Selected Publications

1. Tena, A., Zhang, Y., Kyritsis, N., Devorak, A., Zurita, J., Wei, PC#, and Alt, FW#. Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture. (2020). Proceedings of the National Academy of Sciences U S A 117(19):10541–10546 [Senior authorship]

2. Wang, M., Wei, PC., Lim, C.K., Gallina, I.S., Marshall, S., Marchetto, M.C., Alt, F.W., and Gage, F.H. Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. (2020). Cell Stem Cell 26, 221-233.e6.

3. Wei PC*, Lee CS*, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW. Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay. (2018) Proceedings of the National Academy of Sciences U S A, 115(8):1919-192.

4. Wei PC*, Chang AN*, Kao J, Du Z, Meyers RM, Alt FW#, Schwer B#. Long neural genes harbor recurrent DNA break clusters in neural stem/progenitor cells. (2016) Cell. 164(4):644-55.

5. Schwer B*, Wei PC*, Chang AN, Kao J, Du Z, Meyers RM, Alt FW. Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells. (2016) Proceedings of the National Academy of Sciences U S A. 113(8):2258-63.

6. Huang SC, Wei PC, Hwang-Verslues WW, Kuo WH, Jeng YM, Hu CM, Shew JY, Huang CS, Chang KJ, Lee EY, Lee WH. TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB. (2017) EMBO Mol Med. pii: e201606914. PMID: 28993429

7. Alt FW, Wei PC, and Schwer B. Recurrently breaking genes in neural progenitors: potential roles of DNA breaks in neuronal function, degeneration and cancer. (2017) Genome Editing in Neurosciences (Jaenisch, R. Zhang, F., and Gage, F., Eds); p63-72.

9. Wei PC*, Hsieh YH*, Su MI*, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. (2012) Mol Cell. 48(5):747-59.

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