Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
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- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
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- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
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- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
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- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
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- Cancer Risk Factors and Prevention
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- Biostatistics
- Clinical Epidemiology and Aging Research
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- Preventive Oncology
- Personalized Early Detection of Prostate Cancer
- Digital Biomarkers for Oncology
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- Cellular Immunology
- Molecular Oncology of Gastrointestinal Tumors
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- T Cell Metabolism
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Translational Immunotherapy
- B Cell Immunology
- Immune Diversity
- Structural Biology of Infection and Immunity
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
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- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
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- Medical Physics in Radiology
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- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Molecular Biology of Systemic Radiotherapy
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Molecular Mechanisms of Head and Neck Tumors
- Radiology
- Infection, Inflammation and Cancer
- Tumor Virology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Applied Tumor Biology
- Virotherapy
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Experimental Hepatology, Inflammation and Cancer
- Infections and Cancer Epidemiology
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Cell Biology and Tumor Biology
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Publications of Molecular Genetics 2023
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Lopez, C. ; Schleussner, N. ; Bernhart, S. H. ; Kleinheinz, K. ; Sungalee, S. ; Sczakiel, H. L. ; Kretzmer, H. ; Toprak, U. H. ; Glaser, S. ; Wagener, R. ; Ammerpohl, O. ; Bens, S. ; Giefing, M. ; Sanchez, J. C. G. ; Apic, G. ; Hubschmann, D. ; Janz, M. ; Kreuz, M. ; Mottok, A. ; Muller, J. M. ; Seufert, J. ; Hoffmann, S. ; Korbel, J. O. ; Russell, R. B. ; Schule, R. ; Trumper, L. ; Klapper, W. ; Radlwimmer, B. ; Lichter, P. ; Kuppers, R. ; Schlesner, M. ; Mathas, S. ; Siebert, R.
Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B cell lymphomas.
Haematologica 108(2), 543-554 (2023) [10.3324/haematol.2021.280005]2023
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Schmid, C. D. ; Olsavszky, V. ; Reinhart, M. ; Weyer, V. ; Trogisch, F. A. ; Sticht, C. ; Winkler, M. ; Kürschner, S. W. ; Hoffmann, J. ; Ola, R. ; Staniczek, T. ; Heineke, J. ; Straub, B. K. ; Mittler, J. ; Schledzewski, K. ; Ten Dijke, P. ; Richter, K. ; Dooley, S. ; Géraud, C. ; Goerdt, S. ; Koch, P.-S.
ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver.
Hepatology 77(4), 1211-1227 (2023) [10.1002/hep.32641]2023
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Wahida, A. (First author) ; Buschhorn, L. (First author) ; Fröhling, S. ; Jost, P. J. ; Schneeweiss, A. ; Lichter, P. ; Kurzrock, R.
The coming decade in precision oncology: six riddles.
Nature reviews / Cancer 23(1), 43-54 (2023) [10.1038/s41568-022-00529-3]2023
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Sigismondo, G. (First author) ; Arseni, L. ; Palacio-Escat, N. ; Hofmann, T. G. ; Seiffert, M. ; Krijgsveld, J. (Last author)
Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair.
Nucleic acids research 51(2), 687-711 (2023) [10.1093/nar/gkac1264]2023
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Broséus, J. ; Hergalant, S. ; Vogt, J. ; Tausch, E. ; Kreuz, M. ; Mottok, A. ; Schneider, C. ; Dartigeas, C. ; Roos-Weil, D. ; Quinquenel, A. ; Moulin, C. ; Ott, G. ; Blanchet, O. ; Tomowiak, C. ; Lazarian, G. ; Rouyer, P. ; Chteinberg, E. ; Bernhart, S. H. ; Tournilhac, O. ; Gauchotte, G. ; Lomazzi, S. ; Chapiro, E. ; Nguyen-Khac, F. ; Chery, C. ; Davi, F. ; Hunault, M. ; Houlgatte, R. ; Rosenwald, A. ; Delmer, A. ; Meyre, D. ; Béné, M.-C. ; Thieblemont, C. ; Lichter, P. ; Ammerpohl, O. ; Guéant, J.-L. ; Consortium, I. M. (Collaboration Author) ; Guièze, R. ; Martin-Subero, J. I. ; Cymbalista, F. ; Feugier, P. ; Siebert, R. ; Stilgenbauer, S. ; Bernhart, S. (Contributor)
Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.
Nature Communications 14(1), 309 (2023) [10.1038/s41467-022-34642-6]2023
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Arseni, L. (First author) ; Sharma, R. ; Mack, N. ; Nagalla, D. ; Ohl, S. ; Hielscher, T. ; Singhal, M. ; Engel, R. ; Augustin, H. ; Sandhoff, R. ; Herold-Mende, C. ; Tews, B. ; Lichter, P. ; Seiffert, M. (Last author)
Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression.
Cancers 15(2), 479 (2023) [10.3390/cancers15020479]2023
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Gerstung, M. ; Jolly, C. ; Leshchiner, I. ; et al
Author Correction: The evolutionary history of 2,658 cancers
Nature <London> 614(7948), p. E42 (2023) [10.1038/s41586-022-05601-4]2023
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Rheinbay, E. ; Nielsen, M. M. ; Abascal, F. ; et al
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Nature <London> 614(7948), p. E40 (2023) [10.1038/s41586-022-05599-9]2023
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Calabrese, C. ; Davidson, N. R. ; Demircio?lu, D. ; et al
Author Correction: Genomic basis for RNA alterations in cancer
Nature <London> 614(7948), p. E37 (2023) [10.1038/s41586-022-05596-y]2023
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Alexandrov, L. B. ; Kim, J. ; Haradhvala, N. J. ; et al
Author Correction: The repertoire of mutational signatures in human cancer
Nature <London> 614, E41 (2023) [10.1038/s41586-022-05600-5]2023
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Li, Y. ; Roberts, N. D. ; Wala, J. A. ; et al
Author Correction: Patterns of somatic structural variation in human cancer genomes
Nature <London> 614, E38 (2023) [10.1038/s41586-022-05597-x]2023
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Aaltonen, L. A. ; Abascal, F. ; Abeshouse, A. ; et al
Author Correction: Pan-cancer analysis of whole genomes
Nature <London> 614, E39 (2023) [10.1038/s41586-022-05598-w]2023
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Seiffert, M. (Last author)
TIGIT - an immune checkpoint beyond T cells in chronic lymphocytic leukemia.
Haematologica 108(8), 1979-1981 (2023) [10.3324/haematol.2023.282687]2023
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Faehling, S. (First author) ; Coelho, M. ; Floerchinger, A. ; Schneider, C. ; Stilgenbauer, S. ; Lichter, P. ; Seiffert, M. (Last author) ; Roessner, P. M. (Last author)
Simultaneous Inhibition of PI3Kgamma and PI3Kdelta Deteriorates T-cell Function With Implications for Chronic Lymphocytic Leukemia
HemaSphere 7(3), e840 (2023) [10.1097/HS9.0000000000000840]2023
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Nagy, F. I. ; Adamecz, D. I. ; Baji, Á. ; Kiricsi, Á. ; Huliák, I. ; Rónavári, A. ; Kónya, Z. ; Frank, É. ; Gopisetty, M. K. ; Kiricsi, M.
Semi-Synthetic Dihydrotestosterone Derivatives Modulate Inherent Multidrug Resistance and Sensitize Colon Cancer Cells to Chemotherapy.
Pharmaceutics 15(2), 584 (2023) [10.3390/pharmaceutics15020584]2023
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Bartkowiak, K. ; Mossahebi Mohammadi, P. ; Gärtner, S. ; Kwiatkowski, M. ; Andreas, A. ; Geffken, M. ; Peine, S. ; Verpoort, K. ; Scholz, U. ; Deutsch, T. M. ; Michel, L. L. ; Schneeweiss, A. ; Thewes, V. ; Trumpp, A. ; Müller, V. ; Riethdorf, S. ; Schlüter, H. ; Pantel, K.
Detection and Isolation of Circulating Tumor Cells from Breast Cancer Patients Using CUB Domain-Containing Protein 1.
Journal of proteome research 22(4), 1213-1230 (2023) [10.1021/acs.jproteome.2c00739]2023
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Wahida, A. (First author) ; Conrad, M.
Ferroptosis: Under pressure!
Current biology 33(7), R269 - R272 (2023) [10.1016/j.cub.2023.03.009]2023
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Akdemir, K. C. ; Le, V. T. ; Chandran, S. ; et al
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Nature genetics 55, 1079 (2023) [10.1038/s41588-023-01318-w]2023
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Zapatka, M. ; Borozan, I. ; Brewer, D. S. ; et al
Author Correction: The landscape of viral associations in human cancers
Nature genetics 55(6), 1077 (2023) [10.1038/s41588-023-01316-y]2023
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Buschhorn, L. (First author) ; Odoni, D. I. ; Geuder, J. ; Odinius, T. O. ; Wagner, C. V. ; Jilg, S. ; Höckendorf, U. ; Wahida, A. ; Schlesner, M. ; Reiter, A. ; Jawhar, M. ; Jost, P. J.
Transcriptomic profiling does dot refine mastocytosis diagnosis.
Haematologica nn, nn (2023) [10.3324/haematol.2022.282617]2023
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Pagano, G. ; Botana, I. F. ; Wierz, M. ; Roessner, P. M. ; Ioannou, N. ; Zhou, X. ; Al-Hity, G. ; Borne, C. ; Gargiulo, E. ; Gonder, S. ; Qu, B. ; Stamatopoulos, B. ; Ramsay, A. G. ; Seiffert, M. ; Largeot, A. ; Moussay, E. ; Paggetti, J.
Interleukin-27 potentiates CD8+ T-cell-mediated anti-tumor immunity in chronic lymphocytic leukemia.
Haematologica nn, nn (2023) [10.3324/haematol.2022.282474]2023
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Wong, J. K. L. (First author) ; Jassowicz, L. ; Herold-Mende, C. ; Seiffert, M. ; Mallm, J.-P. ; Lichter, P. ; Zapatka, M. (Last author)
scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis.
BMC bioinformatics 24(1), 326 (2023) [10.1186/s12859-023-05440-8]2023
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Fermi, V. ; Warta, R. ; Wöllner, A. ; Lotsch, C. ; Jassowicz, L. ; Rapp, C. ; Knoll, M. ; Jungwirth, G. ; Jungk, C. ; Dao Trong, P. ; von Deimling, A. ; Abdollahi, A. ; Unterberg, A. ; Herold-Mende, C.
Effective reprogramming of patient-derived M2-polarized glioblastoma-associated microglia/macrophages by treatment with GW2580.
Clinical cancer research nn, nn (2023) [10.1158/1078-0432.CCR-23-0576]2023
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