Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .


These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external media platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name YouTube
Purpose Show YouTube content
Name Twitter
Purpose activate Twitter Feeds

Publications since 2010

Heber N, Kuhn BJ, Strobel TD, Lohrey C, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F (2023)
The Impact of Cycling Hypoxia on the Phenotype of HPV-Positive Cervical Cancer Cells.
J. Med. Virol., 95: e29280

 Strobel TD, Weber M, Heber N, Holzer A, Hoppe-Seyler K, Hoppe-Seyler F (2023)
Revisiting the Role of Endogenous STAT3 in HPV-Positive Cervical Cancer Cells.
J. Med. Virol., 95: e29230

Vučković N, Hoppe-Seyler K, Riemer AB (2023)
Characterization of DoTc2 4510-Identifying HPV16 Presence in a Cervical Carcinoma Cell Line Previously Considered to Be HPV-Negative.
Cancers, 15: 3810.

Schifflers C, Zottnick S, Förster JD, Kruse S, Yang R, Wiethoff H, Bozza M, Hoppe-Seyler K, Heikenwälder M, Harbottle RP, Michiels C, Riemer AB (2023)
Development of an orthotopic HPV16-dependent base of tongue tumor model in MHC-humanized mice.
Pathogens 12: 188.

Yang, D, Strobel TD, Bulkescher J, Tessmer C,  Hofmann I, Hoppe-Seyler F; Hoppe-Seyler K (2022)
FAM57A (Family with Sequence Similarity 57 Member A) Is a Cell-Density-Regulated Protein and Promotes the Proliferation and Migration of Cervical Cancer Cells.
Cells 11: 3309

Frensemeier K, Holzer A, Hoppe-Seyler, K, Hoppe-Seyler F (2022).
Dickkopf-1 (Dkk1) expression is repressed by oncogenic HPVs and regulates the Cisplatin sensitivity of HPV-positive cancer cells in a JNK-dependent manner.
Int. J. Cancer, 151: 2215-2228.

Herrmann AL, Kuhn BJ, Holzer A, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F (2021).
Delineating the switch between senescence and apoptosis in cervical cancer cells under ciclopirox treatment.
Cancers, 13: 4995.

Daum, AK, Dittmann J, Jansen L, Peters S, Dahmen U, Heger JI, Hoppe-Seyler F, Gille A, Clement JH, Runnebaum IB, Dürst M, Backsch C (2021).
ITIH5 shows tumor suppressive properties in cervical cancer cells grown as multicellular tumor spheroids.
Am. J. Transl. Res., 13, 10298-10314.

Hoppe-Seyler K, Herrmann AL, Däschle A, Kuhn BJ, Strobel T, Lohrey C, Bulkescher J, Krijgsveld J, Hoppe-Seyler F (2021).
Effects of Metformin on the virus/host cell crosstalk in HPV-positive cancer cells.
Int. J. Cancer, 149: 1137-1149.

Braun JA, Herrmann AL, Blase JI, Frensemeier K, Bulkescher J, Scheffner M, Galy B, Hoppe-Seyler K, Hoppe-Seyler F (2020).
Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis.
Int. J. Cancer, 146: 461-474.

Bossler F, Kuhn BF, Günther T, Kraemer SJ, Khalkar P, Adrian S, Lohrey C, Holzer A, Shimobayashi M, Dürst M, Mayer A, Rösl F, Grundhoff A, Krijgsveld J, Hoppe-Seyler K, Hoppe-Seyler F (2019).
Repression of Human Papillomavirus Oncogene Expression under Hypoxia is Mediated by PI3K/mTORC2/AKT Signaling.
mBIO, 10: e02323-18.

Bossler F, Hoppe-Seyler K, Hoppe-Seyler F. (2019)
PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells.
Int. J. Mol. Sci. 20: pii: E2188.

Lien YH, Mahato, DR, Hoppe-Seyler F, Fischer WB (2019)
Membrane partitioning of peptide aggregates - coarse grained molecular dynamics simulations.
J. Biomol. Struct. Dyn., Feb 27: 1-9.

Hoppe-Seyler K, Bossler F, Braun JA, Herrmann AL, Hoppe-Seyler F. (2018).
The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets.
Trends in Microbiology, 26: 158-168.

Honegger A, Schilling D, Sültmann H, Hoppe-Seyler K, Hoppe-Seyler F. (2018).
Identification of E6/E7-dependent microRNAs in HPV-positive cancer cells.
Methods in Molecular Biology, 1699: 119-134.

Hoppe-Seyler K, Honegger, A., Bossler F, Sponagel J, Bulkescher J, Lohrey C, Hoppe-Seyler F. (2017).
Viral E6/E7 Oncogene and Cellular Hexokinase 2 Expression in HPV-Positive Cancer Cell Lines.
Oncotarget 8, 106342-106332

Hoppe-Seyler K, Mändl J, Adrian S, Kuhn BJ, Hoppe-Seyler F. (2017).
Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells.
Viruses 9:pii: E174.

Hoppe-Seyler K, Bossler B, Lohrey C, Bulkescher J, Rösl F , Jansen L, Mayer A, Vaupel P, Dürst M, Hoppe-Seyler F. (2017).
Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.
Proc. Natl. Acad. Sci. U. S. A. 114:E990-E998.

Honegger A, Schilling D, Bastian S, Sponagel J, Kuryshev V, Sültmann H, Scheffner M, Hoppe-Seyler K, Hoppe-Seyler F. (2015).
Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells.
PLoS Pathog 11:e1004712.

Stutz C, Reinz E, Honegger A, Bulkescher J, Schweizer J, Zanier K, Travé G, Lohrey C, Hoppe-Seyler K, Hoppe-Seyler F. (2015).
Intracellular analysis of the interaction between the human papillomavirus type 16 E6 oncoprotein and inhibitory peptides.
PLoS ONE 10:e0132339.

Leitz J, Reuschenbach M, Lohrey C, Honegger A, Accardi R, Tommasino M, Llano M, von Knebel Doeberitz M, Hoppe-Seyler K, Hoppe-Seyler F. (2014).
Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene.
PLoS Pathog 10:e1003957.

Zanier K, Stutz C, Kintscher S, Reinz E, Sehr P, Bulkescher J, Hoppe-Seyler K, Travé G, Hoppe-Seyler F. (2014).
The E6AP binding pocket of the HPV16 E6 oncoprotein provides a docking site for a small inhibitory peptide unrelated to E6AP, indicating druggability of E6.
PLoS ONE 9:e112514.

Honegger A, Leitz J, Bulkescher J, Hoppe-Seyler K, Hoppe-Seyler F. (2013).
Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells.
Int J Cancer 133:1631-42.

Wagener N, Bulkescher J, Macher-Goeppinger S, Karapanagiotou-Schenkel I, Hatiboglu G, Abdel-Rahim M, Abol-Enein H, Ghoneim MA, Bastian PJ, Müller SC, Haferkamp A, Hohenfellner M, Hoppe-Seyler F, Hoppe-Seyler K. (2013).
Endogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients.
Br J Cancer 108:973-82.

Hoppe-Seyler K, Sauer P, Lohrey C, Hoppe-Seyler F. (2012).
The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro.
Hepatology 56: 9-16.

Fussbroich B, Wagener N, Macher-Goeppinger S, Benner A, Fälth M, Sültmann H, Holzer A, Hoppe-Seyler K, Hoppe-Seyler, F. (2011).
EZH2 depletion blocks the proliferation of colon cancer cells.
PLoS ONE 6:e21651

Laurenson S, Pett MR, Hoppe-Seyler K, Denk C, Hoppe-Seyler F, Coleman N, Ko Ferrigno P. (2011).
Development of peptide aptamer microarrays for detection of HPV16 oncoproteins in cell extracts.
Anal Biochem 410:161-70

Hoppe-Seyler F, Hoppe-Seyler K. (2011).
Emerging topics in human tumor virology.
Int J Cancer 129:1289-99.

Crnkovic-Mertens I, Bulkescher J, Mensger N, Hoppe-Seyler F, Hoppe-Seyler K. (2010).
Isolation of peptides blocking the function of the anti-apoptotic Livin protein.
Cell Mol Life Sci 11:1895-905.

Mern DS, Hoppe-Seyler K, Hoppe-Seyler F, Hasskarl J, Burwinkel B. (2010).
Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells.
Breast Cancer Res Treat 124:623-33.

Moosmeier MA, Bulkescher J, Hoppe-Seyler K, Hoppe-Seyler F. (2010).
Binding proteins internalized by PTD-fused ligands allow the intracellular sequestration of selected targets by ligand exchange.
Int. J Mol Med 25:557-64.

Wagener N, Macher-Goeppinger S, Pritsch M, Hüsing J, Hoppe-Seyler K, Schirmacher P, Pfitzenmaier J, Haferkamp A, Hoppe-Seyler F, Hohenfellner M. (2010).
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma.
BMC Cancer 10:524.

Moosmeier MA, Bulkescher J, Reed J, Schnölzer M, Heid H, Hoppe-Seyler K, Hoppe-Seyler F. (2010).
Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos.
J Cell Mol Med 14:1935-45.

Full list of publications:

to top
powered by webEdition CMS