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LEO Study

Life without colorectal cancer

The LEO study is a large-scale, scientific study conducted by the Department of Preventive Oncology at the National Center for Tumor Diseases (NCT) Heidelberg together with the Interdisciplinary Endoscopy Center Heidelberg (IEZ). Since 2020, the LEO study team has been recruiting participants in the age group 30-49 as part of the NCT Heidelberg "Proof of Concept Trial." The trial's main objective is to discover and evaluate new screening tests that can detect colorectal cancer and its precursors earlier.

Another focus under development is risk-adapted prevention.

Please note that you can only participate in the study if you speak German.

Aim of the study

The main objective of the study is to discover and evaluate new screening tests that can detect colorectal cancer and its precursors earlier, especially in young adults in the age group of 30-49. Further, the frequency of the disease and the question of how to best identify high-risk groups in which precursors are already present is to be investigated. We want to derive recommendations for a personalized age for starting colorectal cancer screenings.

The study also researches how well the offer of a colonoscopy to examine the bowel for polyps and other suspicious changes is received within the age group of 30-49 years and what results are found. Participants of the LEO study do not commit to any examination. At any given time, they can also decide to only participate in the study parts that include filling out our online questionnaires (LEO Questionnaire I on diet and lifestyle, LEO Health Questionnaire II on health issues) or providing biospecimens to develop simple screening tests.

However, with a colonoscopy, our participants receive an offer that does not currently exist free of charge in the German health care system for this age group. If detected early, the chances of curing most types of cancer are much better. Colorectal cancer can be prevented by screening!

Contact Details

The LEO study is coordinated by the Department of Preventive Oncology at the NCT Heidelberg.
We very much welcome your participation. Prevention research depends on every participant. Only if as many people as possible participate, can new cancer screening methods be developed and evaluated. Those can ensure early cancer detection through simple examinations of bio specimens, such as blood, saliva, urine or stool samples.

If you have any questions about the process, we, the LEO study team will be happy to provide further information.

Your Leo Study Team:
National Center for Tumor Diseases (NCT) Heidelberg
Preventive Oncology
Im Neuenheimer Feld 460
69120 Heidelberg
Phone: 06221-56-34322 

LEO-Study rooms
National Cancer Prevention Center
Prevention clinic
Berliner Str. 45 (Mathematikon), 1. floor
69120 Heidelberg
Phone: 06221 42-4156

Study Management
National Center for Tumor Diseases (NCT) Heidelberg
and German Cancer Research Center (DKFZ)
Prof. Dr. Hermann Brenner
Im Neuenheimer Feld 460
69120 Heidelberg 

Clinical Management
University Hospital Heidelberg
Interdisciplinary Endoscopy Center
Prof. Dr. Peter Sauer, senior physician Dr. Anja Schaible, MSc
Im Neuenheimer Feld 410
69120 Heidelberg 

Data Protection
German Cancer Research Center (DKFZ)
Data Protection Officer
Im Neuenheimer Feld 280
69120 Heidelberg
Phone: 06221-42-0

Heidelberg University Hospital
Data Protection Officer
Im Neuenheimer Feld 672
69120 Heidelberg
Phone: 06221-56-7036

Data protection supervisory authority
State Data Protection and Freedom-of-Information Officer in Baden-Württemberg
P.O. Box 10 29 32, 70025 Stuttgart
Phone: 0711- 61 55 41-716, Fax: 0711-61 55 41-15

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