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A historic success for the German Cancer Research Center (DKFZ): Four DKFZ researchers are receiving one of the prestigious ERC Synergy Grants this year—more than ever before at a single institution in a single funding round. Three of the four international research consortia are coordinated by the DKFZ. In total, the projects will receive approximately 44.5 million euros, of which about 13.7 million euros will go to the DKFZ. The award-winning teams aim to decipher the influence of sex chromosomes on health (Duncan Odom), to use artificial intelligence to predict antigens from antibody sequence alone (Nina Papavasiliou), to understand why cancer risk increases with age (Martina Seiffert) and to detect cancer in children as early as possible (Frank Westermann).