Christopoulos P, Kirchner M, Bozorgmehr F, Endris V, Elsayed M, Budczies J, Ristau J, Penzel R, Herth FJ, Heussel CP, Eichhorn M, Muley T, Meister M, Fischer JR, Rieken S, Lasitschka F, Bischoff H, Sotillo R, Schirmacher P, Thomas M, Stenzinger A. Identifcation of a highly lethal V3+ TP53+ subset in ALK+ lung adenocarcinoma (2018) Int J Cancer. 2018 Sep 26. doi: 10.1002/ijc.31893.

de Cárcer G, Venkateswaran SV, Salgueiro L, El Bakkali A, Somogyi K, Rowald K, Montañés P, Sanclemente M, Escobar B, de Martino A, McGranahan N, Malumbres M, Sotillo R. Plk1 overexpression induces chromosomal instability and suppresses tumor development. (2018) Nat Commun. 2018 Aug 1;9(1):3012. doi: 10.1038/s41467-018-05429-5.


Havas KM, Milchevskaya V, Radic K, Alladin A, Kafkia E, Garcia M, Stolte J, Klaus B, Rotmensz N, Gibson TJ, Burwinkel B, Schneeweiss A, Pruneri G, Patil KR, Sotillo R, Jechlinger M. Metabolic shifts in residual breast cancer drive tumor recurrence. J Clin Invest. 2017 Jun 1;127(6):2091-2105. doi: 10.1172/JCI89914. Epub 2017 May 15.

Domingues PH, Nanduri LS, Seget K, Venkateswaran SV, Agorku D, Vigano C,von Schubert C, Nigg EA, Swanton C, Sotillo R, Bosio A, Storchova Z, Hardt O. (2017) Cellular prion protein PRPC and ecto-5'-nucleotidase are markers of the cellular stress response to aneuploidy. Cancer Res. Apr 4. pii: canres.3052.2016. doi: 10.1158/0008-5472.CAN-16-3052

Buccitelli C, Salgueiro L, Rowald K, Sotillo R, Mardin BR, Korbel JO. (2017) Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation. Genome Res. 27(4):505-511.

Weischenfeldt J, Dubash T, Drainas AP, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm, H, Korbel JO (2017)Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet. 49(1):65-74.

Rowald K, Mantovan M, Passos, J, Buccitelli C, Mardin BR, Korbel JO, Jechlinger M, Sotillo R.(2016)
Negative selection and chromosome instability induced by Mad2 overexpression delay breast cancer but facilitate oncogene-independent outgrowth. Cell Rep.15(12): 2679-91.

Rowald K, Sotillo R. (2014)
Is aneuploidy deciding your fate? Cell Cycle 13(9):1370.

Schvartzman JM, Duijf PH, Sotillo R, Coker C, Benezra R. (2011)
Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Cancer Cell 19(6):701-714.

Sotillo R, Schvartzman JM, Socci ND, Benezra R. (2010)
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464(7287):436-440.

Schvartzman JM*, Sotillo R*, Benezra R. (2010)
Mitotic chromosomal instability and cancer: mouse modelling of the human disease.
Nat. Rev. Cancer 10(2):102-115. *equal contribution

Sotillo R, Schvartzman JM, Benezra R. (2009)
Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity. Cancer Cell 16(6):451-452.

Diaz-Rodríguez E*, Sotillo R*, Schvartzman JM, Benezra R. (2008)
Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. Proc. Natl. Acad. Sci. U.S.A. 105(43):16719-16724.*equal contribution

Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. (2007)
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS ONE 2(11):e1165.

Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. (2007)
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11(1):9-23.

Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. (2005)
Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Res. 65(9):3846-3852.

Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M. (2005)
Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.
Cold Spring Harb. Symp. Quant. Biol. 70:233-240.

Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. (2004)
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6.
Cell 118(4):493-504.

Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. (2003)
Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 35(1):25-31.

Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. (2003)
Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene 22(34):5261-5269.

Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M. (2003).Driving the cell cycle to cancer. Adv. Exp. Med. Biol. 532:1-11.

Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. (2001).
Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20(23):6637-6647.

Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. (2001)
Invasive melanoma in Cdk4-targeted mice. Proc. Natl. Acad. Sci. U.S.A. 98(23):13312-13317.

Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M. (2000)
Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 19(13):3496-3506.

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