Are high blood glucose levels an effect rather than the cause of the disease?

Insulin resistance and elevated blood glucose levels are considered to be the cause of type 2 diabetes. However, scientists from the German Cancer Research Center (DKFZ) and Heidelberg University Hospital have now provided evidence that things might be completely different. They showed in flies that elevated levels of the metabolite MG (methylglyoxal) cause the typical diabetic disturbances of the metabolism and lead to insulin resistance, obesity and elevated blood sugar levels.

Hopp Children's Cancer Center at the NCT

Combination therapy in neuroblastoma: It`s all about the mix

The combination of two cell division inhibitors causes malignant nervous system tumors to die off, as scientists from the "Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ) have shown in experimental studies.The combination strategy could be the key to new targeted therapies against this aggressive type of tumor.

Hopp Children's Cancer Center at the NCT

A molecular map of childhood cancers

Researchers led by Professor Stefan Pfister from the "Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ) have been able to draw an extremely detailed molecular map of childhood cancers. In close collaboration with the German Cancer Consortium (DKTK) and the Society for Pediatric Oncology and Hematology (GPOH), they screened almost 1,000 tumor samples from 24 cancer types for genetic alterations and then classified these alterations. In 50 percent of the samples, they found targets for novel anticancer drugs, thus opening up new therapy approaches. The findings have now been published in Nature.

We are asking for your support

Your Donation for Cancer Research
Latest News

Metastasis: Cell polarity matters

Not only the number of migrating cancer cells determines the risk for metastasis but also their characteristics, scientists from the German Cancer Research Center (DKFZ) have now reported. For circulating cancer cells to be able to invade tissues and settle at other sites in the body, they have to exhibit a specific polarity. This discovery might in future help to better predict individual risk for metastasis and find appropriate therapies that can reduce it.

March: Bowel Cancer Awareness Month

Colorectal cancer: Combined analysis enhances risk prediction

If first-degree relatives are affected by colorectal cancer, this indicates a person's own elevated risk of developing bowel cancer. The same holds true for people who have large numbers of genetic risk markers in their genome. Both factors are usually used alternatively, not combined, to predict risk. Scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now shown that a combination of family history and an analysis of genetic markers helps determine a person's colorectal cancer risk more precisely.


German Cancer Award for Michael Baumann

Michael Baumann, Chairman and Scientific Director of the German Cancer Research Center (DKFZ) in Heidelberg, receives the 2017 German Cancer Award in the category "Translational Research". The science award, which is sponsored by the German Cancer Society and the German Cancer Foundation, is one of the most prestigious distinctions in cancer medicine in Germany.


Search for research topic

Latest News

Breast cancer: How advanced imaging technologies will help avoid unnecessary biopsies

Enhancing the diagnosis of breast cancer is the stated goal of a research team at the German Cancer Research Center (DKFZ) in Heidelberg. The scientists have combined an advanced method of diffusion-weighted MR imaging with intelligent image analysis methods to detect malignant changes in tissues. This method may help avoid many control biopsies following suspicious findings from mammography screening, the scientists have now demonstrated in a study that was supported by the Dietmar Hopp Foundation. This advancement holds promise for substantial improvements in the diagnosis of breast cancer.

ERC Consolidator Grant

European excellence grant for DKFZ researcher

The ERC Consolidator Grants by the European Research Council (ERC) support excellent researchers to help them consolidate their independent career. Ana Martin-Villalba from the German Cancer Research Center (DKFZ) has now received this prestigious ERC grant. Martin-Villalba will use the €2 million grant to investigate how repair processes can be stimulated in the adult brain following injury or disease. Martin-Villalba plans to specifically activate the development potential of stem cells in the brain to replace lost brain cells.

Latest News

“Lightning protectors” protect cells from oxidative damage

Scientists from the German Cancer Research Center (DKFZ) have been able to unravel how acetylcysteine, a well-known agent used as a cough medication, can protect cells from oxidative stress. In the cell, the substance is rapidly transformed into so-called persulfides. These sulfur compounds unfold their protective effect on the cell by diverting oxidation very efficiently towards themselves, similar to a lightning protector.

to top