Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external video platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name Youtube
Purpose External media

Publications Prof. Dr. Ingrid Hoffmann

Selection of Recent Publications

Hassepass, I., Voit, R. and Hoffmann I (2003)
Phosphorylation at serine-75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S phase checkpoint.
J Biol. Chem. 278, 29824-29829.

Warnke S., Kemmler S., Hames RS, Tsai HL, Hoffmann-Rohrer U., Fry AM, and Hoffmann I. (2004)
The polo-like kinase-2 is required for centriole duplication in mammalian cells.
Curr Biol. 14, 1200-1207.

Hassepass, I. and Hoffmann, I. (2004)

Assaying Cdc25 phosphatase activity.
Methods Mol Biol., 281, 153-162.

Hoffmann, I. (2004)
Playing Polo in G1: A novel function of Polo-like kinase-2 in centriole duplication.
Cell Cycle 3(10):1230-1231.

Bachmann, M., Hennemann, H., Hoffmann, I. and Möröy, T. (2004)
A novel function for the oncogenic serine/threonine kinase Pim-1 at the G2/M cell cycle checkpoint is revealed through its direct interaction with Cdc25C.
J. Biol. Chem. 12, 48319-48328.

Volkening, M. and Hoffmann, I. (2005)
Involvement of human MCM8 in pre-replication complex assembly by recruiting hcdc6 to chromatin.
Mol. Cell. Biol., 25, 1560-1568.

Syed, N. , Smith, P., Sullivan, A., Spender, L., Dyer, M., Karran, L., O’Nions, J., Allday, M., Hoffmann, I., Crawford, D., Griffin, L., Farrell, P. and Crook, T. (2006)
Transcriptional silencing of Polo-Like Kinase 2 (Snk/Plk2) is a frequent event in B cell malignancies.
Blood, 107(1):250-6.

Bachmann, M., Hennemann, H., Xiang-Xing, P., Hoffmann, I. and Möröy, T. (2006)

The oncogenic serine/threonine kinase Pim-1 phosphorylates and inhibits the activity of C-TAK1: a novel role for Pim-1 at the G2/M cell cycle checkpoint.
Int J Biochem Cell Biol 38(3):430-43.

Hoffmann, I. (2006)
Protein kinases and the spindle assembly checkpoint, in: Results and Problems in Cell Differentiation.
Cell cycle control Vol II, P. Kaldis, ed. Springer Verlag, Heidelberg, 42:93-109.

Cizmeciolgu, O. and Hoffmann, I. (2006)
Kizuna takes pole position.
Nature Cell Biol. 10, 8(10):1050-1.

Cizmecioglu, O., Warnke, S., Arnold, M., Duensing, S. and Hoffmann, I. (2008)
Plk2-regulated centriole duplication is dependent on its localization to the centrosome and a functional polo-box domain.
Cell Cycle 15;7(22):3548-55.

Timofeev, O., Cizmecioglu, O. Hu E., Orlik, T. and Hoffmann, I. (2009)
The Cdc25A phosphatase has a non-redundant role in regulation of the G2/M phase transition.
FEBS Lett 583(4):841-7.

Kuriyama R, Bettencourt-Dias M, Hoffmann I, Arnold M, and Sandvig L. (2009)
γ-tubulin-containing abnormal centrioles induced by insufficient Plk4 in human HCT116 colorectal cancer cells.
J. Cell Sci. 122(Pt 12):2014-23.

Krause A and Hoffmann I. (2010)

Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.
PLoS One 24;5(3):e9849.

Timofeev, O., Cizmecioglu, O., Settele F., Kempf, T. and Hoffmann I. (2010)
Cdc25 phosphatases are required for timely assembly of Cdk1/CyclinB complex at G2/M transition.
J. Biol. Chem. 285(22):16978-90.

Chang, J., Cizmecioglu, O., Hoffmann, I. and Rhee, K. (2010)
Plk2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.
EMBO J. 29(14):2395-406.

Guernsey, D., Jiang, H, Hussin, J., Arnold, M., Bouyakdan, K., Perry, S., Babineau-Sturk,T., Beis, J, Dumas, D., Evans, S, Ferguson, M., Matsuoka, M, Macgillivray, C., Nightingale, M, Patry, L., Rideout, A., Thomas, A., Orr, A., Hoffmann, I., Michaud, J., Awadalla, P. Meek, D., Ludman, M. and Samuels, M. (2010)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Amer J Hum Genet 87(1):40-51.

Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiß U, Antony C, Hoffmann I (2010)
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
J Cell Biol. 2010 Nov 15;191(4):731-739. Epub 2010 Nov 8.

Commented in: http://jcb.rupress.org/content/early/2010/11/03/jcb.1914if

Tumurbaatar, I., Cizmecioglu, O., Hoffmann, I., Grummt, I, and Voit, R. (2011)
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/CyclinB activity.
Plos One 6, e14711.

Puklowski, A., Homsi, Y., Chauhan, S., Keller, D., Grünwald, V., Kubicka, S., Pich, A., Mann, M., Hoffmann, I., Gönczy, P. and Malek, N. (2011)
The activity of the SCFFbw5 E3-ubiquitin ligase is regulated by the APC/C and Plk4 to control centrosome duplication.
Nat. Cell Biol, 13, 1004-9.

Bahtz, R., Seidler, J., Arnold, M., Haselmann-Weiss, U., Antony, C., Lehmann, W and Hoffmann, I., (2012)
GCP6 is a substrate of Plk4 and required for centriole duplication.
J Cell Sci. 2012 Feb 15;125(Pt 4):981-92. Epub 2012 Mar 7.


Cizmecioglu, O, Krause, A., Bahtz, R., Ehret, L., Malek, N. and Hoffmann, I. (2012)

Phosphorylation of Fbxw7/hCdc4 regulated by Plk2 promotes cyclin E stabilization.
J Cell Sci. 2012 Jan 15;125(Pt 2):486-96. Epub 2012 Feb 2.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2012)
RhoD participates in the regulation of cell-cycle progression and centrosome duplication.
Oncogene. 2012 Jun 4. doi: 10.1038/onc.2012.195.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2013)
The RhoD to centrosomal duplication.
Small GTPases. 2013 Feb 19;4(2).

Zhu M, Settele F, Kotak S, Sanchez-Pulido L, Ehret L, Ponting CP, Gönczy P, Hoffmann I. (2013)
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
J Cell Biol. 2013 Mar 18;200(6):773-787.
Audio file concerning this article

Bärenz, F. and Hoffmann, I. (2013)
DUBing CP110 controls centrosomes numbers, Curr. Biol. 23, 459-460.

Martin, C.A., Ahmad, I., Klingeisen, A., Hussain, M., Bicknell, L., Leitch, A., Nürnberg, G., Toliat, M., Murray, J., Hunt, D., Khan, F., Ali, z., Tinschert, S., Ding, J., Keith, C., Harley, M., Heyn, P., Müller, R., Hoffmann, I., Daire, V., Dollfus, H., Dupuis, L., McElreavey, K., Kariminejad, A., Mendoza-Londono, R., Moore, A., Saggar, A., Schlechter, C., Weleber, R., Thiele, H., Altmüller, J., Höhne, W., Hurles, M., Noegel, A., Baig, S., Nürnberg, P. and Jackson, A., (2014)
Mutations in Plk4, a master regulator of centriole biogenesis cause microcephaly, growth failure and retinopathy.
Nat. Genet. 46,1283–1292.

Kratz, A., Bärenz, F., Richter, K. and Hoffmann, I. (2015)
Plk4-dependent phosphorylation of STIL is required for centriole duplication.
Biology Open 4, 370-377.

Brunk, K., Zhu, M., Bärenz, F., Kratz, AS., Haselmann-Weiss, U., Antony, C. and Hoffmann, I., (2016)
Cep78 is a novel centriolar protein involved in PLK4-induced centriole overduplication.
J Cell Sci 129, 2713-2718.

Kratz, AS., Richter, K., Schlosser, Y., Schmitt, M., Shumilov, A., Delecluse HJ and Hoffmann, I. (2016)
Fbxo28 regulates topoisomerase IIα-dependent DNA decatenation.
Cell Cycle 18:1-13.

Shumilov, A., Tsai, M.H., Schlosser, Y.T., Kratz, AS, Bernhard, K., Fink, S. Tuba, M., Jauch, A., Mautner, J., Kopp-Schneider, A., Feederle, R., Lin, X, Hoffmann, I. and Delecluse HJ. (2017) 
Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.
Nat Comm 8:14257

Vodicska B, Cerikan B, Schiebel E, and Hoffmann I. (2018)
MISP regulates the IQGAP1/Cdc42 complex to collectively orchestrate spindle orientation and mitotic progression. Sci Rep. 8(1):6330.
doi: 10.1038/s41598-018-24682-8. PMID:29679050

Kschonsak YT and Hoffmann I. (2018)
Activated Ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation.
J. Cell Sci. in press doi: 10.1242/jcs.214544. [Epub ahead of print] PMID:29669740

Bärenz F, Kschonsak YT, Meyer A, Jafarpour A, Lorenz H, Hoffmann I. (2018)
Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
Mol Biol Cell. Oct 24 doi: 10.1091/mbc.E18-02-0115. [Epub ahead of print]
PMID: 30354798J


to top
powered by webEdition CMS