Transcript Studies

For the understanding of the complex regulative mechanisms and the investigation of the cellular control management, a simultaneous analysis of the expression of all genes of an organism under various conditions and over time is indispensable. Our emphasis is on studying human cancer material andanalyses particularly at the level of microRNA, with other RNA types also being worked at, although to a lesser extent.Information is gathered for enabling early diagnosis and accurate prognosis, the identification of potentially interesting avenues for therapy as well as the evaluation of the success of disease treatment. For this, the measurements of transcriptional variations are combined with the analysis of epigenetic modulations of the genomic DNA and actual protein expression. For particular microRNA molecules, their mode of action is studied in detail, elucidating the mechanisms by which their activity is transformed into function.

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