Biological mechanism explained

How lymphoma cells form brain metastases

Lymphomas in the central nervous system are rare but dangerous. Scientists at the German Cancer Research Center (DKFZ) have now discovered which molecular mechanism leads to lymphomas forming metastases in the central nervous system. Using a mouse model, the researchers showed that chronic inflammatory processes in aging brains lead to lymphoma cells that have entered the brain tissue being retained instead of being released directly back into the blood. They also identified key molecules of this mechanism in tissue samples from patients with lymphomas of the central nervous system. The researchers therefore hope to have identified a potential approach for developing new therapeutic approaches.

1st National Cancer Prevention Week

Harnessing the full potential of cancer prevention

Around 40 percent of all new cases of cancer diagnosed in Germany every year could be avoided if all the scientifically proven preventive measures were actually implemented. Experts believe that future findings in prevention research will increase this figure even further. A new strategic partnership between the German Cancer Research Center (DKFZ) and German Cancer Aid is designed to harness the considerable potential of prevention more effectively. The press conference to mark the start of the partnership was also attended by Anja Karliczek, Federal Minister of Education and Research, and Jens Spahn, Federal Minister of Health. The partnership is a contribution by DKFZ and German Cancer Aid to the National Decade Against Cancer.

Black sheep:

Why some strains of the Epstein Barr virus cause cancer

The Epstein Barr virus (EBV) is very widespread. More than 90 percent of the world's population is infected – with very different consequences. Although the infection does not usually affect people, in some it can cause glandular fever or various types of cancer. Researchers at the German Cancer Research Center (DKFZ) have now discovered why different virus strains cause very divergent courses of disease.

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First indication of possible role of blood coagulation in lung carcinogenesis

Thrombophilia promotes the progression and metastasis of lung cancer. Up to now, it was not known whether coagulation is also conducive to tumorigenesis. For the first time, researchers from the German Cancer Research Center have now identified a possible role of blood coagulation in the development of lung cancer.

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Founding ceremony of the DKFZ–Hector Cancer Institute at the University Medical Center Mannheim

At a ceremony held on July 31, the German Cancer Research Center (DKFZ), the Medical Faculty Mannheim of Heidelberg University, and Mannheim University Hospital set up a new cooperation project: At the new DKFZ–Hector Cancer Institute at the University Medical Center Mannheim, DKFZ and the University Medical Center Mannheim (UMM) aim to conduct patient-focused translational cancer research at the highest international level. Over the next ten years, the Hector Foundation II is providing 25 million euros for the long-term partnership.

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First branch of the German Cancer Research Center in Dresden for intelligent technologies in the fight against cancer

With support from the State of Saxony, the German Cancer Research Center (DKFZ) plans to step up cancer research considerably at the Dresden site. DKFZ's first branch outside Heidelberg is to work on pioneering technologies that use smart sensors and artificial intelligence to improve the prevention and treatment of cancer. A dedicated building will be erected on the Oncology Campus of Dresden University Medicine at TU Dresden.


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How resistance to important cancer drugs develops

Taxanes, frequently used anti-cancer drugs, block cell division and thereby drive tumor cells into cell death. However, therapy resistance often develops in the course of the treatment. Scientists from the German Cancer Research Center have now discovered how cancer cells degrade a protein that induces cell death in cases of failed mitosis. If this tumor brake is missing, the cancer cells survive and are resistant to the effect of taxanes.

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Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal "Nature", scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results.

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Enzyme responsible for dangerous properties of brain tumor stem cells

The relapse of brain tumors after therapy is driven by cancer stem cells that were not affected by the treatment. In mouse models of glioblastoma, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) were now looking for molecular markers that specifically characterize brain tumor stem cells. They identified an enzyme that is responsible for the threatening stem cell properties of glioblastoma and at the same time represents a possible "Achilles heel" where cancer stem cells could be vulnerable.

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