Research Group Translation Research for Ion Beam Therapy (E0408)

Group Leader: Prof. Dr. Oliver Jäkel (in ch.)

Translational research for ion beam therapy

Our research group focuses on further exploiting and developing the potential of proton and ion beams in radiotherapy and translating its research projects into clinical applications. Our primary research partner is the Heidelberg Ion Beam Therapy Facility (HIT) at the University Hospital Heidelberg.

HIT is the first European hospital based facility for scanned proton and heavy ion radiotherapy and has started its operation in November 2009. The projects at DKFZ have gained extensive experience with this treatment modality within a pilot project at the German heavy ion research center Helmholtzzentrum für Schwerionenforschung GmbH (GSI) in Darmstadt between 1997 and 2008.

Current research topics

  • Dosimetry
    • Track-based, in-vivo assessment of physical and biological dose
    • Subcellular energy deposition and impact on biological response
    • Dosimetry of secondary neutrons
    • Water calorimetry for ion beams (in cooperation with Physikalisch-Technische Bundesanstalt (PTB))
    • Experimental characterization and modeling of detector response
    • Dosimetry in strong magnetic fields
    • Key data for dosimetry in light ion beams
  • Monte Carlo Simulations
    • Simulations for Dosimetry in strong magnetic fields
    • Monte Carlo dose calculation for treatment planning in magnetic fields
    • Simulation for nanodosimetry of light ion beams
  • New imaging modalities for treatment planning
    • Dual energy computed tomography
    • Development of multi-modality phantoms

Selected publications

  • Burigo LN, Oborn BM. (2019), MRI-guided proton therapy planning: accounting for an inline MRI fringe field. Phys Med Biol. 2019 Nov 4;64(21):215015.
  • Burigo LN, Ramos-Méndez J, Bangert M, Schulte RW, Faddegon B. Simultaneous optimization of RBE-weighted dose and nanometric ionization distributions in treatment planning with carbon ions. Phys Med Biol. 2019 Jan 4;64(1):015015.
  • Möhler, C., Wohlfahrt, P., Richter, C. & Greilich, S. (2016), 'Range prediction for tissue mixtures based on dual-energy CT', Physics in Medicine and Biology 61(11), N268.
  • Niklas, M., Abdollahi, A., Akselrod, M. S., Debus, J., Jäkel, O., and Greilich, S. Subcellular spatial correlation of particle traversal and biological response in clinical ion beams. International Journal of Radiation Oncology*Biology*Physics, 2013, 87, 1141-1147.
  • Osinga-Blättermann JM, Brons S, Greilich S, Jäkel O, Krauss A. Direct determination of k Q for Farmer-type ionization chambers in a clinical scanned carbon ion beam using water calorimetry. Phys Med Biol. 2017 Mar 21;62(6):2033-2054

For a full list of articles, theses etc. from the division, see here. For more information on publications related to the group's projects, see here.

Contact

Prof. Dr. Oliver Jäkel (in ch.)

phone: +49 6221 42-2420
fax:      +49 6221 42-2561

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