2023
Braulke T, Carette JE, Palm W. Lysosomal enzyme trafficking: from molecular mechanisms to human diseases. 2023. Trends Cell Biol; in press; doi: 10.1016/j.tcb.2023.06.005
2022
Pechincha C, Groessl S, Kalis R, de Almeida M, Zanotti A, Wittmann M, Schneider M, de Campos RP, Rieser S, Brandstetter M, Schleiffer A, Müller-Decker K, Helm D, Jabs S, Haselbach D, Lemberg MK, Zuber J, Palm W. 2022. Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins. Science; eabn5637. doi: 10.1126/science.abn5637
Ratto E, Chowdhury SR, Siefert NS, Schneider M, Wittmann M, Helm D, Palm W. 2022. Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly. Nature Commun; 13:4848. doi: 10.1038/s41467-022-32515-6
Bielska AA, Harrigan CF, Kyung YJ, Morris Q, Palm W, Thompson CB. 2022. Activating mTOR mutations are detrimental in nutrient-poor conditions. Cancer Res; 22; CAN-22-0121. doi: 10.1158/0008-5472.CAN-22-0121
Darawshi O, Muz B, Naamat SG, Praveen B, Mahameed M, Goldberg K, Dipta P, Shmuel M, Forno F, Boukeileh S, Pahima H, Hermann J, Raab MS, Poos AM, Weinhold N, Rosenbluh C, Gatt ME, Palm W, Azab AK, Tirosh B. 2022. An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma. Cell Death Dis; 13:969. doi: 10.1038/s41419-022-05421-4
Palm W. 2022. Signaling pathways that regulate macropinocytosis in mammalian cells. Springer Textbook Subcell Biochem. 'Macropinocytosis: mechanisms and functions'; 98:143-167. doi: 10.1007/978-3-030-94004-1_8
2021
Palm W. 2021. GOLPH3 tunes up glycosphingolipid synthesis for cell growth. EMBO J; e108070. doi: 10.15252/embj.2021108070
Palm W. 2021. Metabolic plasticity allows cancer cells to thrive under nutrient starvation. Proc Natl Acad Sci USA; 118:e2102057118. doi: 10.1073/pnas.2102057118
Prentzell MT, Rehbein U, Sandoval MC, De Meulemeester AS, Baumeister R, Brohée L, Berdel B, Bockwoldt M, Carroll B, Chowdhury SR, von Deimling A, Demetriades C, Figlia G, Genomics England Research Consortium, Heberle AM, Heiland I, Holzwarth B, Huber LA, Jaworski J, Kędra M, Kern K, Kopach A, Korolchuk VI, van 't Land-Kuper I, Macias M, Nellist M, Palm W, Pusch S, Pittol JMR, Reil M, Reintjes A, Reuter F, Sampson JR, Scheldeman C, Stefan E, Teleman A, Thomas LE, Torres-Quesada O, Trump S, West HD, de Witte P, Woltering S, Yordanov T, Zmorzynska J, Opitz CA, Thedieck K. 2021. The G3BP proteins tether the TSC complex to lysosomes and suppress mTORC1 signaling. Cell, 184:655-674. doi: 10.1016/j.cell.2020.12.024
2020
Palm W and Rodenfels J. 2020. Understanding the role of lipids and lipoproteins in development. Development, 147:dev186411. doi: 10.1242/dev.186411
King B, Araki J, Palm W, Thompson CB. 2020. Yap/Taz promote the scavenging of extracellular nutrients through macropinocytosis. Genes Dev, 34:1345-1358. doi: 10.1101/gad.340661.120
Haneke K, Schott J, Lindner D, Hollensen A, Damgaard C, Mongis C, Knop M, Palm W, Ruggieri A, Stoecklin G. 2020. CDK1 couples proliferation with protein synthesis. J Cell Biol 219:e201906147. doi: 10.1083/jcb.201906147
2018
Palm W. 2018. Metabolic functions of macropinocytosis. Phil Trans R Soc B 374: 20180147. doi: 10.1098/rstb.2018.0285
Redelman-Sidi G, Binyamin A, Gaeta I, Palm W, Thompson CB, Romesser PB, Lowe SW, Bagul M, Doench JG, Root DE, Glickman MS. 2018. The canonical Wnt pathway drives macropinocytosis in cancer. Cancer Res. 78:4658-4670. doi: 10.1158/0008-5472.CAN-17-3199
2017
Palm W, Araki J, King B, DeMatteo RG, Thompson CB. 2017. Critical role for PI3-kinase in regulating the use of proteins as an amino acid source. Proc Natl Acad Sci USA; 114:E8628-E8636. doi: 10.1073/pnas.1712726114
Palm W and Thompson CB. 2017. Nutrient acquisition strategies of mammalian cells. Nature; 546:234-242. doi: 10.1038/nature22379
Thompson CB and Palm W. 2017. Reexamining how cancer cells exploit the body's metabolic resources. Cold Spring Harb Symp Quant Biol. pii: 030734. doi: 10.1101/sqb.2016.81.030734
2016
Krishna S, Palm W, Lee Y, Yang W, Bandyopadhyay U, Xu H, Florey O, Thompson CB, Overholtzer M. 2016. PIKfyve regulates vacuole maturation and nutrient recovery following engulfment. Dev Cell; 38:536-47. doi: 10.1016/j.devcel.2016.08.001
Chio II, Jafarnejad SM, Ponz-Sarvise M, Park Y, Rivera K, Palm W, Wilson J, Sangar V, Hao Y, Öhlund D, Wright K, Fillippi D, Lee EJ, Da Silva B, Schoepfer C, Wilkinson JE, Buscaglia J, DeNicola G, Tiriac H, Hammell M, Crawford H, Schmidt EE, Thompson CB, Pappin DJ, Sonenberg N, Tuveson DA. 2016. NRF2 directs redox-dependent mRNA translation in pancreatic cancer. Cell; 166:963-76. doi: 10.1016/j.cell.2016.06.056
2015
Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB. 2015. GCN2 sustains mTORC1 Suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev; 29:2331-6. doi: 10.1101/gad.269324.115
Palm W, Park Y, Wright K, Pavlova NN, Tuveson DA, Thompson CB. 2015. The utilization of extracellular proteins as nutrients is suppressed by mTORC1. Cell; 162:259-70. doi: 10.1016/j.cell.2015.06.017
2013
Palm W, Swierczynska MM, Kumari, V, Ehrhart-Bornstein M, Bornstein SR, Eaton S. 2013. Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. PLoS Biology; 11:e1001505. doi: 10.1371/journal.pbio.1001505
2012
Baer MM, Palm W, Eaton S, Leptin M, Affolter M. 2012. Microsomal triacylglycerol transfer protein (MTP) is required to expand tracheal lumen in Drosophila in a cell-autonomous manner. J Cell Sci; 15:6038-48. doi: 10.1242/jcs.110452
Carvalho M, Sampaio JL, Palm W, Brankatschk M, Eaton S, Shevchenko A. 2012. Effects of diet and development on the Drosophila lipidome. Mol Syst Biol; 8:600. doi: 10.1038/msb.2012.29
Palm W, Sampaio JL, Brankatschk M, Carvalho M, Mahmoud A, Shevchenko A, Eaton S. 2012. Drosophila lipoproteins – assembly, function, and influence on tissue lipid composition. PLoS Genetics; 8:e1002828. doi: 10.1371/journal.pgen.1002828
2010
Carvalho M, Schwudke D, Sampaio JL, Palm W, Riezman I, Dey G, Gupta GD, Mayor S, Riezman H, Shevchenko A, Kurzchalia TV, Eaton S. 2010. Survival strategies of a sterol auxotroph. Development; 137:3675-85. doi: 10.1242/dev.044560
2009
Palm W, Hockemeyer D, Kibe T, de Lange T. 2009. Functional dissection of human and mouse POT1 proteins. Mol Cell Biol; 29:471-82. doi: 10.1128/MCB.01352-08
2008
Palm W and de Lange T. 2008. How shelterin protects mammalian telomeres. Annu Rev Genet; 42:301-34. doi: 10.1146/annurev.genet.41.110306.130350
Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T. 2008. Engineered telomere degradation models dyskeratosis congenita. Genes Dev; 22:1773-85. doi: 10.1101/gad.1679208
2007
Hockemeyer D, Palm W, Else T, Daniels JP, Takai KK, Ye JZ, Keegan CE, de Lange T, Hammer GD. 2007. Telomere protection by mammalian POT1 requires interaction with TPP1. Nat Struct Mol Biol; 14:754-61. doi: 10.1038/nsmb1270