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List of publications Clarissa Gerhauser


1. Manoochehri M, Borhani N, Gerhäuser C, Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne HJ, Lipka DB, Brüning T, Brauch H, Ko YD, Hamann U. DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy. Int. J. Cancer 2022 Oct 28. doi: 10.1002/ijc.34337. Abstract

2. Llimos G, Gardeux V, Koch U, Kribelbauer JF, Hafner A, Alpern D, Pezoldt J, Litovchenko M, Russeil J, Dainese R, Moia R, Mahmoud AM, Rossi D, Gaidano G, Plass C, Lutsik P, Gerhauser C, Waszak SM, Boettiger A, Radtke F, Deplancke B. A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation. Nat. Commun. 13: 2042 (2022). doi: 10.1038/s41467-022-29625-6. Abstract


1. Manoochehri M, Hielscher T, Borhani N, Gerhäuser C, Fletcher O, Swerdlow AJ, Ko YD, Brauch H, Brüning T, Hamann U. Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients. Clin. Epigenetics 13, 207 (2021). doi: 10.1186/s13148-021-01196-1. Abstract


1. Clarissa Gerhauser, Combination Chemoprevention by Targeting the Epigenome. Chapter 18 in: Natural Products for Cancer Chemoprevention: Single Compounds and Combinations, Eds. John M. Pezzuto and Ole Vang, Springer Full Text (PDF)

2. Sharadha Dayalan Naidu, Lidia Brodziak-Jarosz, Clarissa Gerhäuser, and Albena T. Dinkova-Kostova. The Chemopreventive Power of Isothiocyanates. Chapter 9 in: Natural Products for Cancer Chemoprevention: Single Compounds and Combinations, Eds. John M. Pezzuto and Ole Vang, Springer Full Text (PDF)

3. Bailey MH, Meyerson WU, Dursi LJ, Wang LB, Dong G, Liang WW, Weerasinghe A, Li S, Kelso S; MC3 Working Group; PCAWG novel somatic mutation calling methods working group, Saksena G, Ellrott K, Wendl MC, Wheeler DA, Getz G, Simpson JT, Gerstein MB, Ding L; PCAWG Consortium. Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. Nat Commun. 11: 4748 (2020) Abstract Full Text (PDF)

4. Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N; PCAWG Tumour Subtypes and Clinical Translation, Boutros PC; PCAWG Consortium. Sex differences in oncogenic mutational processes.  Nat Commun. 11: 4330 (2020) Abstract Full Text (PDF)

5. ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature 578: 82-93 (2020). Abstract Full Text (PDF)

6. Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D, Pedersen JS; PCAWG Drivers and Functional Interpretation Group, Johnson R; PCAWG Consortium. Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis. Commun Biol. 3, 56 (2020). doi: 10.1038/s42003-019-0741-7. Abstract

7. Rubanova Y, Shi R, Harrigan CF, Li R, Wintersinger J, Sahin N, Deshwar AG; PCAWG Evolution and Heterogeneity Working Group, Morris QD; PCAWG Consortium. Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. Nat Commun. 11: 731 (2020). doi: 10.1038/s41467-020-14352-7. Abstract

8. Sieverling L, Hong C, Koser SD, Ginsbach P, Kleinheinz K, Hutter B, Braun DM, Cortés-Ciriano I, Xi R, Kabbe R, Park PJ, Eils R, Schlesner M; PCAWG-Structural Variation Working Group, Brors B, Rippe K, Jones DTW, Feuerbach L; PCAWG Consortium. Genomic footprints of activated telomere maintenance mechanisms in cancer. Nat. Commun. 11: 733 (2020) doi: 10.1038/s41467-019-13824-9. Abstract

9. Shuai S; PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein LD; PCAWG Consortium. Combined burden and functional impact tests for cancer driver discovery using DriverPower. Nat Commun. 11: 734 (2020). doi: 10.1038/s41467-019-13929-1. Abstract

10. Cmero M, Yuan K, Ong CS, Schröder J; PCAWG Evolution and Heterogeneity Working Group, Corcoran NM, Papenfuss T, Hovens CM, Markowetz F, Macintyre G; PCAWG Consortium. Inferring structural variant cancer cell fraction. Nat Commun. 11: 730 (2020). doi: 10.1038/s41467-020-14351-8. Abstract

11. Jiao W, Atwal G, Polak P, Karlic R, Cuppen E; PCAWG Tumor Subtypes and Clinical Translation Working Group, Danyi A, de Ridder J, van Herpen C, Lolkema MP, Steeghs N, Getz G, Morris QD, Stein LD; PCAWG Consortium. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. Nat Commun. 11: 728 (2020). doi: 10.1038/s41467-019-13825-8. Abstract

12. Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H, Abd-Rabbo D, Mee MW, Boutros PC; PCAWG Drivers and Functional Interpretation Working Group, Reimand J; PCAWG Consortium. Integrative pathway enrichment analysis of multivariate omics data. Nat Commun. 11: 735 (2020). doi: 10.1038/s41467-019-13983-9. Abstract

13. Zhang Y, Chen F, Fonseca NA, He Y, Fujita M, Nakagawa H, Zhang Z, Brazma A; PCAWG Transcriptome Working Group; PCAWG Structural Variation Working Group, Creighton CJ; PCAWG Consortium. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nat Commun. 11: 736 (2020). doi: 10.1038/s41467-019-13885-w. Abstract

14. Bhandari V, Li CH, Bristow RG, Boutros PC; PCAWG Consortium. Divergent mutational processes distinguish hypoxic and normoxic tumours. Nat Commun. 11: 737 (2020). doi: 10.1038/s41467-019-14052-x. Abstract


1. Schenk A, Pulverer W, Koliamitra C, Bauer C, Ilic S, Heer R, Schier R, Schick V, Boettiger B, Gerhauser C, Bloch W, Zimmer P. Acute Exercise Increases the Expression of KIR2DS4 by Promoter Demethylation in NK-cells. Int J. Sports Med. 2019, 40(1): 62-70. Abstract Full Text (PDF)

 2. Reka Toth, Heiko Schiffmann, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Sören Weidemann, Patrick Lebok, Christoph Fraune, Sarah Minner, Thorsten Schlomm, Guido Sauter, Christoph Plass, Yassen Assenov, Ronald Simon, Jan Meiners and Clarissa Gerhäuser. Random forest-based modelling to detect biomarkers for prostate cancer progression. Clinical Epigenetics 2019, 11(1):148 Abstract Full text (PDF). doi: 10.1186/s13148-019-0736-8.


1. Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov L, Heckmann D, Sidiropoulos N, Waszak SW, Hübschmann D, Urbanucci A, Girma EG, Kuryshev V, Klimczak LJ, Saini N, Stütz AM, Weichenhan D, Böttcher L, Toth R, Hendriksen JD, Koop C, Lutsik P, Matzk S, Warnatz H, Amstislavskiy V, Feuerstein C, Raeder B, Bogatyrova O, Schmitz E, Hube-Magg C, Kluth M, Huland H, Graefen M, Lawerenz C, Henry GH, Yamaguchi TN, Malewska A, Meiners J, Schilling D, Reisinger E, Eils R, Schlesner M, Strand DW, Bristow RG, Boutros PC, von Kalle C, Gordenin D, Sültmann H, Brors B, Sauter G, Plass C, Yaspo ML, Korbel JO, Schlomm T, Weischenfeldt J. Molecular evolution of early onset prostate cancer identifies novel molecular risk markers and clinical trajectories. Cancer Cell 2018, 34(6): 996-1011 Abstract Full Text (PDF)

2. Milenkovic D, Vanden Berghe W, Morand C, Claude S, Van de Sandt A, Gorressen S, Monfoulet LE, Chirumamilla CS, Declerck K, Szarc vel Szic K, Lahtela-Kakkonen M, Gerhauser C, Merx MW, Kelm M. A systems biology network analysis of nutri(epi)genomic changes in endothelial cells exposed to epicatechin metabolites. Sci Rep. 2018; 8: 15487 Abstract Full Text (PDF)

3. Valli V, Heilmann K, Danesi F,  Bordoni A, Gerhauser C, Modulation of adipocyte differentiation and proadipogenic gene expression by sulforaphane, genistein, and docosahexaenoic acid as a first step to counteract obesity. Oxid Med Cell Longev 2018, 1617202. Abstract Full Text (PDF)
4. Assenov Y, Brocks D, Gerhauser C. Epigenetic patterns of tumor heterogeneity, Semin. Cancer Biol. 2018, 51: 12-21. Abstract Full Text (PDF)
5. Gerhauser C, Impact of dietary gut microbial metabolites on the epigenome. Philosophical Transactions B, 373: 20170359, 2018. Abstract Full Text (PDF)


1. Istas G, Declerck K, Pudenz M, Szic KSV, Lendinez-Tortajada V, Leon-Latre M, Heyninck K, Haegeman G, Casasnovas JA, Tellez-Plaza M, Gerhauser C, Heiss C, Rodriguez-Mateos A, Berghe WV. Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease. Sci Rep. 2017; 7(1): 5120. doi: 10.1038/s41598-017-03434-0. Abstract Full Text (PDF)

2. Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhauser C, Oakes CC, Wang T, Plass C. DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nat Genet. 2017; 49(7): 1052-1060. doi: 10.1038/ng.3889. Abstract Full Text (PDF)

3. Szarc Vel Szic K, Declerck K, Crans RAJ, Diddens J, Scherf DB, Gerhäuser C, Vanden Berghe W. Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A. Oncotarget 2017; 8(25): 40434-40453. doi: 10.18632/oncotarget.17107. Abstract Full text (PDF)

4. Dewi D, Mohapatra SR, Blanco Cabañes S, Adam I, Somarribas Patterson LF, Berdel B, Kahloon M, Thürmann L, Loth S, Heilmann K, Weichenhan D, Mücke O, Heiland I, Wimberger P, Kuhlmann JD, Kellner K, Schott S, Plass C, Platten M, Gerhauser C, Trump S, Opitz CA, Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer. Oncoimmunology 2017; 6(2): e1274477. Abstract Full text (PDF)

5. Lehmann L, Soukup ST, Gerhauser C, Vollmer G, Kulling SE. Isoflavonhaltige
Nahrungsergänzungsmittel - Isoflavone-containing dietary supplements. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2017; 60(3): 305-313. Abstract Full text (PDF) (in German)

6. Heilmann K, Toth R, Bossmann C, Klimo K, Plass C, Gerhauser C. Genome-wide Screen for Differentially Methylated Long Noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as Regulated by Enhancer DNA Methylation with Prognostic Relevance for Human Breast Cancer. Oncogene 2017, 36(46): 6446-6461 Abstract Full text (PDF)


1. Talhi O, Brodziak-Jarosz L, Panning J, Orlikova B, Zwergel C, Tzanova T, Philippot S, Pinto DC, Almeida Paz FA, Gerhauser C, Dick T, Jacob C, Diederich M, Bagrel D, Kirsch G, and Silva AM. One-Pot Synthesis of Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential. Eur  J Org Chem. 2016; 2016: 965–975 Full text (PDF)

2. Brodziak-Jarosz L, Fujikawa Y, Pastor-Flores D, Kasikci S, Jirásek P, Pitzl S, Owen RW, Klika KD, Gerhäuser C, Amslinger S, Dick TP. A click chemistry approach identifies target proteins of xanthohumol. Mol Nutr Food Res. 2016; 60: 737-48. Abstract

3. Orsini F, Verotta L, Klimo K, Gerhäuser C. Synthesis of Resveratrol Derivatives and In Vitro Screening for Potential Cancer Chemopreventive Activities. Arch Pharm 2016; 349: 414-27. Abstract  Full Text (PDF)

4. Bock C, Halbritter F, Carmona FC, Tierling S, Datlinger P, Assenov Y, Berdasco M, Bergmann AK, Booher K, Busato F, Campan M, Dahl C, DahmckeCM, Diep D, Fernández AF, Gerhauser C, Haake A, Heilmann K, Holcomb T, Hussmann D, Ito M, Kläver R, Kreutz M, Kulis M, Lopez V, Nair SS, Paul DS, Plongthongkum N, Qu W, Queirós AC, Reinicke F, Sauter G, Schlomm T, Statham A, Stirzaker C, Strogantsev R, Urdinguio RG, Walter K, Weichenhan D, Weisenberger DJ, Beck S, Clark SJ, Esteller M, Ferguson-Smith AC, Fraga MF, Guldberg P, Hansen LL, Laird PW, Martin-Subero JI, Nygren AOH, Peist R, Plass C, Shames DS, Siebert R, Sun X, Tost J, Walter J, Zhang K for the BLUEPRINT consortium. Quantitative comparison of DNA methylation assays for biomarker development and clinical applications. Nat Biotechnol. 2016; 34(7): 726-37. Abstract Full Text (PDF)

5. Siebert R, Gerhauser C, Simon R, Wagener R, Weber U, Sauter G, Plass C, Lichter P. Internationales Krebsgenomkonsortium (ICGC) Sequenzbasierte Analyse und genomweite Katalogisierung von Aberrationen bei Tumoren als Grundlage für die Präzisionsmedizin. Med. Gen. 2016, 28 (4), 416–423. DOI 10.1007/s11825-017-0117-7


1. Blei, T.#, Soukup, S.T.#, Schmalbach, K.#, Pudenz, M.#, Möller, F.J., Egert, B., Wörtz, N., Kurrat, N.A., Müller, D., Vollmer, G., Gerhäuser, C.*, Lehmann, L.*, Kulling, S.E.*, Diel, P.* (#, * equal contribution), Dose-dependent effects of isoflavone exposure during early lifetime on the rat mammary gland: Studies on estrogen sensitivity, isoflavone metabolism and DNA methylation. Mol. Nutr. Food. Res. 2015; 59(2): 270-83.  Abstract

2. Gerhauser, C., Heilmann, K., Pudenz, M. Genome-wide DNA methylation profiling in dietary intervention studies – A users’ perspective. Curr Pharmacol Rep 2015; 1 (1), 31-45.  Full text (PDF)

3. Rücker, H., Al-Rifai, N., Rascle, A., Gottfried,E., Brodziak-Jarosz, L., Gerhäuser, C., Dick, T.P., Amslinger, S., Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site. Org Biomol Chem. 2015; 13 (10), 3040-3047. Abstract Full text (PDF)

4. Kannas, CC; Kalvari, I; Lambrinidis, G; Neophytou, CM; Savva, CG; Kirmitzoglou, I; Antoniou, Z; Achilleos, KG; Scherf, D; Pitta, CA; Nicolaou, CA; Mikros, E; Promponas, VJ; Gerhauser, C; Mehta, RG; Constantinou, AI; Pattichis, CS. LiSIs: An Online Scientific Workflow System for Virtual Screening. Comb Chem High Throughput Screen 2015; 18: 281-95.  Abstract Full text (PDF)


1. Forster T, Rausch V, Zhang Y, Isayev O, Heilmann K, Schoensiegel F, Liu L, Nessling M, Richter K, Labsch S, Nwaeburu CC, Mattern J, Gladkich J, Giese N, Werner J, Schemmer P, Gross W, Gebhard MM, Gerhauser C, Schaefer M, Herr I. Sulforaphane counteracts aggressiveness of pancreatic cancer driven by dysregulated Cx43-mediated gap junctional intercellular communication. Oncotarget 2014; 5: 1621-34. Full text (PDF)

2. Weiss M, Plass C, Gerhauser C. Role of lncRNAs in prostate cancer development and progression (Review). Biol. Chem. 2014, 395 (11): 1275–1290. Full text (PDF)

3. Brocks D, Assenov Y, Minner S, Bogatyrova O, Simon R, Koop C, Oakes C, Zucknick M, Lipka D, Weischenfeldt J, Feuerbach L, Cowper-Sal.lari R, Lupien M, Brors B, Korbel J, Schlomm T, Tanay A, Sauter G, Gerhauser C and Plass C. Epigenetic intratumor heterogeneity and clonal evolution in aggressive prostate cancer. Cell Reports 2014, 8(3): 798-806. Full text (PDF)

4. Pudenz, M., Roth, K., Gerhauser, C. Impact of Soy Isoflavones on the Epigenome in Cancer Prevention  (Review). Nutrients (Special issue Nutritional Epigenetics) 2014, 6, 4218-4272. Full text (PDF) 

5. Witte, T., Plass, C., Gerhauser, C., Pan-cancer patterns of DNA methylation (Review). Genome Medicine 6, 66 (2014)  Full text (PDF)

6. Gerhauser C. Cancer prevention and epigenetics; What role does epigenetics play? Labor & More International Edition 4/2014 int., 6-10 (2014) Full text (PDF)

7. Gerhauser, C. Krebsprävention und Ernährung: Welche Rolle spielt die Epigenetik? Labor & More 6.14, 20-25 (2014) Full text (PDF)

Book Chapter

1. Gerhauser C. Epigenetics, Plant (Poly)phenolics, and Cancer Prevention. Chapter 6 in: Recent Advances in Polyphenol Research, Volume 4 (1st Ed.) Eds. Annalisa Romani, Vincenzo Lattanzio, and Stéphane Quideau. © 2014 John Wiley & Sons, Ltd. Published 2014 by John Wiley & Sons, Ltd. Full text (PDF)


1. Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T. Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer. Cancer Cell 2013; 23:159-70. Full text (PDF)

2. Clarissa Gerhauser. Cancer chemoprevention and nutri-epigenetics - State of the art and future challenges (Review). Topics in Current Chemistry: Special volume "Natural Products in the Prevention of Cancer" 2013; 329:73-132. Full text (PDF)

3. Lipka D, Kuck D, Kliem C, Gerhauser C. Substituted purine and 7-deazapurine compounds as modulators of epigenetic enzymes (WO2012075381): A Patent Evaluation. Expert Opinion on Therapeutic Patents 2013; 23(4):537-43. Full text (PDF)

4. Gerhauser C. Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. Curr Opin Clin Nutr Metab Care. 2013 Full text (PDF)

5. Gerhäuser C. Flavonoide und Glukosinolate: Bioaktiv gegen Krebs, UGB Forum 2/13, 85-88 (2013)

6. Gerhäuser C. Epigenetic DNA methylation profiling as a potential tool in doping research? Journal für Anästhesie und Intensivbehandlung 1-2013, 42-45 (2013)


1. Clarissa Gerhäuser. Cancer cell metabolism, epigenetics and the potential influence of dietary components – A perspective. Biomedical Res. 2012 Full text (PDF)

2. Krohn A, Diedler T, Burkhardt L, Mayer PS, De Silva C, Meyer-Kornblum M, Kötschau D, Tennstedt P, Huang J, Gerhäuser C, Mader M, Kurtz S, Sirma H, Saad F, Steuber T, Graefen M, Plass C, Sauter G, Simon R, Minner S, Schlomm T. Genomic deletion of PTEN is associated with tumor progression and early PSA recurrence in ERG fusion-positive and fusion-negative prostate cancer. Am J Pathol. 2012 Aug;181(2):401-12. Full text (PDF)

3. Faryna M, Konermann C, Aulmann S, Bermejo JL, Brugger M, Diederichs S, Rom J, Weichenhan D, Claus R, Rehli M, Schirmacher P, Sinn HP, Plass C, Gerhauser C. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. FASEB J. 2012; 26(12):4937-50. Full text (PDF)

Book Chapter

1. Strathmann J.  & Gerhauser C.  Anti-proliferative and Apoptosis-Inducing Properties of Xanthohumol, a Prenylated Chalcone from Hops ( Humulus lupulus L.) Chapter 4 in: Natural Compounds as Inducers of Cell Death, Vol. 1, Eds. Marc Diederich and Karoline Nowortya, Springer, 2012 Full text (PDF)


1. Clarissa Gerhäuser
Schach dem Krebs? Einfluss sekundärer Pflanzenstoffe auf die Karzinogenese - Keeping Cancer in Check? The Influence of Phytochemicals on Carcinogenesis. Aktuel Ernahrungsmed 36, Supplement 1: S1–S5 (2011) Full text (PDF)

2. Joseph Huang, Christoph Plass, Clarissa Gerhäuser. Cancer Chemoprevention by targeting the epigenome (Review). Current Drug Targets 12, 1925-1956 (2011) Abstract Full text (PDF) Supplementary Material (PDF)


1. Sabine Parys, Stefan Kehraus, Anja Krick, Karl-Werner Glombitza, Shmuel Carmeli, Karin Klimo, Clarissa Gerhäuser, Gabriele M. König
In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes, Phytochemisty 71, 221-229 (2010) Abstract Full text (PDF)

2. Branislav Radovic, Ragna Hussong, Clarissa Gerhäuser, Walter Meinl, Norbert Frank, Hans Becker and Josef Köhrle.
Xanthohumol, a prenylated chalcone from hops, modulates hepatic expression of genes involved in thyroid hormone distribution and metabolism. Mol. Nutr. Food Res. 54 Suppl 2: S225-35 (2010) Abstract

3. Julia Strathmann, Karin Klimo, Sven W. Sauer, Jürgen G. Okun, Jochen H.M. Prehn, Clarissa Gerhäuser.
Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism. The FASEB J. 24: 2938-50 (2010) Abstract Full text (PDF)


1. Julia Strathmann, Karin Klimo, Renate Steinle, Ragna Hussong, Norbert Frank, and Clarissa Gerhäuser.
Xanthohumol from hops prevents hormone-dependent tumorigenesis in vitro and in vivo. Acta horticulturae, Proceedings of the Second International Humulus Symposium: 179-90 (2009) Full text (PDF)

2. Clarissa Gerhäuser, Karin Klimo, Wolfgang Hümmer, Jana Hölzer, Astrid Petermann, Antonio Garreta-Rufas, Frank-D. Böhmer, Peter Schreier.
Identification of 3-hydroxy-beta-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated Phase 2 response with concomitant anti-inflammatory activity. Mol. Nutr. Food Res. 53, 1237-44 (2009) Abstract (PDF upon request)

3. Ruud Verkerk, Monika C. Schreiner, Angelika Krumbein, Ewa Ciska, Birgit Holst, Ian Rowland, Remi De Schrijver, Magnor Hansen, Clarissa Gerhäuser, Richard Mithen and Matthijs Dekker.
Glucosinolates in Brassica vegetables - The influence of the food supply chain on intake, bioavailability and human health. Mol. Nutr. Food Res. 53 Suppl 2, S219-S265 (2009) Abstract (PDF upon request)

Book Chapters

1. Bartsch, H. and Gerhäuser, C. Molecular Mechanisms of Cancer Induction and Chemoprevention. In S. Knasmüller, D. DeMarini, I.T. Johnson, C. Gerhäuser (Eds.), Chemoprevention of cancer and DNA damage by dietary factors. Weinheim: Wiley-VCH (ISBN 978-3-527-32058-5) April 2009

2. Gerhäuser, C.
Methods used to study alterations of cell signaling and proliferation. In S. Knasmüller, D. DeMarini, I.T. Johnson, C. Gerhäuser (Eds.), Chemoprevention of cancer and DNA damage by dietary factors. Weinheim: Wiley-VCH (ISBN 978-3-527-32058-5) April 2009

3. Gerhäuser, C.
Methods for the assessment of anti-angiogenic activity. In S. Knasmüller, D. DeMarini, I.T. Johnson, C. Gerhäuser (Eds.), Chemoprevention of cancer and DNA damage by dietary factors. Weinheim: Wiley-VCH (ISBN 978-3-527-32058-5) April 2009

4. Gerhäuser, C.
Procyanidins. In S. Knasmüller, D. DeMarini, I.T. Johnson, C. Gerhäuser (Eds.), Chemoprevention of cancer and DNA damage by dietary factors. Weinheim: Wiley-VCH (ISBN 978-3-527-32058-5) April 2009


1. Henriette Zessner, Lydia Pan, Frank Will, Karin Klimo, Jutta Knauft, Regina Niewöhner, Wolfgang Hümmer, Robert Owen, Elke Richling, Norbert Frank, Peter Schreier, Hans Becker, Clarissa Gerhäuser.
Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential. Mol. Nutr. Food Res. 52(S1): 28-44 (2008) Abstract (PDF upon request)

2. Andreas J. Gescher, Clarissa Gerhäuser.
Cancer Chemopreventive Agents in Plants - A Continuing Challenge (editorial). Planta Medica 74: 1523-1525 (2008) Full text (PDF)

3. Clarissa Gerhäuser
Cancer chemopreventive potential of apples, apple juice, and apple components (review). Planta Medica 74: 1608-24 (2008) Abstract Full text (PDF)

4. Gregor Bohr, Karin Klimo, Josef Zapp, Hans Becker and Clarissa Gerhäuser.
Cancer Chemopreventive Potential of Humulones and Isohumulones (Hops alpha- and Iso-alpha-acids): Induction of NAD(P)H:Quinone Reductase as a Novel Mechanism. Natural Product Communications 3:1971-1976 (2008) Full text (PDF)

5. Alexander Pontius, Anja Krick, Stefan Kehraus, Silke Bode, Michael Müller, Karin Klimo, Clarissa Gerhäuser, and Gabriele M. König. Noduliprevenone, a Novel Dimeric Chromanone with Cancer Chemopreventive Potential. Chem. Eur. J. 14: 9860-3 (2008) Full text (PDF)

6. Alexander Pontius, Anja Krick, Ronak Mesry, Stefan Kehraus, Silke E. Foegen, Michael Müller, Karin Klimo, Clarissa Gerhäuser, and Gabriele M. König.
Monodictyochrome A and B, Dimeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis. J. Nat. Prod. 71: 1793–1799 (2008) Abstract Full text (PDF)

Book Chapters

1. Gerhäuser, C. and Becker, H.
Phenolic compounds in beer. Chapter 12 in: V. R. Preedy & R. R. Watson (Eds.), Beer in health and disease prevention. Amsterdam: Elsevier Academic Press (October 2008). Full text (PDF)

2. Gerhäuser, C.
Phenolic beer compounds to prevent cancer. Chapter 68 in: V. R. Preedy & R. R. Watson (Eds.), Beer in health and disease prevention. Amsterdam: Elsevier Academic Press (October 2008). Full text (PDF)

3. Becker, H., Gerhäuser, C., Bohr, G.
Acylphloroglucinol derivatives from hops as anti-inflammatory agents. Chapter 76 in: V. R. Preedy & R. R. Watson (Eds.), Beer in health and disease prevention. Amsterdam: Elsevier Academic Press (October 2008).

4. Gerhäuser, C.
Techniques for assessing anti-cancer effects of beer. Chapter 90 in: V. R. Preedy & R. R. Watson (Eds.), Beer in health and disease prevention. Amsterdam: Elsevier Academic Press (October 2008).


1. Anja Krick, Stefan Kehraus, Clarissa Gerhäuser, Karin Klimo, Martin Nieger, Armin Maier, Heinz-Herbert Fiebig, Iuliana Atodiresei, Gerhard Raabe, Joerg Fleischhauer, and Gabriele M. Koenig.
Potential Cancer Chemopreventive in Vitro Activities of Monomeric Xanthone Derivatives from the Marine Algicolous Fungus Monodictys putredinis. J. Nat. Prod. 70, 353-360 (2007) Abstract Full text (PDF)

2. Gerlinde Pappa, Julia Strathmann, Maria Löwinger, Helmut Bartsch and Clarissa Gerhäuser.
Quantitative combination effects between sulforaphane and 3,3’-diindolylmethane on proliferation of human colon cancer cells in vitro. Carcinogenesis 28, 1471-1477 (2007) Abstract Full text (PDF)

3. Gerlinde Pappa, Helmut Bartsch and Clarissa Gerhäuser.
Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. Mol. Nutr. Food Res. 51(8), 977-984 (2007) Abstract Full text (PDF)

4. Clarissa Gerhäuser. Chemoprävention von Krebs. Forum DKG Sonderheft 2007, 5-8 (2007) Full text (PDF)

Book Chapter

1. Clarissa Gerhäuser.
Chemoprävention. Kap. 3 in: Präventionskonzepte für Gastrointestinale Tumoren. PD Dr. med Frank Kolligs und Prof. Dr. med. Ulrich Beuers (Hrsg.), UNI-MED Verlag AG Bremen - London - Boston (2007), pp. 34 - 42. Full text (PDF)


1. Bertl, E., Bartsch, H., Gerhäuser, C.
Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in cancer chemoprevention. Mol. Cancer Ther. 5, 575-585 (2006) Abstract Full text (PDF)

2. Pappa, G., Lichtenberg, M., Iori, R., Barillari, J., Bartsch, H., Gerhäuser, C.
Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. Mut. Research 599, 76-87 (2006) Abstract Full text (PDF)

3. Gerhäuser, C., Bartsch, H., Crowell, J., De Flora, S., D’Incalci, M., Dittrich, C., Frank, N., Mihich, E., Steffen, C., Tortora, G., Gescher, A.
Development of novel cancer chemopreventive agents in Europe – Neglected Cinderella or rising phoenix? A critical commentary. Eur. J. Cancer 42, 1338-1343 (2006) Abstract Full text (PDF)

4. Bartsch, H., Gerhäuser, C., Nair, J., Lichter, P., Wiestler, O. Präventive Onkologie - das Endziel der Bekämpfung bösartiger Erkrankungen. Heidelberger Jahrbücher 50 (2006), pp. 57-68; Editor Christian Herfarth, Springer Berlin Heidelberg New York


1. Heiss, E. and Gerhäuser, C.
Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA.
Antioxid. Redox. Signal. 7, 1601-1611 (2005) Abstract Full text (PDF)

2. Bohr, G., Gerhäuser, C., Knauft, J., Zapp, J., Becker, H.
Anti-inflammatory acylphloroglucinol derivatives from hop (Humulus lupulus).
J. Natural Prod., 68, 1545-1548 (2005) Abstract Full text (PDF)

3. Wittich, S., Scherf, H., Xie, C., Heltweg, B., Dequiedt, F., Verdin, E., Gerhäuser, C., Jung, M.
Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines.
Anticancer Drugs, 16, 635-643 (2005) Abstract

4. Gerhäuser, C.
Beer constituents as potential cancer chemopreventive agents (Review).
Eur. J. Cancer 41, 1941-1954 (2005) Abstract Full text (PDF)

5. Gerhäuser, C. and Frank, N.
Xanthohumol, a new all-rounder?
Mol. Nutr. Food Res. 49, 821-823 (2005) Abstract (PDF upon request)

6. Gerhäuser, C.
Broad spectrum antiinfective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites.
Mol. Nutr. Food Res. 49, 827-831 (2005) Abstract (PDF upon request)

7. Hanske, L., Hussong, R., Frank, N., Gerhäuser, C., Blaut, M., Braune, A.
Xanthohumol does not affect the composition of rat intestinal microbiota.
Mol. Nutr. Food Res. 49, 868-873 (2005) Abstract (PDF upon request)

8. Ruefer, C.E., Gerhäuser, C., Frank, N., Becker, H., Kulling, S.E.
In vitro phase II metabolism of xanthohumol by human UDP-glucuronosyl transferases and sulfotransferases.
Mol. Nutr. Food Res. 49, 851-856 (2005) Abstract (PDF upon request)

9. Pan, L., Becker, H., Gerhäuser, C.
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor and mitochondrial pathway.
Mol. Nutr. Food Res. 49, 837-843 (2005) Abstract (PDF upon request)

10. Hussong R, Frank N, Knauft J, Ittrich C, Owen R, Becker H, Gerhäuser, C.
A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats.
Mol. Nutr. Food Res. 49, 861-867 (2005) Abstract (PDF upon request)

11. Bartsch H., Gerhäuser, C. and Nair J.
Molekulare Forschungsansätze zur Vorbeugung von Krebserkrankungen
Forum DKG Sonderheft 2005, 6-9 (2005) Full text (PDF)


1. Nookandeh, A., Frank, N., Gerhäuser, C., Steiner, F., Schneider, B., Becker, H.
Xanthohumol metabolites in faeces of rats.
Phytochemistry 65, 561 –570 (2004) Abstract Full text (PDF)

2. Bertl, E., Klimo, K., Heiss, E., Klenke, F., Peschke, P., Becker, H., Eicher, T., Herhaus, C., Kapadia, G., Bartsch, H., Gerhäuser, C.
Identification of novel inhibitors of angiogenesis using a human in vitro anti-angiogenesis assay.
Int. J. Canc. Prev. 1, 47-61 (2004) Abstract

3. Bertl, E., Herhaus, C., Kapadia, G., Becker, H., Eicher, Th., Bartsch, H., Gerhäuser, C.
Inhibition of endothelial cell functions in vitro by novel potential cancer chemopreventive agents.
Biochem. Biophys. Res. Comm. 325, 287-295 (2004) Abstract Full text (PDF)

4. Dittmann, K., Gerhäuser, C., Klimo, K., Hamburger, M.
HPLC-based activity profiling of Salvia miltiorrhiza for MAO A and iNOS inhibitory activities.
Planta Med. 70, 909-913 (2004) Abstract Full text (PDF)

5. Gerhäuser, C.
Flavonoide und Glukosinolate: Bio-aktiv gegen Krebs.
UGB-Forum 3/04, 137-139 (2004)

6. Gerhäuser, C. und Frank, N.
Was Xanthohumol tatsächlich mit Krebszellen macht.
Braumanager 3, 30-31 (2004)


1. Wollenweber, E., Stevens, J.F., Klimo, K., Knauft, J., Frank, F. and Gerhäuser, C.
Cancer Chemopreventive in vitro Activities of Isoflavones Isolated from Iris germanica.
Planta Medica 69, 15-20 (2003) Abstract Full text (PDF)

2. Gerhäuser, C., Klimo, K., Heiss, E., Neumann, I., Gamal Eldeen, A., Knauft, J., Liu, G., Sitthimonchai, S., Frank, N.
Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Mut. Res. 523-524, 163-172 (2003) Abstract Full text (PDF)

3. Gerhäuser, C. and Frank, N.
New Promising Chemopreventive Agents and Mechanisms.
Handbook of Experimental Pharmacology.
Editor: Harri Vainio: Springer Verlag, Heidelberg, pp. 289-305.


1. Wittich, S., Scherf, H.R., Xie, C., Brosch, G., Loidl, P., Gerhäuser, C., Jung, M.
Structure-activity relationships on phenylalanine containing inhibitors of histone deacetylase – In-vitro enzyme inhibition, induction of differentiation and inhibition of proliferation in erythroleukemic cells.
J. Med. Chem. 45, 3296-3309 (2002) Abstract Full text (PDF)

2. Zidorn, C., Spitaler, R., Ellmerer-Müller, E.P., Perry, N.B., Gerhäuser, C., and Stuppner, H.
Structure of tyrolobibenzyl D and biological activity of tyrolobibenzyls from Scorzonera humilis.
Z. Naturforsch. 57c, 614-619 (2002) Abstract Full text (PDF)

3. Gerhäuser, C., Alt, A., Heiss, E., Gamal-Eldeen, A., Klimo, K., Knauft, J., Neumann, I., Scherf, H.-R., Frank, N., Bartsch, H., Becker, H.
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.
Mol. Cancer Ther. 1, 959-969 (2002) Abstract Full text (PDF)

4. Gerhäuser, C., Alt, A.P., Klimo, K., Knauft, J., Frank, N., Becker, H.
Isolation and potential cancer chemopreventive activities of phenolic compounds of beer.
Phytochem. Rev. 1, 369-377 (2002) Full text (PDF)

5. Gerhäuser, C., Alt, A., Heiss, E., Gamal-Eldeen, A., Klimo, K., Knauft, J., Neumann, I., Nookandeh, A., Scherf, H., Frank, N., Bartsch, H., Becker, H.
Identification and cancer chemopreventive potential of Xanthohumol, a prenylated chalcone from hop (Humulus lupulus L.)
Hopfenrundschau International 2002/2003, 50-55 (2002)


1. Heiss, E., Herhaus, C., Klimo, K., Bartsch, H., Gerhäuser, C.
Nuclear factor-kappaB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.
J. Biol. Chem. 276, 32008-32016 (2001) Abstract Full text (PDF)

2. Gerhäuser, C.
Flavonoide und andere pflanzliche Wirkstoffe. Was hat praktische Relevanz? Sollen wir unser Essverhalten ändern?
Akt. Ernähr. Med. 26, 1-7 (2001) Full text (PDF)

3. Gerhäuser, C.
Mechanismen der Krebsentstehung – Ansatzpunkte für die Krebs-Chemoprävention. Ernährungs-Umschau 48, S48 – S51 (2001)


1. Ha, T., Gerhäuser, C., Zhang, W., Ho-Chong-Line, N., and Fourasté, I.
New lanostanoids from Ganoderma Lucidum (Polyporaceae) that induce NAD(P)H:quinone oxidoreductase in cultured Hepa1c1c7 murine hepatoma cells.
Planta Med. 66, 681-684 (2000) Abstract

2. Gerhäuser, C.
Chemoprävention von Krebs durch Naturstoffe.
Pharmazeutische Zeitschrift, (Sonderheft Meran) 4-8 (2000).

3. Gerhäuser, C., Heiss, E., Herhaus, C., Klimo, K.
Potential Chemopreventive Mechanisms of Chalcones.
Chapter 4.4 in: Dietary Anticarcinogens and Antimutagens. Chemical and Biological Aspects.
Editors: Ian Johnson and Roger Fenwick: RCS, Cambridge, UK, pp. 189-192.


1. Lee S.K., Luyengi L., Gerhäuser, C., Mar W., Lee K., Mehta R.G., Kinghorn A.D., Pezzuto J.M.
Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity.
Cancer Lett. 136, 59-65 (1999) Abstract Full text (PDF)

2. Song, L.L., Kosmeder, J.W., Lee, S.K., Gerhäuser, C., Lantvit, D., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M.
Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase 2 detoxification enzymes.
Cancer Res. 59, 578-85 (1999) Abstract Full text (PDF)

3. Jung, M., Brosch, G., Kölle, D., Scherf, H., Gerhäuser, C., Loidl, P.
Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation.
J. Med. Chem. 42, 4669-79 (1999) Abstract


1. Bartsch, H., Gerhäuser, C., Frank, N., Osswald, H. Winde, G.
Krebs-Chemoprävention durch antidysplastische Wirkstoffe: Beispiel Sulindac.
Medizin im Bild, S 1/1998, 16-18 (1998)

2. Gerhäuser, C.and Frank, N.
Chemoprevention of cancer: Mechanisms and strategies for cancer control (an overview). Current Cancer Research 1998. Steinkopff Darmstadt, Springer New York 1998; pp. 78 - 83.

3. Gerhäuser, C. und Frank, N.
Vorbeugen statt heilen? Mechanismen und Ansatzpunkte der Krebs-Chemoprävention (Übersicht). Krebsforschung heute 1998. Steinkopff Darmstadt, 1998; pp. 79 - 86.


1. Bartsch, H., Frank, N., Gerhäuser, C., Owen, R.W., and Berger, M.
International Meeting on Cancer Chemoprevention: Molecular Basis, Mechanisms and Trials.
Eur. J. Cancer Prev. 6, 80-92 (1997)

2. Chang, L.C., Gerhäuser, C., Song, L.L., Farnsworth, N.R., Pezzuto, J.M., and Kinghorn, A.D.
Activity-guided isolation of constituents of Tephrosia purpurea with potential to induce the phase II enzyme quinone reductase.
J. Natural Prod. 60, 869-873 (1997) Abstract

3. Gerhäuser, C., Lee, S.K., Kosmeder, J.W., Moriarty, R.M., Hamel, E., Mehta, R.G., Moon, R.C., and Pezzuto, J.M.
Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.
Cancer Res. 57, 3429-3435 (1997) Abstract Full text (PDF)

4. Gerhäuser, C., You, Y., Liu, J., Moriarty, Hawthorne, M., Mehta, R.G., Moon, R.C., and Pezzuto, J.M.
Cancer chemopreventive potential of sulforamate, a novel analog of sulforaphane that induces Phase 2 drug-metabolizing enzymes.
Cancer Res. 57, 272-278 (1997) Abstract Full text (PDF)

5. Kennelly, E.J., Gerhäuser, C., Song, L.L., Graham, J.G., Beecher, C.C.W., Pezzuto, J.M., and Kinghorn, A.D.
Induction of quinone reductase by withanolides isolated from Physalis philadelphica (Tomatillos).
J. Agr. Food. Chem. 45, 3771-3777 (1997) Abstract

6. Udeani, G.O., Gerhäuser, C., Thomas, C.F., Moon, R.C., Kosmeder, J.W., Kinghorn, A.D., Moriarty, R.M., and Pezzuto, J.M.
Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Cancer Res. 57, 3424-3428 (1997) Abstract Full text (PDF)


1. Gerhäuser, C., Mar, W., Lee, S.K., Suh, N., Luo, Y., Kosmeder, J.W., Luyengi, L., Fong, H.H.S., Kinghorn, A.D., Moriarty, R.M., Mehta, R.G., Constantinou, A., Moon, R.C., Pezzuto, J.M.
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.
Nature Med. 1, 260-266 (1995) Abstract Full text (PDF)

2. Mehta, R.G., Moriarty, R.M., Liu, J., Constantinou, A., Thomas, C.F., Hawthorne, M., You, M., Gerhäuser, C., Pezzuto, J.M., and Moon, R.C.
Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage.
Carcinogenesis 16, 399-404 (1995) Abstract Full text (PDF)

3. Wagner, H., Gerhäuser, C. and Samtleben, R.
Bioactive polymers of higher plants. Proceedings of the Phytochemical Society of Europe Vol. 37: Phytochemistry of Plants Used in Traditional Medicine. K. Hostettmann, A. Marston, M. Maillard, and M. Hamburger: Clarendon Press, Oxford, 1995; pp. 205-225.


1. Wachinger, M., Samtleben, R., Gerhäuser, C., Wagner, H., and Erfle, V.
Bryodin, a singlechain ribosome-inactivating protein, selectively inhibits the growth of HIV-1 infected cells and reduces HIV-1 production.
Res. Exptl. Med. 193, 1-12 (1993) Abstract

2. Gerhäuser, C., Samtleben, R., Tan, G.T., Pezzuto, J.M., Lottspeich, F., and Wagner, H.
Peponin, a ribosome-inactivating protein isolated from the seeds of Cucurbita pepo L. inhibits human immunodeficiency virus type-1 reverse transcriptase.
Pharm. Pharmacol. Lett. 3, 71-75 (1993)


1. Gerhäuser, C., Leonhardt, K., Tan, G.T., Pezzuto, J.M., and Wagner, H.
What is the antiviral principle of Thuja occidentalis L.?
Pharm. Pharmacol. Lett. 2, 127-130 (1992)

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