Stellenangebote

Stellenangebot

Abteilung:

German Cancer Consortium (DKTK) Freiburg

Bezeichnung:

Postdoctoral Fellow in Molecular Biology / Cancer Genetics / RNA Biology

Kennziffer:

319/2017

Ihre Aufgaben:

Our research division explores the molecular mechanisms underlying carcinogenesis with a special emphasis on lung cancer and the role of non-coding RNAs and RNA-Protein complexes (Cell 2007, Nat Cell Biol 2009, Genome Res 2011, Cancer Res 2013, Nat Commun 2014, Nucleic Acids Res 2017) as well as novel types of mutations (EMBO Mol Med 2016). The method spectrum in our lab ranges from innovative techniques from molecular and cell biology like diverse CRISPR techniques (Nucleic Acids Res 2017) or RNA-Protein complex identification (Nature 2015) to applications in bioinformatics and biochemistry. Our lab in Freiburg is newly equipped with state-of-the-art instrumentation.

We are seeking a highly motivated postdoctoral fellow with significant and published experience in the area of molecular biology and cancer research, ideally in RNA biology or lung cancer research. The core project of the postdoctoral fellow will be the functional characterization of molecular aberrations in lung cancer involving but not limited to non-coding RNAs. Research questions will include coding and long non-coding RNAs (lncRNAs) and their regulation, cellular functions and molecular mechanisms as well as epigenetic and post-transcriptional mechanisms of gene regulation. The integration of genomic, transcriptomic, proteomic and functional data will address fundamentally new questions about the interaction and regulation of genes, RNAs and proteins in normal and malignant cells as well as in processes like cell proliferation, migration and drug response. As a comprehensive resource to build on, we have compiled a large panel of 50 lung adenocarcinoma cell lines for which we profiled mutations, mRNA and ncRNA expression, proteomics and phosphoproteomics as well as screened for proliferation, migration, drug response and vulnerabilities using CRISPRi. Jointly with the division head, new projects within the focus area of the lab can also be developed and supported to allow the growth into scientific maturity and independence.

Ihr Profil:

You are a highly motivated postdoctoral fellow with a PhD / Dr. rer. nat. in a life science field and are eager to pursue and lead research projects on the molecular biology of lung cancer or tumor genetics with creativity, ambition, independence and team spirit. You have published experience in techniques of cellular and molecular biology or cancer research. Practical knowledge of bioinformatics would be beneficial. You work efficiently, goal-oriented and accurate, have a deep interest in research and are proficient in English.

The Translation Centre is located in the ZTZ (Center of Translational Cell Research) at the University Medical Center Freiburg.

Wir bieten:

  • Interessanten, vielseitigen Arbeitsplatz
  • Internationales Umfeld
  • Vergütung nach TV-L
  • Möglichkeiten zur Teilzeitarbeit
  • Flexible Arbeitszeiten
  • Gute Fort- und Weiterbildung

Beginn:

as soon as possible

Befristung:

The position is limited to 2 years. The position can in principle be part-time.

Bewerbungsschluss:

January 31, 2018

Weitere Informationen:

Prof. Dr. Sven Diederichs
phone +49 761 270-77571


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