Aurelio Teleman - CV Synopsis

  • 1998 - Bachelor's degree in Biochemistry, Harvard University (Lab of Rich Losick)
  • 2004 - Ph.D., Imperial College London & EMBL (Lab of Steve Cohen)
  • 2006-7 - Staff Scientist, European Molecular Biology Laboratory (EMBL)
  • 2007-12 Junior Group Leader, DKFZ
  • 2012-present Head of Division, DKFZ

Publication List

2017 & In Press

Dong Y, Silbermann M, Speiser A, Forieri I, Linster E, Poschet G, Allboje A, Watanabe M, Sticht C, Teleman A, Deragon J-M, Saito K, Hell R, and Wirtz M. Sulfur availability regulates plant growth via glucose-TOR signaling. (2017) Nature Communications [In Press]

Dräger N, Nachman E, Winterhoff M, Brühmann S, Shah P, Katsinelos T, Boulant S, Teleman AA, Faix J, and Jahn T. Bin1 directly remodels actin dynamics through its BAR domain. (2017) EMBO Reports pii: e201744137. doi: 10.15252/embr.201744137

Romero-Pozuelo J, Demetriades C, Schroeder P and Teleman AA. CycD/Cdk4 and discontinuities in Dpp signaling activate TORC1 in the Drosophila wing disc. (2017) Developmental Cell 42:376-87 doi: 10.1016/j.devcel.2017.07.019

Teleman AA and Perrimon N. Open questions: completing the parts list and finding the integrating signals. BMC Biology (2017) 15:47 doi: 10.1186/s12915-017-0388-0.

Strassburger K, Lorbeer FK, Lutz M, Graf F, Boutros M and Teleman AA. Oxygenation and adenosine deaminase support growth and proliferation of ex vivo cultured Drosophila wing imaginal discs. (2017) Development dev.147538. doi: 10.1242/dev.147538

Schleich S, Acevedo JM, Clemm von Hohenberg K and Teleman AA. Identification of transcripts with short stuORFs as targets for DENR•MCTS1-dependent translation in human cells. (2017) Scientific Reports 7:3722. doi: 10.1038/s41598-017-03949-6

Moraru A, Cakan-Akdogan G, Strassburger K, Males M, Mueller S, Jabs M, Muelleder M, Frejno M, Braeckman BP, Ralser M, and Teleman AA. THADA regulates the organismal balance between energy storage and heat production. (2017) Developmental Cell 41: 72-81

Pfaff DH, Fleming T, Nawroth P and Teleman AA. Evidence against a role for the Parkinsonism-associated protein DJ-1 in methylglyoxal detoxification. (2016) JBC 292:685-690 



Strassburger K and Teleman AA. Protocols to Study Growth and Metabolism in Drosophila. (2016) Methods Mol Biol. 1478:279-290.

Teleman AA. Metabolism meets development at Wiston House. (2016) Development 143:3045-9

Teleman AA. Role for Torsin in Lipid Metabolism. (2016) Dev Cell Aug 8;38(3):223-4. doi: 10.1016/j.devcel.2016.07.015

Haas MA, Ngo L, Li SS, Schleich S, Qu Z, Vanyai HK, Cullen HD, Cardona-Alberich A, Gladwyn-Ng IE, Pagnamenta AT, Taylor JC, Stewart H, Kini U, Duncan KE, Teleman AA, Keays DA, Heng J I-T. De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to defective mRNA translation re-initiation. (2016) Cell Reports [In Press]

Tsokanos F-F, Albert M-A, Demetriades C, Spirohn K, Boutros M, and Teleman AA. eIF4A inactivates TORC1 in response to amino acid starvation. (2016) EMBO Journal pii: e201593118

Demetriades C, Plescher M, and Teleman AA. Lysosomal recruitment of TSC2 is a universal response to cellular stress. (2016) Nature Communications 7:10662. doi: 10.1038/ncomms10662



Cheng Y-S, Seibert O, Klöting N, Dietrich A, Straßburger K, Fernández-Veledo S, Vendrell JJ, Zorzano A, Blüher M, Herzig S, Berriel Diaz M and Teleman AA. PPP2R5C couples hepatic glucose and lipid homeostasis. (2015) PLoS Genetics 11(10):e1005561

Plescher M, Teleman AA and Demetriades C. TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1. (2015) Scientific Reports 5:13828

Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A and Teleman AA. Regulation of mitochondrial morphology and function by Stearoylation of TfR1. (2015) Nature 525:124-8

Tiebe M, Lutz M, De La Garza A, Buechling T, Boutros M and Teleman AA. REPTOR and REPTOR-BP regulate organismal metabolism and transcription downstream of TORC1. (2015) Developmental Cell 33:272-84 [Pubmed]

Senyilmaz D and Teleman AA. Chicken or the egg: Warburg effect and mitochondrial dysfunction. (2015) F1000 Prime Rep 10.12703/P7-41


Schleich S, Strassburger K, Janiesch PC, Koledachkina T, Miller KK, Haneke K, Cheng Y-C, Kuechler K, Stoecklin G, Duncan KE and Teleman AA. DENR•MCT-1 Promotes Translation Reinitiation Downstream of uORFs to Control Tissue Growth. Nature 512: 208-212 [Pubmed]

Demetriades C, Doumpas N, and Teleman AA. Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2. Cell. 156:786-99 [Pubmed]

Doumpas N, Jekely G, and Teleman AA. Wnt6 is required for maxillary palp formation in Drosophila. BMC Biol. 11: 104 [Pubmed]

Doumpas N, Ruiz-Romero M, Blanco E, Edgar B, Corominas M and Teleman AA. Brinker regulates wing disc growth in part via repression of Myc expression. (2013) EMBO Reports. 14:261-8 [Pubmed]

Miguel-Aliaga I, Oliver B, Teleman AA. The flies of Icarus: science with wings in Crete. (2012) EMBO Rep. 13:945-7 [Pubmed]

Straßburger K, Tiebe M, Pinna F, Breuhahn K and Teleman AA. Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. (2012) Developmental Biology. 367:187-96  [Pubmed]

Teleman AA, Ratzenböck I, Oldham S. Drosophila: A Model for Understanding Obesity and Diabetic Complications. (2012) Exp Clin Endocrinol Diabetes. 120:184-5 [Pubmed]

Xu X, Gopalacharyulu P, Seppänen-Laakso T, Ruskeepää AL, Aye C, Carson B, Mora S, Orešič M and Teleman AA. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. (2012) PLoS Genetics. 8:e1002478 [Open-Access Full-length Article]

Pallares C, Cakan-Akdogan G and Teleman AA. Tissue-specific coupling between insulin/IGF and TORC1 signaling via PRAS40 in Drosophila. (2012) Developmental Cell. 22:172-82 [Pubmed]

Albrecht S, Gomes-Barata A, Großhans J, Teleman AA and Dick T. In vivo mapping of hydrogen peroxide and oxidized glutathione reveals chemical and regional specificity of redox homeostasis. (2011) Cell Metabolism. 14:819-29 [Pubmed]

Teleman AA. Privileged signaling for brain growth. (2011) Cell. 146:346-7 [Pubmed]


Francis VA, Zorzano A and Teleman AA. dDOR Is an EcR Coactivator that Forms a Feed-Forward Loop Connecting Insulin and Ecdysone Signaling. (2010) Current Biology 20:1799-808[Pubmed]

Bryk B, Hahn K, Cohen SM and Teleman AA. MAP4K3 regulates body size and metabolism in Drosophila. (2010) Dev Biol. 344:150-7 [Pubmed]

Hahn K, Miranda M, Francis V, Vendrell J, Zorzano A and Teleman AA. PP2A Regulatory Subunit PP2A-B' Counteracts S6K Phosphorylation. (2010) Cell Metabolism 11(5):438-44 [Pubmed]

Teleman AA. miR-200 De-FOGs Insulin Signaling. (2010) Cell Metabolism 11:8-9 [Pubmed]

Mauvezin C, Orpinell M, Francis VA, Mansilla F, Duran J, Boya P, Ribas V, Palacín M, Teleman AA and Zorzano A. The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. (2010) EMBO Reports 11(1):37-44 [Pubmed]

Teleman AA. Molecular mechanism of metabolic regulation by insulin in Drosophila. (2010) Biochemical Journal 425(1):13-26 [Pubmed]

2009 and earlier
Schleich S and Teleman AA. Akt phosphorylates both Tsc1 and Tsc2 in Drosophila, but neither phosphorylation is required for normal animal growth. (2009) PLoS One 4(7):e6305 [Pubmed]

Teleman AA, Hietakangas V, Sayadian AC, Cohen SM. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. (2008) Cell Metab. 7:21-32 [Pubmed]

Easow G, Teleman AA, Cohen S. Isolation of miRNA targets by miRNP purification. (2007) RNA 13:1198-1204. [Pubmed]

Hufnagel L, Teleman AA (co-first author), Rouault H, Cohen SM, Shraiman BI. On the mechanism of wing size determination in fly development. (2007) PNAS 104:3835-40 [Pubmed]

Teleman AA and Cohen SM. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. (2006) Genes Dev 20:417-22 [Pubmed]

Mikeladze-Dvali T, Wernet MF, Pistillo D, Mazzoni EO, Teleman AA, Chen YW, Cohen S, Desplan C. The Growth Regulators warts/lats and melted Interact in a Bistable Loop to Specify Opposite Fates in Drosophila R8 Photoreceptors. (2005) Cell 122:775-87 [Pubmed]

Teleman AA, Chen YW, Cohen SM. Drosophila melted modulates FOXO and TOR activity. (2005) Dev Cell 9:271-81 [Pubmed]

Teleman AA, Chen YW, Cohen SM. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. (2005) Genes Dev 19:1844-8 [Pubmed]

Teleman AA, Strigini M, Cohen SM. Shaping morphogen gradients. (2001) Cell 105:559-62 [Pubmed]

Teleman AA, Cohen SM. Dpp gradient formation in the Drosophila wing imaginal disc. (2000) Cell 103:971-80 [Pubmed]

Teleman AA, Graumann PL, Lin DC, Grossman AD, Losick R. Chromosome arrangement within a bacterium. (1998) Curr Biol 8:1102-9 [Pubmed]

Webb CD, Graumann PL, Kahana JA, Teleman AA, Silver PA, Losick R. Use of time-lapse microscopy to visualize rapid movement of the replication origin region of the chromosome during the cell cycle in Bacillus subtilis. (1998) Mol Microbiol. 28:883-92 [Pubmed]

Gordon GS, Sitnikov D, Webb, CD, Teleman A, Straight A, Losick R, Murray AW, Wright A. Chromosome and low copy plasmid segregation in E. coli: visual evidence for distinct mechanisms. (1997) Cell 90:1113-21 [Pubmed]

Webb CD, Teleman A (co-first author), Gordon S, Straight A, Belmont A, Lin DC, Grossman AD, Wright A, Losick R. Bipolar localization of the replication origin regions of chromosomes in vegetative and sporulating cells of B. subtilis. (1997) Cell 88:667-74 [Pubmed]

Webb CD, Decatur A, Teleman A, Losick R. Use of green fluorescent protein for visualization of cell-specific gene expression and subcellular protein localization during sporulation in Bacillus subtilis. (1995) J Bacteriol. 177:5906-11[Pubmed]

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