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Publications since 2006


Singhal M, Gengenbacher N, La Porta S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med, in press, 2020.

Abdul Pari AA, Singhal M, Hübers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Therhardt D, Géraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke K, Augustin HG", Felcht M": Tumor cell-derived Angiopoietin-2 promotes melanoma metastasis. Cancer Res, in press, 2020 ("equally contributing last authors).

Gaitantzi H, Karch J, Germann L, Cai C, Rausch V, Birgin E, Rahbari N, Seitz T, Hellerbrand C, König C, Augustin HG, Mogler C, de la Torre C, Gretz N, Itzel T, Teufel A, Ebert MPA, Breitkopf-Heinlein K: BMP-9 modulates the hepatic responses to LPS. Cells, 9,pii: E617, 2020.

Singhal M, Augustin HG:  Beyond angiogenesis: Exploiting angiocrine factors to restrict tumor progression and metastasis. Cancer Res, 80:659-62, 2020.

Hofmann I. Plakophilins and their roles in diseased states. Cell Tissue Res. 2020 Jan;379(1):5-12.doi10.1007/s00441-019-03153-0.


Schneller D, Hofer-Warbinek R, Sturtzel C, Lipnik K, Gencelli B, Seltenhammer M, Wen M, Testori J, Bilban M, Borowski A, Windwarder M, Kapel SS, Besemfelder E, Cejka P, Habertheuer A, Schlechta B, Majdic O, Altmann F, Kocher A, Augustin HG, Luttmann W, Hofer E: Cytokine-like 1 is a novel proangiogenic factor secreted by and mediating functions of endothelial progenitor cells. Circ Res, 124: 243-255, 2019.

Kim J, Park JR, Choi J, Park I, Hwang Y, Bae H, Kim Y, Choi W, Yang JM, Han S, Chung TY, Kim P, Kubota Y, Augustin HG, Oh WY, Koh GY: Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration. Science Adv, 5(2):eaau6732, 2019.

Meln I, Wolff G, Gajek T, Koddebusch J, Lerch S, Harbrecht L, Hong W, Bayindir-Buchhalter I, Krunic D, Augustin HG, Vegiopoulos A: Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth. Mol Metab, pii: S2212-8778(19)30092-4, 2019.

Malemir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegioupoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat Med, 25: 641-655, 2019.

Freie Valls A, Knipper K, Giannakouri E, Sarachaga V, Hinterkopf S, Wuehrl M, Shen Y, Radhakrishnan P, Klose J, Ulrich A, Schneider M, Augustin HG, Ruiz de Almodovar C, Schmidt T, VEGFR1(+) Metastasis-Associated Macrophages Contribute to Metastatic Angiogenesis and Influence Colorectal Cancer Patient Outcome. Clin Cancer Res, 25: 5674-85, 2019.

Schreiber C, Saraswati S, Harkins S, Gruber A, Cremers N, Thiele W, Rothley M, Plaumann D, Korn C, Armant O, Augustin HG, Sleemann JP. Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling. PLoS Genet, 15:e1008216, 2019.

Tisch N, Freire-Valls A, Yerbes R, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C,  Adams RH, Heiduschka P, Claesson-Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C. Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest, 129: 5029-107, 2019.

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M: Age-related gliosis promotes central nervous system lymphoma through CCL19-mediated tumor cell retention. Cancer Cell. 36: 250-67, 2019.

Lahav-Ariel L, Caspi M, Nadar-Ponniah PT, Zelikson N, Hofmann I, Hanson KK, Franke WW, Sklan EH, Avraham KB, Rosin-Arbesfeld R. Striatin is a novel modulator of cell adhesion. FASEB J, 33:4729-4740, 2019.

Even I, Reidenbach S, Schlechter T, Berns N, Herold R, Roth W, Krunic D, Riechmann V, Hofmann I, (2019). DLIC1, but not DLIC2, is upregulated in colon cancer and this contributes to proliferative overgrowth and migratory characteristics of cancer cells. FEBS J, 286:803-820, 2019.


La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG: Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest, 128:834-845, 2018.

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C¹, Augustin HG¹: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. Elife, pii:e34423, 2018 (¹equally contributing senior authors).

Singhal S¹, Liu X¹, Inverso D, Jiang K, Dai J, He H, Bartels S, Li W, Abdul Pari AA, Gengenbacher N, Besemfelder E, Hui L, Augustin HG²,  Hu J²: Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med, 215:2497-2508, 2018 (¹equally contributing first authors, ²equally contributing senior authors).

Leibing T, Géraud C, Augustin I, Boutros M, Augustin HG, Okun JG, Langhans CD, Zierow J, Wohlfeil SA, Olsavsky V, Schledzewski K, Goerdt S, Koch PS: Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice. Hepatology, 68: 707-722, 2018.

Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A: Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation, 137: 2592-2608, 2018.

Maida A, Zota A, Vegiopoulos A, Appak-Baskoy S, Augustin HG, Heikenwalder M, Herzig S, Rose AJ: Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance. J Nutr Biochem, 57: 189-196, 2018.

Kim KH, Nakaoka Y, Augustin HG, Koh GY: Myocardial Angiopoietin-1 controls atrial chamber morphogenesis by spatiotemporal degradation of cardiac jelly. Cell Rep, 23: 2455-2466, 2018.

Bauer C, Abdul Pari AA, Umansky V, Utikal J, Boukamp P, Augustin HG, Goerdt S, Géraud C, Felcht M: T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin. Cancer Immunol Immunother, 67: 1147-1157, 2018.

Holm A, Heumann T, Augustin HG: Microvascular mural cell heterogeneity and functional plasticity. Trends Cell Biol, pii: S0962-8924(17)30235-0, 2018.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW: Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis, 21: 425-532, 2018


Gengenbacher N, Singhal M, Augustin HG. Preclinical mouse solid tumour models: status quo, challenges and perspectives. Nat Rev Cancer, 17:751-765, 2017.

Feldner A, Adam M G, Moll I, Komljenovic D, Sahm F, Bäuerle T, Hofmann I, Wolburg H, von Deimling H, Fischer A. Los of Mpdz impairs ependymal cell integrity leading to perinatal-onset hydrocephalus in mice. EMBO Mol Med, 9:890-905, 2017.

Rios Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, Christian S, Hess-Stumpp H, Augustin HG, Müller-Decker K, Nawroth PP, Herzig S, Berriel Diaz M. Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence. Cell Metab, 26: 842-845, 2017.

Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest, 127:3877-3896, 2017. 

Augustin HG, Koh GY. Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology. Science 357: 6353, 2017.

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG. Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun, 8:16106, 2017.

Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, Koh GY. Plastic roles of pericytes in the blood-retinal barrier. Nat Commun, 8:15296, 2017.

Galuschka C, Proynova R, Roth B, Augustin HG, Müller-Decker K. Models in Translational Oncology: A Public Resource Database for Preclinical Cancer Research. Cancer Res, 77:2557-2563, 2017.

Mogler C, König C, Wieland M, Runge A, Besemfelder E, Komljenovic D, Longerich T, Schirmacher P, Augustin HG: Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin. EMBO Mol Med, pii: e201607222, 2017.

Manavski Y, Abel T, Hu J, Kleinlützum D, Buchholz CJ, Belz C, Augustin HG, Boon RA, Dimmeler S: Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A. Proc Natl Acad Sci USA, pii: 201613392, 2017.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel MJ, Ehlting C, Bode JG, Mueller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin HG, Sánchez A, Dooley S, Ten Dijke P: BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut, pii: gutjnl-2016-313314, 2017.

Fantin A, Lampropoulou A, Senatore V, Brash JT, Prahst C, Lange CA, Liyanage SE, Raimondi C, Bainbridge JW, Augustin HG, Ruhrberg C: VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation. J Exp Med, 214: 1049-1064, 2017.

Géraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S: GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest, 127: 1099-1114, 2017.

Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG: Endosialin promotes atherosclerosis through phenotypic remodeling of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol, 37: 495-505, 2017.

Harrill AH, Moggs JG, Adkins KK, Augustin HG, Johnson RC, Leach MW. A synopsis of the "Influence of Epigenetics, Genetics, and Immunology" at the 35th Annual Society of Toxicologic Pathology Symposium. Toxicol Pathol. 45: 114-118, 2017.


Viski C, König C, Kijewska M, Mogler C, Isacke CM, Augustin HG: Endosialin-Expressing Pericytes Promote Metastatic Dissemination. Cancer Res. 76:5313-25, 2016.

Rathnakumar K, Savant S, Giri H, Ghosh A, Fisslthaler B, Fleming I, Ram U, Bera AK, Augustin HG, Dixit M: Angiopoietin-2 mediates thrombin-induced monocyte adhesion and endothelial permeability. J Thromb Haemost. 14:1655-67, 2016.

Van Hengel, J, Van den Broeke C, Libbrecht L, Hofmann I, van Roy F: Inactivation of p120 catenin in mice disturbs intrahepatic bile duct development and aggravates liver carcinogenesis. Eur J Cell Biol. 95, 574-584, 2016.

Han S, Lee SJ, Kim KE, Lee HS, Oh N, Park I, Ko E, Oh SJ, Lee YS, Kim D, Lee S, Lee DH, Lee KH, Chae SY, Lee JH, Kim SJ, Kim HC, Kim S, Kim SH, Kim C, Nakaoka Y, He Y, Augustin HG, Hu J, Song PH, Kim YI, Kim P, Kim I, Koh GY: Amelioration of sepsis by TIE2 activation-induced vascular protection. Sci Transl Med. 8:335ra55, 2016.

Tenhagen M, Klarenbeek S, Schakmann RCJ, Braumuller TM, Hofmann I, van der Groep P, Jonkers J, van der Wall E, Derksen PWB: p120-catenin is critical fort he development of invasive lobular carcinoma in mice. J Mammary Gland Biol Neoplasia.2016 Dec;21(3-4):81-88.doi:10.1007/s10911-016-9358-3. Epub 2016 Jul13.

Botla SK, Savant S, Jandaghi P, Bauer AS, Mücke O, Moskalev EA, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Gaida MM, Buchler MW, Strobel O, Hackert T, Giese NA, Augustin HG, Hoheisel JD: Early epigenetic down-regulation of microRNA-192 expression promotes pancreatic cancer progression. Cancer Res.76:4149-59, 2016.

Augustin HG: Commentary on Folkman: “How Is Blood Vessel Growth Regulated in Normal and Neoplastic Tissue?” Cancer Res. May 15, 2016 76; 2854. doi: 10.1158/0008-5472.CAN-16-1123, 2016.

Shen Z, Liu Y, Dewidar B, Hu J, Park O, Feng T, Xu C, Yu C, Li Q, Meyer C, Ilkavets I, Müller A, Stump-Guthier C, Munker S, Liebe R, Zimmer V, Lammert F, Mertens PR, Li H, Ten Dijke P, Augustin HG, Li J, Gao B, Ebert MP, Dooley S, Li Y, Weng HL: Delta-Like Ligand 4 Modulates Liver Damage by Down-Regulating Chemokine Expression. Am J Pathol. 186:1874-89, 2016.

Roth L, Prahst C, Ruckdeschel T, Savant S, Weström S, Fantin A, Riedel M, Héroult M, Ruhrberg C, Augustin HG: Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation. Sci Signal. 2016 Apr 26;9(425):ra42. doi: 10.1126/scisignal.aad3812.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 Controls Vascular Stability and Pruning through Non-canonical WNT/Ca2+/NFAT Signaling. Dev Cell 36:79-93, 2016.


Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A: Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med. Jul 20. pii: e201404922, 2015.

Klose R, Berger C, Moll I, Adam MG, Schwarz F, Mohr K, Augustin HG, Fischer A:Soluble Notch ligand and receptor peptides act antagonistically during angiogenesis. Cardiovasc Res. in press, 2015.

Yang C, Fischer-Kešo R, Schlechter T, Ströbel P, Marx A, Hofmann I: Plakophilin 1-deficient cells up-regulate SPOCK1: implications for prostate cancer progression. Tumor Biol. 36, 9567-9577, 2015.

Heiss M, Hellström M, Kalén M, May T, Weber H, Hecker M, Augustin HG, Korff T: Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. FASEB J. 29:3076-84, 2015.

Teichert M, Stumpf C, Booken N, Wobser M, Nashan D, Hallermann C, Mogler C, Müller CS, Becker JC, Moritz RK, Andrulis M, Nicolay JP, Goerdt S, Thomas M, Klemke CD, Augustin HG, Felcht M: Aggressive primary cutaneous B-cell lymphomas show increased Angiopoietin-2-induced angiogenesis. Exp Dermatol. 24:424-9, 2015.

Mogler C, Wieland M, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG: Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage. EMBO Mol Med. 7: 332-8, 2015.

Simons M, Alitalo K, Annex B, Augustin HG, Beam C, Berk B, Byzova T, Carmeliet P, Cooke J, Davis G, Eichmann A, Iruela-Arispe L, Keshet E, Sinusas A, Ruhrberg C, Woo J, Dimmeler S: AHA Guidelines: Animal models for measuring angiogenesis and tissue vascularization. Circulation Res, 116:e99-132, 2015

Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, Stösser S, Srivastava K Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R: A functional role for VEGFR1 expressed in peripheral sensory neurons in cancer pain. Cancer Cell, 27:780-96, 2015

Savant S, La Porta S, Budnik A, Busch K, Hu J, Tisch N, Korn C, Valls AF, Benest AV, Terhardt D, Qu X, Adams RH, Baldwin HS, Ruiz de Almodóvar C, Rodewald HR, Augustin HG: The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep, 12:1761-73, 2015

Korn C, Augustin HG: Mechanisms of Vessel Pruning and Regression. Dev Cell, 34:5-17, 2015

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA: MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2. J Mol Cell Cardiol, 88:111-9, 2015.




Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26:880-95, 2014.

Fischer-Kešo R, Breuninger S, Hofmann S, Henn M, Röhrig T, Ströbel P, Stoecklin G, Hofmann I: Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. Mol Cell Biol. 34:4244-56, 2014.

Zheng W, Nurmi H, Appak S, Sabine A, Bovay E, Korhonen EA, Orsenigo F, Lohela M, D'Amico G, Holopainen T, Leow CC, Dejana E, Petrova TV, Augustin HG and Alitalo K: Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions. Genes Dev. 28:1592-603, 2014.

Rappe U, Aschoff M, Hotz-Wagenblatt A, Hofmann I: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing. J Biol Chem.  J289:12421-12434, 2014.

Adam P, Hakroush S, Hofmann I, Reidenbach S, Marx A, Ströbel P: Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall. Virchows Arch. , Jun 13. DOI 10.1007/s00428-014-1606-6, 2014.

Runge A, Hu J, Wieland M, Bergeest JP, Mogler C, Neumann A, Géraud C, Arnold B, Rohr K, Komljenovic D, Schirmacher P, Goerdt S, Augustin HG: An inducible hepatocellular carcinoma model for preclinical evaluation of anti-angiogenic therapy in adult mice. Cancer Res., Jun 6. pii: canres.2311.2013. 2014.

Hu J, Srivastava K, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science, 343:416-9, 2014.

Korn C, Scholz B, Hu J, Srivastava K, Wojtarowicz J, Arnsperger T, Adams RH, Boutros M, Augustin HG, Augustin I: Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis. Development. 141:1757-66, 2014.


Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, Herting F, Yu S, The HH, Martarello L, Gassner C, Stubenrauch KG, Munro K, Augustin HG, Thomas M.: Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy. Clin Cancer Res., 19:6730-40, 2013.

Yang C, Ströbel P, Marx A, Hofmann I: Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis. Virchows Arch., 463:379-90, 2013.

Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG , Fischer A: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res., 113:1206-18, 2013.

Benest AV, Kruse K, Savant S, Thomas M, Laib AM, Loos EK, Fiedler U, Augustin HG: Angiopoietin-2 is critical for cytokine-induced vascular leakage. PLoS One., 8:e70459, 2013.

Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, Arnold B, Hämmerling G, Koch PS, Breuhahn K, Longerich T, Marx A, Weiss C, Damm F, Schmieder A, Schirmacher P, Augustin HG , Goerdt S: Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver Int., 33:1428-40, 2013.

Ziegler T, Horstkotte J, Schwab C, Pfetsch V, Weinmann K, Dietzel S, Rohwedder I, Hinkel R, Gross L, Lee S, Hu J, Soehnlein O, Franz WM, Sperandio M, Pohl U, Thomas M, Weber C, Augustin HG , Fässler R, Deutsch U, Kupatt C: Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest., pii: 66549. 2013.

Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE: Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res 73:1649-57, 2013.

Fischer S, Gesierich S, Griemert B, Schänzer A, Acker T, Augustin HG, Olsson AK, Preissner KT: Extracellular RNA liberates tumor necrosis factor-a to promote tumor cell trafficking and progression. Cancer Res 73:5080-9, 2013.

Im JH, Tapmeier T, Balathasan L, Gal A, Yameen S, Hill S, Smart S, Noterdaeme O, Kelly M, Brady M, Fu W, Kruse K, Bernhard E, Augustin HG, Muschel RJ: G‐CSF rescues tumor growth and neo‐angiogenesis during liver metastasis under host angiopoietin‐2 deficiency. Int J Cancer 132:315‐26, 2013.

Kaluza D, Kroll J, Gesierich S, Manavski Y, Boeckel JN, Doebele C, Zelent A, Rössig L, Zeiher AM, Augustin HG, Urbich C, Dimmeler S: Histone Deacetylase 9 Promotes Angiogenesis by Targeting the Antiangiogenic MicroRNA‐17‐92 Cluster in Endothelial Cells. Arterioscler Thromb Vasc Biol 33:533‐43, 2013.


Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M: Angiopoietin-1 mediates inhibition of hypertension-induced release of Angiopoietin-2 from endothelial cells. Cardiovasc. Res., 94: 510-8, 2012.

Géraud C, Evdokimov K, Straub BK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Augustin HG, Schirmacher P, Peitsch WK, Goerdt S: Unique cell type-specific junctional complexes in fenestrated endothelium of human and rat liver sinusoids. Plos One, 7(4):e34206, 2012.

Liebler SS, Feldner A, Adam MG, Korff T, Augustin HG, Fischer A: No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One 7:e53074, 2012.

Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D: MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res 111:1421-33, 2012.

Dieterich LC, Mellberg S, Langenkamp E, Zhang L, Zieba A, Salomäki H, Teichert M, Huang H, Edqvist PH, Kraus T, Augustin HG, Olofsson T, Larsson E, Söderberg O, Molema G, Pontén F, Georgii-Hemming P, Alafuzoff I, Dimberg A: Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization. J Pathol 228:378-90, 2012.

Munoz WA, Kloc M, Cho K, Lee M, Hofmann I, Sater A, Vleminckx K, McCrea PD. Plakophilin-3 is required for late embryonic amphibian development exhibiting roles in ectodermal and neural tissues. PLoS One, 7(3):e34342, 2012.

Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest, 1;122(6):1991-2005, 2012.

Korn C, Augustin HG. Born to Die: Blood Vessel Regression Research Coming of Age. Circulation, 125:3063-5, 2012.

Kurley SJ, Bierie B, Carnahan RH, Lobdell NA, Davis MA, Hofmann I, Moses HL, Muller WJ, Reynolds AB. p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development, 139:1754-1764, 2012.

Bieback K, Hecker A, Schlechter T, Hofmann I, Brousos N, Redmer, T, Besser D, Klüter H, Müller AM,Becker M. Replicative aging and differentiation potential of human adipose tissue-derived mesenchymal stromal cells expanded in pooled human or fetal bovine serum. Cytotherapy, 14:570-83, 2012.

Medvetz D, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao J.K., Huang H., Henske EP. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion. PLoS One. 7: e47842, 2012.


Kaluza D, Kroll J, Gesierich S, Yao TP, Boon RA, Hergenreider E, Tjwa M, Rössig L, Seto E, Augustin HG, Zeiher AM, Dimmeler S, and Urbich C. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J, 30: 4142–4156, 2011.

Marciano, DK, Brakeman, PR, Lee, Ch-Z, Spivak, N, Eastburn, DJ, Bryant, DM, Beaudoin, GM, Hofmann I, Mostov, KE, Louis F, Reichardt, LF. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development, 138:2099-2109, 2011.

Stoll SJ, Bartsch S, Augustin HG, Kroll J. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. Circ Res., April 14, 2011.

Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG: Differential endothelial transcriptomics identifies Semaphorin 3G as a vascular class 3 semaphorin. Arterioscler Thromb Vasc Biol., 31: 151-9, 2011.

Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, Nasarre P, Hofer-Warbinek R, Bilban M, Augustin HG, Hofer E; The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells. Blood, 117: 2735-44, 2011.

Ehlken C, Martin G, Lange C, Gogaki EG, Fiedler U, Schaffner F, Hansen LL, Augustin HG, Agostini HAT: Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy. Acta Ophthalmol, 89:82-90, 2011.


Breuninger S, Reidenbach S, Sauer CG, Ströbel P, Pfitzenmaier J, Trojan L, Hofmann I. Desmosomal plakophilins in the prostate and prostatic adenocarcinomas: implications for diagnosis and tumor progression. Am J Pathol. 176:2509-19, 2010.

Walter B, Krebs U, Berger I, Hofmann I. Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules. Histochem Cell Biol. Jan;133(1):69-83, 2010.

Thomas M, Felcht M, Kruse K, Kretschmer S, Deppermann C, Biesdorf A, Rohr K, Benest AV, Fiedler U, Augustin HG: Angiopoietin-2 stimulation of endothelial cells induces alphavbeta3 integrin internalization and degradation. J Biol Chem. 285:23842-9, 2010.

Licht AH, Nübel T, Feldner A, Jurisch-Yaksi N, Marcello M, Demicheva E, Hu JH, Hartenstein B, Augustin HG, Hecker M, Angel P, Korff T, Schorpp-Kistner M: Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest. 120:2307-18, 2010.

Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A: Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A, 107:12640-5, 2010.

Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis.Circ Res. 107:592-601, 2010.

Goede V, Coutelle O, Neuneier J, Reinacher-Schick A, Schnell R, Koslowsky TC, Weihrauch MR, Cremer B, Kashkar H, Odenthal M, Augustin HG, Schmiegel W, Hallek M, Hacker UT: Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy. Br J Cancer; 103:1407-14, 2010.

Héroult M, Schaffner F, Pfaff D, Prahst C, Kirmse R, Kutschera S, Riedel M, Ludwig T, Vajkoczy P, Graeser R, Augustin HG: EphB4 promotes site-specific metastatic tumor cell dissemination by interacting with endothelial cell expressed ephrinB2. Mol Cancer Res. 8:1297-3, 2010.


Walter B, Berger I, Hofmann I. The proteins ARVCF and p0071 in renal cell carcinomas and their potential use in the diagnosis of renal tumors. Histopathology, DOI: 10.1111/j.1365-2559.2009.03444.x, 2009.

Kroll J*, Epting D*, Kern K, Dietz CT, Feng Y, Hammes HP, Wieland T, and Augustin HG. Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularisation and sprouting angiogenesis. Am J Physiol Heart Circ Physiol, 296: H893-H899, 2009.

Anna M Laib, Arne Bartol, Abdullah Alajati, Thomas Korff, Holger Weber & Hellmut HG. Spheroid-based human endothelial cell microvessel formation in vivo. Nature Protocols, 4:1202 - 1215 , 2009.

Hofmann I, Schlechter T, Kuhn C, Hergt M, Franke W W. Protein p0071, an armadillo plaque protein that characterizes a specific subtype of adherens junctiona and their functions. J. Cell Sci. 122, 21-24, 2009.

Moll R, Sievers E, Hämmerling B, Schmidt A, Barth M, Kuhn C, Grund C, Hofmann I, Franke W W. Endothelial and virgultar cell formations in the mammalian lymph node sinus: Endothelial differentiation morphotypes characterized by a special kind of junction (complexus adhaerens).  Cell Tissue Res. 335, 109-141, 2009.

Norrmén C, Ivanov KI, Cheng J, Zangger N, Delorenzi M, Jaquet M, Miura N, Puolakkainen P, Horsley V, Hu J, Augustin HG, Ylä-Herttuala S, Alitalo K, Petrova TV: FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1. J Cell Biol. 185:439-57, 2009.

Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL: Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice. J Clin Invest. 119:2359-65, 2009

Tremmel M, Matzke A, Albrecht I, Laib AM, Olaku V, Ballmer-Hofer K, Christofori G, Héroult M, Augustin HG, Ponta H, Orian-Rousseau V: A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis. Blood, 114:5236-44, 2009.


Prahst C, Héroult M, Lanahan AA, Uziel N, Kessler O, Shraga-Heled N, Simons M, Neufeld G, and Augustin HG. Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1. J. Biol. Chem. Vol. 283, Issue 37, 25110-25114, 2008.

Becker R, Lenter MC, Vollkommer T, Boos AM, Pfaff D, Augustin HG and Christian S. Tumor stroma marker endosialin (Tem1) is a binding partner of metastasis-related protein Mac-2 BP/90K. FASEB J, 22: 3059-67, 2008.

Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF & Kalluri R. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 453, 1117-1121, 2008.

Korff T, Braun J, Pfaff D, Augustin HG, and Hecker M. Role of ephrinB2 expression in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment. Blood Vol. 112, No. 1, pp. 73-81, 2008.

Alajati A, Laib AM, Weber H, Boos AM, Bartol A, Ikenberg K, Korff T, Zentgraf H, Obodozie C, Graeser R, Christian S, Finkenzeller G, Stark GB, Héroult M & Augustin HG. Spheroid-based engineering of a human vasculature in mice. Nat Methods. 5(5):439-45, 2008.

Klein D, Demory A, Peyre F, Kroll J, Augustin HG, Helfrich W, Kzhyshkowska J, Schledzewski K, Arnold B, Goerdt S. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology 47:1018 - 1031, 2008

Christian S, Winkler R, Helfrich I, Boos AM, Besemfelder E, Schadendorf D, Augustin HG. Endosialin (tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells. Am J Pathol. 172(2):486-94, 2008.

Goettsch W, Gryczka C, Korff T, Ernst E, Goettsch C, Seebach J, Schnittler HJ, Augustin HG, Morwawietz H: Flow-dependent regulation of Angiopoietin-2. J Cell Physiol, 214: 491-503, 2008

Walter B, Schlechter T, Hergt M, Berger I, Hofmann I. Differential expression pattern of Protein ARVCF in nephron segments of human and mouse kidney. Histochem. Cell Biol. 130, 943-956, 2008.

Hofmann I, Kuhn C, Franke W W. Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell type marker. Cell Tissue Res. 334, 381-399, 2008.

Pfaff D, Heroult M, Riedel N, Reiss Y, Kirmse R, Ludwig L, Korff T, Hecker M, Augustin HG: Involvement of endothelial ephrinB2 in adhesion and transmigration of EphB expressing monocytes. J Cell Sci, 121:3842-50, 2008

Thiel L, Diederich S, Erbar S, Pfaff D, Augustin HG, Maisner A: Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail. Virol J. 5:163, 2008


Nacak TG, Alajati A, Leptien K, Fulda C, Weber H, Miki T, Czeplich FS, Waltenberger J, Wieland T, Augustin HG, Kroll J. The BTB-kelch protein KLEIP controls endothelial migration and sprouting angiogeneiss. Circ. Res. 100: 1155-1163, 2007.

Shraga-Heled N, Kessler O, Prahst C, Kroll J, Augustin HG, Neufeld G. Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor. FASEB J. 21: 915-926, 2007.

Franke W W, Schumacher H, Borrmann C M, Grund C, Winter-Simanowski S, Schlechter T, Pieperhoff S, Hofmann I. The area composita of adhering junctions connecting heart muscle cells of vertebrates. III. Assembly and disintegration of intercalated disks in rat cardiomyocytes growing in culture. Eur. J. Cell Biol. 86, 127-142, 2007.


Fiedler U, Reiss Y, Scharpfenecker M, Grunow V, Koidl S, Thurston G, Gale NW, Witzenrath M, Rosseau S, Suttorp N, Sobke A, Herrmann M, Preissner K, Vajkoczy P, Augustin HG. Angiopoietin-2 sensitizes endothelial cells to TNF and plays a crucial role in the induction of inflammation. Nat. Med. 12:235-239, 2006.

Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, Schaffner F, Augustin HG. Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context dependently with CD31. Arterioscl. Thromb. Vasc. Biol. 26: 468-474, 2006.

Fiedler U, Christian S, Koidl S, Kerjaschki D, Emmett MS, Bates DO, Christofori G, Augustin HG. The sialomucin CD34 is a marker of tumor-associated lymphatic endothelial cells in human tumors. Am. J. Pathol. 168:1045-1053, 2006.

Nacak TG, Leptien K, Fellner D, Augustin HG, Kroll J. The BTB-kelch protein LZTR-1 is a novel trans-Golgi network protein and is degraded upon induction of apoptosis. J. Biol. Chem. 281: 5065-5071, 2006.

Krneta J, Kroll J, Alves F, Prahst C, Sananbenesi F, Dullin C, Kimmina S, Phillips DJ, Augustin HG. Dissociation of angiogenesis and tumorigenesis in activin and follistatin expressing tumors. Cancer Res. 66: 5685-5695, 2006.

Athanasopoulos AN, Economopoulou M, Orlova VV, Sobke A, Schneider D, Weber H, Augustin HG, Eming SA, Schubert U, Linn T, Nawroth PP, Hussain M, Hammes HP, Herrmann M, Preissner KT, Chavakis T. The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms. Blood 107: 2720-2727, 2006.

Hofmann I, Casella M, Schnölzer M, Schlechter T, Spring H, Franke W W. Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. Mol. Biol. Cell. 17, 1388-1398, 2006.

Borrmann C, Grund C, Kuhn C, Hofmann I, Pieperhoff S, Franke W W.  The area composita of adhering junctions connecting heart muscle cells of vertebrates. II. Colocalizations of desmosomal and fascia adhaerens molecules. Eur. J. Cell Biol. 85, 469-485, 2006.

Peitsch W K, Bulkescher J, Spring H, Hofmann I, Goerdt S, Franke W W. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin enriched zone. Exp. Cell Res. 312: 2605-2618, 2006.

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