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Research

Vacant Positions

PhD student – Biomarker identification from N2M2 clinical study material to overcome resistance against targeted therapies in glioblastoma patients (m/w/d)

Contact persons: M. Sc. Dirk Hoffmann (dirk.hoffmann@dkfz-heidelberg.de), PD Dr. Tobias Kessler (t.kessler@dkfz-heidelberg.de)

We are recruiting a PhD student for the biomarker identification from a world-leading open-label, multi-center, phase I/IIa, umbrella NOA-20/N2M2 patient study in which GB patients were assigned to one of eight different drug arms based on biomarker expression (https://clinicaltrials.gov/ct2/show/NCT03158389?term=temsirolimus&cond=Glioblastoma+Multiforme&draw=3&rank=21). The approximately 350 patients have already been recruited and study tissue is available for comprehensive analysis using a state-of-the-art multi-omic approach. The PhD student will characterize the tissues using single-cell RNA sequencing and proteomics. The resulting potential biomarkers that suggest response or resistance to the respective treatments are then spatially corroborated and finally functionally validated using CRISPR modifications and drug combination screens in high-throughput format. Established protocols for all methods are already in place and the PhD student will be initially taught these techniques.

The position is also advertised in the scope of the 2023 summer selection of the international PhD program. Briefly, the German Cancer Research Center houses an international PhD Program with 36 fellowships granted yearly. This PhD Program provides interdisciplinary training and research opportunities for University Graduates who wish to work towards a PhD in the field of Biology and Cancer Research. If you wish to apply, see International PhD Program for further information.

General

We are always seeking motivated researchers to expand our team. If you share our enthusiasm for translational research and want to help patients with devastating brain tumors get in contact with us. Especially postdocs are encouraged who are able to work self-dependent and who can swiftly contribute to the progress of the field.