Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Junior Clinical Cooperation Unit Translational Surgical Oncology

Prof. Dr. Sebastian Schölch

Cholangiocarcinoma organoids

In localized stages, most solid tumors are curable by surgical resection. However, once the disease has spread to distant organs, the tumors are generally considered a systemic disease and are incurable in the majority of cases. Systemic spread is a consequence of tumor cell seeding into the blood stream. Tumor cells in circulation are called circulating tumor cells (CTC), single tumor cells found in distant organs are called disseminated tumor cells (DTC). CTC and DTC are the biological correlate of metastasis and are therefore the main reason for cancer-associated mortality. We are interested in the biological traits of CTC and DTC and the mechanisms enabling these cells to perform the complex process of metastasis. To investigate these mechanisms we use patient samples as well as state-of-the-art preclinical models such as genetically engineered mouse models and 3D organoid culture. In the past we were able to identify differentially regulated surface proteins in CTC which enable these cells to escape the immune system while in circulation. Future goals include the identification of actionable targets on CTC to develop agents which may be used to prevent metastatic spread of solid tumors.


Prof. Dr. Sebastian Schölch
Translational Surgical Oncology (A430)
Tel: +49 621 / 383-5253
Fax: +49 621 / 383-3809

Chirurgische Klinik
Universitätsmedizin Mannheim
Ruprecht-Karls-Universität Heidelberg
Theodor-Kutzer-Ufer 1-3
68167 Mannheim

Selected Publications

  • Maier CF, Schölch C, Zhu L, Nzomo MM, L’hoest H, Marschall U, Reißfelder C, Schölch S. Weekday-dependent long-term outcomes in gastrointestinal cancer surgery: a german population-based retrospective cohort study. Int J Surg. 2023 Jul 6. doi: 10.1097/JS9.0000000000000580. Online ahead of print.
  • Jin F, Zhu L, Shao J, Yakoub M, Schmitt L, Reißfelder C, Loges S, Benner A, Schölch S. Circulating tumour cells in patients with lung cancer universally indicate poor prognosis. Eur Respir Rev. 31. Dezember 2022;31(166):220151.
  • Tao J*, Zhu L*, Yakoub M, Reißfelder C, Loges S, Schölch S. Cell-Cell Interactions Drive Metastasis of Circulating Tumor Microemboli. Cancer Res. 2022;82(15):2661-2671
  • Steinert G*, Schölch S*, Niemietz T*, et al. Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer. Cancer Res. 2014;74(6):1694-1704
to top
powered by webEdition CMS