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PRAME-specific T-cell therapy in an adolescent with metastatic kidney tumor

Researchers and physicians at the Hopp Children's Cancer Center Heidelberg (KiTZ) and other leading cancer centers report an exceptional treatment success in an adolescent with an advanced, therapy-resistant kidney tumor. Using a novel, personalized T-cell therapy, they succeeded in completely pushing back the tumor disease despite multiple metastases. The individual compassionate-use treatment has now been published in the New England Journal of Medicine and underscores the potential of cellular Immunotherapies also for children and adolescents with solid tumors. The clinical trial building on these findings, planned for 2027, will be funded by the Dietmar Hopp Foundation with around 1.8 million euros over a period of four years at KiTZ. The "Hopp Children's Cancer Center Heidelberg" (KiTZ) is a joint institution of the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD), and Heidelberg University (Uni HD).

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DKFZ on X

DKFZ

@DKFZ

13.08.2026

Wie lässt sich die Immuntherapie noch gezielter auf einzelne Patient:innen zuschneiden? Ein Beitrag der @XgegenKrebs zeigt, wie Forschung & klinische Versorgung dabei immer enger zusammenrücken - und welche Chancen sich daraus für die Krebsmedizin ergeben. https://t.co/I0nitBCunB

DKFZ

@DKFZ

12.08.2026

Jugendschutz vor Lobbyinteresse: Warum das bestehende Verbot von Nikotinbeuteln im Sinne des Jugendschutzes und des vorbeugenden Gesundheitsschutzes sinnvoll ist und erhalten bleiben sollte, erläutert eine aktuelle Veröffentlichung des DKFZ. https://t.co/CSkRCjhbmf

DKFZ

@DKFZ

11.08.2026

Researchers from DKFZ, @hi_stem_lab & @uniklinik_hd have characterized T cells in cases of multiple myeloma and acute myeloid leukemia: A specific group of T cells can recognize and fight cancer cells, but is often not sufficiently activated. https://t.co/9jfcxfyB1a

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