Award

Meyenburg Prize 2019 for outstanding research on leukemia

The Meyenburg Prize 2019, which carries prize money of 50,000 euros, goes to Benjamin L. Ebert from the Dana-Farber Cancer Institute in Boston for his outstanding research results on the pathogenesis and treatment of leukemia. The award ceremony will take place on Thursday, November 7, 2019 as part of a symposium at the German Cancer Research Center.

DKTK Tübingen

Bispecific antibody to be tested for treatment of prostate cancer

Prostate carcinoma is the most common type of cancer in men. If the tumor metastasizes, it is not curable by established treatment modalities.. The German Cancer Consortium (DKTK) is launching a clinical phase I study in November to test a bispecific antibody with the aim of achieving a significant improvement for patientswith this type of cancer. The bispecific antibody has been developed in Tübingen. The study is supported by the Helmholtz Validation Fund and the DKTK.

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Protein misfolding as a risk marker for Alzheimer’s disease – up to 14 years before the diagnosis

In symptom-free individuals, the detection of misfolded amyloid-β protein in the blood indicated a considerably higher risk of Alzheimer's disease – up to 14 years before a clinical diagnosis was made. Amyloid-β folding proved to be superior to other risk markers evaluated, as shown by scientists from the German Cancer Research Center (DKFZ), Ruhr University Bochum (RUB), the Saarland Cancer Registry, and the Network Aging Research at Heidelberg University.

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HPV vaccination rate of 70 percent is possible and reasonable

Germany needs to agree on a target for the HPV vaccination rate in order to protect more people against cancer caused by human papillomavirus (HPV). Representatives from the health sector, research, and politics attended a Round Table to Eradicate HPV-Related Cancer to achieve this goal in response to an invitation from the German Cancer Research Center (DKFZ) and the Preventa Foundation. The participants agreed on the goal of achieving a vaccination rate of at least 70 percent among 15-year-olds across the country within the next five years. School vaccinations, invitation processes, vaccination consultations, uniform prescription processes throughout Germany, and a centrally managed information campaign can help achieve this goal.

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Familial risk of colorectal cancer: the genes only tell part of the story

On the basis of a current epidemiological study, scientists at the German Cancer Research Center (DKFZ) conclude that the role of genes has been overestimated in patients with a higher familial risk of colorectal cancer. Other risk factors such as family dietary habits presumably have a greater impact that previously assumed. This will have implications for future calculations of individual risk and for the ensuing recommendations.

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Neurons promote growth of brain tumor cells

In a current paper published in the journal “Nature”, Heidelberg-based researchers and physicians describe how neurons in the brain establish contact with aggressive glioblastomas and thus promote tumor growth / New tumor activation mechanism provides starting points for clinical trials

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Biological mechanism explained

How lymphoma cells form brain metastases

Lymphomas in the central nervous system are rare but dangerous. Scientists at the German Cancer Research Center (DKFZ) have now discovered which molecular mechanism leads to lymphomas forming metastases in the central nervous system. Using a mouse model, the researchers showed that chronic inflammatory processes in aging brains lead to lymphoma cells that have entered the brain tissue being retained instead of being released directly back into the blood. They also identified key molecules of this mechanism in tissue samples from patients with lymphomas of the central nervous system. The researchers therefore hope to have identified a potential approach for developing new therapeutic approaches.

1st National Cancer Prevention Week

Harnessing the full potential of cancer prevention

Around 40 percent of all new cases of cancer diagnosed in Germany every year could be avoided if all the scientifically proven preventive measures were actually implemented. Experts believe that future findings in prevention research will increase this figure even further. A new strategic partnership between the German Cancer Research Center (DKFZ) and German Cancer Aid is designed to harness the considerable potential of prevention more effectively. The press conference to mark the start of the partnership was also attended by Anja Karliczek, Federal Minister of Education and Research, and Jens Spahn, Federal Minister of Health. The partnership is a contribution by DKFZ and German Cancer Aid to the National Decade Against Cancer.

Black sheep:

Why some strains of the Epstein Barr virus cause cancer

The Epstein Barr virus (EBV) is very widespread. More than 90 percent of the world's population is infected – with very different consequences. Although the infection does not usually affect people, in some it can cause glandular fever or various types of cancer. Researchers at the German Cancer Research Center (DKFZ) have now discovered why different virus strains cause very divergent courses of disease.

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