Lunch Talk Series

© Biomed X

We are happy to announce that the DKFZ PostDoc Network (PDN) and BioMed X Innovaton Center launch a new monthly scientific networking event -"Lunch Talk Series"- at the German Cancer Research Center (DKFZ).

With the “Lunch Talk Series” group leaders from the BioMed X Innovation Center and the DKFZ PostDoc Network invite other life science scientists to join them for a monthly scientific exchange.


Each “Lunch Talk” will start at 11:00 a.m. with a scientific presentation in one of the research areas: cell biology, immunology, bioinformatics, neuroscience, epigenetics, and nanomaterials. In line with the topic, each “Lunch Talk” will be hosted by one of BioMed X's research group leaders and by the DKFZ PostDoc Network.

The talk will be followed at 12:00 p.m. by a sponsored walking lunch for all participants in order to encourage informal discussions and cross-institutional exchange. Participation is free of charge and open to all researchers and students in the field of life sciences.

 

Upcoming Seminar

Thursday, April 19th, 2018 11:00

DKFZ, Communication Center, K1+K2

Im Neuenheimer Feld 280, Heidelberg

 

Dr. Robert Prevedel

EMBL Heidelberg, Germany

"Imaging Brains in Action - Using Advanced Optical Techniques to Visualize Dynamic Events in Living Organisms"

 

Host: Dr. Dagmar Ehrnhöfer, BioMed X

 

Next Seminars

Dr. Jacqui Shields

MRC Cancer Unit, University of Cambridge, UK

"Stromal function in the evolving tumour microenvironment: a role in immune modulation?"

 

Abstract:

‘The recent success of immunotherapy platforms to harness and reactivate the immune response represent a major therapeutic advancement, however, many patients still fail to respond or do not see lasting benefits. While tumours frequently contain immune infiltrates, our immune system is often unable to mount an effective anti-tumour response, and rather than clearing the lesion, immune populations may promote disease progression and metastasis. Despite these observations, the mechanisms employed by a growing tumour to avoid immune destruction remain unclear, thus increasing our understanding of anti-tumour immunity and the suppressive networks at play during malignant transition will be fundamental to the development of improved strategies and design of new, targeted therapeutic platforms. Recent evidence indicates that non-cancerous support cells within tumours, referred to as the stroma are emerging as key sources of tumour-promoting inflammation, but little is known how or when in tumour evolution these functions are acquired. We take a multidisciplinary approach to explore the mechanisms and evolution of stromal-mediated immune dysfunction in the tumour microenvironment and uncouple the immunoregulatory systems governing their suppressive function. As part of this global aim we have demonstrated that one of the most abundant stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T cells in an antigen specific-antigen dependent manner resulting in T cell deletion. CAFs also stimulate recruitment of neutrophils and neutrophil extracellular trap formation. Moreover, we have shown that lymph nodes draining a tumour (TDLNs) form part of the extended tumour microenvironment, adapting to tumour-derived signals. LN stromal cells, particularly fibroblastic reticular cells (FRCs), which provide critical structural support and regulate immunity and transport properties of LNs, expand prior to the onset of metastasis and undergo significant remodelling. Profiling of populations from individual resting or TDLNs revealed significant transcriptional alterations in these cells. Of major interest was the observation of downregulated CCL21 and IL-7, two key guidance and T cell survival cues. Coincident with this, altered immune cell composition aberrant immune localization were detected. In summary, we now beginning to obtain insight into the complexities of stromal interactions that support immune dysfunction as tumours develop, both via direct and indirect mechanisms by multiple players and at multiple sites.’

Previous Seminars

 

  • March 27th, 2018 - Prof. Dr. Hendrik Dietz, Technical University of Munich, Germany, “Molecular Systems Engineering with DNA”
  • February 22nd, 2018 - Prof. Dr. Ir. Albert van den Berg, University of Twente, The Netherlands: “Labs, Cells and Organs on a Chip: Technologies and Biomedical Applications”
  • January 18th, 2018 - Dr. Florian I. Schmidt, Institute of Innate Immunity, University of Bonn, Germany: “Alpaca Nanobodies as Tools to Study the Cell Biology of the Immune System”
  • December 19th, 2017 - Matthias Selbach, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany: "Proteome dynamics"
  • November 2nd, 2017 - Simone Picelli, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany: “Single-cell RNA-sequencing made simple, efficient and inexpensive”
  • October 4th, 2017 - Frank Pfrieger, Institute of Cellular and Integrative Neuroscience (INCI), CNRS, University of Strasbourg, France: “

    Neuron-glia interactions: models matter”

  • July 11th 2017 - Amit Agarwal, Johns Hopkins University, Baltimore, USA: “Decoding Microdomain Calcium Signals in Astrocytes”
    June 21st, 2017 - Simon Anders, University of Heidelberg, ZMBH, Germany: “Diving in the data deluge: Interactive tools for visual exploration of big data”
  • May 18th, 2017 - Matthias Leisegang, Institute for Cardiovascular Physiology, Goethe-University Frankfurt, Germany: “Long noncoding RNAs in the control of endothelial gene regulatory networks”
  • April 12th, 2017 - Stefan Diez, B CUBE - Center for Molecular Bioengineering, Technische Universität Dresden: “Biomolecular Motors: From Biological Function to Nanotechnological Applications”
  • March 16th, 2017 - Mohamed Bentires-Alj, 

    Friedrich Miescher Institute (FMI) for Biomedical Research, Basel, Switzerland: “

    Cancer targeted therapy and tumor heterogeneity: Act locally, think globally”
  • February 14th, 2017 - Michael N. Hall, Biozentrum, University of Basel, Switzerland: “mTOR signaling in growth and metabolism”
  • January 19th, 2017 - Bassem Hassan, 

    Institut du Cerveau et de la Moëlle épinière – ICM (Brain and Spine Institute), Paris, France: “

    Transcriptional regulation of neurogenesis”
  • December 15th, 2016 - Harald Janovjak, Assistant Professor in Synthetic Physiology, Institute of Science and Technology, Austria: “Synthetic physiology - Remote control of cellular signals”
  • November 28th, 2016 - Elias Hobeika, Research Group Leader, Institute for Immunology, Ulm University, Germany: “Maintenance of mature B-cells in health and disease”
  • October 24th, 2016 - Andreas Offenhäusser, Director at the Peter Grünberg Institute at FZ Jülich: “Bioelectronics: building connections between bio systems and electronics”
  • September 22nd, 2016 - Ulrich Stelzl, Professor at the Institute of Pharmaceutical Sciences (IPW), Department of Pharmaceutical Chemistry, University of Graz, Austria: “Studying post-translational protein modification in a human protein interaction network context”
  • May 13, 2016 - Dimitrios Tzalis, Founder and CEO of Taros: “European Lead Factory - Boosting European Drug Discovery”
  • April 11, 2016 - Janos Vörös, Institute for Biomedical Engineering, ETH Zurich: “Next generation biosensors based on nanotechnology: Miniaturized immunofiltration, plasmonic coupled particles and molography"
  • March 24th, 2016 - Oliver Rocks, Group Leader Rho GTPase Signaling, Max-Delbrueck-Center for Molecular Medicine, Berlin: “A systematic analysis of the Rho GEF/GAP regulatory proteins”
  • February 18, 2016 - Markus Zweckstetter, German Center for Neurodegenerative Diseases & Max Planck Institute for Biophysical Chemistry, Göttingen: “Molecular mechanisms of Tau function and Alzheimer pathology”
  • January 18, 2016 - Petr Broz, Basel University: “Molecular mechanisms of inflammasome assembly and signalling”
  • December 10, 2015 - Thijn Brummelkamp, Netherlands Cancer Institute: "Genetics in haploid human cells to study disease networks"
  • November 12, 2015 - Almut Schulze, Department of Biochemistry and Molecular Biology Theodor-Boveri-Institute, Biocenter, Würzburg: "Targeting Cancer Metabolism”
  • October 12, 2015 - Stefan Knapp, Goethe University Frankfurt, DKTK partner site, "Strategies for the design of selective kinase chemical tools and their role in target validation"

 

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