PhD/Postdoc Position in "Lipid-receptor interactions in brain and pancreatic cancers"

Project description:

Using primary material from surgical specimens of brain tumors or pancreatic ductal adenocarcinoma we plan to identify a molecular switch converting pro-tumor signals into death ones in cancer cells. This project combines lipidomics, proteomics and advanced microscopy methods, as well as organoids and preclinical models of cancer and shall set the foundations for anti-cancer therapies.

The project will additionally involve the analysis and integration of multiple types of data and their application on questions of tumor stem cell biology. The candidate will be exposed to a highly interdisciplinary research environment. We offer rewarding work on applied projects, in the stimulating research environment of Heidelberg, and in tight collaboration with both experimental as well as computational scientists, providing you the chance to gain experience in diverse research topics and to get an optimal start for your scientific career.

Desired qualifications:

We are looking for highly motivated outstanding researchers curious about fundamental questions related to the field of CD95 biology as a molecular switch between life and death. Applicants should add a CV, letters of recommendation, and a short outline of their research interests.
In addition, the candidate should have:
• a degree in life sciences
• a strong interest in biochemistry incl. lipidomics and/or advanced microscopy
• experience in two of the following fields: lipidomics, genome editing, confocal and superresolution microscopy

Furthermore, we expect passion for science, independent thinking, fluency in written and spoken English and interdisciplinary communication skills.

Contact Information:
Prof. Ana Martin-Villalba
a.martin-villalba@dkfz.de

Please visit our web page for further information on our research and recent publications.

Group homepage: https://www.dkfz.de/en/neurobiologie-von-gehirntumoren/index.php

PhD/Postdoc Position in "Computational Biology"

Project description:

The position is part of the ERC consolidator grant REBUILDCNS, which aims at increasing the potential of endogenous adult stem cells to repair the diseased brain. Analysis of single cell sequencing data from this project will be used to trace the cells' history (clonal analysis) and to unravel fundamental questions of stem cells isolated from healthy or injured brain.

The successful candidate's tasks will focus on the development, testing and application of computational tools, and will involve programming. Applying statistical methods and acquiring knowledge in stem cell biology and regenerative medicine. The close interaction between a computational lab and a neurobiology lab, provides a unique opportunity for a scientist interested in interdisciplinary work and lateral thinking.

Desired qualifications:

The ideal candidate should be highly motivated and have experience in at least one of the following areas:
- A degree in a quantitative subject such as bioinformatics, statistics, computer science, physics, genomics or a related field
- Experience in at least one programming language (R or Python, optional: C/C++)
- Experience in working on Linux systems
- Experience in next generation sequencing data analysis is desired, but not required
Researchers from all disciplines aiming at attaining a PhD, with a recently completed PhD or who are about to finish their PhD are welcome to apply. Postdoctoral candidates are expected to have a published record of achievements that would enable them to successfully apply for postdoctoral fellowships. In additions, applicants should send a CV, letter of recommendation and a short outline of their research interests.

Contact Information:
Prof. Ana Martin-Villalba
a.martin-villalba@dkfz.de

Please visit our web page for further information on our research and recent publications.

Group homepage: https://www.dkfz.de/en/neurobiologie-von-gehirntumoren/index.php

We are always seeking highly motivated new members for our research team.

For specified positions please take a look at the links below.

DKFZ International PhD Program

Please take note that, in additon to advertised PhD studentships, the German Cancer Research Center houses an international PhD Program with 36 fellowships granted annually. This PhD Program provides interdisciplinary training and research opportunities for University Graduates who wish to work towards a PhD in the field of Biology and Cancer Research. If you wish to apply, see http://www.dkfz.de/phd for further information.

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