Press Releases

No. 41 | 16. September 2019 | by Rei

Biological mechanism explained: How lymphoma cells form brain metastases

Using a special microscopy technique, scientists can observe single lymphom...
© Heikenwälder/DKFZ

Lymphomas in the central nervous system are rare but dangerous. Scientists at the German Cancer Research Center (DKFZ) have now discovered which molecular mechanism leads to lymphomas forming metastases in the central nervous system. Using a mouse model, the researchers showed that chronic inflammatory processes in aging brains lead to lymphoma cells that have entered the brain tissue being retained instead of being released directly back into the blood. They also identified key molecules of this mechanism in tissue samples from patients with lymphomas of the central nervous system. The researchers therefore hope to have identified a potential approach for developing new therapeutic approaches.

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No. 38 | 09. September 2019 | by Rei

Black sheep: Why some strains of the Epstein Barr virus cause cancer

Epstein Barr viruses in blood vessels
© Adobe Stock

The Epstein Barr virus (EBV) is very widespread. More than 90 percent of the world's population is infected – with very different consequences. Although the infection does not usually affect people, in some it can cause glandular fever or various types of cancer. Researchers at the German Cancer Research Center (DKFZ) have now discovered why different virus strains cause very divergent courses of disease.

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No. 36 | 29. July 2019 | by Grö

First branch of the German Cancer Research Center in Dresden for intelligent technologies in the fight against cancer

© Adobe Stock, lunamarina

With support from the State of Saxony, the German Cancer Research Center (DKFZ) plans to step up cancer research considerably at the Dresden site. DKFZ's first branch outside Heidelberg is to work on pioneering technologies that use smart sensors and artificial intelligence to improve the prevention and treatment of cancer. A dedicated building will be erected on the Oncology Campus of Dresden University Medicine at TU Dresden.

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No. 37c | 12. August 2019 | by Mau/Koh

First indication of possible role of blood coagulation in lung carcinogenesis

Protein factors trigger the activation of the blood platelets and their sub...
© Adobe Stock

Thrombophilia promotes the progression and metastasis of lung cancer. Up to now, it was not known whether coagulation is also conducive to tumorigenesis. For the first time, researchers from the German Cancer Research Center have now identified a possible role of blood coagulation in the development of lung cancer.

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No. 37 | 31. July 2019 | by Koh

Founding ceremony of the DKFZ–Hector Cancer Institute at the University Medical Center Mannheim

Prof. Dr. Hans-Jürgen Hennes, Medizinischer Geschäftsführer und Ärztlicher ...
© Carina Kircher, DKFZ

At a ceremony held on July 31, the German Cancer Research Center (DKFZ), the Medical Faculty Mannheim of Heidelberg University, and Mannheim University Hospital set up a new cooperation project: At the new DKFZ–Hector Cancer Institute at the University Medical Center Mannheim, DKFZ and the University Medical Center Mannheim (UMM) aim to conduct patient-focused translational cancer research at the highest international level. Over the next ten years, the Hector Foundation II is providing 25 million euros for the long-term partnership.

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No. 35c | 23. July 2019 | by Koh

How resistance to important cancer drugs develops

Many Cancer drugs act on the microtubules of the mitotic spindle (green).
© Afunguy, Wikipedia

Taxanes, frequently used anti-cancer drugs, block cell division and thereby drive tumor cells into cell death. However, therapy resistance often develops in the course of the treatment. Scientists from the German Cancer Research Center have now discovered how cancer cells degrade a protein that induces cell death in cases of failed mitosis. If this tumor brake is missing, the cancer cells survive and are resistant to the effect of taxanes.

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No. 35 | 17. July 2019 | by Koh

Making cancer stem cells visible to the immune system - New results may enable innovative treatment concept against leukemia

NK cells (red) attack normal leukemia cells (green). Leukemia stem cells (b...
© Schürch/Lengerke, University and University Hospital of Basel

Leukemia stem cells protect themselves against the immune defense by suppressing a target molecule for killer cells. This protective mechanism can be tricked with drugs. In the journal "Nature", scientists from Basel, Tübingen and Heidelberg describe the new therapeutic approaches that can possibly be derived from these results.
Joint press release of the German Cancer Research Center (DKFZ), the German Cancer Consortium (DKTK), and the University Hospital Tübingen

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No. 33 | 11. July 2019 | by Koh

Enzyme responsible for dangerous properties of brain tumor stem cells

GPD1-positive cells (red) express protein Sox2 (green) and are located at t...
© DKFZ

The relapse of brain tumors after therapy is driven by cancer stem cells that were not affected by the treatment. In mouse models of glioblastoma, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) were now looking for molecular markers that specifically characterize brain tumor stem cells. They identified an enzyme that is responsible for the threatening stem cell properties of glioblastoma and at the same time represents a possible "Achilles heel" where cancer stem cells could be vulnerable.

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No. 32 | 10. July 2019 | by Koh

“Highly cited” - Nine DKFZ researchers in the top class

DKFZ
© dkfz.de

Scientists whose work is being cited very often by peers are regarded as exceptionally acknowledged and influential in their fields. Therefore, citation counts are a common benchmark for assessing the scientific performance of individual researchers. For 2018, nine scientists from the German Cancer Research Center (DKFZ) reached a top place in this assessment: They rank in the top 1% of the world's highly cited researchers for their field.

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No. 30 | 24. June 2019 | by Koh

Lung cancer screening: Women benefit significantly

© Wikimedia Commons

Is computed tomography suitable for detecting lung cancer at a very early stage and thus still well treatable? Scientists at the German Cancer Research Center have investigated this with the LUSI study started in 2007. The results of the study, which is funded by the Deutsche Forschungsgemeinschaft and the Dietmar Hopp Foundation, are now available: Taken together, the screening slightly but not significantly reduced lung cancer mortality in both sexes. In contrast, the researchers observed a significant 69 percent reduction in relative risk among women. The results confirm comparable European studies which, taken together, provide strong arguments for the introduction of systematic lung cancer screening for high-risk groups.

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