Cancer epigenetics
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Lyko, F. (2018). The DNA methyltransferase family: a versatile toolkit for epigenetic regulation. Nat. Rev. Genet. 19: 81-92.
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Rodriguez-Paredes, M., Bormann, F., Raddatz, G., Gutekunst, J., Lucena-Porcel, C., Köhler, F., Wurzer, E., Schmidt, K., Gallinat, S., Wenck, H., Röwert-Huber, J., Denisova, E., Feuerbach, L., Park, J., Brors, B., Herpel, E., Nindl, I., Hofmann, T.G., Winnefeld, M., and Lyko, F. (2018). Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin. Nat. Commun. 9: 577.
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Abu-Remaileh, M., Bender, S., Raddatz, G., Ansari, I., Cohen, D., Gutekunst, J., Musch, T. Linhart, H., Breiling, A., Pikarsky, E., Bergman, Y., and Lyko, F. (2015). Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer. Cancer Res. 75: 2120-2130.
Epitranscriptomics
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Legrand, C., Tuorto, F., Hartmann, M., Liebers, R., Jacob, D., Helm, M., and Lyko, F. (2017). Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs. Genome Res. 27: 1589-1596.
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Tuorto, F., Herbst, F., Alerasool, N., Bender, S., Popp, O., Federico, G., Reitter, S., Liebers, R., Stoecklin, G., Gröne, H.J., Dittmar, G., Glimm, H., and Lyko, F. (2015). The tRNA methyltransferase Dnmt2 is required for accurate polypeptide synthesis during haematopoiesis. EMBO J. 34: 2350-2362.
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Tuorto, F., Liebers, R., Musch, T., Schaefer, M., Hofmann, S., Kellner, S., Frye, M., Helm, M., Stoecklin, G., and Lyko, F. (2012). RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Nat. Struct. Mol. Biol. 19: 900-905.
Marbled crayfish
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Gutekunst, J., Andriantsoa, R., Falckenhayn, C., Hanna, K., Stein, W., Rasamy, J., and Lyko, F. (2018). Clonal genome evolution and rapid invasive spread of the marbled crayfish. Nat. Ecol. Evol. 2: 567-573.
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Lyko, F. (2017). The marbled crayfish (Decapoda: Cambaridae) represents an independent new species. Zootaxa 4363: 544-552.
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Vogt, G., Falckenhayn, C., Schrimpf, A., Schmid, K., Hanna, K., Panteleit, J., Helm, M., Schulz R., and Lyko, F. (2015). The marbled crayfish as a paradigm for saltational speciation by autopolyploidy and parthenogenesis in animals. Biol. Open 4, 1583-1594.
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