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Neuronal Signaling and Morphogenesis

CHS Junior Research Group Neuronal Signaling and Morphogenesis

Dr. Annarita Patrizi


Our ability to sense, understand, and respond to the surrounding world depends upon the complex, intricate set of neuronal connections that make up the human CNS. These connections are created, sculpted and refined during human brain development, a protracted process that arguably extends throughout the entire lifespan. Any developmental insults to these processes can result in the onset of neurodevelopmental disorders or the formation of brain neoplasms. Our laboratory focuses on understanding how intrinsic and extrinsic factors mediate the development and refinement of brain circuits. One important source of such signals is the choroid plexus, a unique interface between blood and cerebrospinal fluid (CFS). By employing a multitiered approach, ranging from molecular and cellular analysis to high-resolution microscopy and 2D and 3D in vitro modeling supported by transcriptomic analysis, we aim to unbiasedly dissect the role of choroid plexus-CSF axis during healthy and pathological brain development and aging.


Dr. Annarita Patrizi
Neuronal Signaling and Morphogenesis (A320)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 581
69120 Heidelberg
Tel: +49 6221 42-1551

Selected Publications

  • Scarpetta, V., Bodaleo, F., Salio, C. et al. Morphological and mitochondrial changes in murine choroid plexus epithelial cells during healthy aging. Fluids Barriers CNS 20, 19 (2023).
  • Kim Hoa Ho, Valentina Scarpetta, Chiara Salio, Elisa D’Este, Martin Meschkat, Christian A. Wurm, Matthias Kneussel, Carsten Janke, Maria M. Magiera, Marco Sassoè-Pognetto, Monika S. Brill, Annarita Patrizi. Intrinsic microtubule destabilization of multiciliated choroid plexus epithelial cells during postnatal lifetime. bioRxiv 2023.01.10.523428
  • Christian Thomas, Patrick Soschinski, Melissa Zwaig, Spyridon Oikonomopoulos, Konstantin Okonechnikov, Kristian W Pajtler, Martin Sill, Leonille Schweizer, Arend Koch, Julia Neumann, Ulrich Schüller, Felix Sahm, Laurèl Rauschenbach, Kathy Keyvani, Martin Proescholdt, Markus J Riemenschneider, Jochen Segewiß, Christian Ruckert, Oliver Grauer, Camelia-Maria Monoranu, Katrin Lamszus, Annarita Patrizi, Uwe Kordes, Reiner Siebert, Marcel Kool, Jiannis Ragoussis, William D Foulkes, Werner Paulus, Barbara Rivera, Martin Hasselblatt, The genetic landscape of choroid plexus tumors in children and adults, Neuro-Oncology, Volume 23, Issue 4, April 2021, Pages 650–660
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