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Press Releases

No. 66b | 23. November 2022

How blood cancer cells renew themselves

© Wikimedia Commons

Scientists at Heidelberg University Hospital, the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and HI-STEM gGmbH* have discovered a new mechanism for the self-renewal of leukemia stem cells. The study results help to better understand the aggressive course of acute myeloid leukemia.

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No. 66 | 22. November 2022

ERC Starting Grant for Chong Sun

Chong Sun
© Jung/ DKFZ

With its "Starting Grants", the European Research Council (ERC) aims to pave the way for excellent young scientists to pursue independent careers. This year, immunologist Chong Sun from the German Cancer Research Center (DKFZ) will receive the prestigious funding: He plans to investigate why therapeutic T cells often fail to infiltrate a tumor and thus develop their full efficacy against cancer cells.

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No. 65 | 09. November 2022

New Molecular Microscopy Uncovers how Breast Cancer Spreads

© A. Lomakin / EMBL-EBI, DKFZ

Researchers have created a tool that maps how breast cancer grows in previously unseen detail, and highlights how the cells around the tumour may be the key to controlling the spread of disease. The new technology can trace which populations of breast cancer cells are responsible for the spread of the disease, and for the first time highlights how the location of cancer cells could be as important as mutations in tumor growth The new study is published now in Nature.

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No. 58 | 24. October 2022 | by Koh

How tumors suppress the development of metastases

Squamous cell carcinoma of the skin expressing the messenger angiopoietin-l...
© Augustin/DKFZ

Why do metastases often only appear after the original tumor has been surgically removed? Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim Medical Faculty of Heidelberg University have now published an explanation for this phenomenon. They were able to identify a messenger substance of the cancer cells that locally promotes the growth of the primary tumor. In the blood, the messenger is split into two fragments, one of which suppresses metastasis. Tumor-bearing mice treated with the metastasis-inhibiting fragment survived cancer longer than untreated animals.

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No. 57 | 17. October 2022 | by Koh

Takeda Oncology Research Award 2022 to Arlou Kristina Angeles

Arlou Kristina Angeles
© Jutta Jung / DKFZ

In some patients with non-small cell lung cancer, tumor cells carry genetic alterations that accelerate cancer growth. There are agents that prevent this, but cancer cells often develop resistance to these drugs. Arlou Kristina Angeles (German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg) has shown that tracking tumor DNA in the patient's blood is one way of detecting therapy resistance or disease progression at an early stage. This research can help adapt the treatment strategy for those affected as quickly as possible. Arlou Kristina Angeles received the 2022 Takeda Oncology Research Award for her findings.

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No. 56c | 10. October 2022 | by Koh

A specific inhibitor allows to study an enigmatic enzyme

The inhibitor DKFZ-748 binds to the enzyme HDAC 10.
© Steimbach / DKFZ

The enzyme HDAC10 is involved in a variety of cellular processes associated with the development of a number of diseases. However, it is often not known exactly what role HDAC10 plays in the disease process. Scientists from the German Cancer Research Center (DKFZ) have now for the first time synthesized a highly selective inhibitor that can be used to study the function of HDAC10.

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No. 56 | 06. October 2022 | by Koh

Iron deficiency suppresses important arm of the innate immune system

Light microscopic image of a neutrophil in a blood smear.
© Wikipedia

Two proteins ensure that cells can take up iron when needed. If both control proteins are switched off in mice, the animals develop severe anemia, as expected. Supprisingly, at the same time a cell type of the innate immune defense, the neutrophils, also dramatically decreases, as scientists from the German Cancer Research Center now have shown for the first time. Iron deficiency, a known defense mechanism against infectious pathogens, is a double edged sword, as it simultaneously curbs the defensive power of an important arm of the innate immune system.

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No. 54 | 28. September 2022 | by Koh

First successful trial for early detection of HPV-related cancer of the pharynx

© DKFZ, Professor Dr. Hanswalter Zentgraf

Screening trials for the early detection of rare diseases often fail due to insufficient predictive power of the results. For the rare HPV-related cancer of the pharynx, scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) now relied on the combined detection of antibodies against two different viral proteins in a proof-of concept trial. This enabled them to significantly improve the positive predictive value of the test results.

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No. 53c | 26. September 2022

UNCAN.eu: a European initiative to better understand cancer

© uncan.eu

The Coordination and Support Action "4.UNCAN.eu" had its official kick-off on September 8-9 2022 with a public event hosted by Inserm at les Cordeliers, Paris, France.

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No. 52 | 21. September 2022 | by Koh

ERC funding: How to deliver gene therapies to a specific target site?

Nina Papavasiliou
© Jutta Jung / DKFZ

With its "Proof of Concept" grants, the European Research Council ERC supports scientists in further developing the commercial potential of their research results. Nina Papavasiliou from the German Cancer Research Center (DKFZ) is now receiving the prestigious grant for the second time: she wants to advance the development of a "molecular delivery service" that ensures that therapeutic genes reach the right address in the body in a targeted manner. One of the aims of this project is to develop more targeted cancer vaccines.

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