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Selected Publications

Hölting TLB, Cidre-Aranaz F, Matzek D, Popper B, Jacobi SJ, Funk CM, Geyer FH, Li J, Piseddu I, Cadilha BL, Ledderose S, Zwilling J, Ohmura S, Anz D, Künkele A, Klauschen F, Grünewald TG*, Knott MML*. Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma. (2022) Mol Cancer 21(1):199 [pubmed]

Cidre-Aranaz F§, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, Dirksen U, Grünewald TGP§. Small round cell sarcomas. (2022) Nat Rev Dis Primers 8(1):66 [pubmed]

Cidre-Aranaz F, Li J, Hölting TLB, Orth MF, Imle R, Kutschmann S, Ammirati G, Ceranski K, Carreño-Gonzalez MJ, Kasan M, Marchetto A, Funk CM, Bestvater F, Bersini S, Arrigoni C, Moretti M, Thiel U, Baumhoer D, Sahm F, Pfister SM, Hartmann W, Dirksen U, Romero-Pérez L, Banito A, Ohmura S, Musa J, Kirchner T, Knott MML*, Grünewald TG*. Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma. (2022) Mol Cancer 21(1):1 [pubmed]

Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Hölting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Pérez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F*, Grünewald TGP*. Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. (2021) Nat Commun 12(1):5356 [pubmed]

Ohmura S, Marchetto A, Orth MF, Li J, Jabar S, Ranft A, Vinca E, Ceranski K, Carreño-Gonzalez MJ, Romero-Pérez L, Wehweck FS, Musa J, Bestvater F, Knott MML, Hölting TLB, Hartmann W, Dirksen U, Kirchner T, Cidre-Aranaz F, Grünewald TGP§. Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma. (2021) Mol Cancer 20(1):97 [pubmed]

Marchetto A, Ohmura S, Orth MF, Knott MML, Colombo MV, Arrigoni C, Bardinet V, Saucier D, Wehweck FS, Li J, Stein S, Gerke JS, Baldauf MC, Musa J, Dallmayer M, Romero-Pérez L, Hölting TLB, Amatruda JF, Cossarizza A, Henssen AG, Kirchner T, Moretti M, Cidre-Aranaz F, Sannino G, Grünewald TG. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma. (2020) Nat Commun 11(1):2423 [pubmed]

Musa J, Cidre-Aranaz F, Aynaud MM, Orth MF, Knott MML, Mirabeau O, Mazor G, Varon M, Hölting TLB, Grossetête S, Gartlgruber M, Surdez D, Gerke JS, Ohmura S, Marchetto A, Dallmayer M, Baldauf MC, Stein S, Sannino G, Li J, Romero-Pérez L, Westermann F, Hartmann W, Dirksen U, Gymrek M, Anderson ND, Shlien A, Rotblat B, Kirchner T, Delattre O, Grünewald TGP. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. (2019) Nat Commun 10(1):4128 [pubmed]

Vriens K*, Christen S*, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TG, Fendt SM. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. (2019) Nature 566(7744):403-406 [pubmed]

Grünewald TG*, Cidre-Aranaz F*, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. (2018) Nat RevDis Primers 4(1):5 [pubmed]

Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, Mirabeau O, Cidre-Aranaz F, Tirode F, Zaidi S, Perot G, Jonker AH, Lucchesi C, Le Deley MC, Oberlin O, Marec-Bérard P, Véron AS, Reynaud S, Lapouble E, Boeva V, Rio Frio T, Alonso J, Bhatia S, Pierron G, Cancel-Tassin G, Cussenot O, Cox DG, Morton LM, Machiela MJ, Chanock SJ, Charnay P, Delattre O. Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. (2015) Nat Gen 47(9):1073-8 [pubmed]

§ corresponding author, * shared senior authorship

Complete List of Publications

2024

Martins LR, Sieverling L, Michelhans M, Schiller C, Erkut C, Grünewald TGP, Triana S, Fröhling S, Velten L, Glimm H, Scholl C. Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung. (2024) Nat Commun. 15(1):2246 [pubmed]

Pires C, Saramago A, Moura MM, Li J, Donato S, Marques IJ, Belo H, Machado AC, Cabrera R, Grünewald TGP, Leite V, Cavaco BM. Identification of Germline FOXE1 and Somatic MAPK Pathway Gene Alterations in Patients with Malignant Struma Ovarii, Cleft Palate and Thyroid Cancer. (2024) Int J Mol Sci; 25(4):1966 [pubmed]

Weniger M, Mattes M, Grünewald TGP, Köhler K, Hübner A, Beuschlein F, Reisch N. Quantitative Characterization of Ectopic Adrenal Gene Expression in Fetal Testes in 21-Hydroxylase Deficient Mice. (2024) Horm Metab Res 56(1):38-44. doi: 10.1055/a-2216-0269. PMID: 38171371 [pubmed]

 

2023

Grünewald TGP, Postel-Vinay S, Nakayama RT, Berlow NE, Bolzicco A, Cerullo V, Dermawan JK, Frezza AM, Italiano A, Jin JX, Le Loarer F, Martín-Broto J, Pecora A, Perez-Martinez A, Tam YB, Tirode F, Trama A, Pasquali S, Vescia M, Wortmann L, Wortmann M, Yoshida A, Webb K, Huang PH, Keller C, Antonescu CR. Translational Aspects of Epithelioid Sarcoma - Current Consensus. (2023) Clin Cancer Res doi: 10.1158/1078-0432.CCR-23-2174. Epub ahead of print [pubmed]

Kasan M, Siebenlist J, Sill M, Öllinger R, de Álava E, Surdez D, Dirksen U, Oehme I, Scotlandi K, Delattre O, Müller-Nurasyid M, Rad R, Strauch K, Grünewald TG, Cidre-Aranaz F. Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell lines. (2023) bioRxiv https://doi.org/10.1101/2023.11.20.567802

Funk CM, Ehlers AC, Orth MF, Aljakouch K, Li J, Hölting TLB, Will R, Willis F, Vinca E, Ohmura S, Imle R, Siebenlist J, Knott MML, Zahnow F, Sastre A, Alonso J, Sahm F, Loboda A, Peterziel H, Schneider M, Banito A, Leprivier G, Hartmann W, Dirksen U, Witt O, Oehme I, Pfister SM, Romero-Pérez L, Krijgsveld J, Cidre-Aranaz F, Grünewald TG*, Musa J*. Chromosome 8 gain drives cancer progression by hijacking the translation factor 4E-BP1 sensitizing for targeted CDK4/6 inhibition. (2023) bioRxiv https://doi.org/10.1101/2022.12.11.519935

Willis F, Buck L, Musa J, Hinz U, Mechtersheimer G, Seidensaal K, Fröhling S, Büchler MW, Schneider M. Long-term quality of life after resection of retroperitoneal soft tissue sarcoma. (2023) Eur J Surg Oncol 49(11):106977 [pubmed]

Musa J, Willis F, Harnoss JM, Rompen IF, Sauerteig C, Kochendoerfer SM, Grünewald TGP, Al-Saeedi M, Schneider M, Harnoss JC. A century of retroperitoneal soft-tissue sarcoma research: From single center experience to precision oncology? A bibliometric analysis of past, present, and future perspectives. (2023) Eur J Surg Oncol 49(9):106948 [pubmed]

Rompen IF, Nienhüser H, Crnovrsanin N, Musa J, Haag GM, Longerich T, Fiedler T, Müller-Stich BP, Sisic L, Billeter AT. Clinical Characteristics and Oncological Outcomes of Surgically Treated Early-Onset Gastric Adenocarcinoma - a Retrospective Cohort Study. (2023) J Cancer. 21;14(9):1470-1478. [pubmed]

Ceranski AK, Carreño-Gonzalez MJ, Ehlers AC, Colombo MV, Cidre-Aranaz F, Grünewald TGP. Hypoxia and HIFs in Ewing sarcoma: new perspectives on a multi-facetted relationship. (2023) Mol Cancer 13;22(1):49 [pubmed]

Lee OW, Rodrigues C, Lin SH, Luo W, Jones K, Brown DW, Zhou W, Karlins E, Khan SM, Baulande S, Raynal V, Surdez D, Reynaud S, Rubio RA, Zaidi S, Grossetête S, Ballet S, Lapouble E, Laurence V, Pierron G, Gaspar N, Corradini N, Marec-Bérard P, Rothman N, Dagnall CL, Burdett L, Manning M, Wyatt K, Yeager M, Chari R, Leisenring WM, Kulozik AE, Kriebel J, Meitinger T, Strauch K, Kirchner T, Dirksen U, Mirabello L, Tucker MA, Tirode F, Armstrong GT, Bhatia S, Robison LL, Yasui Y, Romero-Pérez L, Hartmann W, Metzler M, Diver WR, Lori A, Freedman ND, Hoover RN, Morton LM, Chanock SJ, Grünewald TGP, Delattre O, Machiela MJ. Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding. (2023) Am J Hum Genet S0002-9297(23)00017-4. doi: 10.1016/j.ajhg.2023.01.017. Epub ahead of print [pubmed]

Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu XZ, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de la Calle Arregui C, Floris G, Swinnen JV, Marine JC, Lambrechts D, Pelechano V, Mazzone M, Zanivan S, Cools J, Wildiers H, Baud V, Grünewald TGP, Ben-David U, Desmedt C, Malanchi I, Fendt SM. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. (2023) Nat Cancer doi: 10.1038/s43018-023-00513-2. Epub ahead of print [pubmed]

Kim JY, Zschaeck S, Debus J, Weykamp F. Combined Hyperthermia and Re-Irradiation in Non-Breast Cancer Patients: A Systematic Review. (2023) Cancers (Basel). 25;15(3):742 [pubmed]

 

2022

Orth MF, Surdez D, Faehling T, Ehlers AC, Marchetto A, Grossetête S, Volckmann R, Zwijnenburg DA, Gerke JS, Zaidi S, Alonso J, Sastre A, Baulande S, Sill M, Cidre-Aranaz F, Ohmura S, Kirchner T, Hauck SM, Reischl E, Gymrek M, Pfister SM, Strauch K, Koster J, Delattre O, Grünewald TGP. Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation. (2022) Cell Rep 41(10):111761 [pubmed]

Hölting TLB, Cidre-Aranaz F, Matzek D, Popper B, Jacobi SJ, Funk CM, Geyer FH, Li J, Piseddu I, Cadilha BL, Ledderose S, Zwilling J, Ohmura S, Anz D, Künkele A, Klauschen F, Grünewald TG*, Knott MML*. Neomorphic DNA-binding enables tumor-specific therapeutic gene expression in fusion-addicted childhood sarcoma. (2022) Mol Cancer 21(1):199 [pubmed]

Cidre-Aranaz F§, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, Dirksen U, Grünewald TGP§. Small round cell sarcomas. (2022) Nat Rev Dis Primers 8(1):66 [pubmed]

Pasello M, Giudice AM, Cristalli C, Manara MC, Mancarella C, Parra A, Serra M, Magagnoli G, Cidre-Aranaz F, Grünewald TGP, Bini C, Lollini PL, Longhi A, Donati DM, Scotlandi K. ABCA6 affects the malignancy of Ewing sarcoma cells via cholesterol-guided inhibition of the IGF1R/AKT/MDM2 axis. (2022) Cell Oncol (Dordr) doi: 10.1007/s13402-022-00713-5. Epub ahead of print [pubmed]

Shulman DS, Whittle SB, Surdez D, Bailey KM, de Álava E, Yustein JT, Shlien A, Hayashi M, Bishop AJR, Crompton BD, DuBois SG, Shukla N, Leavey PJ, Lessnick SL, Kovar H, Delattre O, Grünewald TGP, Antonescu CR, Roberts RD, Toretsky JA, Tirode F, Gorlick R, Janeway KA, Reed D, Lawlor ER, Grohar PJ. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. (2022) NPJ Precis Oncol 17;6(1):65 [pubmed]

Akagbosu B, Tayyebi Z, Shibu G, Paucar Iza YA, Deep D, Parisotto YF, Fisher L, Pasolli HA, Thevin V, Elmentaite R, Knott M, Hemmers S, Jahn L, Friedrich C, Verter J, Wang ZM, van den Brink M, Gasteiger G, Grünewald TGP, Marie JC, Leslie C, Rudensky AY, Brown CC. Novel antigen presenting cell imparts Treg-dependent tolerance to gut microbiota. (2022) Nature doi: 10.1038/s41586-022-05309-5. Epub ahead of print [pubmed]

Puerto-Camacho P, Díaz-Martín J, Olmedo-Pelayo J, Bolado-Carrancio A, Salguero-Aranda C, Jordán-Pérez C, Esteban-Medina M, Álamo-Álvarez I, Delgado-Bellido D, Lobo-Selma L, Dopazo J, Sastre A, Alonso J, Grünewald TGP, Bernabeu C, Byron A, Brunton VG, Amaral AT, Álava E. Endoglin and MMP14 Contribute to Ewing Sarcoma Spreading by Modulation of Cell-Matrix Interactions. (2022) Int J Mol Sci 23(15):8657 [pubmed]

Rasmussen SV, Jin JX, Bickford LR, Woods AD, Sahm F, Crawford KA, Nagamori K, Goto H, Torres KE, Sidoni A, Rudzinski ER, Thway K, Jones RL, Ciulli A, Wright H, Lathara M, Srinivasa G, Kannan K, Huang PH, Grünewald TGP, Berlow NE, Keller C. Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology. (2022) Clin Transl Med 12(7):e961. doi: 10.1002/ctm2.961 [pubmed]

Deng Q, Natesan R, Cidre-Aranaz F, Arif S, Liu Y, Rasool RU, Wang P, Mitchell-Velasquez E, Das CK, Vinca E, Cramer Z, Grohar PJ, Chou M, Kumar-Sinha C, Weber K, Eisinger-Mathason TSK, Grillet N, Grünewald T, Asangani IA. Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1. (2022) Cell Rep 39(11):110971 [pubmed]

Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernández-García J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Elsen JV, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Brussel TV, Sotlar K, Lewis MT, Bartsch H, Wuhrer M, Veelen PV, Carmeliet P, Cools J, Morrison SJ, Marine JC, Lambrechts D, Mazzone M, Hannon GJ, Lunt SY, Grünewald TGP, Park M, Rheenen JV, Fendt SM. PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. (2022) Nature doi: 10.1038/s41586-022-04758-2. Epub ahead of print [pubmed]

Vibert J, Saulnier O, Collin C, Petit F, Borgman KJE, Vigneau J, Gautier M, Zaidi S, Pierron G, Watson S, Gruel N, Hénon C, Postel-Vinay S, Deloger M, Raynal V, Baulande S, Laud-Duval K, Hill V, Grossetête S, Dingli F, Loew D, Torrejon J, Ayrault O, Orth MF, Grünewald TGP, Surdez D, Coulon A, Waterfall JJ, Delattre O. Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions. (2022) Mol Cell S1097-2765(22)00382-3. doi: 10.1016/j.molcel.2022.04.019. Epub ahead of print [pubmed]

Berthold R, Isfort I, Erkut C, Heinst L, Grünewald I, Wardelmann E, Kindler T, Åman P, Grünewald TGP, Cidre-Aranaz F, Trautmann M, Fröhling S, Scholl C, Hartmann W. Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma. (2022) Oncogenesis 11(1):20 [pubmed]

Voeltzke K, Scharov K, Funk CM, Kahler A, Picard D, Hauffe L, Orth MF, Remke M, Esposito I, Kirchner T, Schramm A, Rotblat B, Grünewald TGP, Reifenberger G, Leprivier G. EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma.(2022) Cell Death Discov. 8(1):157 [pubmed]

Hauffe L, Picard D, Musa J, Remke M, Grünewald TGP, Rotblat B, Reifenberger G, Leprivier G. Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) expression in glioblastoma is driven by ETS1- and MYBL2-dependent transcriptional activation. (2022) Cell Death Discov. 8(1):91 [pubmed]

Cidre-Aranaz F, Li J, Hölting TLB, Orth MF, Imle R, Kutschmann S, Ammirati G, Ceranski K, Carreño-Gonzalez MJ, Kasan M, Marchetto A, Funk CM, Bestvater F, Bersini S, Arrigoni C, Moretti M, Thiel U, Baumhoer D, Sahm F, Pfister SM, Hartmann W, Dirksen U, Romero-Pérez L, Banito A, Ohmura S, Musa J, Kirchner T, Knott MML*, Grünewald TG*. Integrative gene network and functional analyses identify a prognostically relevant key regulator of metastasis in Ewing sarcoma. (2022) Mol Cancer 21(1):1 [pubmed]

 

2021

García-García L, Fernández-Tabanera E, Cervera ST, Melero-Fernández de Mera RM, Josa S, González-González L, Rodríguez-Martín C, Grünewald TGP, Alonso J. The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes. (2021) Cancers (Basel) 13(22):5668 [pubmed]

Li J, Ohmura S, Marchetto A, Orth MF, Imle R, Dallmayer M, Musa J, Knott MML, Hölting TLB, Stein S, Funk CM, Sastre A, Alonso J, Bestvater F, Kasan M, Romero-Pérez L, Hartmann W, Ranft A, Banito A, Dirksen U, Kirchner T, Cidre-Aranaz F*, Grünewald TGP*. Therapeutic targeting of the PLK1-PRC1-axis triggers cell death in genomically silent childhood cancer. (2021) Nat Commun 12(1):5356 [pubmed]

Sole A, Grossetête S, Heintzé M, Babin L, Zaïdi S, Revy P, Renouf B, De Cian A, Giovannangeli C, Pierre-Eugène C, Janoueix-Lerosey I, Couronné L, Kaltenbach S, Tomishima M, Jasin M, Grünewald TGP, Delattre O, Surdez D, Brunet E. Unraveling Ewing sarcoma tumorigenesis originating from patient-derived Mesenchymal Stem Cells. (2021) Cancer Res canres.3837.2020. doi: 10.1158/0008-5472.CAN-20-3837. Epub ahead of print. [pubmed]

Ohmura S, Marchetto A, Orth MF, Li J, Jabar S, Ranft A, Vinca E, Ceranski K, Carreño-Gonzalez MJ, Romero-Pérez L, Wehweck FS, Musa J, Bestvater F, Knott MML, Hölting TLB, Hartmann W, Dirksen U, Kirchner T, Cidre-Aranaz F, Grünewald TGP§. Translational evidence for RRM2 as a prognostic biomarker and therapeutic target in Ewing sarcoma. (2021) Mol Cancer 20(1):97 [pubmed]

Zöllner SK, Amatruda JF, Bauer S, Collaud S, de Álava E, DuBois SG, Hardes J, Hartmann W, Kovar H, Metzler M, Shulman DS, Streitbürger A, Timmermann B, Toretsky JA, Uhlenbruch Y, Vieth V, Grünewald TGP, Dirksen U. Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives. (2021) J Clin Med 10(8):1685 [pubmed]

Sipol A, Hameister E, Xue B, Hofstetter J, Barenboim M, Öllinger R, Jain G, Prexler C, Rubio RA, Baldauf MC, Franchina DG, Petry A, Schmäh J, Thiel U, Gorlach A, Cario G, Brenner D, Richter G, Grünewald TGP, Rad R, Wolf E, Ruland J, Sorensen PH, Burdach SEG. MondoA Drives B-ALL Malignancy through Enhanced Adaptation to Metabolic Stress. (2021) Blood Epub ahead of print. PMID: 33908607 [pubmed]

Jansky S, Sharma AK, Körber V, Quintero A, Toprak UH, Wecht EM, Gartlgruber M, Greco A, Chomsky E, Grünewald TGP, Henrich KO, Tanay A, Herrmann C, Höfer T, Westermann F. Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma. (2021) Nat Genet Epub ahead of print. PMID: 33767450 [pubmed]

Broadfield LA, Gonçalves Duarte JA, Schmieder R, Broekaert D, Veys K, Planque M, Vriens K, Karasawa Y, Napolitano F, Fujita S, Fujii M, Eto M, Holvoet B, Vangoitsenhoven R, Fernandez-Garcia J, Van Elsen J, Dehairs J, Zeng J, Dooley J, Alba Rubio R, van Pelt J, Grünewald TGP, Liston A, Mathieu C, Deroose CM, Swinnen JV, Lambrechts D, di Bernardo D, Kuroda S, De Bock K, Fendt SM. Fat induces glucose metabolism in non-transformed liver cells and promotes liver tumorigenesis (2021) Cancer Res 9:canres.1954.2020. Epub ahead of print. PMID: 33687947 [pubmed]

Koelsche C, Schrimpf D, Stichel D, Sill M, Sahm F, Reuss DE, Blattner M, Worst B, Heilig CE, Beck K, Horak P, Kreutzfeldt S, Paff E, Stark S, Johann P, Selt F, Ecker J, Sturm D, Pajtler KW, Reinhardt A, Wefers AK, Sievers P, Ebrahimi A, Suwala A, Fernández-Klett F, Casalini B, Korshunov A, Hovestadt V, Kommoss FKF, Kriegsmann M, Schick M, Bewerunge-Hudler M, Milde T, Witt O, Kulozik AE, Kool M, Romero-Pérez L, Grünewald TGP, Kirchner T, Wick W, Platten M, Unterberg A, Uhl M, Abdollahi A, Debus J, Lehner B, Thomas C, Hasselblatt M, Paulus W, Hartmann C, Staszewski O, Prinz M, Hench J, Frank S, Versleijen-Jonkers YMH, Weidema ME, Mentzel T, Griewank K, de Álava E, Martín JD, Gastearena MAI, Chang KT, Low SYY, Cuevas-Bourdier A, Mittelbronn M, Mynarek M, Rutkowski S, Schüller U, Mautner VF, Schittenhelm J, Serrano J, Snuderl M, Büttner R, Klingebiel T, Buslei R, Gessler M, Wesseling P, Dinjens WNM, Brandner S, Jaunmuktane Z, Lyskjær I, Schirmacher P, Stenzinger A, Brors B, Glimm H, Heining C, Tirado OM, Sáinz-Jaspeado M, Mora J, Alonso J, Del Muro XG, Moran S, Esteller M, Benhamida JK, Ladanyi M, Wardelmann E, Antonescu C, Flanagan A, Dirksen U, Hohenberger P, Baumhoer D, Hartmann W, Vokuhl C, Flucke U, Petersen I, Mechtersheimer G, Capper D, Jones DTW, Fröhling S, Pfister SM, von Deimling A. Sarcoma classification by DNA methylation profiling. (2021) Nat Commun 12(1):498 [pubmed]

Machiela MJ, Grünewald TGP. Germline Variation and Somatic Alterations in Ewing Sarcoma. (2021) Methods Mol Biol 2226:3-14 [pubmed]

Marchetto A, Romero-Pérez L. Western Blot Analysis in Ewing Sarcoma. (2021) Methods Mol Biol 2226:15-25 [pubmed]

Romero-Pérez L, Grünewald TGP. Tissue Preservation and FFPE Samples: Optimized Nucleic Acids Isolation in Ewing Sarcoma. (2021) Methods Mol Biol 2226:27-38 [pubmed]

Marcilla D, Machado I, Grünewald TGP, Llombart-Bosch A, de Álava E. (Immuno)histological Analysis of Ewing Sarcoma. (2021) Methods Mol Biol 2226:49-64 [pubmed]

Knott MML, Cidre-Aranaz F. Ewing Sarcoma-Specific (Re)expression Models. (2021) Methods Mol Biol 2226:119-138 [pubmed]

Funk CM, Musa J. Proliferation Assessment by Trypan Blue Exclusion in Ewing Sarcoma. (2021) Methods Mol Biol 2226:151-158 [pubmed]

Musa J, Cidre-Aranaz F. Drug Screening by Resazurin Colorimetry in Ewing Sarcoma. (2021) Methods Mol Biol 2226:159-166 [pubmed]

Cidre-Aranaz F. Analysis of Migration and Invasion in Ewing Sarcoma. (2021) Methods Mol Biol 2226:167-179 [pubmed]

Cidre-Aranaz F, Ohmura S. Tumor Growth Analysis of Ewing Sarcoma Cell Lines Using Subcutaneous Xenografts in Mice. (2021) Methods Mol Biol 2226:191-199 [pubmed]

 

2020

Gartlgruber M, Sharma AK, Quintero A, Dreidax D, Jansky S, Park YG, Gogolin S, Meder J, Doncevic D, Saary P, Toprak UH, Afanasyeva E, Koster J, Versteeg R, Grünewald TGP, Jones DTW, Pfister SM, Henrich KO, van Nes J, Herrmann C, Westermann F. Super enhancers define regulatory subtypes and cell identity in neuroblastoma. (2020) Nat Cancer 2(1): 114-128 [pubmed]

Rinaldi G, Pranzini E, Van Elsen J, Broekaert D, Funk CM, Planque M, Doglioni G, Altea-Manzano P, Rossi M, Geldhof V, Teoh ST, Ross C, Hunter KW, Lunt SY, Grünewald TGP, Fendt SM. In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition. (2020) Mol Cell S1097-2765(20)30827-3. Epub ahead of print. PMID: 33340488 [pubmed]

Grünewald TG. Integrative molecular pathology of cancer. (2020) Pathologe Epub ahead of print. PMID: 33263807 [pubmed]

Fahr L, Sunami Y, Maeritz N, Steiger K, Grünewald TGP, Gericke M, Kong B, Raulefs S, Mayerle J, Michalski CW, Regel I, Kleeff J. Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis. (2020) Pancreatology 10:S1424-3903(20)30783-3 [pubmed]

Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D. Sarcoma treatment in the era of molecular medicine. (2020) EMBO Mol Med e11131 [pubmed]

Willier S, Raedler J, Blaeschke F, Stenger D, Pazos Escudero M, Jurgeleit F, Grünewald TGP, Binder V, Schmid I, Albert MH, Wolf A, Feuchtinger T. Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells. (2020) J Immunother Cancer 8(2):e001052 [pubmed]

Lin SH, Sampson JN, Grünewald TGP, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetête-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Kontny U, González-Neira A, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Miller J, Freedman ND, Rothman N, Carter BD, Dagnall CL, Burdett L, Jones K, Manning M, Wyatt K, Zhou W, Yeager M, Cox DG, Hoover RN, Khan J, Armstrong GT, Leisenring WM, Bhatia S, Robison LL, Kulozik AE, Kriebel J, Meitinger T, Metzler M, Krumbholz M, Hartmann W, Strauch K, Kirchner T, Dirksen U, Mirabello L, Tucker MA, Tirode F, Morton LM, Chanock SJ, Delattre O, Machiela MJ. Low-frequency variation near common germline susceptibility loci are associated with risk of Ewing sarcoma. (2020) PLoS One 15(9):e0237792 [pubmed]

Marchetto A, Grünewald TGP. SOX6: a double-edged sword for Ewing sarcoma. (2020) Mol Cell Oncol 7(5):1783081 [pubmed]

Schober, SJ, Thiede M, Gassmann H, Prexler C, Xue B, Schirmer D, Wohlleber D, Stein S, Grünewald TG, Busch DH, Richter GHS, Burdach SEG, Thiel U. MHC Class I-Restricted TCR-Transgenic CD4 + T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo. (2020) Cells 9(7):e1581 [pubmed]

Triki M, Rinaldi G, Planque M, Broekaert D, Winkelkotte AM, Maier CR, Janaki Raman S, Vandekeere A, Van Elsen J, Orth MF, Grünewald TG, Schulze A, Fendt SM. mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis. (2020) Cell Rep 31(12):107806 [pubmed]

Stenger D, Stief TA, Käuferle T, Willier S, Rataj F, Schober K, Vick B, Lotfi R, Wagner B, Grünewald TG, Kobold S, Busch DH, Jeremias I, Blaeschke F, Feuchtinger TF. Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR. (2020) Blood 005185 [pubmed]

Marchetto A, Ohmura S, Orth MF, Knott MML, Colombo MV, Arrigoni C, Bardinet V, Saucier D, Wehweck FS, Li J, Stein S, Gerke JS, Baldauf MC, Musa J, Dallmayer M, Romero-Pérez L, Hölting TLB, Amatruda JF, Cossarizza A, Henssen AG, Kirchner T, Moretti M, Cidre-Aranaz F, Sannino G, Grünewald TG. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma. (2020) Nat Commun 11(1):2423 [pubmed]

Galai G, Ben-David H, Levin L, Orth MF, Grünewald TG, Pilosof S, Berstein S, Rotblat B. Pan-Cancer Analysis of Mitochondria Chaperone-Client Co-Expression Reveals Chaperone Functional Partitioning. (2020) Cancers (Basel) 12(4):825 [pubmed]

Orth MF, Buecklein VL, Kampmann E, Subklewe M, Noessner E, Cidre-Aranaz F, Romero-Pérez L, Wehweck FS, Lindner L, Issels R, Kirchner T, Altendorf-Hofmann A, Grünewald TG*, Knösel T*. A comparative view on the expression patterns of PD-L1 and PD-1 in soft tissue sarcomas. (2020) Cancer Immunol Immunother 69(7):1353-1362 [pubmed]

Orth MF, Hölting TLB, Dallmayer M, Wehweck FS, Paul T, Musa J, Baldauf MC, Surdez D, Delattre O, Knott MML, Romero-Pérez L, Kasan M, Cidre-Aranaz F, Gerke JS, Ohmura S, Li J, Marchetto A, Henssen AG, Özen Ö, Sugita S, Hasegawa T, Kanaseki T, Bertram S, Dirksen U, Hartmann W, Kirchner T, Grünewald TGP. High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma. (2020) Cancers (Basel) 12(3):644 [pubmed]

Aynaud MM, Mirabeau O, Gruel N, Grossetête S, Boeva V, Durand S, Surdez D, Saulnier O, Zaïdi S, Gribkova S, Fouché A, Kairov U, Raynal V, Tirode F, Grünewald TG, Bohec M, Baulande S, Janoueix-Lerosey I, Vert JP, Barillot E, Delattre O, Zinovyev A. Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution. (2020) Cell Rep 30(6):1767-1779.e6 [pubmed]

Rodríguez-Núñez P, Romero-Pérez L, Amaral AT, Puerto-Camacho P, Jordán C, Marcilla D, Grünewald TG, Alonso J, de Alava E, Díaz-Martín J. Hippo pathway effectors YAP1/TAZ induce an EWS-FLI1-opposing gene signature and associate with disease progression in Ewing sarcoma. (2020) J Pathol 250(4):374-386 [pubmed]

Steinestel K, Trautmann M, Jansen EP, Dirksen U, Rehkämper J, Mikesch JH, Gerke JS, Orth MF, Sannino G, Arteaga MF, Rossig C, Wardelmann E, Grünewald TG, Hartmann W. Focal adhesion kinase confers pro-migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma. (2020) Mol Oncol 14(2):248-260 [pubmed]

Gerke JS, Orth MF, Tolkach Y, Romero-Pérez L, Wehweck FS, Stein S, Musa J, Knott MML, Hölting TLB, Li J, Sannino G, Marchetto A, Ohmura S, Cidre-Aranaz F, Müller-Nurasyid M, Strauch K, Stief C, Kristiansen G, Kirchner T, Buchner A, Grünewald TGP. Integrative clinical transcriptome analysis reveals TMPRSS2-ERG dependency of prognostic biomarkers in prostate adenocarcinoma. (2020) Int J Cancer 146(7):2036-2046 [pubmed]

Kommoss FKF, Stichel D, Schrimpf D, Kriegsmann M, Tessier-Cloutier B, Talhouk A, McAlpine JN, Chang KTE, Sturm D, Pfister SM, Romero-Pérez L, Kirchner T, Grünewald TGP, Buslei R, Sinn HP, Mechtersheimer G, Schirmacher P, Schmidt D, Lehr HA, Sahm F, Huntsman DG, Gilks CB, Kommoss F, von Deimling A, Koelsche C. DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics. (2020) J Cancer Res Clin Oncol 146(1):97-104 [pubmed]

 

2019

Knott MML, Hölting TLB, Ohmura S, Kirchner T, Cidre-Aranaz F, Grünewald TGP. Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies. (2019) Cancer Metastasis Rev 38(4):625-642 [pubmed]

Musa J, Grünewald TGP. Interaction between somatic mutations and germline variants contributes to clinical heterogeneity in cancer. (2019) Mol Cell Oncol 7(1):1682924 [pubmed]

Musa J, Cidre-Aranaz F, Aynaud MM, Orth MF, Knott MML, Mirabeau O, Mazor G, Varon M, Hölting TLB, Grossetête S, Gartlgruber M, Surdez D, Gerke JS, Ohmura S, Marchetto A, Dallmayer M, Baldauf MC, Stein S, Sannino G, Li J, Romero-Pérez L, Westermann F, Hartmann W, Dirksen U, Gymrek M, Anderson ND, Shlien A, Rotblat B, Kirchner T, Delattre O, Grünewald TGP. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes. (2019) Nat Commun 10(1):4128 [pubmed]

Sannino G, Marchetto A, Ranft A, Jabar S, Zacherl C, Alba-Rubio R, Stein S, Wehweck FS, Kiran MM, Hölting TLB, Musa J, Romero-Pérez L, Cidre-Aranaz F, Knott MML, Li J, Jürgens H, Sastre A, Alonso J, Da Silveira W, Hardiman G, Gerke JS, Orth MF, Hartmann W, Kirchner T, Ohmura S, Dirksen U, Grünewald TGP. Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients. (2019) EBioMedicine 47:156-162 [pubmed]

Romero-Pérez L, Surdez D, Brunet E, Delattre O, Grünewald TGP. STAG Mutations in Cancer. (2019) Trends Cancer 5(8):506-520 [pubmed]

Jones DTW, Banito A, Grünewald TGP, Haber M, Jäger N, Kool M, Milde T, Molenaar JJ, Nabbi A, Pugh TJ, Schleiermacher G, Smith MA, Westermann F, Pfister SM. Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours. (2019) Nat Rev Cancer 19(8):420-438 [pubmed]

Koelsche C, Kriegsmann M, Kommoss FKF, Stichel D, Kriegsmann K, Vokuhl C, Grünewald TGP, Romero-Pérez L, Kirchner T, de Alava E, Diaz-Martin J, Hartmann W, Baumhoer D, Antonescu CR, Szuhai K, Flucke U, Dirksen U, Pfister SM, Jones DTW, Mechtersheimer G, von Deimling A. DNA methylation profiling distinguishes Ewing-like sarcoma with EWSR1-NFATc2 fusion from Ewing sarcoma. (2019) J Cancer Res Clin Oncol. 145(5):1273-1281 [pubmed]

Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TG. Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma. (2019) Cell Death Dis. 10(2):116 [pubmed]

Shannan B, Matschke J, Chauvistre H, Vogel F, Klein D, Meier F, Westphal D, Bruns J, Rauschenberg R, Utikal J, Forschner A, Berking C, Terheyden P, Dabrowski E, Gutzmer R, Rafei-Shamsabadi D, Meiss F, Heinzerling L, Zimmer L, Varaljai R, Hoewner A, Horn S, Klode J, Stuschke M, Scheffler B, Marchetto A, Sannino G, Grünewald TG, Schadendorf D, Jendrossek V, Roesch A. Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV600E-inhibition in melanoma. (2019) Eur J Cancer 109:137-153 [pubmed]

Vriens K*, Christen S*, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TG, Fendt SM. Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity. (2019) Nature 566(7744):403-406 [pubmed]

Brandl L, Horst D, Grünewald TG, Mayerle J, Sendelhofert A, Neumann J, Kirchner T, De Toni EN. Clinical evidence on the interaction between MLK4, KRAS and microsatellite instability to determine the prognosis of early-stage colorectal carcinoma. (2019) Cellular Physiology and Biochemistry 53(5):820-831 [pubmed]

Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TLB, Cidre-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MML, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TG. Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma. (2019) Int J Cancer 144(4):859-867 [pubmed]

Musa J, Li J, Grünewald TG. Hepatitis B virus large surface protein is priming for hepatocellular carcinoma development via induction of cytokinesis failure. (2019) J Pathol. 247(1):6-8 [pubmed]

 

2018

Machiela MJ, Grünewald TG, Surdez D, Reynaud S, Mirabeau O, Karlins E, Rubio RA, Zaidi S, Grossetete-Lalami S, Ballet S, Lapouble E, Laurence V, Michon J, Pierron G, Kovar H, Gaspar N, Kontny U, González-Neira A, Picci P, Alonso J, Patino-Garcia A, Corradini N, Bérard PM, Freedman ND, Rothman N, Dagnall CL, Burdett L, Jones K, Manning M, Wyatt K, Zhou W, Yeager M, Cox DG, Hoover RN, Khan J, Armstrong GT, Leisenring WM, Bhatia S, Robison LL, Kulozik AE, Kriebel J, Meitinger T, Metzler M, Hartmann W, Strauch K, Kirchner T, Dirksen U, Morton LM, Mirabello L, Tucker MA, Tirode F, Chanock SJ, Delattre O. Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility. (2018) Nat Commun 9(1):3184 [pubmed]

Baldauf MC*, Gerke JS*, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Özen Ö, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grünewald TG. Systematic identification of cancer-specific MHC-binding peptides with RAVEN. (2018) OncoImmunology 7(9):e1481558 [pubmed]

Froelich MF, Stintzing S, Kumbrink J, Grünewald TG, Mansmann U, Heinemann V, Kirchner T, Jung A. (2018) The DNA-polymorphism rs849142 is associated with skin toxicity induced by targeted anti-EGFR therapy using cetuximab. Oncotarget 9(54):30279-30288 [pubmed]

Grünewald TG*, Cidre-Aranaz F*, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. (2018) Nat RevDis Primers 4(1):5 [pubmed]

Baldauf MC*, Gerke JS*, Orth MF, Dallmayer M, Baumhoer D, de Alava E, Hartmann W, Kirchner T, Grünewald TG. Are EWSR1-NFATc2-positive sarcomas really Ewing sarcoma? (2018) Modern Pathology 31(6):997-999 [pubmed]

Lamprecht S*, Kaller M*, Schmidt EV, Blaj C, Schiergens TS, Engel J, Jung A, Hermeking H, Grünewald TG, Kirchner T, Horst D. PBX3 is part of an EMT regulatory network in colorectal cancer and indicates poor outcome. (2018) Clinical Cancer Research 24(8):1974-1986 [pubmed]

Li J, Dallmayer M, Kirchner T, Musa J, Grünewald TG. PRC1: Linking Cytokinesis, Chromosomal Instability, and Cancer Evolution. (2018) Trends in Cancer 4(1):59-73 [pubmed]

 

2017 

Steinestel K, Grünewald TG, Hartmann W. The role of focal adhesions in Ewing's sarcoma. (2017) Pathologe 38(Suppl 2):169-171 [pubmed]

Grünewald TG. Functional Genomics of Ewing sarcoma. (2017) Pathologe 38(Suppl 2):198-201 [pubmed]

Sannino G, Marchetto A, Kirchner T, Grünewald TG. Epithelial to mesenchymal and mesenchymal to epithelial transition in mesenchymal tumors – a paradox in sarcomas? (2017) Cancer Res 77(17):4556-61 [pubmed]

Baldauf MC*, Orth MF*, Dallmayer M*, Marchetto A, Gerke JS, Rubio AR, Kiran MM, Musa J, Knott MML, Ohmura S, Li J, Akpolat N, Akatli AN, Özen Ö, Dirksen U, Hartmann W, de Alava E, Baumhoer D, Sannino G, Kirchner T, Grünewald TG. Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets. (2017) Oncotarget 9(2):1587-1601 [pubmed]

Boeva V, Louis-Brennetot C, Peltier A, Durand S, Pierre-Eugène C, Raynal V, Etchevers H, Thomas S, Lermine A, Daudigeos-Dubus E, Geoerger G, Orth MF, Grünewald TG, Diaz E, Ducos B, Surdez D, Carcaboso AM, Medvedeva I, Deller T, Combaret V, Lapouble E, Pierron G, Grossetête-Lalami S, Baulande S, Schleiermacher G, Barillot E, Rohrer H, Delattre O, Janoueix-Lerosey I. Heterogeneity of neuroblastoma cell identity revealed by transcriptional circuitries. (2017) Nature Genetics 49(9):1408-1413 [pubmed]

Musa J, Aynaud MM, Mirabeau O, Delattre O, Grünewald TG. MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis. (2017) Cell Death & Dis. 6(5):e1312239 [pubmed]

Boekstegers AM, Blaeschke F, Schmid I, Wiebking V, Immler S, Hoffmann F, Bochmann K, Müller S, Grünewald TG, Feucht J, Feuchtinger T. MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD. (2017) Bone Marrow Transplant 52(8):1221-1224 [pubmed]

Sannino G, Orth MF, Grünewald TG. Next steps in Ewing sarcoma (epi-)genomics. (2017) Future Oncol 13(14):1207-1211 [pubmed]

Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, Verfaillie C, Grünewald TG, Fendt SM. Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. (2017) Nat Commun 8:15267 [pubmed]

Thiel U, Schober S, Einspieler I, Kirschner A, Thiede M, Schirmer D, Gall K, Blaeschke F, Rubio RA, Grünewald TG, Richter GH, von Lüttichau T, Sorensen PH, Busch DH, Burdach S. Ewing Sarcoma Partial Regression without GvHD by Chondromodulin-I/HLA-A*02:01-Specific Allorestricted T Cell Receptor Transgenic T Cells. (2017) OncoImmunology 6(5):e1312239 [pubmed]

Kirschner A, Thiede M, Grünewald TG, Rubio RA, Richter GH, Kirchner T, Busch DH, Burdach S, Thiel U. Pappalysin-1 T cell receptor transgenic allo-restricted T cells kill Ewing sarcoma in vitro and in vivo. (2017) OncoImmunology 6(2):e1273301 [pubmed]

 

2016

Thiel U, Wawer A, von Luettichau I, Bender HU, Blaeschke F, Grünewald TG, Steinborn M, Röper B, Bonig H, Klingebiel T, Bader P, Koscielniak E, Paulussen M, Dirksen U, Juergens H, Kolb HJ, Burdach SE. Bone marrow involvement identifies a subgroup of advanced Ewing sarcoma patients with fatal outcome irrespective of therapy in contrast to curable patients with multiple bone metastases but unaffected marrow. (2016) Oncotarget 7(43):70959-70968 [pubmed]

Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, Elia I, Buescher JM, Orth MF, Davidson SM, Grünewald TG, De Bock K, Fendt SM. Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis. (2016) Cell Reports 17(3):837-848 [pubmed]

Kirschner A, Thiede M, Blaeschke F, Richter GH, Gerke JS, Baldauf MC, Grünewald TG, Busch DH, Burdach S, Thiel U. Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens. (2016) Oncotarget 7(35):56584-56597 [pubmed]

Blaeschke F*, Thiel U*, Kirschner A, Thiede M, Rubio RA, Schirmer D, Kirchner T, Richter GH, Mall S, Klar R, Riddell S, Busch DH, Krackhardt A, Grünewald TG, Burdach S. Human HLA-A*02:01/CHM1+ allo-restricted T cell receptor transgenic CD8+ T cells specifically inhibit Ewing sarcoma growth in vitro and in vivo. (2016) Oncotarget 7(28):43267-43280 [pubmed]

Cidre-Aranaz F, Grünewald TG, Surdez D, García-García L, Carlos Lázaro J, Kirchner T, González-González L, Sastre A, García-Miguel P, López-Pérez SE, Monzón S, Delattre O, Alonso J. EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma. (2016) Oncogene 36(6):766-776 [pubmed]

Schirmer D, Grünewald TG, Klar R, Schmidt O, Wohlleber D, Rubío RA, Uckert W, Thiel U, Bohne F, Busch DH, Krackhardt AM, Burdach S, Richter GH. Transgenic antigen-specific, HLA-A*02:01-allo-restricted cytotoxic T cells recognize tumor-associated target antigen STEAP1 with high specificity. (2016) OncoImmunology 5(6):e1175795 [pubmed]

Grünewald TG, Gilardi-Hebenstreit P, Charnay P, Delattre O. Cooperation between a somatic mutation and a genetic susceptibility variant in Ewing sarcoma. (2016) Med. Sci. (Paris) 32(4):323-6 [pubmed]

Sannino G, Pasqualini L, Ricciardelli E, Montilla P, Soverchia L, Ruggeri B, Falcinelli S, Renzi A, Ludka C, Kirchner T, Grünewald TG, Ciccocioppo R, Ubaldi M, Hardiman G. Acute stress enhances the expression of neuroprotection- and neurogenesis-associated genes in the hippocampus of a mouse restraint model. (2016) Oncotarget 7(8):8455-65 [pubmed]

Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O. The second European interdisciplinary Ewing sarcoma research summit - A joint effort to deconstructing the multiple layers of a complex disease. (2016) Oncotarget 7(8):8613-24 [pubmed]

Grünewald TG, Fulda S. Biology-Driven Targeted Therapy of Pediatric Soft-Tissue and Bone Tumors: Current Opportunities and Future Challenges. (2016) Front Oncol. 6:39 [pubmed]

Musa J, Orth MF, Dallmayer M, Baldauf M, Pardo C, Rotblat B, Kirchner T, Leprivier G, Grünewald TG. Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis. (2016) Oncogene 35(36):4675-88 [pubmed]

Knott MM, Dallmayer M, Grünewald TG. Next steps in preventing Ewing sarcoma progression. (2016) Future Oncol. 12(1):1-4 [pubmed]

 

2015

Grünewald TG, Delattre O. Cooperation between somatic mutations and germline susceptibility variants in tumorigenesis - a dangerous liaison. (2015) Mol Cell Oncol. 3(3):e1086853 [pubmed]

Sahay D, Leblanc R, Grünewald TG, Ambatipudi S, Ribeiro J, Clézardin P, Peyruchaud O. The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer. (2015) Oncotarget 6(24):20604-20 [pubmed]

Grünewald TG, Bernard V, Gilardi-Hebenstreit P, Raynal V, Surdez D, Aynaud MM, Mirabeau O, Cidre-Aranaz F, Tirode F, Zaidi S, Perot G, Jonker AH, Lucchesi C, Le Deley MC, Oberlin O, Marec-Bérard P, Véron AS, Reynaud S, Lapouble E, Boeva V, Rio Frio T, Alonso J, Bhatia S, Pierron G, Cancel-Tassin G, Cussenot O, Cox DG, Morton LM, Machiela MJ, Chanock SJ, Charnay P, Delattre O. Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite. (2015) Nat Gen 47(9):1073-8 [pubmed]

Vaman VSA, Poppe H, Houben R, Grünewald TG, Goebeler M, Butt E. LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression. (2015) PLoS One 10(6):e0129219 [pubmed]

Miller IV, Grünewald TG. Tumour-derived exosomes: Tiny envelopes for big stories. (2015) Biol Cell 107(9):287-305 [pubmed]

El-Naggar AM, Veinotte CJ, Cheng H, Grünewald TG, Negri GL, Somasekharan SP, Corkery DP, Tirode F, Mathers J, Khan D, Kyle AH, Baker JH, LePard NE, McKinney S, Hajee S, Bosiljcic M, Leprivier G, Tognon CE, Minchinton AI, Bennewith KL, Delattre O, Wang Y, Dellaire G, Berman JN, Sorensen PH. Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis. (2015) Cancer Cell 27(5):682-97 [pubmed]

Somasekharan SP, El-Naggar A, Leprivier G, Cheng H, Hajee S, Grünewald TG, Zhang F, Ng T, Delattre O, Evdokimova V, Wang Y, Gleave M, Sorensen PH. YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1. (2015) J Cell Biol. 208(7):913-29 [pubmed]

Orth MF, Cazes A, Butt E, Grünewald TG. An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. (2015) Oncotarget 6(1):26-42 [pubmed]

Rotblat B, Grünewald TG. Translating cancer-omics into function. (2015) Biol Cell 00;1-2 Special issue „Canceromics"

 

2014 and earlier

Frietsch JJ*, Kastner C*, Grünewald TG, Schweigel H, Nollau P, Ziermann J, Clement JH, La Rosée P, Hochhaus A, Butt E. LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia. (2014) Oncotarget 5(14):5257-71 [pubmed]

Hailer A*, Grünewald TG*, Orth M, Reiss C, Kneitz B, Spahn M, Butt E. Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration. (2014) Oncotarget 5(12):4144-4153 [pubmed]

Rotblat B*, Grünewald TG*, Leprivier G*, Melino G, Knight RA. Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers. (2013) Oncotarget 4(12):2577 90 [pubmed]

Thiel U, Koscielniak E, Blaeschke F, Grünewald TG, Badoglio M, Diaz MA, Paillard C, Prete A, Ussowicz M, Lang P, Fagioli F, Lutz P, Ehninger G, Schneider P, Santucci A, Bader P, Gruhn B, Faraci M, Antunovic P, Styczynski J, Krüger WH, Castagna L, Rohrlich P, Ouachée-Chardin M, Salmon A, Peters C, Bregni M, Burdach S. Allogeneic stem cell transplantation for patients with advanced rhabdomyosarcoma: a retrospective assessment. (2013) Br J Cancer 109(10):2523-32 [pubmed]

Grünewald TG*, Willier S*, Janik D, Unland R, Reiss C, Prazeres da Costa O, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E. The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth. (2013) Biol Cell 105(11):535-47 [pubmed]

Willier S, Butt E, Grünewald TG. Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. (2013) Biol Cell 105(8):317-33 [pubmed]

Miller IV, Raposo G, Welsch U, Prazeres da Costa O, Thiel U, Lebar M, Maurer M, Bender HU, von Luettichau I, Richter GH, Burdach S, Grünewald TG. First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications. (2013) Biol Cell 105(7):289-303 [pubmed]

Richter GH, Fasan A, Hauer K, Grünewald TG, Berns C, Rössler S, Naumann I, Staege MS, Fulda S, Esposito I, Burdach S. G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1. (2013) J Pathol. 230(1):70-81 [pubmed]

Hauer K, Calzada-Wack J, Steiger K, Grünewald TG, Baumhoer D, Plehm S, Buch T, Prazeres da Costa O, Esposito I, Burdach S, Richter GH. DKK2 mediates osteolysis, invasiveness, and metastatic spread in Ewing sarcoma. (2013) Cancer Res. 73(2):967-77 [pubmed]

Grünewald TG, Bach H, Cossarizza A, Matsumoto I. The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. (2012) Biol Cell 104(11):641-57 [pubmed]

Thiel U, Wolf P, Wawer A, Blaeschke F, Grünewald TG, von Lüttichau IT, Klingebiel T, Bader P, Borkhardt A, Laws HJ, Handgretinger R, Lang P, Schlegel PG, Eyrich M, Gruhn B, Ehninger G, Koscielniak E, Klein C, Sykora KW, Holler E, Mauz-Körholz C, Woessmann W, Richter GH, Schmidt AH, Peters C, Dirksen U, Jürgens H, Bregni M, Burdach S. Human leukocyte antigen distribution in German Caucasians with advanced Ewing's sarcoma. (2012) Klin Padiatr. 224(6):353-8 [pubmed]

Wernicke CM, Richter GH, Beinvogl BC, Plehm S, Schlitter AM, Bandapalli OR, Prazeres da Costa O, Hattenhorst UE, Volkmer I, Staege MS, Esposito I, Burdach S, Grünewald TG. MondoA is highly overexpressed in acute lymphoblastic leukemia cells and modulates their metabolism, differentiation and survival. (2012) Leuk Res. 36(9):1185-92 [pubmed]

Grünewald TG*, Greulich N*, Kontny U, Frühwald M, Rutkowski S, Kordes U, Scheurlen W, Schmidt W, Stachel D, Metzler M, Mittler U, Graf N, Benesch M, Burdach S. Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature. (2012) Klin Padiatr. 224(3):124-31 [pubmed]

Grünewald TG*, Ranft A*, Esposito I*, da Silva-Buttkus P, Aichler M, Baumhoer D, Schaefer KL, Ottaviano L, Poremba C, Jundt G, Jürgens H, Dirksen U, Richter GH, Burdach S. High STEAP1 expression is associated with improved outcome of Ewing's sarcoma patients. (2012) Annals of Oncol. 23(8):2185-90 [pubmed]

Willier S, Butt E, Richter GH, Burdach S, Grünewald TG. Defining the role of TRIP6 in cell physiology and cancer. (2011) Biol Cell 103(12):573-91 [pubmed]

Grünewald TG, Diebold I, Esposito I, Plehm S, Hauer K, Thiel U, da Silva-Buttkus P, Neff F, Unland R, Müller-Tidow C, Zobywalski C, Lohrig K, Lewandrowski U, Sickmann A, Prazeres da Costa O, Görlach A, Cossarizza A, Butt E, Richter GH, Burdach S. STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors. (2012) Mol Cancer Res. 10(1):52-65 [pubmed]

Wernicke CM*, Grünewald TG*, Juenger H, Kuci S, Kuci Z, Koehl U, Mueller I, Doering M, Peters C, Lawitschka A, Kolb HJ, Bader P, Burdach S, von Luettichau I. (2011) Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases. Int Arch Med. 4(1):27 [pubmed]

Grünewald TG, Herbst SM, Heinze J, Burdach S. Understanding tumor heterogeneity as functional compartments - superorganisms revisited. (2011) J Transl Med. 9:79 [pubmed]

Traenka C*, Remke M*, Korshunov A, Bender S, Hielscher T, Northcott PA, Witt H, Ryzhova M, Felsberg J, Benner A, Riester S, Scheurlen W, Grünewald TG, von Deimling A, Kulozik AE, Reifenberger G, Taylor MD, Lichter P, Butt E, Pfister SM. Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma. (2010) Cancer Res. 70(20):8003-14 [pubmed]

Grünewald TG*, Damke L*, Maschan M, Petrova U, Surianinova O, Esipenko A, Konovalov D, Behrends U, Schiessl J, Wörtler K, Burdach S, von Luettichau I. First report of effective and feasible treatment of multifocal lymphangiomatosis (Gorham-Stout) with bevacizumab in a child. (2010) Annals of Oncol. 21(8):1733-4 [pubmed]

Frietsch JJ*, Grünewald TG*, Jasper S, Kammerer U, Herterich S, Kapp M, Honig A, Butt E. Nuclear localisation of LASP-1 correlates with poor long-term survival in female breast cancer. (2010) Br J Cancer 102(11):1645-53 [pubmed]

Grünewald TG, von Luettichau I, Welsch U, Dörr HG, Höpner F, Kovacs K, Burdach S, Rabl W. First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child. (2010) Eur J Endocrinol. 162(4):813-8 [pubmed]

Grünewald TG, von Luettichau I, Weirich G, Wawer A, Behrends U, Prodinger PM, Jundt G, Bielack SS, Gradinger R, Burdach S. Sclerosing epithelioid fibrosarcoma of the bone: a case report of high resistance to chemotherapy and a survey of the literature. (2010) Sarcoma 2010:431627 [pubmed]

Grünewald TG, Pasedag SM, Butt E. Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. (2009) Transl Oncol. 2(3):107-16 [pubmed]

Engel JB, Honig A, Schönhals T, Weidler C, Häusler S, Krockenberger M, Grünewald TG, Dombrowski Y, Rieger L, Dietl J, Wischhusen J. Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation. (2008) Eur J Obstet Gynecol Reprod Biol. 141(1):64-9 [pubmed]

Grünewald TG, Butt E. The LIM and SH3 domain protein family: structural proteins or signal transducers or both? (2008) Mol Cancer 7:31 [pubmed]

Grünewald TG*, Kammerer U*, Kapp M, Eck M, Dietl J, Butt E, Honig A. Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma. (2007) BMC Cancer 7:198 [pubmed]

Grünewald TG, Kammerer U, Winkler C, Schindler D, Sickmann A, Honig A, Butt E. Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation. (2007) Br J Cancer 96(2):296-305 [pubmed]

Grünewald TG, Kammerer U, Schulze E, Schindler D, Honig A, Zimmer M, Butt E. Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells. (2006) Exp Cell Res. 312(7):974-82 [pubmed]

§ corresponding author, * shared senior authorship

Book Chapters

Tirode F, Grünewald TGP. Molecular aspects of Ewing's sarcomas. (2021) Academic Press

Cidre-Aranaz F*, Grünewald TG* (Eds.). Ewing Sarcoma: Methods and Protocols. (2021) Springer Protocols

Triche TJ, Grünewald TG, Cotter J, Hiemenz MC, Korshunov A, Hicks J, Sorensen PH. Diagnostic pathology of pediatric solid and central nervous system malignancies. (2020) Pizzo & Poplack's Pediatric Oncology

Grünewald TG, Nathrath M, Richter GH, Sorensen PH, Wackerhage H. Pathogenese von Knochentumoren und Weichteilsarkomen. (2017) TZM Tumormanual Knochentumore und Weichteilsarkome

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