Publications of Molecular Genetics
2020
Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.
Leukemia 34(1), 100-114 (2020) [10.1038/s41375-019-0507-8]
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Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL.
Leukemia 34(1), 115-127 (2020) [10.1038/s41375-019-0513-x]
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Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation.
International journal of cancer 146(5), 1281-1292 (2020) [10.1002/ijc.32649]
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CD8+ T-cells of CLL-bearing mice acquire a transcriptional program of T-cell activation and exhaustion.
Leukemia and lymphoma 61(2), 351-356 (2020) [10.1080/10428194.2019.1660972]
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TBET-expressing Th1 CD4+ T cells accumulate in chronic lymphocytic leukaemia without affecting disease progression in Eµ-TCL1 mice.
British journal of haematology 189(1), 133-145 (2020) [10.1111/bjh.16316]
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Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.
Acta neuropathologica 139(2), 243-257 (2020) [10.1007/s00401-019-02101-0]
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Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data.
Nature protocols 15(2), 479-512 (2020) [10.1038/s41596-019-0251-6]
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Genomic basis for RNA alterations in cancer.
Nature <London> 578(7793), 129 - 136 (2020) [10.1038/s41586-020-1970-0]
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The evolutionary history of 2,658 cancers.
Nature <London> 578(7793), 122 - 128 (2020) [10.1038/s41586-019-1907-7]
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The landscape of viral associations in human cancers.
Nature genetics 52(3), 320-330 (2020) [10.1038/s41588-019-0558-9]
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.
Nature genetics 52(3), 294-305 (2020) [10.1038/s41588-019-0564-y]
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Hypoxia and the hypoxia inducible factor 1? activate protein kinase A by repressing RII beta subunit transcription.
Oncogene 39(16), 3367-3380 (2020) [10.1038/s41388-020-1223-6]
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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Genome medicine 12(1), 29 (2020) [10.1186/s13073-020-00724-7]
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Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response.
Neuro-Oncology 22(9), 1327-1338 (2020) [10.1093/neuonc/noaa035]
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HIF-1?: a potential treatment target in chronic lymphocytic leukemia.
Haematologica 105(4), 856 - 858 (2020) [10.3324/haematol.2019.246330]
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Vimentin S-glutathionylation at Cys328 inhibits filament elongation and induces severing of mature filaments in vitro.
The FEBS journal 287(24), 5304-5322 (2020) [10.1111/febs.15321]
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Germline Elongator mutations in Sonic Hedgehog medulloblastoma
Nature <London> 580(7803), 396 - 401 (2020) [10.1038/s41586-020-2164-5]
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Leucine and branched chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling.
Biochemical journal 477(9), 1579-1599 (2020) [10.1042/BCJ20190754]
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DNA methylation of chronic lymphocytic leukemia with differential response to chemotherapy.
Scientific data 7(1), 133 (2020) [10.1038/s41597-020-0456-0]
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The landscape of chromothripsis across adult cancer types.
Nature Communications 11(1), 2320 (2020) [10.1038/s41467-020-16134-7]
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Pan-cancer analysis of whole genomes.
Nature <London> 578(7793), 82 - 93 (2020) [10.1038/s41586-020-1969-6]
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Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels.
Nature cell biology 22(7), 896 - 906 (2020) [10.1038/s41556-020-0532-x]
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Effect of Divalent Cations on the Structure and Mechanics of Vimentin Intermediate Filaments.
Biophysical journal 119(1), 55 - 64 (2020) [10.1016/j.bpj.2020.05.016]
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Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
International journal of molecular sciences 21(15), E5586 (2020) [10.3390/ijms21155586]
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IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Cell 182(5), 1252-1270.e34 (2020) [10.1016/j.cell.2020.07.038]
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LifeTime and improving European healthcare through cell-based interceptive medicine.
Nature <London> 587(7834), 377-386 (2020) [10.1038/s41586-020-2715-9]
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Patterns of somatic structural variation in human cancer genomes.
Nature <London> 578(7793), 112 - 121 (2020) [10.1038/s41586-019-1913-9]
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T-cells in chronic lymphocytic leukemia: Guardians or drivers of disease?
Leukemia 34(8), 2012 - 2024 (2020) [10.1038/s41375-020-0873-2]
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Nature Communications 11(1), 4748 (2020) [10.1038/s41467-020-18151-y]
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Chromothripsis in Human Breast Cancer.
Cancer research 80(22), 4918 - 4931 (2020) [10.1158/0008-5472.CAN-20-1920]
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Dual Functional States of R406W-Desmin Assembly Complexes Cause Cardiomyopathy With Severe Intercalated Disc Derangement in Humans and in Knock-In Mice
Circulation 142(22), 2155 - 2171 (2020) [10.1161/CIRCULATIONAHA.120.050218]
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Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype.
Nature Communications 11(1), 6434 (2020) [10.1038/s41467-020-20225-w]
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NOX2-Derived Reactive Oxygen Species in Cancer.
Oxidative medicine and cellular longevity 2020, rticle ID 7095902 (2020) [10.1155/2020/7095902]
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.
Nature Communications 11(1), 736 (2020) [10.1038/s41467-019-13885-w]
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The repertoire of mutational signatures in human cancer.
Nature <London> 578(7793), 94 - 101 (2020) [10.1038/s41586-020-1943-3]
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Integrative pathway enrichment analysis of multivariate omics data.
Nature Communications 11(1), 735 (2020) [10.1038/s41467-019-13983-9]
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Combined burden and functional impact tests for cancer driver discovery using DriverPower.
Nature Communications 11(1), 734 (2020) [10.1038/s41467-019-13929-1]
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Divergent mutational processes distinguish hypoxic and normoxic tumours.
Nature Communications 11(1), 737 (2020) [10.1038/s41467-019-14052-x]
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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Nature Communications 11(1), 731 (2020) [10.1038/s41467-020-14352-7]
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Pathway and network analysis of more than 2500 whole cancer genomes.
Nature Communications 11(1), 729 (2020) [10.1038/s41467-020-14367-0]
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
Nature Communications 11(1), 728 (2020) [10.1038/s41467-019-13825-8]
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Inferring structural variant cancer cell fraction.
Nature Communications 11(1), 730 (2020) [10.1038/s41467-020-14351-8]
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Sex differences in oncogenic mutational processes
Nature Communications 11(1), 4330 (2020) [10.1038/s41467-020-17359-2]
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Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis
Communications biology 3(1), 56 (2020) [10.1038/s42003-019-0741-7]
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Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
Nature <London> 578(7793), 102 - 111 (2020) [10.1038/s41586-020-1965-x]
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