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D. Herp, J. Ridinger, D. Robaa, S. A. Shinsky, K. Schmidtkunz, T. Z. Yesiloglu, T. Bayer, P. Sehr, N. Gunkel, A. K. Miller, D. W. Christianson, I. Oehme, W. Sippl, M. Jung "First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Inhibitors of Neuroblastoma Cell Colony Growth That Increase Lysosome Accumulation" ChemRxiv Preprint.
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M. Morgen, R. R. Steimbach, M. Géraldy, L. Hellweg, P. Sehr, J. Ridinger, O. Witt , I. Oehme, C. J. Herbst‐Gervasoni, J. D. Osko, N. J. Porter, D. W. Christianson, N. Gunkel, A. K. Miller "Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors" ChemMedChem, 2020, 15, 1163–1174.
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Chen, X., Chen, X., Steimbach, R.R., Wu, T., Li, H., Dan, W., Shi, P., Cao, C., Li, D., Miller, A.K., Gao, J., Zhu, Y. "Novel 2, 5-Diketopiperazine Derivatives as Potent Selective Histone Deacetylase 6 Inhibitors: Rational Design, Synthesis and Antiproliferative Activity" Eur. J. Med. Chem. 2020, 187, 111950.
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De Vita, E., Smits, N., van den Hurk, H., Beck, E.M., Hewitt, J., Baillie, G., Russell, E., Pannifer, A., Hamon, V., Morrison, A., McElroy, S.P., Jones, P., Ignatenko, N.A., Gunkel, N., Miller, A.K. "Synthesis and Structure–Activity Relationships of N-(4-Benzamidino)-Oxazolidinones–Potent and Selective Inhibitors of Kallikrein-Related Peptidase 6" ChemMedChem, 2020, 15, 79-95.
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Geraldy, M., Morgen, M., Sehr, P., Steimbach, R.R., Ridinger, J., Oehme, I., Witt, O., Malz, M., Nogueira, M.S., Koch, O., Gunkel, N., Miller, A.K. "Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated" J. Med. Chem. 2019, 62, 4426–4443.
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De Vita, E., Schüler, P., Lovell, S., Lohbeck, J., Kullmann, S., Rabinovich, E., Sananes, A., Heßling, B., Hamon, V., Papo, N., Heß, J., Tate, E.W., Gunkel, N., and Miller, A.K. “Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity” J. Med. Chem. 2018, 61, 8859–8874.
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Kolbinger, F.R., Koeneke, E. Ridinger, J., Heimburg, T., Bayer, T., Sippl, W., Jung, M., Gunkel, N. Miller, A.K., Witt, O., Oehme, I. “The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines” Archives of Toxicology, 2018, 92, 2649–2664.
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Ridinger, J., Koeneke, E., Kolbinger, F.R., Koerholz, K., Mahboobi, S., Gunkel, N., Miller, A.K., Peterziel, H., Hamacher-Brady, A., Witt, O., Oehme, I. “Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance” Scientific Reports 2018, 8, 10039.
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Sananes, A., Cohen, I., Shahar, A., Hockla, A., De Vita, E., Miller, A.K., Radisky, E., Papo, N. “A selective, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering” J. Biol. Chem. 2018, 293, 12663–12680.
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Longuespée, R., Wefers, A.K., De Vita, E., Miller, A.K., Reuss, D.E., Wick, W., Herold-Mende, C., Kriegsmann, M., Schirmacher, P., von Deimling, A., Pusch, S. “Rapid detection of 2-hydroxyglutarate in frozen sections of IDH mutant tumors by MALDI-TOF mass spectrometry” Acta Neuropathol. Commun. 2018, 6, 21.
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Moraru, A., Wiederstein, J., Pfaff, D., Fleming, T., Miller, A.K., Nawroth, P., Teleman, A.A.“Elevated levels of the reactive metabolite methylglyoxal recapitulate progression of Type 2 Diabetes” Cell Metabolism, 2018, 27, 926–934.
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Morgen, M., Jöst, C., Malz, M., Janowski, R., Niessing, D., Klein, C.D., Gunkel, N., Miller, A.K. “Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity” ACS Chem Biol. 2016, 11, 1001-1011.
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Fritzching, B., Zhou-Suckow, Z., Trojanek, J.B., Schubert, S.C., Schatterny, J., Hirtz, S., Agrawal, R., Muley, T., Kahn, N., Sticht, C., Gunkel, N., Welte, T., Randell, S.H., Länger, F., Schnabel, P., Herth, F.J.F., Mall, M.A. "Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease." Am. J. Respir. Crit. Care Med. 2015, 191, 902–913.
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Seidensaal, K., Nollert, A., Feige, A.H., Muller, M., Fleming, T., Gunkel, N., Zaoui, K., Grabe, N., Weichert, W., Weber, K.J., Plinkert, P., Simon, C., Hess, J. “Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma” Mol Cancer. 2015, 14, 204.
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Senyilmaz, D., Virtue, S., Xu, X., Tan, C.Y., Griffin, J.L., Miller, A.K., Vidal-Puig, A., Teleman, A.A. “Regulation of mitochondrial morphology and function by stearoylation of TFR1” Nature 2015, 525, 124-128.
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Pusch, S., Schweizer, L., Beck, A.C., Lehmler, J.M., Weissert, S., Balss, J., Miller, A.K., von Deimling, A. “D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma” Acta Neuropathol. Commun. 2014 , 2, 19.
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Miller, A.K., Banghart, M.R., Beaudry, C., Suh, J.M., Trauner, D. "Development of novel Lewis acid catalyzed cycloisomerizations: synthesis of bicyclo[3.1.0]hexenes and cyclopentenones." Tetrahedron, 2003, 59, 8919–8930.
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Alanine, A., Flohr, A., Miller, A.K., Norcross, R.D., Claus, R. "Preparation of N-benzothiazol-2-yl amides having affinity toward the A2a adenosine receptor." PCT Int. Appl. 2001, WO2001097786
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Berger, J., Flippin, L.A., Greenhouse, R., Jaime-Figueroa, S., Liu, Y., Miller, A.K., Putman, D.G., Weinhardt, K.K., Zhao, S.-H. "Preparation of 2-amino-4-aryppyrimidines as 5-HT2B antagonists." 1999, US5958934
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