Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Division of Medical Physics in Radiology

Prof. Dr. sc. techn. Mark E. Ladd

3D mapping of intracellular pH in a glioma patient using phosphorus-31 MR spectroscopic imaging at 7 Tesla (method according to Korzowski A et al., 2020, Magn Reson Med, 84:1707-1723). (Left) Interpolated pH maps overlaid on a clinical contrast-enhanced MR image. (Right) pH values are calculated via the chemical shift difference between phosphocreatine and inorganic phosphate.

The Division of Medical Physics in Radiology develops new methods for imaging-based diagnostic and therapeutic procedures. Our research focuses on novel hardware as well as software-based acquisition and reconstruction strategies for magnetic resonance imaging (MRI), positron emission tomography (PET), and optical tomography. We strive to improve and individualize cancer patient treatment by acquiring quantitative biomedical information about tumors and metastases with non-invasive imaging methods. For example, we are expanding the diagnostic value of MRI by using very powerful magnetic fields (7 or 9.4 Tesla) to depict the distribution of sodium, oxygen, potassium, and chlorine inside the body. Another approach to capture metabolic processes is hyperpolarization of carbon in various chemical substrates, which are then injected into the body and measured with MRI. By optimizing MRI diffusion techniques, we have been able to greatly improve the diagnostic accuracy of breast cancer screening, and we are investigating how maps of tissue susceptibility correlate with disease. An additional emerging MR imaging contrast is provided by Chemical Exchange Saturation Transfer (CEST) imaging, which allows detection and measurement of glucose or mobile proteins. Furthermore, we are exploring new detector concepts for simultaneous PET and optical imaging.

Medical imaging continues to be one of the key technologies for cancer detection, characterization, and therapy monitoring. Despite the enormous technological advances achieved in the past decades, imaging still has enormous potential to reveal more information about the metabolic, physiologic, and functional parameters of tumors and metastases. This information can then be used to choose the best therapy for each individual patient. In collaboration with clinical divisions of the DKFZ and partners at the university hospital, we are working to translate our developments into standard patient use. This includes state-of-the-art imaging protocols at our MR imagers located at the National Center for Tumor Diseases (NCT).


Prof. Dr. sc. techn. Mark E. Ladd
Medical Physics in Radiology (E020)
Tel: +49 6221 42 2550
Fax: +49 6221 42 2585


Sabine Fritz
Tel.: +49 6221 42 2553
Fax.: +49 6221 42 2585

Selected Publications

  • Ludwig D, Laun FB, Klika KD, Rauch J, Ladd ME, Bachert P, Kuder TA. Diffusion pore imaging in the presence of extraporal water. J Magn Reson 339:107219 (2022).
  • Paech D, Nagel AM, Schultheiss MN, Umathum R, Regnery S, Scherer M, Wick A, Platt T, Wick W, Bendszus M, Unterberg A, Schlemmer HP, Ladd ME, Niesporek SC. Quantitative dynamic oxygen 17 MRI at 7.0 T for the cerebral oxygen metabolism in glioma. Radiology 295(1):181-189 (2020).
  • Korzowski A, Weinfurtner N, Mueller S, Breitling J, Goerke S, Schlemmer HP, Ladd ME, Paech D, Bachert P. Volumetric mapping of intra- and extracellular pH in the human brain using 31 P MRSI at 7T. Magn Reson Med 84(4):1707-1723 (2020).
  • Orzada S, Solbach K, Gratz M, Brunheim S, Fiedler TM, Johst S, Bitz AK, Shooshtary S, Abuelhaija A, Voelker MN, Rietsch SHG, Kraff O, Maderwald S, Flöser M, Oehmigen M, Quick HH, Ladd ME. A 32-channel parallel transmit system add-on for 7T MRI. PLoS One 14(9):e0222452 (2019).
to top
powered by webEdition CMS