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Joint Subproject 2

Viral and host determinants of SARS-CoV-2 replication: Common pathways as targets for broad-spectrum antiviral therapy

Cortese et al., Cell Host & Microbe 2020

In this project we aim to identify the viral and host cell factors responsible for SARS-CoV-2 replication. A particular focus is put on the formation of the viral replication organelle (RO) and its genome amplification machinery. We will decipher those factors that are commonly used by other RNA viruses forming analogous ROs (e.g. other coronaviruses). Conserved factors will be tested for suitability as targets for broad-spectrum antiviral drugs to be employed e.g. as pan-coronavirus inhibitors, in line with the Transfer mission of COVIPA. Complementary to that we will study the morphological alterations induced by SARS-CoV-2 in infected cells and how they contribute to cytopathogenicity.

Carsten Sachse 

Nils-Alexander Lakomek 

Ralf Bartenschlager 

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