Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
- Publications
- Open Positions
- Funding
- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Primary Cancer Prevention
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Policy and Implementation Research for Cancer Prevention
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
- News
- Imaging and Radiooncology
- Radiology
- Research
- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
- Staff
- Patients
- Research
- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
- Research
- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
- News
- Vacancies
- Radiation Oncology
- Molecular Radiooncology
- Nuclear Medicine
- Translational Radiation Oncology
- Translational Radiotheranostics
- Interactive Machine Learning
- Intelligent Systems and Robotics in Urology
- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
- Radiology
- Cell Biology and Tumor Biology
- Research Groups A-Z
- Junior Research Groups
- Core Facilities
- News
- List of Core Facilities
- Antibodies
- Cellular Tools
- Center for Preclinical Research
- Central Library
- Chemical Biology
- Dieter Morszeck Biorepository
- Electron Microscopy
- Flow Cytometry
- Information Technology ITCF
- Light Microscopy
- Metabolomics
- Microarray
- Microbiological Diagnostics
- Next Generation Sequencing
- Omics IT and Data Management
- Proteomics
- Radiopharmaceuticals and Preclinical Trials
- Single-cell Open Lab
- Small Animal Imaging
- Transgenic Service
- Tumor Models
- OMERO@DKFZ
- List of Technologies
- DKFZ Core Facilities Publication Policy
- Enabling Technology
- Data Science @ DKFZ
- INFORM
- Baden-Württemberg Cancer Registry
- Cooperations & Networks
- National Cooperations
- International Cooperations
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Program
- Members of the Program Committee
- Call
- Publication Database
- German-Israeli Cancer Research Schools
- Archive
- Heidelberg - Israel, Science and Culture
- Symposium 40 Years of German-Israeli Cooperation
- 35th Anniversary Symposium
- 34th Meeting of the DKFZ-MOST Program
- 40th Anniversary Publication
- 30th Anniversary Publication
- 20th Anniversary Publication
- Flyer - The Cancer Cooperation Program
- List Publications 1976-2004
- Highlight-Projects
- Cooperational Research Program with Israel: DKFZ - MOST in Cancer Research
- Cooperations with industrial companies
- DKFZ PostDoc Network
- Cross Program Topic RNA@DKFZ
- Cross Program Topic Epigenetics@dkfz
- Cross Program Topic Single Cell Sequencing
- WHO Collaborating Centers
- DKFZ Site Dresden
- Health + Life Science Alliance Heidelberg Mannheim
Publications (2018-2024)
- The dynamic genetic determinants of increased transcriptional divergence in spermatids
J Panten, T Heinen, C Ernst, N Eling, RE Wagner, M Satorius, JC Marioni, Nature Communications 2024 - The cycling and aging mouse female reproductive tract at single-cell resolution
I Winkler, A Tolkachov, F Lammers, P Lacour, K Daugelaite, N Schneider, ...Cell 2024 - Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice
MC Funk, JG Gleixner, F Heigwer, D Vonficht, E Valentini, Z Aydin, ...Developmental Cell 2023 - Four-Core Genotypes mice harbour a 3.2 MB XY translocation that perturbs Tlr7 dosage
J Panten, SD Prete, JP Cleland, LM Saunders, J van Riet, A Schneider, ...BioRxiv 2023 - An interactive cellular ecosystem blocks epithelial transformation in naked mole-rat
M Behm, P Baeza Centurión, L Penso-Dolfin, FJ Botey Bataller, ...BioRxiv 2023 - A transcriptional and regulatory map of mouse somite maturation
X Ibarra-Soria, E Thierion, GF Mok, AE Münsterberg, DT Odom, ...Developmental Cell 2023 - Superovulation and aging perturb oocyte-granulosa cell communication
K Daugelaite, P Lacour, I Winkler, ML Koch, A Schneider, N Schneider, ...BioRxiv 2023 - Strand-resolved mutagenicity of DNA damage and repair
CJ Anderson, L Talmane, J Luft, MD Nicholson, J Connelly, O Pich, ...Biorxiv 2022 - LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions
M Roller, E Stamper, D Villar, O Izuogu, F Martin, AM Redmond, ...Genome Biology 2021 - Functional signatures of evolutionarily young CTCF binding sites
D Azazi, JM Mudge, DT Odom, P Flicek BMC Biology 2020 - Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains
E Kentepozidou, SJ Aitken, C Feig, K Stefflova, X Ibarra-Soria, DT Odom, ...Genome Biology 2020 - Pervasive lesion segregation shapes cancer genome evolution
SJ Aitken, CJ Anderson, F Connor, O Pich, V Sundaram, C Feig, ...Nature 2020 - A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division
L Stojic, ATL Lun, P Mascalchi, C Ernst, AM Redmond, J Mangei, AR Barr, ...Nature Communications 2020 - Bookmarking by non-pioneer transcription factors during liver development establishes competence for future gene activation
P Karagianni, P Moulos, D Schmidt, DT Odom, I Talianidis Cell Reports 2020 - Crisflash: open-source software to generate CRISPR guide RNAs against genomes annotated with individual variation
ALS Jacquin, DT Odom, M Lukk Bioinformatics 2019 - IL‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response
HC Chen, N Eling, CP Martinez‐Jimenez, LMN O'Brien, V Carbonaro, ... EMBO Reports 2019 - Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia
M Yang, M Vesterlund, I Siavelis, LH Moura-Castro, A Castor, T Fioretos, ...Nature Communications 2019 - Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis
C Ernst, N Eling, CP Martinez-Jimenez, JC Marioni, DT Odom Nature Communications 2019 - CTCF maintains regulatory homeostasis of cancer pathways
SJ Aitken, X Ibarra-Soria, E Kentepozidou, P Flicek, C Feig, JC Marioni, ...Genome Biology 2018 - Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species
R Lowe, C Barton, CA Jenkins, C Ernst, O Forman, DS Fernandez-Twinn, ...Genome Biology 2018 - Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci
J Lilue, AG Doran, IT Fiddes, M Abrudan, J Armstrong, R Bennett, ...Nature Genetics 2018 - Chromosome assembly of large and complex genomes using multiple references
M Kolmogorov, J Armstrong, BJ Raney, I Streeter, M Dunn, F Yang, ...Genome Research 2018 - Integrative detection and analysis of structural variation in cancer genomes
JR Dixon, J Xu, V Dileep, Y Zhan, F Song, VT Le, GG Yardımcı, ...Nature Genetics 2018