Press Releases

No. 62 | 16. November 2018 | by Mat

Mayer Foundation provides €1.5 million for research on Ewing sarcoma in children

Ewing sarcoma cells are small, round and undifferentiated. Without using mo...
© Grünewald/LMU München

In a new research consortium, scientists from the "Hopp Children's Cancer Center Heidelberg" (KiTZ), together with working groups from Ludwig Maximilian University of Munich (LMU) and the West German Cancer Centre (WTZ) of Essen University, have teamed up to advance research on Ewing sarcoma and derive approaches for novel diagnosis and therapy methods on this basis. The Gert und Susanna Mayer Stiftung will support the project by providing funds of €1.5 million over a five-year period.
The "Hopp Children's Cancer Center Heidelberg" (KiTZ) is a joint institution of the German Cancer Research Center (DKFZ), Heidelberg University Hospital (UKHD) and Heidelberg University.

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No. 59 | 12. November 2018 | by Koh

Defective DNA damage repair leads to chaos in the genome

© EMBL / P. Riedinger

Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known for a few years: If an important DNA repair system of the cells has failed, this promotes fragmentation and defective assembly of the genetic material. Cancer cells with such a repair defect can now possibly be treated by a specific group of drugs.

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No. 58 | 05. November 2018 | by Koh

Breast cancer: Stress signaling promotes metastasis and therapy resistance

Early lung metastasis in a mouse: Red: active JNK signaling cells; green: c...
© Tsunaki Hongu/DKFZ

Scientists from the German Cancer Research Centre (DKFZ) and the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) have identified a central switch protein in breast cancer that promotes tumor metastasis in response to cellular stress. The switch triggers a stem cell program in the cancer cells that promotes the aggressive spread of the tumor. Chemotherapeutics also activate the switch, and this undermines therapeutic efficacy. By identifying the molecular players involved in the stress-induced spread of breast cancer, the researchers have identified previously unknown possible target structures that could be useful for the development of future therapies.

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No. 54c | 24. October 2018 | by Mat

A faster lane towards effective therapies of childhood brain cancer

Molecular analyses can deliver valuable additional information about the ex...
© KiTZ

Scientists of the „Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ), the German Cancer Consortium (DKTK) and the German Cancer Research Center (DKFZ), in collaboration with colleagues from Seattle, U.S.A., have built a collection of tumor models that can be used to test anticancer drugs for treating childhood brain cancer. The biobank and database can be accessed by scientists worldwide and is an important resource for cancer research. Children suffering from brain cancer may also benefit from it. The researchers have now published their results in NATURE MEDICINE.
The „Hopp Children's Cancer Center at the NCT Heidelberg" (KiTZ) is a joint institution of the Heidelberg University Hospital and the German Cancer Research Center (DKFZ).

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No. 57 | 30. October 2018 | by Koh

Physical exercise in cancer therapy – the more individualized, the better

Cancer patient during resistance training
© University Hospital, Media Center Heidelberg

Regular exercise not only reduces the risk of cancer. Physical training can also support the therapy of a tumor disease. An international consortium of researchers, including scientists from the German Cancer Research Center (DKFZ) and the National Center for Tumor Diseases (NCT) Heidelberg, has discovered: Patients who exercise regularly not only feel physically fitter and stronger, they also rate their own quality of life as better and suffer less frequently from chronic fatigue syndrome. However, some patient groups seem to benefit more than others.

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No. 55 | 24. October 2018 | by Koh

Understanding the "wiring diagrams" of genes in complex tissues

© Benedikt Rauscher/DKFZ

How is the activity of all genes in cells of higher organisms interconnected? And how are the genetic "wiring diagrams" of the cells in complex tissues coordinated with each other? Scientists from the German Cancer Research Center, the European Molecular Biology Laboratory and the University of Heidelberg are now planning to investigate this in two model organisms, Drosophila and Arabidopsis. The European Research Council (ERC) is funding the "DECODE" project with a Synergy Grant.

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No. 54c | 23. October 2018

Strong cooperation with Weizmann Institute of Science

from left to right.: Michael Baumann, Chairman and Scientific Director DKFZ...
© DKFZ

No. 54 | 19. October 2018 | by Mat

Taking a look at the genes of brain tumors may help making the right therapy decision

Diagnosis „primitive neuroectodermal tumor of the CNS“: Tumor cells are sma...
© Dominik Sturm / KiTZ

Researchers from the „Hopp-Children’s Cancer Center Heidelberg“ (KiTZ) together with colleagues from the US, showed substantial molecular diversity behind seemingly similar embryonal brain tumors in children. The scientists could reveal the impact of identifying this molecular diversity on the diagnosis and treatment approach. The investigations, which were conducted in the context of a clinical study, were supported by the German Cancer Consortium (DKTK).

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No. 53 | 18. October 2018 | by Koh

Takeda Oncology Research Award 2018 to Rocio Sotillo

Rocio Sotillo
© Jutta Jung/DKFZ

A certain form of lung cancer is characterized by two genes that are accidentally fused. The fusion produces a growth signal for the cells. These tumors respond well to a targeted drug that deprives the cancer cells of the growth stimulus. Several molecular variants of cancer-promoting gene fusion exist. Rocio Sotillo of the German Cancer Research Center and the German Center for Lung Research (DZL) has discovered that one of these variants is associated with a more aggressive disease, which also rapidly develops resistance to the cancer drug. For these results Sotillo has now received the Takeda Oncology Research Prize 2018, endowed with 30,000 euros.

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No. 52 | 08. October 2018 | by Koh

Machine Learning to Accellerate Drug Research

Automated microscopy documents changes in cells after treatment with a test...
© M. Boutros, Deutsches Krebsforschungszentrum

The European Research Council (ERC) is awarding a "proof-of-concept grant" to scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Heidelberg University for the first time to enable them to develop new drugs more cheaply and quickly using image-based analyses.

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