Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds
Regulatory Genomics and Cancer Evolution

Division of Regulatory Genomics and Cancer Evolution

Dr. Duncan Odom

Comparing the functionof genetic sequences among mammals can reveal the mechanisms of normal and cancer evolution. Image courtesy of C Ernst.
© dkfz.de

Dr Odom’s laboratory studies how genetic sequence information shapes the cell's DNA regulatory landscape and thus the trajectory of cancer genome evolution. We are mainly an experimental genomics laboratory with long-standing collaborative alliances with other - particularly computational - research groups. The breadth of our three major scientific themes provides substantial latitude to tailor particular projects to the scientific interest of incoming students and postdocs.

First, we are testing how genetic sequence variation shapes genome regulation and gene expression in phenotypically normal somatic tissues. One strategy is to profile and compare regulatory architectures and function among closely- and distantly-related mammals. Our laboratory is known for its early pioneering application of interspecies comparisons to reveal the extensive and rapid turn-over of tissue-specific transcription factor binding, CTCF/insulator elements, polymerase occupancies, and enhancer activities. We are actively developing novel approaches to integrate recently developed single-cell transcriptional, spatial, and epigenomic datasets [funded by an ERC Advanced Grant].

Second, we are establishing the earliest mechanisms of cancer genome formation. We are use chemical carcinogenesis to create and analyse liver tumours in multiple different mammalian species. This approach is the first artificially created and carefully controlled tumour cohorts that can be reliably and quantitatively compared, in order to reveal the underlying principles of cancer genome evolution. Our work has recently discovered that chemical carcinogen-driven tumours can carry megabase scale mutational asymmetries, and we are exploiting this to test how mutations are first established in the cancer genome.

Third, we are exploring how ageing interacts with genetic diversity in shaping genome stability. We exploit closely related mouse species with a similar organismal phenotype, but with highly divergent genomes. We have used this strategy to begin exploring how tissue function changes in the bone marrow and the female reproductive tract. Recent published studies from the Odom lab have used single-cell transcriptional analysis to demonstrate how ageing can result in substantial increases in cell-to-cell transcriptional variability in the immune system.

Contact

Dr. Duncan Odom
Regulatory Genomics and Cancer Evolution (B270)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg

Selected Publications

  • Roller et al (2021) LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions. Genome Biology. 1-43.
  • S Aitken et al (2020) Pervasive lesion segregation shapes cancer genome evolution. Nature, 265-270.
  • S Aitken et al (2018) CTCF maintains regulatory homeostasis of cancer pathways. Genome Biology, 1-17.
  • C Martinez-Jimenez et al (2017) Aging increases cell-to-cell transcriptional variability upon immune stimulation. Science, 1433-1436.
to top
powered by webEdition CMS