Molecular principles in neural stem cells, neurogenesis and brain diseases

Molecular principles in neural stem cells, neurogenesis and brain diseases

Coexpression of the stem cell specific transcription factor Sox2 (red) and the chromatin remodeler CHD7 in neural stem cells
© Dr. Haikun Liu

We generated a series of mouse models that allow us to precisely manipulate gene expression in neural stem cells and brain tumor stem cells in vivo. In this project, we are dedicated to unravel how the dynamic transcriptional regulations are involved in regulating the identity, activity and fate of NSCs. We are systematically analyzing the role of essential transcription factors and chromatin regulators in neurogenesis in order to generalize the molecular principles of cell identity determination. In particular we are interested in studying transcription regulators which are mutated in human neurological disorders and brain cancers (Nr2e1, CHD7, CHD8 and EZH2), the mouse models and human iPS cell derived brain organoid culture are used to mimic the human disease phenotype and test therapeutic strategy of relevant diseases. 

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