation therapy
  • Incorporation of additional optimization parameters into automated radiation therapy planning

All projects are carried out in collaboration with reknown colleagues in the field:

We are constantly looking for motivated individuals coming from a physics, math, and/or computer science background with a genuine interest in medical physics in radiation oncology. If you are interested to join our research group for your Bachelor, Master, and PhD thesis or for a postdoc position, do not hesitate and get in touch. In particular, we a currently looking for a HiWi (with good C++ knowledge or experience in Software Development).



  • Dr. Mark Bangert (part-time Postdoc)
  • Amit Ben Antony Bennan (PhD student)
  • Noa Homolka (PhD student)
  • Paul Anton Meder (MSc student)
  • Martina Palkowitsch (MSc student)
  • Pia Stammer (associated PhD student from KIT)
  • Dr. Niklas Wahl (Group leader)


With our work we try to support open science. As such we make a lot of our programming work freely available via our group's github site. Most notably, we maintain the Matlab-based open-source toolkit for dose calculation and optimization in radiotherapy optimization matRad.


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