EPIC-Heidelberg

First indication of possible role of blood coagulation in lung carcinogenesis

Thrombophilia promotes the progression and metastasis of lung cancer. Up to now, it was not known whether coagulation is also conducive to tumorigenesis. For the first time, researchers from the German Cancer Research Center have now identified a possible role of blood coagulation in the development of lung cancer.

Deadline 15th September 2019

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Founding ceremony of the DKFZ–Hector Cancer Institute at the University Medical Center Mannheim

At a ceremony held on July 31, the German Cancer Research Center (DKFZ), the Medical Faculty Mannheim of Heidelberg University, and Mannheim University Hospital set up a new cooperation project: At the new DKFZ–Hector Cancer Institute at the University Medical Center Mannheim, DKFZ and the University Medical Center Mannheim (UMM) aim to conduct patient-focused translational cancer research at the highest international level. Over the next ten years, the Hector Foundation II is providing 25 million euros for the long-term partnership.

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How resistance to important cancer drugs develops

Taxanes, frequently used anti-cancer drugs, block cell division and thereby drive tumor cells into cell death. However, therapy resistance often develops in the course of the treatment. Scientists from the German Cancer Research Center have now discovered how cancer cells degrade a protein that induces cell death in cases of failed mitosis. If this tumor brake is missing, the cancer cells survive and are resistant to the effect of taxanes.

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Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal "Nature", scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results.

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Enzyme responsible for dangerous properties of brain tumor stem cells

The relapse of brain tumors after therapy is driven by cancer stem cells that were not affected by the treatment. In mouse models of glioblastoma, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) were now looking for molecular markers that specifically characterize brain tumor stem cells. They identified an enzyme that is responsible for the threatening stem cell properties of glioblastoma and at the same time represents a possible "Achilles heel" where cancer stem cells could be vulnerable.

"Highly cited"

Nine DKFZ researchers in the top class

Scientists whose work is being cited very often by peers are regarded as exceptionally acknowledged and influential in their fields. Therefore, citation counts are a common benchmark for assessing the scientific performance of individual researchers. For 2018, nine scientists from the German Cancer Research Center (DKFZ) reached a top place in this assessment: They rank in the top 1% of the world's highly cited researchers for their field.

Lung cancer screening

Women benefit significantly

Is computed tomography suitable for detecting lung cancer at a very early stage and thus still well treatable? Scientists at the German Cancer Research Center have investigated this with the LUSI study started in 2007. The results of the study, which is funded by the Deutsche Forschungsgemeinschaft and the Dietmar Hopp Foundation, are now available: Taken together, the screening slightly but not significantly reduced lung cancer mortality in both sexes. In contrast, the researchers observed a significant 69 percent reduction in relative risk among women. The results confirm comparable European studies which, taken together, provide strong arguments for the introduction of systematic lung cancer screening for high-risk groups.

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