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Selected publications

Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK, Kappl R, Schulze A, Friedmann Angeli JP, Dick TP (2022). Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals. Nature Chemical Biology — [News & Views]

Schilling D, Barayeu U, Steimbach RR, Talwar D, Miller AK, Dick TP (2022) Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers. Angewandte Chemie Int. Ed. e202203684

Talwar D, Messens J, Dick TP (2020) A role for annexin A2 in scaffolding the peroxiredoxin 2–STAT3 redox relay complex. Nature Communications 11:4512

Ezeriņa D, Takano Y, Hanaoka K, Urano Y, Dick TP (2018) N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production. Cell Chemical Biology 25:447 — [Commentary]

Stöcker S, Maurer M, Ruppert T, Dick TP (2017) A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation. Nature Chemical Biology 14:148

Morgan B, Van Laer K, Owusu T, Ezerina D, Pastor-Flores D, Amphonsah P, Tursch A, Dick TP (2016) Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nature Chemical Biology 12: 437

Fujikawa Y, Roma L, Sobotta MC, Rose AJ, Berriel Diaz M, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP (2016) Mouse redox histology using genetically encoded probes. Science Signaling 9: rs1

Peralta D, Bronowska AK, Morgan B, Dóka E, Van Laer K, Nagy P, Gräter F, Dick TP (2015) A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nature Chemical Biology 11:156

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nature Chemical Biology 11:64 — [Commentary]

Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nature Chemical Biology 9:119 — [Commentary]

Albrecht SC, Barata AG, Grosshans J, Teleman AA, Dick TP (2011) In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis. Cell Metabolism 14:819 — [Commentary]

Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real-time imaging of the intracellular glutathione redox potential. Nature Methods 5:553

Kienast A, Preuss M, Winkler M, Dick TP (2007) Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nature Immunology 8:864 — [Commentary]

Further selected publications

Kritsiligkou P, Shen TK, Dick TP (2021). A comparison of Prx- and OxyR-based H2O2 probes expressed in S. cerevisiae. J Biol Chem 297:100866

Pastor-Flores D, Talwar D, Pedre B, Dick TP (2020) Real-time monitoring of peroxiredoxin oligomerization dynamics in living cells. Proc Natl Acad Sci U S A 117:16313 — [Commentary]

Barata AG, Dick TP (2020) A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway. Redox Biol 28:101340

Stottmeier B, Dick TP (2016) Redox sensitivity of the MyD88 immune signaling adapter. Free Radic Biol Med 101:93

Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, Dick TP (2013) Polysulfides link H2S to protein thiol oxidation. Antioxid Redox Signal 19:1749

Sobotta MC, Barata AG, Schmidt U, Mueller S, Millonig G, Dick TP (2013) Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments.Free Radic Biol Med 60:325

Morgan B, Sobotta MC, Dick TP (2011) Measuring EGSH and H2O2 with roGFP2-based redox probes. Free Radic Biol Med 51:1943

Engelhard J, Christian BE, Weingarten L, Kuntz G, Spremulli LL, Dick TP (2011) In situ kinetic trapping reveals a fingerprint of reversible protein thiol oxidation in the mitochondrial matrix. Free Radic Biol Med 50:1234

Gutscher M, Sobotta MC, Wabnitz GH, Ballikaya S, Meyer AJ, Samstag Y, Dick TP (2009) Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases. J Biol Chem 284:31532

Schwertassek U, Balmer Y, Gutscher M, Weingarten L, Preuss M, Engelhard J, Winkler M, Dick TP (2007) Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1. EMBO J 26:3086

Selected reviews

Talwar D, Dick TP (2022) Chapter 14 - Thiol peroxidase-based redox relays. In Redox Chemistry and Biology of Thiols, B. Alvarez, M.A. Comini, G. Salinas, & M. Trujillo, eds., Academic Press, pp. 307–320

Pedre B, Barayeu U, Ezeriņa D, Dick TP (2021). The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species. Pharmacol Ther 228:107916

Pedre B, Dick TP (2021) 3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking. Biol Chem 402:223

Stöcker S, Van Laer K, Mijuskovic A, Dick TP (2017) The conundrum of H2O2 signaling and the emerging role of peroxiredoxins as redox relay hubs. Antioxid Redox Signal 28:558

Ezerina D, Morgan B, Dick TP (2014) Imaging dynamic redox processes with genetically encoded probes. J Mol Cell Cardiol 73:43

Fujikawa Y, Morgan B, Dick TP (2013) Fluorescent imaging of redox species in multicellular organisms. In ‘Oxidative Stress and Redox Regulation’ Eds. U. Jakob and D. Reichmann, Springer Press (March 28, 2013)

Meyer AJ, Dick TP (2010) Fluorescent protein-based redox probes. Antioxid Redox Signal 13:621

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