Cookie Settings

We use cookies to optimize our website. These include cookies that are necessary for the operation of the site, as well as those that are only used for anonymous statistic. You can decide for yourself which categories you want to allow. Further information can be found in our data privacy protection .

Essential

These cookies are necessary to run the core functionalities of this website and cannot be disabled.

Name Webedition CMS
Purpose This cookie is required by the CMS (Content Management System) Webedition for the system to function correctly. Typically, this cookie is deleted when the browser is closed.
Name econda
Purpose Session cookie emos_jcsid for the web analysis software econda. This runs in the “anonymized measurement” mode. There is no personal reference. As soon as the user leaves the site, tracking is ended and all data in the browser are automatically deleted.
Statistics

These cookies help us understand how visitors interact with our website by collecting and analyzing information anonymously. Depending on the tool, one or more cookies are set by the provider.

Name econda
Purpose Statistics
External media

Content from external video platforms is blocked by default. If cookies from external media are accepted, access to this content no longer requires manual consent.

Name Youtube
Purpose External media

Clinical Cooperation Unit Applied Tumor Biology

Prof. Dr. med. Magnus von Knebel Doeberitz

The Clinical Cooperation Unit Applied Tumor Biology is part of the Department of Applied Tumor Biology of Heidelberg University Hospital and also part of the Molecular Medicine Partner Unit of the European Molecular Biology Laboratory (MMPU-EMBL). Our major scientific interests relate to basic mechanisms of carcinogenesis triggered by human papillomaviruses and DNA mismatch repair deficiency that account for about 10 percent of all human cancers. We aim to identify diagnostic markers and therapeutic targets. We design and organize clinical trials to validate the clinical impact of respective markers and targets. Furthermore, we have successfully established “spin-off” companies to guarantee the “clinical translation” of scientific concepts into commercially available certified products. Examples of diagnostic markers developed by our group are p16INK4a and the CINtec® product line, which are used as diagnostic markers for HPV-induced lesions in histo- and cytopathology. Within the past few years, these markers became the new global gold standard in the diagnostics of HPV-associated neoplasms. In more recent work we explored a vaccine that targets p16INK4a as antigen. Initial clinical trials showed that this vaccine elicits substantial T-cell responses in patients without causing side effects. Further research activities are focusing on the epigenetic regulation of human papillomavirus infections as well as immune evasion strategies of HPV-triggered pre-cancers and cancers.

For DNA mismatch repair deficient (MSI-H) cancers we identified a new group of highly immunogenic frame shift induced antigens that were also successfully tested in a phase I/IIa clinical trial. Further research relates to immune evasion strategies of MSI-H cancers, particularly relevant for patients with the most abundant hereditary colorectal cancer syndrome (Lynch syndrome). For both examples we were able to develop new diagnostic tests as well as new therapeutic concepts based on the delineation of basic molecular mechanism triggering carcinogenesis. Based on our research we were able to develop clinical pipelines that led to the successful translation of basic concepts into clinically applicable new medical products.

Contact

Prof. Dr. med. Magnus von Knebel Doeberitz
Applied Tumor Biology (F210)
Tel: +49 6221 42 2487

Selected Publications

  • Bergeron C. et al. (2015). The clinical impact of using p16(INK4a) immunochemistry in cervical histopathology and cytology: an update of recent developments. Int J Cancer, 136(12), 2741–2751.
  • Reuschenbach M. et al. (2015). Methylation status of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers. Cancer, 121(12), 1966–1976.
  • Chaiwongkot A. et al. (2013). Differential methylation of E2 binding sites in episomal and integrated HPV 16 genomes in preinvasive and invasive cervical lesions. Int J Cancer, 132(9), 2087–2094.
  • Kloor M. et al. (2012). Prevalence of mismatch repair-deficient crypt foci in Lynch syndrome: a pathological study. Lancet Oncol, 13(6), 598–606.
to top
powered by webEdition CMS