Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds
Chemical Biology Core Facility

Chemical Biology Core Facility

Small molecule screening facility

Ligand docked into target protein

Ligand docked into target protein
© dkfz.de

Small inhibitory molecules are widely used as therapeutic agents, but they are also excellent “biotool” compounds for basic research. They are often used as experimental tools to address important biological questions via loss-of-function experiments. The aim of this core facility is to provide research groups with inhibitory molecules against their target of interest and enable them to answer essential questions in their research. The facility assists groups in the development of primary and secondary assays for screening against our in-house compound library and guides them through the process of identifying tool compounds for their specific target. Specifically, this core facility provides the following services:

  • Assay development and high-throughput screening
  • Binding affinity studies for small molecules and antibodies using the Biacore surface plasmon resonance technology (SPR)
  • Computational screening using ligand-based and structure-based design strategies


The Chemical Biology Core Facility is a collaboration between DKFZ and the European Molecular Biology Laboratory (EMBL) in Heidelberg, and is located at EMBL. For further information on this service, please visit this site.

Medicinal chemistry support is usually required following a small molecule screen. Here, the research group “Cancer Drug Development” headed by Dr. Aubry Miller offers assistance on a collaborative basis.

Contact

Dr. Ulrike Uhrig

Head of Chemical Biology Core Facility (acting)

E-Mail: ulrike.uhrig@embl.de 

Phone ++49 (0)6221 387- 8935

to top
powered by webEdition CMS