PhD and postdoc positions are available!
Highly motivated candidates with a strong success record and solid background in molecular biology or bioinformatics are encouraged to apply via email to Aurélie Ernst. Please send your CV with grades, your publication list, a description of research interests, and the contact details of two referees.
Postdoc position in computational cancer biology
ERC funded, German Cancer Research Center (DKFZ) in collaboration with European Molecular Biology Laboratory (EMBL) in Heidelberg
We are looking for a postdoctoral scientist (bioinformatics / computational biology) to work on chromosome instability in space and time and understand the early stages of cancer development, using data from single-cell multiome and spatial profiling in the brain and the colon. The project is funded through the ERC "Unstable Genome".
The Huber group develops statistical and machine learning methods for modern biotechnologies, applies them to biological discovery, and translates them into reusable tools (https://www.huber.embl.de/)
The Ernst group aims at elucidating how chromosome instability leads to massive genome
rearrangements and deciphering implications for cancer patients.
https://www.dkfz.de/en/genominstabilitaet-in-tumoren/index.php
Your role
As part of the research team, you will participate in the overall project and shape your own research profile in one or several of the following areas:
- Integrative data analysis for biological discovery
- Single-cell multiome data analysis at ultra-large scale (>100 000 cells per donor)
- Spatial transcriptomics
- Clonal evolution and phylogeny
- Copy-number changes and complex rearrangements and their impact on the transcriptome at single-cell resolution
- Clone fitness and selection, interactions between tumor cells and the microenvironment
- Data science, quality assurance, advanced visualization and model checking
- Develop scalable and robust software for scientific computing.
You will be able to contribute both to scientific discovery by analysis of primary data, and to the development of more broadly usable computational methods and tools.
You have
A PhD relevant to computational biology, e.g., in bioinformatics, systems biology, or in statistics, physics, computer science with demonstrated interest in the life sciences. You have experience in scientific computing and are familiar with R/Bioconductor and/or Python for data science. In your application, please include links to prior research outputs such as software packages, data analysis notebooks, technical reports, PhD thesis.
The position is available immediately. The initial term of employment is 3 years and may be extended up to a total of 5 years. The position is co-supervised by Wolfgang Huber and Aurélie Ernst. The interested applicants should send the following documents to Wolfgang Huber (wolfgang.huber@embl.org) and Aurélie Ernst (a.ernst@dkfz.de): a cover letter, a curriculum vitae, a publication list, and a brief description of current research interests and expertise (max 1 page) as a single pdf file.
Postdoc position in cancer biology
ERC funded, German Cancer Research Center (DKFZ) in Heidelberg
We are looking for a postdoctoral scientist (experimental) to work on chromosome instability in space and time and understand the early stages of cancer development, using data from single-cell multiome and spatial profiling in the brain and the colon. The project is funded through the ERC "Unstable Genome".
The Ernst group aims at elucidating how chromosome instability leads to massive genome
rearrangements and deciphering implications for cancer patients.
https://www.dkfz.de/en/genominstabilitaet-in-tumoren/index.php
Your role
As part of the research team, you will participate in the overall project and shape your own research profile in the following areas:
- Chromosome instability
- Early cancer development and clonal evolution
- Single-cell multiome analysis at ultra-large scale
- Spatial transcriptomics analysis
- Interactions between tumor cells and the microenvironment
- Dissecting the complex microenvironment of tumors by Multiplexed Ion Beam Imaging
- Mouse models of chromosome instability
- Human pre-cancer landscape, with a strong focus on the brain and the colon
- Clonal evolution and phylogeny analysis
- Analysis of copy-number changes and complex rearrangements as well as their impact on the transcriptome at single-cell resolution
- Clone fitness and selection
You have
A PhD in Biological Sciences or a related field. We are looking for a range of talents, which should include some of the following:
Experience with laboratory animal work (preferably mouse) and FELASA certification or similar is an advantage. If not already completed, you will be required to take the course for Laboratory Animal Science. A cancer biology background and a basic understanding of computational biology will be valued.
The position is available immediately. The initial term of employment is 3 years and may be extended up to a total of 5 years. The interested applicants should send the following documents to Aurélie Ernst (a.ernst@dkfz.de): a cover letter, a curriculum vitae, a publication list, and a brief description of current research interests and expertise (max 1 page) as a single pdf file.