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Publications

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;
Epithelial TGF? engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Nature Communications 13(1), 7551 () [10.1038/s41467-022-35134-3]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Review Article)  ;
From organoids to bedside: advances in modeling, decoding and targeting of colorectal cancer
International journal of cancer nn, nn () [10.1002/ijc.34297]  GO BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article  ;  ;  ;  ;  ;
Modeling Colorectal Cancer Progression Reveals Niche-Dependent Clonal Selection
Cancers 14(17), 4260 () [10.3390/cancers14174260]  GO DBCoverage BibTeX | EndNote: XML, Text | RIS

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Rgs16 promotes antitumor CD8+ T cell exhaustion.
Science immunology 7(71), eabh1873 () [10.1126/sciimmunol.abh1873]  GO BibTeX | EndNote: XML, Text | RIS

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Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Gut 71(12), 2502-2517 () [10.1136/gutjnl-2021-326183]  GO BibTeX | EndNote: XML, Text | RIS

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MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression.
Cancer discovery 11(5), 1228 - 1247 () [10.1158/2159-8290.CD-20-0652]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade.
Nature Communications 12(1), 3414 () [10.1038/s41467-021-23731-7]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Oncogenic BRAF, unrestrained by TGF?-receptor signalling, drives right-sided colonic tumorigenesis.
Nature Communications 12(1), 3464 () [10.1038/s41467-021-23717-5]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;  ;
BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer.
Cell death and differentiation 28(12), 3282 - 3296 () [10.1038/s41418-021-00816-w]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Active elimination of intestinal cells drives oncogenic growth in organoids.
Cell reports 36(1), 109307 () [10.1016/j.celrep.2021.109307]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity
Cancer cell 39(9), 1227 - 1244.e20 () [10.1016/j.ccell.2021.06.017]  GO BibTeX | EndNote: XML, Text | RIS

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LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
Med 2(11), 1231 - 1252.e10 () [10.1016/j.medj.2021.10.002]  GO BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Book/Journal Article  ;  ;  ;
Genome-Wide Analysis of c-MYC-Regulated mRNAs and miRNAs and c-MYC DNA-Binding by Next-Generation Sequencing.
Methods in molecular biology 2318, 119-160 () [DOI: 10.1007/978-1-0716-1476-1_7]  GO BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article  ;
Stromal WNTer Keeps the Tumor Cold and Drives Metastasis.
Developmental cell 56(1), 3 - 4 () [10.1016/j.devcel.2020.12.011]  GO BibTeX | EndNote: XML, Text | RIS

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Advances in colon cancer research: in vitro and animal models.
Current opinion in genetics & development 66, 50 - 56 () [10.1016/j.gde.2020.12.003]  GO BibTeX | EndNote: XML, Text | RIS

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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Nature genetics 53(1), 16 - 26 () [10.1038/s41588-020-00753-3]  GO BibTeX | EndNote: XML, Text | RIS

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WNT and ?-Catenin in Cancer: Genes and Therapy
Annual review of cancer biology 4(1), 177 - 196 () [10.1146/annurev-cancerbio-030419-033628]  GO BibTeX | EndNote: XML, Text | RIS

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A MYC-GCN2-eIF2? negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.
Nature cell biology 21(11), 1413 - 1424 () [10.1038/s41556-019-0408-0]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.
Nature Communications 10(1), 723 () [10.1038/s41467-019-08586-3]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Cancer cell 36(3), 319 - 336 () [10.1016/j.ccell.2019.08.003]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells.
Nature Communications 9(1), 3573 () [10.1038/s41467-018-06001-x]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair.
The EMBO journal 36(1), 3 - 4 () [10.15252/embj.201695973]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Mouse models of intestinal cancer.
The journal of pathology 238(2), 141 - 151 () [10.1002/path.4645]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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MicroRNAs as regulators and mediators of c-MYC function.
Biochimica et biophysica acta / Gene regulatory mechanisms 1849(5), 544 - 553 () [10.1016/j.bbagrm.2014.04.003]  GO BibTeX | EndNote: XML, Text | RIS

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Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.
British journal of cancer 113(10), 1460 - 1466 () [10.1038/bjc.2015.362]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Colorectal cancers mimic structural organization of normal colonic crypts.
PLOS ONE 9(8), e104284 () [10.1371/journal.pone.0104284]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer.
Cancer research 74(2), 532 - 542 () [10.1158/0008-5472.CAN-13-2203]  GO BibTeX | EndNote: XML, Text | RIS

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IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.
The journal of clinical investigation 124(4), 1853 - 1867 () [10.1172/JCI73531]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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AP4 is required for mitogen- and c-MYC-induced cell cycle progression.
OncoTarget 5(17), 7316 - 7327 () [10.18632/oncotarget.2348]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and ?-catenin predicts distant metastasis of colon cancer.
Clinical cancer research 19(3), 710 - 720 () [10.1158/1078-0432.CCR-12-1703]  GO BibTeX | EndNote: XML, Text | RIS

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Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness.
OncoTarget 4(9), 1399 - 1415 () [10.18632/oncotarget.1202]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.
Journal of experimental medicine 210(7), 1331 - 1350 () [10.1084/jem.20120812]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Contribution to a book  ;  ;
Genome-wide analysis of c-MYC-regulated mRNAs and miRNAs, and c-MYC DNA binding by next-generation sequencing.
The Myc Gene / Soucek, Laura (Editor) ; Totowa, NJ : Humana Press, 2013, Chapter 11 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-62703-428-9=978-1-62703-429-6 ; doi:10.1007/978-1-62703-429-6 Totowa, NJ : Humana Press, Methods in Molecular Biology 1012, 145 - 185 () [10.1007/978-1-62703-429-6_11]  GO BibTeX | EndNote: XML, Text | RIS

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SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition
The EMBO journal 32(23), 3079 - 3095 () [10.1038/emboj.2013.236]  GO BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article  ;  ;
AP4 directly downregulates p16 and p21 to suppress senescence and mediate transformation.
Cell death & disease 4(8), e775 () [10.1038/cddis.2013.282]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.
PLOS ONE 7(12), e51654 () [10.1371/journal.pone.0051654]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 109(45), 18384 - 18389 () [10.1073/pnas.1209171109]  GO pmc   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3?.
BMC cancer 11(1), 137 () [10.1186/1471-2407-11-137]  GO DBCoverage   Download fulltextFulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.
Cell cycle 10(24), 4256 - 4271 () [10.4161/cc.10.24.18552]  GO BibTeX | EndNote: XML, Text | RIS

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Expression, cellular distribution, and prognostic relevance of TRAIL receptors in hepatocellular carcinoma.
Clinical cancer research 16(22), 5529 - 5538 () [10.1158/1078-0432.CCR-09-3403]  GO BibTeX | EndNote: XML, Text | RIS

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