We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential enable/disable

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name	Webedition CMS
Purpose	This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name	econda
Purpose	Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

Statistics enable/disable

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name	econda
Purpose	Statistics

External media enable/disable

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name	YouTube
Purpose	Show YouTube content
Name	Twitter
Purpose	activate Twitter Feeds

Research

Head and Neck Tumors

Madeleine Gross

Madeleine Gross

Functional analysis of prognostic important chromosomal regions in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) is a malignant neoplasm with an incidence of more than 900.000 persons, per year, world wide. It belongs to the 6 most common human cancers. Characteristic for these carcinomas are amplifications of specific chromosomal regions, e.g. 3q25-qter and 11q13, within which several known oncogenes and potential candidate genes are present, and which may be involved in the development and progression of HNSCC. Preliminary work in our division has identified several candidate genes. The aim of this current project is to analyse the functional impact of the candidate genes on progression and metastasis in HNSCC. The generation of stablely transfected cell lines with the RMCE (Recombinase-mediated cassette exchange) approach will be the basis for long term studies. In these studies, the candidate genes will be permanently over expressed or knocked down and the function of these genes characterized.

Collaborations
Dr. med., Dr. med. dent. Kolja Freier, Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie der Universität Heidelberg