Publications

Selected publications

Morgan B, Van Laer K, Owusu T, Ezerina D, Pastor-Flores D, Amphonsah P, Tursch A, Dick TP (2016) Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nature Chemical Biology 12: 437-443

Fujikawa Y, Roma L, Sobotta MC, Rose AJ, Berriel Diaz M, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP (2016) Mouse redox histology using genetically encoded probes. Science Signaling 9: rs1

Peralta D, Bronowska AK, Morgan B, Dóka E, Van Laer K, Nagy P, Gräter F, Dick TP (2015) A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nature Chemical Biology 11:156-163

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nature Chemical Biology 11:64-70[News & Views]

Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nature Chemical Biology 9:119-125[News & Views]

Albrecht SC, Barata AG, Grosshans J, Teleman AA, Dick TP (2011) In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis. Cell Metabolism 14:819-829[Preview]

Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real-time imaging of the intracellular glutathione redox potential. Nature Methods 5:553-559

Kienast A, Preuss M, Winkler M, Dick TP (2007) Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nature Immunology 8:864-872[News & Views]

 


2017

Stöcker S, Van Laer K, Mijuskovic A, Dick TP (2017) The conundrum of H2O2 signaling and the emerging role of peroxiredoxins as redox relay hubs. Antioxid Redox Signal, doi: 10.1089/ars.2017.7162

Cabezas-Wallscheid N, Buettner F, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer FB, Pastor-Flores D, Roma LP, Renders S, Zeisberger P, Przybylla A, Schonberger K, Scognamiglio R, Altamura S, Florian CM, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinic D, Geiger H, Schroeder T, Benes V, Dick TP, Rieger MA, Stegle O, Trumpp A (2017) Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell 169:807-823

Pastor-Flores D, Becker K, Dick TP (2017) Monitoring yeast mitochondria with peroxiredoxin-based redox probes: the influence of oxygen and glucose availability. Interface Focus 7:20160143

Muller A, Schneider JF, Degrossoli A, Lupilova N, Dick TP, Leichert LI (2017a) Fluorescence spectroscopy of roGFP2-based redox probes responding to various physiologically relevant oxidant species in vitro. Data Brief 11:617-627

Muller A, Schneider JF, Degrossoli A, Lupilova N, Dick TP, Leichert LI (2017b) Systematic in vitro assessment of responses of roGFP2-based probes to physiologically relevant oxidant species. Free Radic Biol Med 106:329-338

Yofe I, Soliman K, Chuartzman SG, Morgan B, Weill U, Yifrach E, Dick TP, Cooper SJ, Ejsing CS, Schuldiner M, Zalckvar E, Thoms S (2017) Pex35 is a regulator of peroxisome abundance. J Cell Sci 130:791-804

2016

Stottmeier B, Dick TP (2016) Redox sensitivity of the MyD88 immune signaling adapter. Free Radic Biol Med 101:93-101

Morgan B, Van Laer K, Owusu T, Ezerina D, Pastor-Flores D, Amphonsah P, Tursch A, Dick TP (2016) Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes. Nat Chem Biol 12:437-443

Breckwoldt MO, Armoundas AA, Aon MA, Bendszus M, O`Rourke B, Schwarzländer M, Dick TP, Kurz FT (2016) Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters. Sci Rep 6: 23251

Fujikawa Y, Roma LP, Sobotta MC, Rose AJ, Berriel Diaz M, Locatelli G, Breckwoldt MO, Misgeld T, Kerschensteiner M, Herzig S, Müller-Decker K, Dick TP (2016) Mouse redox histology using genetically encoded probes. Sci Signal 9: rs1

Van Laer K, Dick TP (2016) Utilizing Natural and Engineered Peroxiredoxins As Intracellular Peroxide Reporters. Mol Cells 39: 46-52

Dóka E, Pader I, Bíró A, Johansson K, Cheng Q, Ballagó K, Prigge JR, Pastor-Flores D, Dick TP, Schmidt EE, Arnér ESJ, Nagy P (2016) Novel persulfide detection method reveals protein persulfide and polysulfide reducing functions of thioredoxin- and glutathione-systems. Sci Adv, Vol. 2, e1500968

Brodziak-Jarosz L, Fujikawa Y, Pastor-Flores D, Kasikci S, Jirasek P, Pitzl S, Owen RW, Gerhauser C, Amslinger S, Dick TP (2016) A click chemistry approach identifies target proteins of xanthohumol. Mol Nutr Food Res 60: 737-748

Talhi O, Brodziak-Jarosz L, Panning J, Orlikova B, Zwergel C, Tzanova T, Philippot S, Pinto D, Almeida Paz FA, Gerhäuser C, Dick TP, Jacob C, Diederich M, Bagrel D, Kirsch G, Silva AMS (2016) One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential. Eur J Org Chem 2016: 965-975

2015

Dick TP, Ralser M (2015) Metabolic Remodeling in Times of Stress: Who Shoots Faster than His Shadow? Mol Cell 59:519-521

Schwarzländer M, Dick TP, Meyer AJ, Morgan B (2015) Dissecting Redox Biology using Fluorescent Protein Sensors. Antioxid Redox Signal 24:680-712

Herrmann JM, Becker K, Dick TP (2015) Highlight: Dynamics of thiol-based redox switches. Biol Chem 396:385-387

Greiner R, Dick TP (2015) Real-Time Assays for Monitoring the Influence of Sulfide and Sulfane Sulfur Species on Protein Thiol Redox States. Meth Enzymol 555:57-77

Leichert LI, Dick TP (2015) Incidence and physiological relevance of protein thiol switches. Biol Chem 396:389-399

Walter D, Lier A, Geiselhart A, Thalheimer FB, Huntscha S, Sobotta MC, Moehrle B, Brocks D, Bayindir I, Kaschutnig P, Muedder K, Klein C, Jauch A, Schroeder T, Geiger H, Dick TP, Holland-Letz T, Schmezer P, Lane SW, Rieger MA, Essers MA, Williams DA, Trumpp A, Milsom MD (2015) Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature 520:549–552

Rücker H, Al-Rifai N, Rascle A, Gottfried E, Brodziak-Jarosz L, Gerhauser C, Dick TP, Amslinger S (2015) Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site. Org Biomol Chem 13:3040-3047

Peralta D, Bronowska AK, Morgan B, Dóka E, Van Laer K, Nagy P, Gräter F, Dick TP (2015) A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. Nat Chem Biol 11:156-163

Sobotta MC, Liou W, Stöcker S, Talwar D, Oehler M, Ruppert T, Scharf AN, Dick TP (2015) Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling. Nat Chem Biol 11:64-70

with News & Views: Redox biology: Signaling via a peroxiredoxin sensor

2014

Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP (2014) The ‘mitoflash’ probe cpYFP does not respond to superoxide. Nature 514: E12-E14

Elbaz-Alon Y, Morgan B, Clancy A, Amoako TN, Zalckvar E, Dick TP, Schwappach B, Schuldiner M (2014) The yeast oligopeptide transporter Opt2 is localized to peroxisomes and affects glutathione redox homeostasis. FEMS Yeast Res 14:1055-67

Schwertassek U, Haque A, Krishnan N, Greiner R, Weingarten L, Dick TP, Tonks NK (2014) Reactivation of oxidized PTP1B and PTEN by thioredoxin 1. FEBS J 281:3545-58

Breckwoldt MO, Pfister FM, Bradley PM, Marinkovic P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzlander M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T (2014) Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo. Nat Med 20:555-560

Ezerina D, Morgan B, Dick TP (2014) Imaging dynamic redox processes with genetically encoded probes. J Mol Cell Cardiol 73:43-49

Albrecht SC, Sobotta MC, Bausewein D, Aller I, Hell R, Dick TP, Meyer AJ (2014) Redesign of genetically encoded biosensors for monitoring mitochondrial redox status in a broad range of model eukaryotes. J Biomol Screen 19:379-386

2013

Nagy P, Dick TP, Greiner R, Palinkas Z, Nagy A (2013) Redox-, coordination- and solution-chemistry of sulfide in relation to some of its biological actions. Nitric Oxide 31 (Suppl. 2): S51

Barata AG, Dick TP (2013) In Vivo Imaging of H2O2 Production in Drosophila. Methods Enzymol 526:61-82 

Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, Dick TP (2013) Polysulfides link H2S to protein thiol oxidation. Antioxid Redox Signal 19:1749-1765

Fujikawa Y, Morgan B, Dick TP (2013) Fluorescent imaging of redox species in multicellular organisms. In ‘Oxidative Stress and Redox Regulation’ Eds. U. Jakob and D. Reichmann, Springer Press (March 28, 2013)

Sobotta MC, Barata AG, Schmidt U, Mueller S, Millonig G, Dick TP (2013) Exposing cells to H2O2: a quantitative comparison between continuous low-dose and one-time high-dose treatments.Free Radic Biol Med 60:325-335 

Wittig R, Richter V, Wittig-Blaich S, Weber P, Strauss WSL, Bruns T, Dick TP, Schneckenburger H (2013) Biosensor-expressing spheroid cultures for imaging of drug-induced effects in three dimensions. J Biomol Screen 18:736-743

Birk J, Meyer M, Aller I, Hansen HG, Odermatt A, Dick TP, Meyer AJ, Appenzeller-Herzog C (2013) Endoplasmic reticulum: Reduced and oxidized glutathione revisited. J Cell Sci 126:1604-1617

Gibbs-Flournoy EA, Simmons SO, Bromberg PA, Dick TP, Samet JM (2013) Monitoring Intracellular Redox Changes in Ozone-Exposed Airway Epithelial Cells. Environ Health Perspect 121:312-317

Morgan B, Ezerina D, Amoako TN, Riemer J, Seedorf M, Dick TP (2013) Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis. Nat Chem Biol 9:119-125

with News & Views: A black hole for oxidized glutathione


Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM (2013) Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal 18:1597-1612

2012

Herrmann JM, Dick TP (2012) Redox Biology on the rise. Biol Chem 393:999-1004

Millonig G, Ganzleben I, Peccerella T, Casanovas G, Brodziak-Jarosz L, Breitkopf-Heinlein K, Dick TP, Seitz HK, Muckenthaler MU, Mueller S (2012) Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3). J Biol Chem 287:37472-37482

Schwarzlander M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Muller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ (2012) Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol 22:503-508

Kojer K, Bien M, Gangel H, Morgan B, Dick TP, Riemer J (2012) Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J 31:3169-3182

2011

Albrecht SC, Barata AG, Grosshans J, Teleman AA, Dick TP (2011) In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis. Cell Metab 14:819-829

with Preview: Seeing the Light: Probing ROS In Vivo Using Redox GFP

Morgan B, Sobotta MC, Dick TP (2011) Measuring EGSH and H2O2 with roGFP2-based redox probes. Free Radic Biol Med 51:1943-1951

Engelhard J, Christian BE, Weingarten L, Kuntz G, Spremulli LL, Dick TP (2011) In situ kinetic trapping reveals a fingerprint of reversible protein thiol oxidation in the mitochondrial matrix. Free Radic Biol Med 50:1234-1241

2010

Braun NA, Morgan B, Dick TP, Schwappach B (2010) The yeast CLC protein counteracts vesicular acidification during iron starvation. J Cell Sci 123:2342-2350

Meyer AJ, Dick TP (2010) Fluorescent protein-based redox probes. Antioxid Redox Signal 13:621-650

Reth M, Dick TP (2010) Voltage control for B cell activation. Nat Immunol 11:191-192

2009

Gutscher M, Sobotta MC, Wabnitz GH, Ballikaya S, Meyer AJ, Samstag Y, Dick TP (2009) Proximity-based protein thiol oxidation by H2O2-scavenging peroxidases. J Biol Chem 284:31532-31540

2008

Gutscher M, Pauleau AL, Marty L, Brach T, Wabnitz GH, Samstag Y, Meyer AJ, Dick TP (2008) Real-time imaging of the intracellular glutathione redox potential. Nat Methods 5:553-559

2007

Kienast A, Preuss M, Winkler M, Dick TP (2007) Redox regulation of peptide receptivity of major histocompatibility complex class I molecules by ERp57 and tapasin. Nat Immunol 8:864-872

with News & Views: Construction and destruction of MHC class I in the peptide-loading complex

Schwertassek U, Balmer Y, Gutscher M, Weingarten L, Preuss M, Engelhard J, Winkler M, Dick TP (2007) Selective redox regulation of cytokine receptor signaling by extracellular thioredoxin-1. EMBO J 26:3086-3097

Schwertassek U, Weingarten L, Dick TP (2007) Identification of redox-active cell-surface proteins by mechanism-based kinetic trapping. Sci STKE 2007:pl8

to top