Publications

Jones DTW, Banito A, Grünewald TGP, Haber M, Jäger N, Kool M, Milde T, Molenaar JJ, Nabbi A, Pugh TJ, Schleiermacher G, Smith MA, Westermann F, Pfister SM. Molecular characteristics and therapeutic vulnerabilities across paediatric solid tumours. Nat Rev Cancer. (2019) Aug;19(8):420-438.

Loizou E, Banito A, Livshits G, Ho YJ, Koche RP, Sánchez-Rivera FJ, Mayle A, Chen CC, Kinalis S, Bagger FO, Kastenhuber ER, Durham BH, Lowe SW. A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. Cancer Discov. (2019) Jul;9(7):962-979

Lujambio A, Banito A. Functional screening to identify senescence regulators in cancer. Curr Opin Genet Dev. (2019) Feb;54:17-24.

Banito A, Li X, Laporte A, Roe JS, Huang CH, Dancsok A, Tschaharganeh DF, Tasdemir N, Ladanyi M, Jones KB, Capecchi MR, Vakoc CR, Torsten N, Lowe SW. SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to drive synovial sarcoma. Cancer Cell. (2018) March; 33 (3): 527-541.

Aarts M, Beolchi P, Banito A, Carroll T, Kulisic M, Kaemena D, Dharmalingam G, Martin N, Reik W, Zuber J, Chandra T and Gil J. Coupling shRNA screens with single-cell RNA-Seq identifies mechanisms regulating senescence during reprogramming. Genes Dev. (2017) Oct 15;31(20):2085-2098.

Tordella L, Khan S, Hohmeyer A, Banito A, Klotz S, Raguz S, Martin N, Dhamarlingam G, Carroll T,González Meljem JM, Deswal S, Martínez-Barbera JP, García-Escudero R, Zuber J, Zender L, Gil J. SWI/SNF regulates a transcriptional program that induces senescence to prevent liver cancer. Genes Dev. (2016) Oct 1;30(19):2187-2198.

Tasdemir N*, Banito A*, Roe JS*, Alonso-Curbelo D*, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen C, Fennell M, Chicas A, Vakoc C, Lowe SW. BRD4 connects enhancer remodelling to senescence immune surveillance. Cancer Discov. (2016) June; 6(6): 612-29.*equal contribution.

Herranz N, Gallage S, Mellone M, Wuestefeld T, Klotz S, Hanley CJ, Raguz S, Acosta JC, Innes AJ, Banito A, Georgilis A, Montoya A, Wolter K, Dharmalingam G, Faull P, Carroll T, Martínez-Barbera JP, Cutillas P, Reisinger F, Heikenwalder M, Miller RA, Withers D, Zender L, Thomas GJ, Gil J. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol. (2015) Sep;17(9):1205-17.

Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, Longerich T, Enikolopov G, Lowe SW. p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell. (2014) Jul 31;158(3):579-92.

Banito A and Lowe SW (2013). A new development in senescence. Cell. (2013) Nov 21;155(5):977-8.

Acosta JC*, Banito A*, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. (2013) Aug;15(8):978-90.*equal contribution.

Banito A and Gil, J. Enhancing reprogramming to pluripotency by controlling senescence. Tumor Dormancy, Quiescence and Senescence. (2013) Vol 1, 195-205.

Marqués-Torrejón MÁ, Porlan E, Banito A, Gómez-Ibarlucea E, Lopez-Contreras AJ, Fernández-Capetillo O, Vidal A, Gil J, Torres J, Fariñas I. Cyclin-dependent kinase inhibitor p21 controls adult neural stem cell expansion by regulating Sox2 gene expression. Cell Stem Cell. (2013) Jan 3;12(1):88-100.

O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Lavial F, Masui O, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J. (2012) MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation. Cell Stem Cell. (2012) Jan 6;10(1):33-46.

Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AG. ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell. (2010) Jun 4,547-556.

Banito A and Gil J. Induced pluripotent stem cells and senescence: learning the biology to improve the technology. EMBO Rep (2010) 11, 353-359.

Pita JM, Banito A, Cavaco BM, and Leite V. Gene expression profiling associated with the progression to poorly differentiated thyroid carcinomas. Br J Cancer (2009) 101, 1782-1791.

Banito A, Rashid ST, Acosta JC, Li S, Pereira CF, Geti I, Pinho S, Silva JC, Azuara V, Walsh M, Vallier L, Gil J. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev (2009) 23, 2134-2139.

Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenfuhr M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. (2009) 23, 1177-1182.

Cavaco BM, Batista PF, Martins C, Banito A, do Rosario F, Limbert E, Sobrinho LG, and Leite, V. Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations. Endocr Relat Cancer (2008) 15, 207-215.

Acosta JC, O'Loghlen A, Banito A, Raguz, S, and Gil J. Control of senescence by CXCR2 and its ligands. Cell Cycle. (2008) 7, 2956-2959.

Pinto AE, Silva G, Banito A, Leite V, Soares J. Aneuploidy and high S-phase as biomarkers of poor clinical outcome in poorly differentiated and anaplastic thyroid carcinoma. Oncol Rep (2008) 20, 913-919.

Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. (2008). Chemokine signalling via the CXCR2 receptor reinforces senescence. Cell. (2008) 133, 1006-1018.

Banito A, Pinto AE, Espadinha C, Marques AR, and Leite V. Aneuploidy and RAS mutations are mutually exclusive events in the development of well-differentiated thyroid follicular tumours. Clin Endocrinol (Oxf) (2007) 67, 706-711.

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