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Molecular principles in neural stem cells, neurogenesis and brain diseases

Molecular principles in neural stem cells, neurogenesis and brain diseases

Coexpression of the stem cell specific transcription factor Sox2 (red) and the chromatin remodeler CHD7 in neural stem cells
© Haikun Liu, Ph.D.

We generated a series of mouse models and human organoid models that allow us to precisely manipulate gene expression in neural stem cells and brain tumor stem cells. In this project, we are dedicated to unravel how the dynamic transcriptional regulations are involved in regulating the identity, activity and fate of NSCs. We are systematically analyzing the role of essential transcription factors and chromatin regulators in neurogenesis in order to generalize the molecular principles of cell identity determination. In particular we are interested in studying transcription regulators like Nr2e1 and Chd7 which are mutated in human neurological disorders and brain cancers.

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