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Selected Publications / Patents

Kreutzer L, Weber P, Heider T, Heikenwälder M, Riedl T, Baumeister P, Klauschen F, Belka C, Walch A, Zitzelsberger H, Hess J, Unger K.
Simultaneous metabolite MALDI-MSI, whole exome and transcriptome analysis from formalin-fixed paraffin-embedded tissue sections.
Lab Invest. 2022 Aug 31. doi: 10.1038/s41374-022-00829-0. Online ahead of print.PMID: 36045222

Rosenberg N, Van Haele M, Lanton T, Brashi N, Bromberg Z, Adler H, Giladi H, Peled A, Goldenberg DS, Axelrod JH, Simerzin A, Chai C, Paldor M, Markezana A, Yaish D, Shemulian Z, Gross D, Barnoy S, Gefen M, Amran O, Claerhout S, Fernández-Vaquero M, García-Beccaria M, Heide D, Shoshkes-Carmel M, Schmidt Arras D, Elgavish S, Nevo Y, Benyamini H, Tirnitz-Parker JEE, Sanchez A, Herrera B, Safadi R, Kaestner KH, Rose-John S, Roskams T, Heikenwalder M, Galun E.
Combined hepatocellular-cholangiocarcinoma derives from liver progenitor cells and depends on senescence and IL6 trans-signaling.
J Hepatol. 2022 Aug 18:S0168-8278(22)02995-6. doi: 10.1016/j.jhep.2022.07.029. Online ahead of print.PMID: 35988690

Donne R, Saroul-Ainama M, Cordier P, Hammoutene A, Kabore C, Stadler M, Nemazanyy I, Galy-Fauroux I, Herrag M, Riedl T, Chansel-Da Cruz M, Caruso S, Bonnafous S, Öllinger R, Rad R, Unger K, Tran A, Couty JP, Gual P, Paradis V, Celton-Morizur S, Heikenwalder M, Revy P, Desdouets C.
Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD.
Dev Cell. 2022 Jun 23:S1534-5807(22)00412-9. doi: 10.1016/j.devcel.2022.06.003. Online ahead of print.PMID: 35768000

Peiseler M, Schwabe R, Hampe J, Kubes P, Heikenwälder M, Tacke F.
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease - novel insights into cellular communication circuits.
J Hepatol. 2022 Jun 21:S0168-8278(22)00375-0. doi: 10.1016/j.jhep.2022.06.012. Online ahead of print.PMID: 35750137 Review.

Gallage S, García-Beccaria M, Szydlowska M, Rahbari M, Mohr R, Tacke F, Heikenwalder M.
The therapeutic landscape of hepatocellular carcinoma.
Med (N Y). 2021 May 14;2(5):505-552. doi: 10.1016/j.medj.2021.03.002. Epub 2021 Apr 27.PMID: 35590232 Free article. Review.

Leslie J, Mackey JBG, Jamieson T, Ramon-Gil E, Drake TM, Fercoq F, Clark W, Gilroy K, Hedley A, Nixon C, Luli S, Laszczewska M, Pinyol R, Esteban-Fabró R, Willoughby CE, Haber PK, Andreu-Oller C, Rahbari M, Fan C, Pfister D, Raman S, Wilson N, Müller M, Collins A, Geh D, Fuller A, McDonald D, Hulme G, Filby A, Cortes-Lavaud X, Mohamed NE, Ford CA, Raffo Iraolagoitia XL, McFarlane AJ, McCain MV, Ridgway RA, Roberts EW, Barry ST, Graham GJ, Heikenwälder M, Reeves HL, Llovet JM, Carlin LM, Bird TG, Sansom OJ, Mann DA.
CXCR2 inhibition enables NASH-HCC immunotherapy.
Gut. 2022 Apr 27:gutjnl-2021-326259. doi: 10.1136/gutjnl-2021-326259. Online ahead of print.PMID: 35477863 Free article.

Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M.
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury.
Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1.PMID: 35383158 Free article.

Michelet M, Alfaiate D, Chardès B, Pons C, Faure-Dupuy S, Engleitner T, Farhat R, Riedl T, Legrand AF, Rad R, Rivoire M, Zoulim F, Heikenwälder M, Salvetti A, Durantel D, Lucifora J.
Inducers of the NF-κB pathways impair hepatitis delta virus replication and strongly decrease progeny infectivity in vitro.
JHEP Rep. 2021 Dec 14;4(3):100415. doi: 10.1016/j.jhepr.2021.100415. eCollection 2022 Mar.PMID: 35141510 Free PMC article.

Quintavalle C, Meyer-Schaller N, Roessler S, Calabrese D, Marone R, Riedl T, Picco-Rey S, Panagiotou OA, Uzun S, Piscuoglio S, Boldanova T, Bian CB, Semela D, Jochum W, Cathomas G, Mertz KD, Diebold J, Mazzucchelli L, Koelzer VH, Weber A, Decaens T, Terracciano LM, Heikenwalder M, Hoshida Y, Andersen JB, Thorgeirsson SS, Matter MS.
miR-579-3p Controls Hepatocellular Carcinoma Formation by Regulating the Phosphoinositide 3-Kinase-Protein Kinase B Pathway in Chronically Inflamed Liver.
Hepatol Commun. 2022 Feb 8. doi: 10.1002/hep4.1894. Online ahead of print.PMID: 35132819 Free article.

Gallage S, Barragan Avila JE, Heikenwalder M.
Lethal lipotoxicity for liver cancer therapy.
Nat Cancer. 2021 Feb;2(2):138-140. doi: 10.1038/s43018-021-00175-y.PMID: 35122080 No abstract available.

Ramadori P, Kam S, Heikenwalder M.
T cells: Friends and foes in NASH pathogenesis and hepatocarcinogenesis.
Hepatology. 2022 Apr;75(4):1038-1049. doi: 10.1002/hep.32336. Epub 2022 Feb 4.PMID: 35023202 Review.

Deczkowska A, David E, Ramadori P, Pfister D, Safran M, Li B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A, Ben-Ari Z, Heikenwälder M, Elinav E, Amit I.
Publisher Correction: XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Nat Med. 2022 Jan;28(1):214. doi: 10.1038/s41591-021-01668-0.PMID: 35022579 No abstract available.

Gallage S, Ali A, Barragan Avila JE, Herebian D, Karimi MM, Irvine EE, McHugh D, Schneider AT, Vucur M, Keitel V, Gil J, Withers DJ, Luedde T, Heikenwalder M.
Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH.
Cell Mol Gastroenterol Hepatol. 2022;13(3):875-878. doi: 10.1016/j.jcmgh.2021.11.012. Epub 2021 Dec 6.PMID: 34883280 Free PMC article. No abstract available.

Li X, Ramadori P, Pfister D, Seehawer M, Zender L, Heikenwalder M.
The immunological and metabolic landscape in primary and metastatic liver cancer.
Nat Rev Cancer. 2021 Jul 29. doi: 10.1038/s41568-021-00383-9. Online ahead of print. PMID: 34326518 Review.

O'Connor T, Heikenwalder M.
CCL2 in the Tumor Microenvironment.
Adv Exp Med Biol. 2021;1302:1-14. doi: 10.1007/978-3-030-62658-7_1. PMID: 34286437

Rappez L, Stadler M, Triana S, Gathungu RM, Ovchinnikova K, Phapale P, Heikenwalder M, Alexandrov T.
SpaceM reveals metabolic states of single cells.
Nat Methods. 2021 Jul;18(7):799-805. doi: 10.1038/s41592-021-01198-0. Epub 2021 Jul 5. PMID: 34226721

Quitt O, Luo S, Meyer M, Xie Z, Golsaz-Shirazi F, Loffredo-Verde E, Festag J, Bockmann JH, Zhao L, Stadler D, Chou WM, Tedjokusumo R, Wettengel JM, Ko C, Noeßner E, Bulbuc N, Shokri F, Lüttgau S, Heikenwälder M, Bohne F, Moldenhauer G, Momburg F, Protzer U.
T cell engager antibodies enable T cells to control HBV infection and to target HBsAg-positive hepatoma in mice.
J Hepatol. 2021 Jun 23:S0168-8278(21)00443-8. doi: 10.1016/j.jhep.2021.06.022. Online ahead of print. PMID: 34171437

Inverso D, Shi J, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Vélez PA, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG.
A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie-Wnt signaling axis in the liver.
Dev Cell. 2021 Jun 7;56(11):1677-1693.e10. doi: 10.1016/j.devcel.2021.05.001. Epub 2021 May 25. PMID: 34038707 Free PMC article.

Deczkowska A, David E, Ramadori P, Pfister D, Safran M, At The B, Giladi A, Jaitin DA, Barboy O, Cohen M, Yofe I, Gur C, Shlomi-Loubaton S, Henri S, Suhail Y, Qiu M, Kam S, Hermon H, Lahat E, Ben Yakov G, Cohen-Ezra O, Davidov Y, Likhter M, Goitein D, Roth S, Weber A, Malissen B, Weiner A, Ben-Ari Z, Heikenwälder M, Elinav E, Amit I.
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Nat Med. 2021 Jun;27(6):1043-1054. doi: 10.1038/s41591-021-01344-3. Epub 2021 May 20. PMID: 34017133

Pinyol R, Torrecilla S, Wang H, Montironi C, Piqué-Gili M, Torres-Martin M, Wei-Qiang L, Willoughby CE, Ramadori P, Andreu-Oller C, Taik P, Lee YA, Moeini A, Peix J, Faure-Dupuy S, Riedl T, Schuehle S, Oliveira CP, Alves VA, Boffetta P, Lachenmayer A, Roessler S, Minguez B, Schirmacher P, Dufour JF, Thung SN, Reeves HL, Carrilho FJ, Chang C, Uzilov AV, Heikenwalder M, Sanyal A, Friedman SL, Sia D, Llovet JM.
Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis.
J Hepatol. 2021 May 13:S0168-8278(21)00326-3. doi: 10.1016/j.jhep.2021.04.049. Online ahead of print. PMID: 33992698

Riedl T, Faure-Dupuy S, Rolland M, Schuehle S, Hizir Z, Calderazzo S, Zhuang X, Wettengel J, Lopez MA, Barnault R, Mirakaj V, Prokosch S, Heide D, Leuchtenbergeg C, Schneider M, Heßling B, Stottmeier B, Wessbecher IM, Schirmacher P, McKeating JA, Protzer U, Durantel D, Lucifora J, Dejardin E, Heikenwalder M
HIF1α-mediated RelB/APOBEC3B downregulation allows Hepatitis B Virus persistence.
Hepatology. 2021 May 15. doi: 10.1002/hep.31902. Online ahead of print. PMID: 33991110

Stadler D, Kächele M, Jones AN, Hess J, Urban C, Schneider J, Xia Y, Oswald A, Nebioglu F, Bester R, Lasitschka F, Ringelhan M, Ko C, Chou WM, Geerlof A, van de Klundert MA, Wettengel JM, Schirmacher P, Heikenwälder M, Schreiner S, Bartenschlager R, Pichlmair A, Sattler M, Unger K, Protzer U.
Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20.
EMBO Rep. 2021 Jun 4;22(6):e49568. doi: 10.15252/embr.201949568. Epub 2021 May 9. PMID: 33969602 Free PMC article.

Rusu PM, Chan AY, Heikenwalder M, Müller OJ, Rose AJ.
Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21.
Nutrients. 2021 Apr 26;13(5):1469. doi: 10.3390/nu13051469. PMID: 33926065.

Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. J
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis.
Hepatol. 2021 Apr 16:S0168-8278(21)00244-0. doi: 10.1016/j.jhep.2021.03.029.

Müller K, Honcharova-Biletska H, Koppe C, Egger M, Chan LK, Schneider AT, Küsgens L, Böhm F, Boege Y, Healy ME, Schmitt J, Comtesse S, Castoldi M, Preisinger C, Szydlowska M, Focaccia E, Gaisa NT, Loosen SH, Jörs S, Tacke F, Roderburg C, Keitel V, Bode JG, Boor P, Davis RJ, Longerich T, Geisler F, Heikenwalder M, Weber A, Vucur M, Luedde T.
JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2007194118. doi: 10.1073/pnas.2007194118

Lagnado A, Leslie J, Ruchaud-Sparagano MH, Victorelli S, Hirsova P, Ogrodnik M, Collins AL, Vizioli MG, Habiballa L, Saretzki G, Evans SA, Salmonowicz H, Hruby A, Geh D, Pavelko KD, Dolan D, Reeves HL, Grellscheid S, Wilson CH, Pandanaboyana S, Doolittle M, von Zglinicki T, Oakley F, Gallage S, Wilson CL, Birch J, Carroll B, Chapman J, Heikenwalder M, Neretti N, Khosla S, Masuda CA, Tchkonia T, Kirkland JL, Jurk D, Mann DA, Passos JF.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner.
EMBO J. 2021 Mar 25:e106048. doi: 10.15252/embj.2020106048. [Online ahead of print]

Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller F, Ramadori P, Leone V, Garcia-Caceres C, Gruber T, Seifert G, Kabat AM, Malm JP, Reider S, Effenberger M, Roth S, Billeter AT, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Böttler T, Tacke F, Dufour JF, Haller D, Murray PJ, Heeren R, Zehn D, Böttcher JP, Heikenwälder M, Knolle PA.
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature. 2021 Mar 24. doi: 10.1038/s41586-021-03233-8. [Online ahead of print]

Pfister D, Núñez NG, Pinyol R, Govaere O, Pinter M, Szydlowska M, Gupta R, Qiu M, Deczkowska A, Weiner A, Müller F, Sinha A, Friebel E, Engleitner T, Lenggenhager D, Moncsek A, Heide D, Stirm K, Kosla J, Kotsiliti E, Leone V, Dudek M, Yousuf S, Inverso D, Singh I, Teijeiro A, Castet F, Montironi C, Haber PK, Tiniakos D, Bedossa P, Cockell S, Younes R, Vacca M, Marra F, Schattenberg JM, Allison M, Bugianesi E, Ratziu V, Pressiani T, D'Alessio A, Personeni N, Rimassa L, Daly AK, Scheiner B, Pomej K, Kirstein MM, Vogel A, Peck-Radosavljevic M, Hucke F, Finkelmeier F, Waidmann O, Trojan J, Schulze K, Wege H, Koch S, Weinmann A, Bueter M, Rössler F, Siebenhüner A, Dosso S, Mallm JP, Umansky V, Jugold M, Luedde T, Schietinger A, Schirmacher P, Emu B, Augustin HG, Billeter A, Müller-Stich B, Kikuchi H, Duda DG, Kütting F, Waldschmidt DT, Ebert MP, Rahbari N, Mei HE, Schulz AR, Ringelhan M, Malek N, Spahn S, Bitzer M, Ruiz de Galarreta M, Lujambio A, Dufour JF, Marron TU, Kaseb A, Kudo M, Huang YH, Djouder N, Wolter K, Zender L, Marche PN, Decaens T, Pinato DJ, Rad R, Mertens JC, Weber A, Unger K, Meissner F, Roth S, Jilkova ZM, Claassen M, Anstee QM, Amit I, Knolle P, Becher B, Llovet JM, Heikenwalder M.
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Nature. 2021 Mar 24. doi: 10.1038/s41586-021-03362-0. [Online ahead of print.]

Okun JG, Rusu PM, Chan AY, Wu Y, Yap YW, Sharkie T, Schumacher J, Schmidt KV, Roberts-Thomson KM, Russell RD, Zota A, Hille S, Jungmann A, Maggi L, Lee Y, Blüher M, Herzig S, Keske MA, Heikenwalder M, Müller OJ, Rose AJ.
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
Nat Metab. 2021 Mar;3(3):394-409. doi: 10.1038/s42255-021-00369-9. Epub 2021 Mar 18.

Bund T, Nikitina E, Chakraborty D, Ernst C, Gunst K, Boneva B, Tessmer C, Volk N, Brobeil A, Weber A, Heikenwalder M, Zur Hausen H, de Villiers EM.
Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions.
Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2025830118. doi: 10.1073/pnas.2025830118.

Leone V, Ali A, Weber A, Tschaharganeh DF, Heikenwalder M.
Liver Inflammation and Hepatobiliary Cancers.
Trends Cancer. 2021 Mar 2:S2405-8033(21)00041-8. doi: 10.1016/j.trecan.2021.01.012. [Online ahead of print.]

Wing PAC, Liu PJ, Harris JM, Magri A, Michler T, Zhuang X, Borrmann H, Minisini R, Frampton NR, Wettengel JM, Mailly L, D'Arienzo V, Riedl T, Nobre L, Weekes MP, Pirisi M, Heikenwalder M, Baumert TF, Hammond EM, Mole DR, Protzer U, Balfe P, McKeating JA.
Hypoxia inducible factors regulate hepatitis B virus replication by activating the basal core promoter.
J Hepatol. 2021 Jan 29:S0168-8278(21)00042-8. doi: 10.1016/j.jhep.2020.12.034. [Online ahead of print.]

Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N, Trumpp A.
Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
Nat Commun. 2021 Jan 27;12(1):608. doi: 10.1038/s41467-020-20801-0

Wanner-Seleznik GM, Reding T, Chen R, Gupta AK, Lenggenhager D, Browning J, Segerer S, Heikenwalder M, Graf R.
Amelioration of Murine Autoimmune Pancreatitis by Targeted LTβR Inhibition and Anti-CD20 Treatment.
Immunohorizons. 2020 Nov 5;4(11):688-700. doi: 10.4049/immunohorizons.2000079.

Conlon TM, John-Schuster G, Heide D, Pfister D, Lehmann M, Hu Y, Ertüz Z, Lopez MA, Ansari M, Strunz M, Mayr C, Ciminieri C, Costa R, Kohlhepp MS, Guillot A, Günes G, Jeridi A, Funk MC, Beroshvili G, Prokosch S, Hetzer J, Verleden SE, Alsafadi H, Lindner M, Burgstaller G, Becker L, Irmler M, Dudek M, Janzen J, Goffin E, Gosens R, Knolle P, Pirotte B, Stoeger T, Beckers J, Wagner D, Singh I, Theis FJ, de Angelis MH, O'Connor T, Tacke F, Boutros M, Dejardin E, Eickelberg O, Schiller HB, Königshoff M, Heikenwalder M*, Yildirim AÖ*.
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature. 2020 Nov 4. doi: 10.1038/s41586-020-2882-8.
*Equally contributed

Scherr AL, Mock A, Gdynia G, Schmitt N, Heilig CE, Korell F, Rhadakrishnan P, Hoffmeister P, Metzeler KH, Schulze-Osthoff K, Illert AL, Boerries M, Trojan J, Waidmann O, Falkenhorst J, Siveke J, Jost PJ, Bitzer M, Malek NP, Vecchione L, Jelas I, Brors B, Glimm H, Stenzinger A, Grekova SP, Gehrig T, Schulze-Bergkamen H, Jäger D, Schirmacher P, Heikenwalder M, Goeppert B, Schneider M, Fröhling S, Köhler BC.
Identification of BCL-XL as highly active survival factor and promising therapeutic target in colorectal cancer.
Cell Death Dis. 2020 Oct 17;11(10):875. doi: 10.1038/s41419-020-03092-7.

Munkhbaatar E, Dietzen M, Agrawal D, Anton M, Jesinghaus M, Boxberg M, Pfarr N, Bidola P, Uhrig S, Höckendorf U, Meinhardt AL, Wahida A, Heid I, Braren R, Mishra R, Warth A, Muley T, Poh PSP, Wang X, Fröhling S, Steiger K, Slotta-Huspenina J, van Griensven M, Pfeiffer F, Lange S, Rad R, Spella M, Stathopoulos GT, Ruland J, Bassermann F, Weichert W, Strasser A, Branca C, Heikenwalder M, Swanton C, McGranahan N, Jost PJ.
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.
Nat Commun.2020 Sep 10;11(1):4527. doi: 10.1038/s41467-020-18372-1.

Hartstra AV, Schüppel V, Imangaliyev S, Schrantee A, Prodan A, Collard D, Levin E, Dallinga-Thie G, Ackermans MT, Winkelmeijer M, Havik SR, Metwaly A, Lagkouvardos I, Nier A, Bergheim I, Heikenwalder M, Dunkel A, Nederveen AJ, Liebisch G, Mancano G, Claus SP, Benítez-Páez A, la Fleur SE, Bergman JJ, Gerdes V, Sanz Y, Booij J, Kemper E, Groen AK, Serlie MJ, Haller D, Nieuwdorp M.
Infusion of donor feces affects the gut-brain axis in humans with metabolic syndrome.
Mol Metab.2020 Sep 8;42:101076. doi: 10.1016/j.molmet.2020.101076.

Hoefflin R, Harlander S, Schäfer S, Metzger P, Kuo F, Schönenberger D, Adlesic M, Peighambari A, Seidel P, Chen CY, Consenza-Contreras M, Jud A, Lahrmann B, Grabe N, Heide D, Uhl FM, Chan TA, Duyster J, Zeiser R, Schell C, Heikenwalder M, Schilling O, Hakimi AA, Boerries M, Frew IJ.
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Nat Commun. 2020 Aug 17;11(1):4111. doi: 10.1038/s41467-020-17873-3.

Ramadori P, Li X, Heikenwalder M.
PKCλ/ι Loss Induces Metabolic Reprogramming in Liver Cancer: Hitting Two Birds with One Stone?
Cancer Cell. 2020 Aug 10;38(2):152-154. doi: 10.1016/j.ccell.2020.07.003.

Li H, Limenitakis JP, Greiff V, Yilmaz B, Schären O, Urbaniak C, Zünd M, Lawson MAE, Young ID, Rupp S, Heikenwälder M, McCoy KD, Hapfelmeier S, Ganal-Vonarburg SC, Macpherson AJ.
Mucosal or systemic microbiota exposures shape the B cell repertoire.
Nature.2020 Aug;584(7820):274-278. doi: 10.1038/s41586-020-2564-6. Epub 2020 Aug 5.

Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, Schneider A, Manske K, Sperl LE, Wettmarshausen J, Müller C, Laschinger M, Hartmann D, Hüser N, Perrochi F, Schmitt-Kopplin P, Hagn F, Zender L, Hornung V, Borner C, Pichlmair A, Kashkar H, Klingenspor M, Prinz M, Schreiner S, Conrad M, Jost PJ, Zischka H, Steiger K, Krönke M, Zehn D, Protzer U, Heikenwälder M, Knolle PA, Wohlleber D.
Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
J Hepatol. 2020 Jun 26:S0168-8278(20)30398-6. doi: 10.1016/j.jhep.2020.06.026.

Chandrashekar DS, Golonka RM, Yeoh BS, Gonzalez DJ, Heikenwälder M, Gerwirtz AT, Varambally S, Vijay-Kumar M.
Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer.
PLoS One. 2020 Jun 19;15(6):e0234726. doi: 10.1371/journal.pone.0234726.

Yap YW, Rusu PM, Chan AY, Fam BC, Jungmann A, Solon-Biet SM, Barlow CK, Creek DJ, Huang C, Schittenhelm RB, Morgan B, Schmoll D, Kiens B, Piper MDW, Heikenwälder M, Simpson SJ, Bröer S, Andrikopoulos S, Müller OJ, Rose AJ.
Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution.
Nat Commun. 2020 Jun 9;11(1):2894. doi: 10.1038/s41467-020-16568-z.

Drescher HK, Schippers A, Rosenhain S, Gremse F, Bongiovanni L, Bruin A, Eswaran S, Gallage SU, Pfister D, Szydlowska M, Heikenwalder M, Weiskirchen S, Wagner N, Trautwein C, Weiskirchen R, Kroy DC.
L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.
Cells. 2020 Apr 29;9(5):1106. doi: 10.3390/cells9051106.

Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B.
Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal.
Nat Immunol. 2020 May;21(5):555-566. doi: 10.1038/s41590-020-0666-9. Epub 2020 Apr 23.

Roth S, Zamzow K, Gaida MM, Heikenwälder M, Tjaden C, Hinz U, Bose P, Michalski CW, Hackert T.
Evolution of the immune landscape during progression of pancreatic intraductal papillary mucinous neoplasms to invasive cancer.
EBioMedicine. 2020 Apr;54:102714. doi: 10.1016/j.ebiom.2020.102714. Epub 2020 Apr 4.

Singh V, Yeoh BS, Abokor AA, Golonka RM, Tian Y, Patterson AD, Joe B, Heikenwalder M, Vijay-Kumar M.
Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota.
Gut Microbes. 2020 Jul 3;11(4):1077-1091. doi: 10.1080/19490976.2020.1743492. Epub 2020 Mar 30.

Healy ME, Boege Y, Hodder MC, Böhm F, Malehmir M, Scherr AL, Jetzer J, Chan LK, Parrotta R, Jacobs K, Clerbaux LA, Kreutzer S, Campbell A, Gilchrist E, Gilroy K, Rodewald AK, Honcharova-Biletska H, Schimmer R, Vélez K, Büeler S, Cammareri P, Kalna G, Wenning AS, McCoy KD, Gomez de Agüero M, Schulze-Bergkamen H, Klose CSN, Unger K, Macpherson AJ, Moor AE, Köhler B, Sansom OJ, Heikenwälder M, Weber A.
MCL1 Is Required for Maintenance of Intestinal Homeostasis and Prevention of Carcinogenesis in Mice.
Gastroenterology. 2020 Jul;159(1):183-199. doi: 10.1053/j.gastro.2020.03.017. Epub 2020 Mar 14.

Ramadori P, Klag T, Malek NP, Heikenwalder M.
Platelets in chronic liver disease, from bench to bedside.
JHEP Rep. 2019 Oct 25;1(6):448-459. doi: 10.1016/j.jhepr.2019.10.001. eCollection 2019 Dec.

Hirsova P, Bohm F, Dohnalkova E, Nozickova B, Heikenwalder M, Gores GJ, Weber A.
Hepatocyte apoptosis is tumor promoting in murine nonalcoholic steatohepatitis.
Cell Death Dis. 2020 Feb 3;11(2):80. doi: 10.1038/s41419-020-2283-9.

Michler T, Kosinska AD, Festag J, Bunse T, Su J, Ringelhan M, Imhof H, Grimm D, Steiger K, Mogler C, Heikenwalder M, Michel ML, Guzman CA, Milstein S, Sepp-Lorenzino L, Knolle P, Protzer U.
Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice.
Gastroenterology. 2020 May;158(6):1762-1775.e9. doi: 10.1053/j.gastro.2020.01.032. Epub 2020 Jan 28.

Bresnahan E, Ramadori P, Heikenwalder M, Zender L, Lujambio A.
Novel patient-derived preclinical models of liver cancer.
J Hepatol. 2020 Feb; 72(2): 239-249. doi: 10.1016/j.jhep.2019.09.028.

Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, Blank P, Lampl S, Neuhaus K, Durantel D, Farhat R, Weber A, Lenggenhager D, Kündig TM, Staeheli P, Protzer U, Wohlleber D, Holzmann B, Binder M, Breuhahn K, Assmus LM, Nattermann J, Abdullah Z, Rolland M, Dejardin E, Lang PA, Lang KS, Karin M, Lucifora J, Kalinke U, Knolle PA, Heikenwalder M. J Hepatol.
A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
2020 May; 72(5): 960-975. doi: 10.1016/j.jhep.2019.12.019. Epub 2020 Jan 15.

Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE, Innes AJ, Birch J, Glegola J, Manshaei S, Heide D, Dharmalingam G, Harbig J, Olona A, Behmoaras J, Dauch D, Uren AG, Zender L, Vernia S, Martínez-Barbera JP, Heikenwalder M, Withers DJ, Gil J.
Cardiac glycosides are broad-spectrum senolytics.
Nat Metab. 2019 Nov 1(11): 1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21.

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.
Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001.
Li K, Neumann K, Duhan V, Namineni S, Hansen AL, Wartewig T, Kurgyis Z, Holm CK, Heikenwalder M, Lang KS, Ruland J.
The uric acid crystal receptor Clec12A potentiates type I interferon responses.
Proc Natl Acad Sci U S A. 2019 Aug 26. pii: 201821351. doi: 10.1073/pnas.1821351116. [Epub ahead of print]

Mayer AE, Löffler MC, Loza Valdés AE, Schmitz W, El-Merahbi R, Viera JT, Erk M, Zhang T, Braun U, Heikenwalder M, Leitges M, Schulze A, Sumara G.
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling.
Sci Signal. 2019 Aug 6;12(593). pii: eaav9150. doi: 10.1126/scisignal.aav9150.

Faure-Dupuy S, Delphin M, Aillot L, Dimier L, Lebossé F, Fresquet J, Parent R, Sebastian Matter M, Rivoire M, Bendriss-Vermare N, Salvetti A, Heide D, Flores L, Klumpp K, Lam A, Zoulim F, Heikenwälder M, Durantel D, Lucifora J.
Hepatitis B Virus-induced modulation of liver macrophage function promotes hepatocyte infection.
J Hepatol. 2019 Jul 23. pii: S0168-8278(19)30422-2. doi: 10.1016/j.jhep.2019.06.032. [Epub ahead of print]

Moeini A, Torrecilla S, Tovar V, Montironi C, Andreu-Oller C, Peix J, Higuera M, Pfister D, Ramadori P, Pinyol R, Solé M, Heikenwälder M, Friedman SL, Sia D, Llovet JM.
An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents.
Gastroenterology. 2019 Jul 22. pii: S0016-5085(19)41121-9. doi: 10.1053/j.gastro.2019.07.028. [Epub ahead of print]

Koppe C, Reisinger F, Wehr K, Vucur M, Trautwein C, Tacke F, Heikenwalder M, Luedde T.
An NF-kappaB- and IKK-Independent Function of NEMO Prevents Hepatocarcinogenesis by Suppressing Compensatory Liver Regeneration.Cancers (Basel). 
2019 Jul 17;11(7). pii: E999. doi: 10.3390/cancers11070999.
Rusu P, Shao C, Neuerburg A, Acikgöz AA, Wu Y, Zou P, Phapale P, Shankar TS, Döring K, Dettling S, Körkel-Qu H, Bekki G, Costa B, Guo T, Friesen O, Schlotter M, Heikenwalder M, Tschaharganeh DF, Bukau B, Kramer G, Angel P, Herold-Mende C, Radlwimmer B, Liu HK.

GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile. 
Cell Stem Cell. 2019 Jul 3. pii: S1934-5909(19)30268-1. doi: 10.1016/j.stem.2019.06.004. [Epub ahead of print]

Heikenwalder M, Lorentzen A.
The role of polarisation of circulating tumour cells in cancer metastasis.
Cell Mol Life Sci. 2019 Jun 19. doi: 10.1007/s00018-019-03169-3. Review.
Schneider A, Kurz S, Manske K, Janas M, Heikenwälder M, Misgeld T, Aichler M, Weissmann SF, Zischka H, Knolle P, Wohlleber D.

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.
Sci Rep. 2019 Jun 11;9(1):8492. doi: 10.1038/s41598-019-44922-9.

Gamm M, Schaub A, Jones AN, Wolf C, Behrens G, Lichti J, Essig K, Macht A, Pircher J, Ehrlich A, Davari K, Chauhan D, Busch B, Wurst W, Feederle R, Feuchtinger A, Tschöp MH, Friedel CC, Hauck SM, Sattler M, Geerlof A, Hornung V, Heissmeyer V, Schulz C, Heikenwalder M, Glasmacher E.
Immune homeostasis and regulation of the interferon pathway require myeloid-derived Regnase-3.
J Exp Med. 2019 May 24. pii: jem.20181762. doi: 10.1084/jem.20181762.
Baazim H, Schweiger M, Moschinger M, Xu H, Scherer T, Popa A, Gallage S, Ali A, Khamina K, Kosack L, Vilagos B, Smyth M, Lercher A, Friske J, Merkler D, Aderem A, Helbich TH, Heikenwälder M, Lang PA, Zechner R, Bergthaler A.
CD8+ T cells induce cachexia during chronic viral infection.
Nat Immunol. 2019 May 20. doi: 10.1038/s41590-019-0397-y.
Rubio K, Singh I, Dobersch S, Sarvari P, Günther S, Cordero J, Mehta A, Wujak L, Cabrera-Fuentes H, Chao CM, Braubach P, Bellusci S, Seeger W, Günther A, Preissner KT, Wygrecka M, Savai R, Papy-Garcia D, Dobreva G, Heikenwalder M, Savai-Pullamsetti S, Braun T, Barreto G.

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis.
Nat Commun. 2019 May 20;10(1):2229. doi: 10.1038/s41467-019-10066-7.

Mejías-Luque R, Lozano-Pope I, Wanisch A, Heikenwälder M, Gerhard M, Obonyo M.
Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection.
Sci Rep. 2019 May 7;9(1):7030. doi: 10.1038/s41598-019-43417-x.

Sajic T, Ciuffa R, Lemos V, Xu P, Leone V, Li C, Williams EG, Makris G, Banaei-Esfahani A, Heikenwalder M, Schoonjans K, Aebersold R.
A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model.
Sci Rep. 2019 May 6;9(1):6913. doi: 10.1038/s41598-019-43091-z.

Anstee QM, Reeves HL, Kotsiliti E, Govaere O, Heikenwalder M.
From NASH to HCC: current concepts and future challenges.
Nat Rev Gastroenterol Hepatol. 2019 Apr 26. doi: 10.1038/s41575-019-0145-7.

Friemel J, Frick L, Unger K, Egger M, Parrotta R, Boege YT, Adili A, Karin M, Luedde T, Heikenwalder M, Weber A. 
Characterization of HCC mouse models: Towards an etiology-oriented subtyping approach.
Mol Cancer Res. 2019 Apr 9. pii: molcanres.1045.2018. doi: 10.1158/1541-7786.MCR-18-1045. 

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.
Platelet GPIbαis a mediator and potential interventional target for NASH and subsequent liver cancer.
Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. 

Weber J, de la Rosa J, Grove CS, Schick M, Rad L, Baranov O, Strong A, Pfaus A, Friedrich MJ, Engleitner T, Lersch R, Öllinger R, Grau M, Menendez IG, Martella M, Kohlhofer U, Banerjee R, Turchaninova MA, Scherger A, Hoffman GJ, Hess J, Kuhn LB, Ammon T, Kim J, Schneider G, Unger K, Zimber-Strobl U, Heikenwälder M, Schmidt-Supprian M, Yang F, Saur D, Liu P, Steiger K, Chudakov DM, Lenz G, Quintanilla-Martinez L, Keller U, Vassiliou GS, Cadiñanos J, Bradley A, Rad R.
PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice.
Nat Commun. 2019 Mar 29;10(1):1415. doi: 10.1038/s41467-019-09180-3.

Roblek M, Protsyuk D, Becker PF, Stefanescu C, Gorzelanny C, Glaus Garzon JF, Knopfova L, Heikenwalder M, Luckow B, Schneider SW, Borsig L.
CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.
Mol Cancer Res. 2018 Dec 14. pii: molcanres.0530.2018. doi: 10.1158/1541-7786.MCR-18-0530.  

Elßner C, Goeppert B, Longerich T, Scherr AL, Stindt J, Nanduri LK, Rupp C, Kather JN, Schmitt N, Kautz N, Breuhahn K, Ismail L, Heide D, Hetzer J, García-Beccaria M, Hövelmeyer N, Waisman A, Urbanik T, Mueller S, Gdynia G, Banales JM, Roessler S, Schirmacher P, Jäger D, Schölch S, Keitel V, Heikenwalder M, Schulze-Bergkamen H, Köhler BC.
Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
Gastroenterology. 2018 Nov 13. pii: S0016-5085(18)35260-0. doi: 10.1053/j.gastro.2018.11.018. 

Xia Y, Schlapschy M, Morath V, Roeder N, Vogt EI, Stadler D, Cheng X, Dittmer U, Sutter K, Heikenwalder M, Skerra A, Protzer U.
PASylated interferon αefficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice.
Antiviral Res. 2018 Nov 12;161:134-143. doi: 10.1016/j.antiviral.2018.11.003. 

Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A.
Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.
Mol Metab. 2018 Oct 23. pii: S2212-8778(18)30837-8. doi: 10.1016/j.molmet.2018.10.007. 

Gallage S, Kotsiliti E, Heikenwalder M.
When Soluble Fibers Meet Hepatocellular Carcinoma: The Dark Side of Fermentation.
Cell Metab. 2018 Nov 6;28(5):673-675. doi: 10.1016/j.cmet.2018.10.009.

Worsch S, Heikenwalder M, Hauner H, Bader BL.
Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice.
Nutr Metab (Lond). 2018 Sep 26;15:65. doi: 10.1186/s12986-018-0291-x. eCollection 2018.

Plantamura E, Dzutsev A, Chamaillard M, Djebali S, Moudombi L, Boucinha L, Grau M, Macari C, Bauché D, Dumitrescu O, Rasigade JP, Lippens S, Plateroti M, Kress E, Cesaro A, Bondu C, Rothermel U, Heikenwälder M, Lina G, Bentaher-Belaaouaj A, Marie JC, Caux C, Trinchieri G, Marvel J, Michallet MC.
MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype.
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10404-10409. doi: 10.1073/pnas.1722372115. Epub 2018 Sep 24.

Seehawer M, Heinzmann F, D'Artista L, Harbig J, Roux PF, Hoenicke L, Dang H, Klotz S, Robinson L, Doré G, Rozenblum N, Kang TW, Chawla R, Buch T, Vucur M, Roth M, Zuber J, Luedde T, Sipos B, Longerich T, Heikenwälder M, Wang XW, Bischof O, Zender L.
Necroptosis microenvironment directs lineage commitment in liver cancer.
Nature. 2018 Oct;562(7725):69-75. doi: 10.1038/s41586-018-0519-y. Epub 2018 Sep 12. 

Roy S, Hooiveld GJ, Seehawer M, Caruso S, Heinzmann F, Schneider AT, Frank AK, Cardenas DV, Sonntag R, Luedde M, Trautwein C, Stein I, Pikarsky E, Loosen S, Tacke F, Ringelhan M, Avsaroglu SK, Goga A, Buendia MA, Vucur M, Heikenwalder M, Zucman-Rossi J, Zender L, Roderburg C, Luedde T.
microRNA 193a-5p Regulates Levels of Nucleolar- and Spindle-associated Protein 1 to Suppress Hepatocarcinogenesis.
Gastroenterology. 2018 Aug 27. pii: S0016-5085(18)34918-7. doi: 10.1053/j.gastro.2018.08.032. [Epub ahead of print]

Coleman OI, Lobner EM, Bierwirth S, Sorbie A, Waldschmitt N, Rath E, Berger E, Lagkouvardos I, Clavel T, McCoy KD, Weber A, Heikenwalder M, Janssen KP, Haller D.
Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.
Gastroenterology. 2018 Jul 28. pii: S0016-5085(18)34816-9. doi: 10.1053/j.gastro.2018.07.028. [Epub ahead of print]

Georgilis A, Klotz S, Hanley CJ, Herranz N, Weirich B, Morancho B, Leote AC, D'Artista L, Gallage S, Seehawer M, Carroll T, Dharmalingam G, Wee KB, Mellone M, Pombo J, Heide D, Guccione E, Arribas J, Barbosa-Morais NL, Heikenwalder M, Thomas GJ, Zender L, Gil J.
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells.
Cancer Cell. 2018 Jul 9;34(1):85-102.e9. doi: 10.1016/j.ccell.2018.06.007.

Bayindir-Buchhalter I, Wolff G, Lerch S, Sijmonsma T, Schuster M, Gronych J, Billeter AT, Babaei R, Krunic D, Ketscher L, Spielmann N, Hrabe de Angelis M, Ruas JL, Müller-Stich BP, Heikenwalder M, Lichter P, Herzig S, Vegiopoulos A.
Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors.
EMBO Mol Med. 2018 Aug;10(8). pii: e8613. doi: 10.15252/emmm.201708613.

Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwälder M, Ng IO, Chow P, Albani S, Chew V.
Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma.
Gut. 2018 Jul 3. pii: gutjnl-2018-316510. doi: 10.1136/gutjnl-2018-316510. [Epub ahead of print]

Cheung PF, Neff F, Neander C, Bazarna A, Savvatakis K, Liffers ST, Althoff K, Lee CL, Moding EJ, Kirsch DG, Saur D, Bazhin AV, Trajkovic-Arsic M, Heikenwälder M, Siveke JT.
Notch-induced myeloid reprogramming in spontaneous pancreatic ductal adenocarcinoma by dual genetic targeting.
Cancer Res. 2018 May 29. pii: canres.0052.2018. doi: 10.1158/0008-5472.CAN-18-0052. [Epub ahead of print] 

Maida A, Zota A, Vegiopoulos A, Appak-Baskoy S, Augustin HG, Heikenwalder M, Herzig S, Rose AJ.
Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance
J Nutr Biochem. 2018 Apr 7;57:189-196. doi: 10.1016/j.jnutbio.2018.03.027. [Epub ahead of print]

Babaei R, Schuster M, Meln I, Lerch S, Ghandour RA, Pisani DF, Bayindir-Buchhalter I, Marx J, Wu S, Schoiswohl G, Billeter AT, Krunic D, Mauer J, Lee YH, Granneman JG, Fischer L, Müller-Stich BP, Amri EZ, Kershaw EE, Heikenwälder M, Herzig S, Vegiopoulos A.
Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.
Sci Signal. 2018 Apr 24;11(527). pii: eaai7838. doi: 10.1126/scisignal.aai7838.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.
Single cell polarity in liquid phase facilitates tumour metastasis.
Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

Ringelhan M, Pfister D, O'Connor T, Pikarsky E, Heikenwalder M.
The immunology of hepatocellular carcinoma.
Nat Immunol. 2018 Mar;19(3):222-232. doi: 10.1038/s41590-018-0044-z. Epub 2018 Jan 29. Review.

Seeger H, Lindenmeyer MT, Cohen CD, Jaeckel C, Nelson PJ, Chen J, Edenhofer I, Kozakowski N, Regele H, Boehmig G, Brandt S, Wuethrich RP, Heikenwalder M, Fehr T, Segerer S.
Lymphotoxin expression in human and murine renal allografts.
PLoS One. 2018 Jan 4;13(1):e0189396. doi: 10.1371/journal.pone.0189396. eCollection 2018.

Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U. 
Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.
Cell Syst. 2017 Dec 13. pii: S2405-4712(17)30538-0. doi: 10.1016/j.cels.2017.11.010.

Yuan D, García-Beccaria M, Heikenwalder M.
Intrinsic and environmental factors in intrahepatic cholangiocarcinoma development.
Oncoscience. 2017 Oct 1;4(9-10):117-119. doi: 10.18632/oncoscience.365. eCollection 2017 Sep.

Heine A, Flores C, Gevensleben H, Diehl L, Heikenwälder M, Ringelhan M, Janssen KP, Nitsche U, Garbi N, Brossart P, Knolle PA, Kurts C, Höchst B.  
Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination. 
Oncoimmunology. 2017 Jun 16;6(8):e1338995. doi: 10.1080/2162402X.2017.1338995. eCollection 2017.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwälder M*, Weber A*. 
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.
*Co-corresponding, co-last-author

Hösel M, Quasdorff M, Ringelhan M, Kashkar H, Debey-Pascher S, Sprinzl MF, Bockmann JH, Arzberger S, Webb D, von Olshausen G, Weber A, Schultze JL, Büning H, Heikenwälder M, Protzer U.
Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication.
Cell Mol Gastroenterol Hepatol. 2017 Jul 19;4(3):339-363. doi: 10.1016/j.jcmgh.2017.07.003.

Heikenwälder M, Pikarsky E.
Learning the Roles of the Hepatic Adaptive Immune System in Hepatocellular Carcinoma-Nature's Guide for Successful Cancer Immunotherapy.
Semin Liver Dis. 2017 Aug;37(3):210-218. doi: 10.1055/s-0037-1606255.

Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwälder M, van den Broek M, Borsig L, Halin C.
Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.
Am J Pathol. 2017 Aug 17. pii: S0002-9440(17)30330-9. doi: 10.1016/j.ajpath.2017.07.008.

Seleznik GM, Reding T, Peter L, Gupta A, Steiner SG, Sonda S, Verbeke CS, Dejardin E, Khatkov I, Segerer S, Heikenwälder M, Graf R.
Development of autoimmune pancreatitis is independent of CDKN1A/p21-mediated pancreatic inflammation.
Gut. 2017 Aug 3. pii: gutjnl-2016-313458. doi: 10.1136/gutjnl-2016-313458.

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M.
Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.
Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006.

Bergmann H, Roth S, Pechloff K, Kiss EA, Kuhn S, Heikenwälder M, Diefenbach A, Greten FR, Ruland J.
Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.
Eur J Immunol. 2017 Jun 6. doi: 10.1002/eji.201646765.

Hanin G, Yayon N, Tzur Y, Haviv R, Bennett ER, Udi S, Krishnamoorthy YR, Kotsiliti E, Zangen R, Efron B, Tam J, Pappo O, Shteyer E, Pikarsky E, Heikenwalder M, Greenberg DS, Soreq H.
miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression.
Gut. 2017 Apr 5. pii: gutjnl-2016-312869. doi: 10.1136/gutjnl-2016-312869.

Wolf Y, Shemer A, Polonsky M, Gross M, Mildner A, Yona S, David E, Kim KW, Goldmann T, Amit I, Heikenwalder M, Nedospasov S, Prinz M, Friedman N, Jung S.
Autonomous TNF is critical for in vivo monocyte survival in steady state and inflammation.
J Exp Med. 2017 Apr 3;214(4):905-917. doi: 10.1084/jem.20160499

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwälder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.
Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.
Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.

Muschaweckh A, Buchholz VR, Fellenzer A, Hessel C, König PA, Tao S, Tao R, Heikenwälder M, Busch DH, Korn T, Kastenmüller W, Drexler I, Gasteiger G.
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells.
J Exp Med. 2016 Dec 12;213(13):3075-3086.

Macpherson AJ, Heikenwälder M, Ganal-Vonarburg SC.
The Liver at the Nexus of Host-Microbial Interactions.
Cell Host Microbe. 2016 Nov 9;20(5):561-571. doi: 10.1016/j.chom.2016.10.016. Review.

Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D.
Mitochondrial function controls intestinal epithelial stemness and proliferation.
Nat Commun. 2016 Oct 27;7:13171. doi: 10.1038/ncomms13171. 

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. 

Eggert T, Wolter K, Ji J, Ma C, Yevsa T, Klotz S, Medina-Echeverz J, Longerich T, Forgues M, Reisinger F, Heikenwalder M, Wang XW, Zender L, Greten TF.
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression.
Cancer Cell. 2016 Oct 10;30(4):533-547. doi: 10.1016/j.ccell.2016.09.003. 

Jucker M, Heikenwalder M.
Immune receptor for pathogenic α-synuclein.
Science. 2016 Sep 30;353(6307):1498-1499. 

Pikarsky E, Heikenwalder M.
Focal and Local: About Ectopic Lymphoid Structures, Intrahepatic Myeloid Aggregates for T-Cell Expansion, and Other Immune Cell Aggregates in the Liver.
Gastroenterology. 2016 Sep 28. pii: S0016-5085(16)35124-1. doi: 10.1053/j.gastro.2016.09.029. [Epub ahead of print]

Maida A, Zota A, Sjøberg KA, Schumacher J, Sijmonsma TP, Pfenninger A, Christensen MM, Gantert T, Fuhrmeister J, Rothermel U, Schmoll D, Heikenwälder M, Iovanna JL, Stemmer K, Kiens B, Herzig S, Rose AJ.
A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.
J Clin Invest. 2016 Sep 1;126(9):3263-78. doi: 10.1172/JCI85946. Epub 2016 Aug 22.

Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG.
Peripheral blood CD34+ cells efficiently engraft human cytokine knock-in mice.
Blood. 2016 Aug 19. pii: blood-2015-10-676452. [Epub ahead of print]

Scherr AL, Gdynia G, Salou M, Radhakrishnan P, Duglova K, Heller A, Keim S, Kautz N, Jassowicz A, Elssner C, He YW, Jaeger D, Heikenwalder M, Schneider M, Weber A, Roth W, Schulze-Bergkamen H, Koehler BC.
Bcl-xL is an oncogenic driver in colorectal cancer.
Cell Death Dis. 2016 Aug 18;7(8):e2342. doi: 10.1038/cddis.2016.233.

Grünwald B, Harant V, Schaten S, Frühschütz M, Spallek R, Höchst B, Stutzer K, Berchtold S, Erkan M, Prokopchuk O, Martignoni M, Esposito I, Heikenwalder M, Gupta A, Siveke J, Saftig P, Knolle P, Wohlleber D, Krüger A.
Pancreatic Pre-malignant Lesions Secrete TIMP1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Pre-Metastatic Niche in the Liver.
Gastroenterology. 2016 Aug 6. pii: S0016-5085(16)34890-9. doi: 10.1053/j.gastro.2016.07.043. [Epub ahead of print]

Wolf B, Krieg K, Falk C, Breuhahn K, Keppeler H, Biedermann T, Schmid E, Warmann S, Fuchs J, Vetter S, Thiele D, Nieser M, Avci-Adali M, Skokowa Y, Schöls L, Hauser S, Ringelhahn M, Yevsa T, Heikenwalder M, Kossatz-Boehlert U.
Inducing differentiation of premalignant hepatic cells as a novel therapeutic strategy in hepatocarcinoma.
Cancer Res. 2016 Aug 3. pii: canres.3453.2015. [Epub ahead of print]

Endig J, Buitrago-Molina LE, Marhenke S, Reisinger F, Saborowski A, Schütt J, Limbourg F, Könecke C, Schreder A, Michael A, Misslitz AC, Healy ME, Geffers R, Clavel T, Haller D, Unger K, Finegold M, Weber A, Manns MP, Longerich T, Heikenwälder M, Vogel A.
Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development.
Cancer Cell. 2016 Aug 8;30(2):308-23. doi: 10.1016/j.ccell.2016.06.009. Epub 2016 Jul 28.

Rivkin M, Simerzin A, Zorde-Khvalevsky E, Chai C, Yuval JB, Rosenberg N, Harari-Steinfeld R, Schneider R, Amir G, Condiotti R, Heikenwalder M, Weber A, Schramm C, Wege H, Kluwe J, Galun E, Giladi H.
Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-derived Erythropoietin and Anemia.
Gastroenterology. 2016 Jul 28. pii: S0016-5085(16)34827-2. doi: 10.1053/j.gastro.2016.07.031. [Epub ahead of print]

Michler T, Große S, Mockenhaupt S, Röder N, Stückler F, Knapp B, Ko C, Heikenwalder M, Protzer U, Grimm D.
Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA.
EMBO Mol Med. 2016 Sep 1;8(9):1082-98. doi: 10.15252/emmm.201506172.

Lesina M, Wörmann SM, Morton J, Diakopoulos KN, Korneeva O, Wimmer M, Einwächter H, Sperveslage J, Demir IE, Kehl T, Saur D, Sipos B, Heikenwälder M, Steiner JM, Wang TC, Sansom OJ, Schmid RM, Algül H.
RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.
J Clin Invest. 2016 Aug 1;126(8):2919-32. doi: 10.1172/JCI86477. Epub 2016 Jul 25.

Dolowschiak T, Mueller AA, Pisan LJ, Feigelman R, Felmy B, Sellin ME, Namineni S, Nguyen BD, Wotzka SY, Heikenwalder M, von Mering C, Mueller C, Hardt WD.
IFN-γ Hinders Recovery from Mucosal Inflammation during Antibiotic Therapy for Salmonella Gut Infection.
Cell Host Microbe. 2016 Aug 10;20(2):238-49. doi: 10.1016/j.chom.2016.06.008. Epub 2016 Jul 21.

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M.
Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
EMBO J. 2016 Aug 15;35(16):1730-44. doi: 10.15252/embj.201693801. Epub 2016 Jul 13.

Höckendorf U, Yabal M, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder M, Spiekermann K, Slotta-Huspenina J, Groß O, Jost PJ.
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells.
Cancer Cell. 2016 Jul 11;30(1):75-91. doi: 10.1016/j.ccell.2016.06.002.

Weber A, Heikenwalder M.
P(URI)fying Novel Drivers of NASH and HCC: A Feedforward Loop of IL17A via White Adipose Tissue.
Cancer Cell. 2016 Jul 11;30(1):15-7. doi: 10.1016/j.ccell.2016.06.010.

Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, Weiskirchen R, Tacke F, Vucur M, Trautwein C, Lüscher B, Preisinger C, Heikenwalder M, Luedde T.
IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator receptor-interacting protein kinase 1.
Hepatology. 2016 Jul 11. doi: 10.1002/hep.28723. [Epub ahead of print]

Gautheron J, Vucur M, Schneider AT, Severi I, Roderburg C, Roy S, Bartneck M, Schrammen P, Diaz MB, Ehling J, Gremse F, Heymann F, Koppe C, Lammers T, Kiessling F, Van Best N, Pabst O, Courtois G, Linkermann A, Krautwald S, Neumann UP, Tacke F, Trautwein C, Green DR, Longerich T, Frey N, Luedde M, Bluher M, Herzig S, Heikenwalder M, Luedde T.
The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.
Nat Commun. 2016 Jun 21;7:11869. doi: 10.1038/ncomms11869.

Bolze F, Bast A, Mocek S, Morath V, Yuan D, Rink N, Schlapschy M, Zimmermann A, Heikenwalder M, Skerra A, Klingenspor M.
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation.
Diabetologia. 2016 Sep;59(9):2005-12. doi: 10.1007/s00125-016-4004-6. Epub 2016 Jun 7.

Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef SA, Mc Guire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R, van Loo G.
A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.
Cell Death Dis. 2016 Jun 2;7(6):e2250. doi: 10.1038/cddis.2016.154.

Mejías-Luque R, Zöller J, Anderl F, Loew-Gil E, Vieth M, Adler T, Engler DB, Urban S, Browning JL, Müller A, Gerhard M, Heikenwalder M.
Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.
Gut. 2016 Apr 13. pii: gutjnl-2015-310783. doi: 10.1136/gutjnl-2015-310783. [Epub ahead of print]

Blank T, Detje CN, Spieß A, Hagemeyer N, Brendecke SM, Wolfart J, Staszewski O, Zöller T, Papageorgiou I, Schneider J, Paricio-Montesinos R, Eisel UL, Manahan-Vaughan D, Jansen S, Lienenklaus S, Lu B, Imai Y, Müller M, Goelz SE, Baker DP, Schwaninger M, Kann O, Heikenwalder M, Kalinke U, Prinz M.
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.
Immunity. 2016 Apr 19;44(4):901-12. doi: 10.1016/j.immuni.2016.04.005.

Spinner S, Crispatzu G, Yi JH, Munkhbaatar E, Mayer P, Höckendorf U, Müller N, Li Z, Schader T, Bendz H, Hartmann S, Yabal M, Pechloff K, Heikenwalder M, Kelly GL, Strasser A, Peschel C, Hansmann ML, Ruland J, Keller U, Newrzela S, Herling M, Jost PJ.
Re-activation of mitochondrial apoptosis inhibits T-cell lymphoma survival and treatment resistance.
Leukemia. 2016 Jul;30(7):1520-30. doi: 10.1038/leu.2016.49. Epub 2016 Mar 8.

Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, Rupp S, Uchimura Y, Li H, Steinert A, Heikenwalder M, Hapfelmeier S, Sauer U, McCoy KD, Macpherson AJ.
The maternal microbiota drives early postnatal innate immune development.
Science. 2016 Mar 18;351(6279):1296-302. doi: 10.1126/science.aad2571

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.
Tumor-necrosis factor impairs CD4+ T cell-mediated immunological control in chronic viral infection.
Nat Immunol. 2016 Mar 7. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF.
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Nature. 2016 Mar 10;531(7593):253-7

Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, Schweiger MR, Borsig L, Heikenwalder M, Lehrach H, Moelling K.
Transcriptional signature induced by a C-terminal c-Src mutant in a human breast cell line.
FEBS J. 2016 Feb 26

Maresch R, Mueller S, Veltkamp C, Öllinger R, Friedrich M, Heid I, Steiger K, Weber J, Engleitner T, Barenboim M, Klein S, Louzada S, Banerjee R, Strong A, Stauber T, Gross N, Geumann U, Lange S, Ringelhan M, Varela I, Unger K, Yang F, Schmid RM, Vassiliou GS, Braren R, Schneider G, Heikenwalder M, Bradley A, Saur D, Rad R.
Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice.
Nat Commun. 2016 Feb 26;7:10770

Sunami Y, Ringelhan M, Kokai E, Lu M, O'Connor T, Lorentzen A, Weber A, Rodewald AK, Müllhaupt B, Terracciano L, Gul S, Wissel S, Leithäuser F, Krappmann D, Riedl P, Hartmann D, Schirmbeck R, Strnad P, Hüser N, Kleeff J, Friess H, Schmid RM, Geisler F, Wirth T, Heikenwalder M.
Canonical NF-?B signaling in hepatocytes acts as a tumor-suppressor in HBV surface antigen-driven HCC by controlling the UPR.
Hepatology. 2016 Jan 11

Matter MS, Marquardt JU, Andersen JB, Quintavalle C, Korokhov N, Stauffer JK, Kaji K, Decaens T, Quagliata L, Elloumi F, Hoang T, Molinolo A, Conner EA, Weber A, Heikenwalder M, Factor VM, Thorgeirsson SS.
Oncogenic driver genes and the inflammatory microenvironment dictate liver tumor phenotype.
Hepatology. 2016 Feb 4

Roblek M, Strutzmann E, Zankl C, Adage T, Heikenwalder M, Atlic A, Weis R, Kungl A, Borsig L.
Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding.
Neoplasia. 2016 Jan;18(1):49-59

Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V.
Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
Gut. 2015 Dec 15

Weber J, Öllinger R, Friedrich M, Ehmer U, Barenboim M, Steiger K, Heid I, Mueller S, Maresch R, Engleitner T, Gross N, Geumann U, Fu B, Segler A, Yuan D, Lange S, Strong A, de la Rosa J, Esposito I, Liu P, Cadiñanos J, Vassiliou GS, Schmid RM, Schneider G, Unger K, Yang F, Braren R, Heikenwälder M, Varela I, Saur D, Bradley A, Rad R.
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice.
Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13982-7

Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M*, Ben-Neriah Y, Pikarsky E. *Co-corresponding
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nat Immunol. 2015 Dec;16(12):1235-44

Nowicka AM, Häuselmann I, Borsig L, Bolduan S, Schindler M, Schraml P, Heikenwalder M, Moch H.
A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.
Oncogene. 2015 Oct 26

Chávez MN, Schenck TL, Hopfner U, Centeno-Cerdas C, Somlai-Schweiger I, Schwarz C, Machens HG, Heikenwalder M, Bono MR, Allende ML, Nickelsen J, Egaña JT.
Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration.
Biomaterials. 2016 Jan;75:25-36

Xia Y, Stadler D, Lucifora J, Reisinger F, Webb D, Hösel M, Michler T, Wisskirchen K, Cheng X, Zhang K, Chou WM, Wettengel JM, Malo A, Bohne F, Hoffmann D, Eyer F, Thimme R, Falk CS, Thasler WE, Heikenwalder M, Protzer U.
Interferon-? and Tumor Necrosis Factor-a Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.
Gastroenterology. 2016 Jan;150(1):194-205

Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M*, Segerer S. *Co-corresponding, Co-last
The lymphotoxin ß receptor is a potential therapeutic target in renal inflammation.
Kidney Int. 2015 Sep 23

Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT.
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
Nat Med. 2015 Oct;21(10):1163-71

Mu X, Español-Suñer R, Mederacke I, Affò S, Manco R, Sempoux C, Lemaigre FP, Adili A, Yuan D, Weber A, Unger K, Heikenwälder M, Leclercq IA, Schwabe RF.
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment.
J Clin Invest. 2015 Oct 1;125(10):3891-903

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J.
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Nat Cell Biol. 2015 Sep;17(9):1205-17. Erratum in: Nat Cell Biol. 2015 Oct;17(10):1370

Weber A, O'Connor T, Heikenwalder M.
Next Generation of Preclinical Liver Cancer Models.
Clin Cancer Res. 2015 Oct 1;21(19):4254-6

Dargel C, Bassani-Sternberg M, Hasreiter J, Zani F, Bockmann JH, Thiele F, Bohne F, Wisskirchen K, Wilde S, Sprinzl MF, Schendel DJ, Krackhardt AM, Uckert W, Wohlleber D, Schiemann M, Stemmer K, Heikenwälder M, Busch DH, Richter G, Mann M, Protzer U.
T Cells Engineered to Express a T-Cell Receptor Specific for Glypican-3 to Recognize and Kill Hepatoma Cells In Vitro and in Mice.
Gastroenterology. 2015 Oct;149(4):1042-52

Boutaffala L, Bertrand MJ, Remouchamps C, Seleznik G, Reisinger F, Janas M, Bénézech C, Fernandes MT, Marchetti S, Mair F, Ganeff C, Hupalowska A, Ricci JE, Becher B, Piette J, Knolle P, Caamano J, Vandenabeele P, Heikenwalder M*, Dejardin E. *Co-corresponding, Co-last
NIK promotes tissue destruction independently of the alternative NF-?B pathway through TNFR1/RIP1-induced apoptosis.
Cell Death Differ. 2015 Dec;22(12):2020-33

Jörs S, Jeliazkova P, Ringelhan M, Thalhammer J, Dürl S, Ferrer J, Sander M, Heikenwalder M, Schmid RM, Siveke JT, Geisler F.
Lineage fate of ductular reactions in liver injury and carcinogenesis.
J Clin Invest. 2015 Jun;125(6):2445-57

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
EMBO J. 2015 Jun 12;34(12):1612-29.

O Connor T, Borsig L, Heikenwalder M
CCL2-CCR2 Signaling in Disease Pathogenesis.
Endocr Metab Immune Disord Drug Targets. 2015;15(2): 105-18

Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A
Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.
Hepatology. 2015;61(1): 238-48

Seubert B, Cui H, Simonavicius N, Honert K, Schäfer S, Reuning U, Heikenwalder M, Mari B, Krüger A
Tetraspanin CD63 acts as a pro-metastatic factor via ?-catenin stabilization.
Int J Cancer. 2015;136(10): 2304-15

Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, Galle PR, Weinmann A, Heikenwälder M, Protzer U
Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion.
J Hepatol. 2015;62(4): 863-70

Ringelhan M, O'Connor T, Protzer U, Heikenwalder M
The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.
J Pathol. 2015;235(2): 355-67

Protzer U, Böhm F, Longerich T, Seebach J, Heidary Navid M, Friemel J, Marques-Maggio E, Bawohl M, Heikenwalder M, Schirmacher P, Dutkowski P, Clavien PA, Schemmer P, Schnitzler P, Gotthardt D, Müllhaupt B, Weber A
Molecular detection of hepatitis E virus (HEV) in liver biopsies after liver transplantation.
Mod Pathol. 2015;28(4): 523-32

Rad R, Rad L, Wang W, Strong A, Ponstingl H, Bronner IF, Mayho M, Steiger K, Weber J, Hieber M, Veltkamp C, Eser S, Geumann U, Öllinger R, Zukowska M, Barenboim M, Maresch R, Cadiñanos J, Friedrich M, Varela I, Constantino-Casas F, Sarver A, Ten Hoeve J, Prosser H, Seidler B, Bauer J, Heikenwälder M, Metzakopian E, Krug A, Ehmer U, Schneider G, Knösel T, Rümmele P, Aust D, Grützmann R, Pilarsky C, Ning Z, Wessels L, Schmid RM, Quail MA, Vassiliou G, Esposito I, Liu P, Saur D, Bradley A
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer.
Nat Genet. 2015;47(1): 47-56

Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwälder M, Hemmer B, Drexler I, Korn T
?4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets.
Acta Neuropathol Commun. 2014;2: 27

Boettcher S, Gerosa RC, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz MG
Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
Blood. 2014;124(9): 1393-403

Wyler L, Napoli CU, Ingold B, Sulser T, Heikenwälder M, Schraml P, Moch H
Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression.
Br J Cancer. 2014;110(3): 686-94

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwalder M
Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes.
Cancer Cell. 2014;26(4): 549-64

Luedde M, Lutz M, Carter N, Sosna J, Jacoby C, Vucur M, Gautheron J, Roderburg C, Borg N, Reisinger F, Hippe HJ, Linkermann A, Wolf MJ, Rose-John S, Lüllmann-Rauch R, Adam D, Flögel U, Heikenwalder M, Luedde T, Frey N
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Cardiovasc Res. 2014;103(2): 206-16

Heikenwalder M, Protzer U
LINE(1)s of Evidence in HBV-Driven Liver Cancer.
Cell Host Microbe. 2014;15(3): 249-50

Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ
XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation.
Cell Rep. 2014;7(6): 1796-808

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, Ruland J
Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation.
Cell Rep. 2014;9(4): 1292-305

Ringelhan M, Reisinger F, Yuan D, Weber A, Heikenwalder M
Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation.
Curr Protoc Pharmacol. 2014;67: 14.31.1-14.31.17

Seleznik GM, Zoller J, O'Connor T, Graf R, Heikenwalder M
The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
Cytokine Growth Factor Rev. 2014;25(2): 125-37

Gautheron J, Vucur M, Reisinger F, Cardenas DV, Roderburg C, Koppe C, Kreggenwinkel K, Schneider AT, Bartneck M, Neumann UP, Canbay A, Reeves HL, Luedde M, Tacke F, Trautwein C, Heikenwalder M, Luedde T
A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis.
EMBO Mol Med. 2014;6(8): 1062-74

Hösel M, Lucifora J, Michler T, Holz G, Gruffaz M, Stahnke S, Zoulim F, Durantel D, Heikenwalder M, Nierhoff D, Millet R, Salvetti A, Protzer U, Büning H
Hepatitis B virus infection enhances susceptibility toward adeno-associated viral vector transduction in vitro and in vivo.
Hepatology. 2014;59(6): 2110-20

Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D
Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.
J Hepatol. 2014;61(3): 600-8

Eisele YS, Fritschi SK, Hamaguchi T, Obermüller U, Füger P, Skodras A, Schäfer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M
Multiple Factors Contribute to the Peripheral Induction of Cerebral ?-Amyloidosis.
J Neurosci. 2014;34(31): 10264-10273

Lucifora J, Xia Y, Reisinger F, Stadler D, Heikenwälder M, Protzer U
[Specific degradation of nuclear hepatitis B virus covalently closed circular DNA].
Med Sci (Paris). 2014;30(8-9): 724-6

Unger K, Heikenwälder M
Analysis of chromosomal aberrations in murine HCC.
Methods Mol Biol. 2014;1193: 213-26

Waldschmitt N, Berger E, Rath E, Sartor RB, Weigmann B, Heikenwalder M, Gerhard M, Janssen KP, Haller D
C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation.
Mucosal Immunol. 2014;7(6): 1452-66

Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.
Nat Immunol. 2014;15(11): 1079-89

Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M
Inflammatory chemokines and metastasis--tracing the accessory.
Oncogene. 2014;33(25): 3217-24

Franceschi V, Stellari FF, Mangia C, Jacca S, Lavrentiadou S, Cavirani S, Heikenwalder M, Donofrio G
In vivo image analysis of BoHV-4-based vector in mice.
PLoS ONE. 2014;9(4): e95779

Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U
Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA.
Science. 2014;343(6176): 1221-8

Xia Y, Lucifora J, Reisinger F, Heikenwalder M, Protzer U
Virology. Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Science. 2014;344(6189): 1237

Ludwig T, Worsch S, Heikenwalder M, Daniel H, Hauner H, Bader BL
Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice.
Am J Physiol Endocrinol Metab. 2013;304(11): E1140-56

Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas DV, Kreggenwinkel K, Koppe C, Hammerich L, Hakem R, Unger K, Weber A, Gassler N, Luedde M, Frey N, Neumann UP, Tacke F, Trautwein C, Heikenwalder M, Luedde T
RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation.
Cell Rep. 2013;4(4): 776-90

Ringelhan M, Heikenwalder M, Protzer U
Direct effects of hepatitis B virus-encoded proteins and chronic infection in liver cancer development.
Dig Dis. 2013;31(1): 138-51

Heikenwalder M, Borsig L
Pathways of metastasizing intestinal cancer cells revealed: how will fighting metastases at the site of cancer cell arrest affect drug development?
Future Oncol. 2013;9(1): 1-4

Krebs K, Böttinger N, Huang LR, Chmielewski M, Arzberger S, Gasteiger G, Jäger C, Schmitt E, Bohne F, Aichler M, Uckert W, Abken H, Heikenwalder M, Knolle P, Protzer U
T cells expressing a chimeric antigen receptor that binds hepatitis B virus envelope proteins control virus replication in mice.
Gastroenterology. 2013;145(2): 456-65

Sprinzl MF, Reisinger F, Puschnik A, Ringelhan M, Ackermann K, Hartmann D, Schiemann M, Weinmann A, Galle PR, Schuchmann M, Friess H, Otto G, Heikenwalder M, Protzer U
Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.
Hepatology. 2013;57(6): 2358-68

Vogel KU, Edelmann SL, Jeltsch KM, Bertossi A, Heger K, Heinz GA, Zöller J, Warth SC, Hoefig KP, Lohs C, Neff F, Kremmer E, Schick J, Repsilber D, Geerlof A, Blum H, Wurst W, Heikenwälder M, Schmidt-Supprian M, Heissmeyer V
Roquin paralogs 1 and 2 redundantly repress the Icos and Ox40 costimulator mRNAs and control follicular helper T cell differentiation.
Immunity. 2013;38(4): 655-68

Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA
Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.
Nat Immunol. 2013;14(6): 574-83

Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M
A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.
Nat Neurosci. 2013;16(11): 1618-26

Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M
Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
Nat Neurosci. 2013;16(3): 273-80

Willimsky G, Protzer U, Knolle P, Heikenwalder M
Adoptive T-cell therapy to treat liver cancer: Is the liver microenvironment key?
Oncotarget. 2013;4(8): 1117-8

Felmy B, Songhet P, Slack EM, Müller AJ, Kremer M, Van Maele L, Cayet D, Heikenwalder M, Sirard JC, Hardt WD
NADPH Oxidase Deficient Mice Develop Colitis and Bacteremia upon Infection with Normally Avirulent, TTSS-1- and TTSS-2-Deficient Salmonella Typhimurium.
PLoS ONE. 2013;8(10): e77204

Kruglov AA, Grivennikov SI, Kuprash DV, Winsauer C, Prepens S, Seleznik GM, Eberl G, Littman DR, Heikenwalder M, Tumanov AV, Nedospasov SA
Nonredundant function of soluble LT?3 produced by innate lymphoid cells in intestinal homeostasis.
Science. 2013;342(6163): 1243-6

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Cancer Cell. 2012;22(1): 91-105

Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A
Follicular dendritic cells emerge from ubiquitous perivascular precursors.
Cell. 2012;150(1): 194-206

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA
TNF-induced target cell killing by CTL activated through cross-presentation.
Cell Rep. 2012;2(3): 478-87

Bauer J, Namineni S, Reisinger F, Zöller J, Yuan D, Heikenwälder M
Lymphotoxin, NF-?B, and cancer: the dark side of cytokines.
Dig Dis. 2012;30(5): 453-68

Huang LR, Gäbel YA, Graf S, Arzberger S, Kurts C, Heikenwalder M, Knolle PA, Protzer U
Transfer of HBV genomes using low doses of adenovirus vectors leads to persistent infection in immune competent mice.
Gastroenterology. 2012;142(7): 1447-1450.e3

Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, Macpherson A, Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M
Lymphotoxin ? receptor signaling promotes development of autoimmune pancreatitis.
Gastroenterology. 2012;143(5): 1361-74

Chew V, Chen J, Lee D, Loh E, Lee J, Lim KH, Weber A, Slankamenac K, Poon RT, Yang H, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP
Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma.
Gut. 2012;61(3): 427-38

Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG
Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells.
J Immunol. 2012;188(12): 5824-8

Chew V, Tow C, Huang C, Bard-Chapeau E, Copeland NG, Jenkins NA, Weber A, Lim KH, Toh HC, Heikenwalder M, Ng IO, Nardin A, Abastado JP
Toll-like receptor 3 expressing tumor parenchyma and infiltrating natural killer cells in hepatocellular carcinoma patients.
J Natl Cancer Inst. 2012;104(23): 1796-807

Hoos A, Wolf MJ, Bauer J, Borsig L, Heikenwalder M
Endothelial chemokine receptors as facilitators of tumor cell extravasation?
Oncotarget. 2012;3(9): 919-20

Loetscher Y, Wieser A, Lengefeld J, Kaiser P, Schubert S, Heikenwalder M, Hardt WD, Stecher B
Salmonella transiently reside in luminal neutrophils in the inflamed gut.
PLoS ONE. 2012;7(4): e34812

O'Connor T, Frei N, Sponarova J, Schwarz P, Heikenwalder M, Aguzzi A
Lymphotoxin, but Not TNF, Is Required for Prion Invasion of Lymph Nodes.
PLoS Pathog. 2012;8(8): e1002867

Attems J, Alpar A, Spence L, McParland S, Heikenwalder M, Uhlén M, Tanila H, Hökfelt TG, Harkany T
Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
Proc Natl Acad Sci U S A. 2012;109(16): 6259-64

Wolf MJ, Seleznik GM, Heikenwalder M
Lymphotoxin's link to carcinogenesis: friend or foe? from lymphoid neogenesis to hepatocellular carcinoma and prostate cancer.
Adv Exp Med Biol. 2011;691: 231-49

Silva A, Weber A, Bain M, Reding T, Heikenwalder M, Sonda S, Graf R
COX-2 is not required for the development of murine chronic pancreatitis.
Am J Physiol Gastrointest Liver Physiol. 2011;300(6): G968-75

Attems J, Ittner A, Jellinger K, Nitsch RM, Maj M, Wagner L, Götz J, Heikenwalder M
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.
J Neural Transm. 2011;118(5): 737-45

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Nature. 2011;479(7374): 547-51

Siegert S, Huang HY, Yang CY, Scarpellino L, Carrie L, Essex S, Nelson PJ, Heikenwalder M, Acha-Orbea H, Buckley CD, Marsland BJ, Zehn D, Luther SA
Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide.
PLoS ONE. 2011;6(11): e27618

Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, Bridel C, Mertz K, Zirdum E, Petsch B, Fuchs TJ, Stitz L, Aguzzi A
Aerosols transmit prions to immunocompetent and immunodeficient mice.
PLoS Pathog. 2011;7(1): e1001257

Weber A, Boege Y, Reisinger F, Heikenwälder M
Chronic liver inflammation and hepatocellular carcinoma: persistence matters.
Swiss Med Wkly. 2011;141: w13197

Haybaeck J, Zeller N, Heikenwalder M
The parallel universe: microRNAs and their role in chronic hepatitis, liver tissue damage and hepatocarcinogenesis.
Swiss Med Wkly. 2011;141: w13287

Peters R, Wolf MJ, van den Broek M, Nuvolone M, Dannenmann S, Stieger B, Rapold R, Konrad D, Rubin A, Bertino JR, Aguzzi A, Heikenwalder M, Knuth AK
Efficient generation of multipotent mesenchymal stem cells from umbilical cord blood in stroma-free liquid culture.
PLoS ONE. 2010;5(12): e15689

Selected Publications prior 01.11.2010

Aerosols transmit prions to immunocompetent and immunodeficient mice
Mathias Heikenwalder *, Johannes Haybaeck *, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J. Fuchs, Lothar Stitz and Adriano Aguzzi.
PLOS Pathogens, November 2010, in press.

Peripherally Applied Ab-Containing Inoculates Induce Cerebral b-Amyloidosis.
Eisele, Y., Obermüller, U., Heilbronner, G., Baumann, F., Kaeser, S., Wolburg, H., Walker L., Staufenbiel, M., Heikenwalder, M., Jucker, M
Science. 2010 Oct 21. [Epub ahead of print]

Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?
Vucur, M., Roderburg, C., Bettermann, K., Tacke, F., Heikenwalder, M., Trautwein, C. and Luedde, T.
Oncotarget. October 2010, in press.

The unexpected role of lymphotoxin signaling in carcinogenesis: From lymphoid neogenesis to liver and prostate cancer development
Wolf M, Seleznik G, Zeller N and Heikenwalder M.
Oncogene. 2010, in press

Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immuneresponses
Hapfelmeier S, Lawson M, Slack E, Kirundi J, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer M, Endt K, Geuking M, Curtiss 3rd R, McCoy K, and Macpherson A.
Science. 2010, in press

TAK1 suppresses a NEMO-dependent, but NF-kB independent pathway to liver cancer.
Bettermann K, Vucur M, Koppe C, Heymann F, Haybaeck J, Weber A, Weiskirchen R, Liedtke C, Gassler N, Müller M, Akira S, Tacke F, Heikenwalder M, Trautwein C, and Luedde T.
Cancer CELL. 2010 May 18;17(5):481-96

Hepatocyte-specific deletion of Mcl-1 triggers proliferation and hepatocarcinogenesis in mice.
Weber A, Boger R, Vick B, Urbanik T, Haybaeck J, Zoller S, Teufel A, Krammer P, Opferman J, Galle P, Schuchmann M, Heikenwalder M, Schulze-Bergkamen H.
Hepatology. 2009 Nov 30; DOI: 10.1002/hep.23479.

A lymphotoxin-driven pathway to chronic hepatitis induced liver cancer.
Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Rolf Graf, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A and Heikenwalder M.
Cancer CELL. 2009 Oct 6;16(4):295-308.

Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas.
Heikenwalder M, Kurrer MO, Margalith I, Kranich J, Zeller N, Haybaeck J, Polymenidou M, Matter M, Bremer J, Jackson WS, Lindquist S, Sigurdson CJ, Aguzzi A.
Immunity. 2008 Dec 19;29(6):998-1008.

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.
Heikenwalder M,* Baenziger S,* Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.
Blood. 2009 Jan 8;113(2):377-88.

Overexpression of lymphotoxin in T cells induces fulminant thymic involution.
Heikenwalder M,* Prinz M,* Zeller N, Lang KS, Junt T, Rossi S, Tumanov A, Schmidt H, Priller J, Flatz L, Rülicke T, Macpherson AJ, Holländer GA, Nedospasov SA, Aguzzi A.
Am J Pathol. 2008 Jun;172(6):1555-70.

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, Mack M, Heikenwalder M, Brück W, Priller J, Prinz M.
Nature Neuroscience 2007 Dec;10(12):1544-53.

Insights into prion strains and neurotoxicity.
Aguzzi A, Heikenwalder M, Polymenidou M.
Nature Reviews in Molecular and Cellular Biology. 2007 Jul;8(7):552-61.

Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-g C-/- mice.
Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF.
PNAS. 2006 Oct 24;103(43):15951-6. Epub 2006 Oct 12.

Pathogenesis of prion diseases: current status and future outlook.
Aguzzi A, Heikenwalder M.
Nature Reviews in Microbiology. 2006 Oct;4(10):765-75.

Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signaling.
Lang KS, Georgiev P, Recher M, Navarini AA, Bergthaler A, Heikenwalder M, Harris NL, Junt T, Odermatt B, Clavien PA, Pircher H, Akira S, Hengartner H, Zinkernagel RM.
J Clin Invest. 2006 Sep;116(9):2456-63.

Coincident scrapie infection and nephritis lead to urinary prion excretion.
Heikenwalder M,* Seeger H,* Zeller N,* Kranich J, Schwarz P, Gaspert A, Seifert B, Miele G, Aguzzi A.
Science. 2005 Oct 14;310(5746):324-6.

Prions, cytokines, and chemokines: a meeting in lymphoid organs.
Aguzzi A, Heikenwalder M.
Immunity. 2005 Feb;22(2):145-54.

Chronic lymphocytic inflammation specifies the organ tropism of prions.
Heikenwalder M, Zeller N, Seeger H, Prinz M, Klöhn PC, Schwarz P, Ruddle N, Weissmann C, Aguzzi A.
Science. 2005 Feb 18;307(5712):1107-10.

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration.
Heikenwalder M, Polymenidou M, Junt T, Sigurdson C, Wagner H, Akira S, Zinkernagel R, Aguzzi A.
Nature Medicine 2004 Feb;10(2):187-92.

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Heikenwalder M,* Prinz M,* Junt T, Schwarz P, Glatzel M, Heppner FL, Fu YX, Lipp M, Aguzzi A.
Nature. 2003 Oct 30;425(6961):957-62.

Prion diseases: Cannibals and garbage piles.
Aguzzi A, Heikenwalder M.
Nature. 2003 May 8;423(6936):127-9.
* gleichermaßen zur Publikation beigetragen.


Blockers of Light, LTa1b2 and LTa2b1 or its receptor LTbR for the prevention and treatment of chronic hepatitis and hepatocellular carcinoma“. Patent-application Heikenwälder, Aguzzi und Universität Zürich, 10-2008; accepted 04-2010.

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