Latest News

Cancer drugs promote stem cell properties of colorectal cancer

Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center have now discovered that a certain group of cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells. This can lead to the accumulation of tumor cells with stem cell characteristics that are resistant to many therapies and can lead to relapses. The researchers thus provide a possible explanation for why these drugs are not effective in colorectal cancer.

Deadline 31st May 2019

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Glioblastoma

Fatty acid metabolism as a possible new therapeutic approach

In order to gain enough energy for their rapid growth, glioblastoma cells reprogram their fatty acid metabolism. How they do this has been unclear until now. Researchers at the German Cancer Research Center in Heidelberg have now discovered that a protein called ACBP (acyl-CoA-binding protein) enhances the transport of fatty acids into the mitochondria. This provides glioblastoma cells with the necessary energy source for their rapid growth. This discovery is not only scientifically relevant, but may also offer new therapeutic approaches for an aggressive tumor with a poor prognosis.

DKTK

Fighting colon cancer with killer cells

Genetically modified immune cells can successfully destroy colon cancer cells. This has been demonstrated for the first time by scientists from the German Cancer Consortium (DKTK) at Georg Speyer House in Frankfurt using mini-tumors produced in the lab. They are making use of a new approach in cancer immunotherapy: genetically modified natural killer cells. Using patient-specific tumor cultures, scientists can now run tests in the lab to see how effective the killer cells will be in individual patients.

Latest News

Targeted approach to therapy for rare type of bone cancer

Chordomas are rare bone tumors for which only few options of treatment exist. Scientists and doctors from the National Center for Tumor Diseases (NCT), the German Cancer Research Center (DKFZ), and Heidelberg University Hospital (UKHD) have discovered a particular genetic trait of chordomas in advanced stages after conducting gene analysis.

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Latest News

Artificial intelligence helps to better assess treatment response of brain tumors

A team from Heidelberg University Hospital and the German Cancer Research Centre has developed a new method for the automated image analysis of brain tumors. In their recent publication, the authors show that machine learning methods carefully trained on standard magnetic resonance imaging (MRI) are more reliable and precise than established radiological methods in the treatment of brain tumors. Thus, they make a valuable contribution to the individualized treatment of tumors. In addition, the validated method is an important first step towards the automated high-throughput analysis of medical image data of brain tumors.

Blocking platelets

A possible option to prevent fatty liver disease and liver cancer

Blood platelets which interact with liver cells and immune cells play a major role in the development of fatty liver disease, non-alcoholic fatty liver inflammation and liver cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg and from Zurich University and University Hospital have now shown in a publication. The researchers have also worked out new approaches for using drugs to keep the development of fatty liver disease in check, thus preventing liver cancer in the long term.

Latest News

The evolution of brain tumors

Scientists from the German Cancer Research Center found in a recent study that only three different genetic alterations drive the early development of malignant glioblastomas. At least one of these three cancer drivers was present in all tumors investigated. However, it is the activation of telomerase that leads to rapid growth. The tumors develop for up to seven years before they become noticeable as symptoms and are diagnosed. However, in contrast to their early development, glioblastomas, which return after therapy, share virtually no concurrent genetic alterations.

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