Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Immune Modulation in Cancer

Dr. Martina Seiffert


Dr. Martina Seiffert
Team Leader
Contact: → Contactform
Tel.: 06221 42-4586


My group is interested in tumor immunology and the microenvironment in non-Hodgkin B-cell lymphoma and brain metastasis of breast and lung cancer, with a focus on cancer-induced immune suppression and inflammation as a driver of disease. We aim at identifying mediators and molecular mechanisms of crosstalk between the cancer cells and their surrounding neighbourhood, whereby we concentrate on immune cells of the myeloid and lymphoid lineages. We use our findings to develop and test novel immunotherapy approaches in patient-derived coculture and genetic mouse models.

Schematic presentation of the approaches we use to decipher the heterogeneity and pathological relevance of the tumor microenvironment in B-cell lymphoma and brain metastasis of breast and lung cancer.

The complex cellular and molecular composition of tumors is essential for their pathobiology. In the past, we were able to identify molecular mechanisms and candidate molecules that are responsible for cancer-induced remodeling of the microenvironment and the immune system.

Our current work focusses on an in-depth characterization of immune and stromal cells in B-cell lymphoma and brain metastases, with the goal to identify novel mechanisms of tumor support and immune escape, and to suggest candidate genes and pathways for the development of novel therapy approaches. This includes also the identification of prognostic or predictive markers and unravelling mechanisms of treatment resistance. We are specifically interested in cancer-associated T-cell exhaustion, in myeloid-derived suppressor cell function, and in mediators that are responsible for both of these phenotypes, including secreted factors and vesicles.

We use single-cell transcriptome and flow cytometry analyses of primary tumor tissue and blood, spatial analyses including multiplex tissue staining and in-situ transcript quantification, ATAC-seq and chromatin immunoprecipitation followed by DNA-sequencing to decipher transcription factor regulatory networks, proteome analyses, as well as functional and treatment studies in vitro and in mouse models to validate the relevance of identified candidate genes and pathways.

To this end, we cooperate with academic and industrial partners and are in close contact with our colleagues in the clinic.

Selected Publications

to top
powered by webEdition CMS