Research
- Research Topics
- Cell Biology and Tumor Biology
- Stem Cells and Cancer
- Inflammatory Stress in Stem Cells
- Experimental Hematology
- Molecular Embryology
- Signal Transduction and Growth Control
- Epigenetics
- Redox Regulation
- Vascular Oncology and Metastasis
- Clinical Neurobiology
- Molecular Neurogenetics
- Molecular Neurobiology
- Mechanisms Regulating Gene Expression
- Molecular Biology of Centrosomes and Cilia
- Dermato-Oncology
- Pediatric Leukemia
- Tumour Metabolism and Microenvironment
- Personalized Medical Oncology
- Molecular Hematology - Oncology
- Cancer Progression and Metastasis
- Translational Surgical Oncology
- Neuronal Signaling and Morphogenesis
- Cell Signaling and Metabolism
- Cell Fate Engineering and Disease Modeling
- Cancer Drug Development
- Cell Morphogenesis and Signal Transduction
- Functional and Structural Genomics
- Molecular Genome Analysis
- Molecular Genetics
- Pediatric Neurooncology
- Cancer Genome Research
- Chromatin Networks
- Functional Genome Analysis
- Theoretical Systems Biology
- Neuroblastoma Genomics
- Signaling and Functional Genomics
- Signal Transduction in Cancer and Metabolism
- RNA-Protein Complexes and Cell Proliferation
- Systems Biology of Signal Transduction
- Areas of Interest
- Advancement of clinical proteomics for systems medicine
- Bridging from the single cell to the cell population – Epo-induced cellular responses and erythroleukemia
- Deciphering tumor microenvironment interactions determining lung cancer development
- Mechanisms controlling the compensation of liver injury and towards model-based biomarkers for early detection of liver cancer
- Application of dynamic pathway modelling for personalized medicine
- Group Members
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- Teaching
- Areas of Interest
- Molecular thoracic Oncology
- Proteomics of Stem Cells and Cancer
- Computational Genomics and System Genetics
- Applied Functional Genomics
- Applied Bioinformatics
- Translational Medical Oncology
- Metabolic crosstalk in cancer
- Pediatric Glioma Research
- Cancer Epigenomics
- Translational Pediatric Sarcoma Research
- Artificial Intelligence in Oncology
- Mechanisms of Genomic Variation and Data Science
- Neuropathology
- Pediatric Oncology
- Neurooncology
- Somatic Evolution and Early Detection
- Translational Control and Metabolism
- Soft-Tissue Sarcoma
- Precision Sarcoma Research
- Brain Mosaicism and Tumorigenesis
- Mechanisms of Genome Control
- Translational Gastrointestinal Oncology and Preclinical Models
- Translational Lymphoma Research
- Mechanisms of Leukemogenesis
- Genome Instability in Tumors
- Developmental Origins of Pediatric Cancer
- Brain Tumor Translational Targets
- Translational Functional Cancer Genomics
- Regulatory Genomics and Cancer Evolution
- SPRINT
- Cancer Risk Factors and Prevention
- Cancer Epidemiology
- Biostatistics
- Clinical Epidemiology and Aging Research
- Health Economics
- Physical Activity, Prevention and Cancer
- Primary Cancer Prevention
- Personalized Early Detection of Prostate Cancer
- Digital prevention, diagnostics and therapy guidance
- Policy and Implementation Research for Cancer Prevention
- Tumorigenesis and molecular cancer prevention
- Genomic Epidemiology
- Cancer Survivorship
- Immunology, Infection and Cancer
- Structural Biology of Infection and Immunity
- Cellular Immunology
- B Cell Immunology
- Immune Diversity
- Immunoproteomics
- Personalized Immunotherapy
- mRNA Cancer Immunotherapies
- Tumor Immunology and Tumor Immunotherapy
- Infections and Cancer Epidemiology
- Pathogenesis of Virus-Associated Tumors
- Immunotherapy and Immunoprevention
- Virus-associated Carcinogenesis
- Chronic Inflammation and Cancer
- Microbiome and Cancer
- Molecular Oncology of Gastrointestinal Tumors
- Applied Tumor Immunity
- Neuroimmunology and Brain Tumor Immunology
- Applied Tumor Biology
- Virotherapy
- Adaptive Immunity and Lymphoma
- Dermal Oncoimmunology
- Immune Regulation in Cancer
- Systems Immunology and Single Cell Biology
- Pediatric Immuno-Oncology
- Epithelium Microbiome lnteractions
- Experimental Hepatology, Inflammation and Cancer
- GMP & T Cell Therapy
- Tumorvirus-specific Vaccination Strategies
- Mammalian Cell Cycle Control Mechanisms
- Molecular Therapy of Virus-Associated Cancers
- DNA Vectors
- Episomal-Persistent DNA in Cancer- and Chronic Diseases
- Immune Monitoring
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- Computational Radiology Research Group
- Contrast Agents In Radiology Research Group
- Neuro-Oncologic Imaging Research Group
- Radiological Early Response Assessment Of Modern Cancer Therapies
- Imaging In Monoclonal Plasma Cell Disorders
- 7 Tesla MRI - Novel Imaging Biomarkers
- Functional Imaging
- Visualization And Forensic Imaging
- PET/MRI
- Dual- and Multienergy CT
- Radiomics Research Group
- Prostate Research Group
- Bone marrow
- Musculoskeletal Imaging
- Microstructural Imaging Research Group
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- Medical Physics in Radiology
- X-Ray Imaging and Computed Tomography
- Federated Information Systems
- Translational Molecular Imaging
- Medical Physics in Radiation Oncology
- Biomedical Physics in Radiation Oncology
- Intelligent Medical Systems
- Medical Image Computing
- Radiooncology - Radiobiology
- Smart Technologies for Tumor Therapy
- Team
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- Microrobots and Miniaturize Devices for Minimally-invasive Surgery
- Magnetic localization and sensing for biomedical devices
- Nanorobots for Targeted Delivery in Deep Biological Tissues
- 3D Additive Manufacturing of Soft Materials as In Vitro Tumor Models
- Surgical Simulation on Cyber-physical Organ Models
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- Multiparametric methods for early detection of prostate cancer
- Translational Molecular Imaging in Oncologic Therapy Monitoring
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Cancer Genome Research
Head: Prof. Dr. Holger Sültmann
Senior Scientists and Postdocs: PD Dr. Sabine Klauck, Dr. Arlou Kristina Angeles, Dr. Ann-Kathrin Daum, Dr. Florian Janke, Dr. Astrid Laut, Dr. Kate Glennon, Dr. Isabell Berneburg
Collaborating physicians closely associated with the division: Prof. Dr. Petros Christopoulos (Thoraxklinik Heidelberg), Dr. Anja Riediger (Clinical Cooperation Unit "Multiparametric Methods for the Detection of Prostate Cancer", DKFZ and Urological Clinic Heidelberg)
PhD and MD students: Simay Dolaner, Myesha Jahin, Mateo Gasser
Technical assistants: Sabrina Gerhardt, Simon Ogrodnik
Contact:
Prof. Dr. rer. nat. Holger Sültmann
DKFZ and NCT Heidelberg
Im Neuenheimer Feld 460
69120 Heidelberg, Germany
Tel.: ++49 6221 565934
Fax: ++49 6221 565382
E-Mail: h.sueltmann@dkfz.de
(Directions)
Cancer cells differ from normal cells by their microenvironment, altered (epi)genomes, as well as gene and protein expression. The characterization of such changes in tumors and tumor stages is essential for understanding the mechanisms of tumor progression and the definition of molecular markers for diagnosis and prognosis. Tumor heterogeneity in space and time determines therapy success and patient survival. Therefore, precision medicine approaches in cancer research need to address the following key questions:
- tumor risk stratification with multimodal biomarkers
- mechanisms of tumor progression and therapy failure
- therapy response prediction using noninvasive approaches.
Former group members:
Dr. Fawaz Al-Shaheri, Emma Brkic, Philippe Decruyenaere, Ana Rodríguez Ces, Prof. Dr. Peter Altevogt, Dr. Simone Bauer, Dr. Chiara Dalle Fratte, Philipp Hecht, Dr. Steffen Dietz, Alessa Klär, Niclas Flosdorf, Louise Appenheimer, Saskia Müller, Enrico Black, Dr. Doreen Heckmann-Nötzel, Dr. Sebastian Weingart, Lisa Gu, Sabrina Müller, Dr. Leonie Ratz, Dr. Anja Riediger, Dr. Vladimir Kuryshev, Clementine Mercé, Dr. Julia Romic-Pickl, Dr. Sajo Kaduthanam, Dr. Uwe Schirmer, Daniel Reidenbach, Denise Keitel, Dr. Ruprecht Kuner, Dr. Helen Hülsmann, Dr. Holger Armbruster, Dr. Mark Laible, Dr. Daniela Wuttig, Dr. Julia Starmann, Jennifer Metzger, Marina Gonzalez, Dr. Lukasz Kacprzyk, Dr. Stephan Gade, Sara Myers, Dr. Maria Fälth, Tatjana Andrasiuk, Dr. Rainer Will, Dr. Marc Johannes, Dr. Jan Christoph Brase, Dr. Stephanie Wittig-Blaich, Dr. Melanie Bewerunge-Hudler, Rita Schatten, Angelika Wörner, Thorsten Kühlwein, Dr. Nicole Chui Pressinotti, Dr. Caroline End, Prof. Dr. Tim Beißbarth, Dr. Alberto Calabró, Dr. Mark Fellmann, Dr. Christian Löbke, Dr. Markus Ruschhaupt, Dr. Van Duc Luu, Dr. Michael Stojanov, Andreas Buneß, Dr. Claudia Heine, Prof. Dr. Holger Fröhlich, Prof. Dr. Achim Tresch, Dr. Jörg Schneider, Dr. Katharina Finis, Dr. Wolfgang Huber, Dr. Markus Vogt, Prof. Dr. Florian Haller, Gabi Rottsahl, Claudia Grosser
Support:
German Cancer Consortium (DKTK)
German Center for Lung Research (DZL)
German Federal Ministry for Science and Education (BMBF).
Bruno und Helene Jöster Stiftung
Heidelberg Institute for Personalized Oncology (HIPO)