Primary research articles:

  1. Kaymak, I., Maier, C. R., Schmitz, W., Campbell, A., Dankworth, B., Ade, C. P., Walz, S., Paauwe, M., Kalogirou, C., Marouf, H., Rosenfeldt, M., Gay, D. M., McGregor, G., Sansom, O. J. & Schulze, A. Mevalonate pathway provides ubiquinone to maintain pyrimidine synthesis and survival in p53-deficient cancer cells exposed to metabolic stress Cancer Res (accepted for publication).
  2. Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., Costa da Silva, M., Ingold, I., Goya Grocin, A., Xavier da Silva, T., Panzilius, E., Scheel, C., Mourão, A., Buday, K., Sato, M., Wanninger, J., Vignane, T., Mohana, V., Rehberg, M., Flatley, A., Schepers, A., Kurz, n., White, D., Sauer, M., Sattler, M., Tate, E., Schmitz, W., Schulze, A., O'Donnell, V., Proneth, B., Popowicz, G., Pratt, D., Friedmann Angeli, J. P. & Conrad, M. FSP1 is a glutathione-independent ferroptosis suppressor. Nature, doi:10.1038/s41586-019-1707-0 (2019).
  3. Schmidt, S., Gay, D., Uthe, F., Denk, S., Paauwe, M., Matthes, N., Diefenbacher, M., Bryson, S., Warrander, F., Erhard, F., Ade, C., Baluapuri, A., Walz, S., Jackstadt, R., Ford, C., Vlachogiannis, G., Valeri, N., Otto, C., Schülein-Völk, C., Maurus, K., Schmitz, W., Knight, J., Wolf, E., Strathdee, D., Schulze, A., Germer, C., Rosenwald, A., Sansom, O., Eilers, M. & Wiegering, A. A MYC/GCN2/eIF2a negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nat Cell Biol (in press).
  4. Mayer, A. E., Loffler, M. C., Loza Valdes, A. E., Schmitz, W., El-Merahbi, R., Viera, J. T., Erk, M., Zhang, T., Braun, U., Heikenwalder, M., Leitges, M., Schulze, A. & Sumara, G. The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling. Sci Signal 12, doi:10.1126/scisignal.aav9150 (2019).
  5. Gouw, A. M., Margulis, K., Liu, N. S., Raman, S. J., Mancuso, A., Toal, G. G., Tong, L., Mosley, A., Hsieh, A. L., Sullivan, D. K., Stine, Z. E., Altman, B. J., Schulze, A., Dang, C. V., Zare, R. N. & Felsher, D. W. The MYC Oncogene Cooperates with Sterol-Regulated Element-Binding Protein to Regulate Lipogenesis Essential for Neoplastic Growth. Cell Metab 30, 556-572 e555, doi:10.1016/j.cmet.2019.07.012 (2019).
  6. Jones, D. T., Valli, A., Haider, S., Zhang, Q., Smethurst, E. A., Schug, Z. T., Peck, B., Aboagye, E. O., Critchlow, S. E., Schulze, A., Gottlieb, E., Wakelam, M. J. O. & Harris, A. L. 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers. Mol Cancer Ther 18, 376-388, doi:10.1158/1535-7163.MCT-17-0857 (2019).
  7. Miess, H., Dankworth, B., Gouw, A. M., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, D. W., Peck, B. & Schulze, A. The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma. Oncogene 37, 5435-5450, doi:10.1038/s41388-018-0315-z (2018).
  8. Loffler, M. C., Mayer, A. E., Trujillo Viera, J., Loza Valdes, A., El-Merahbi, R., Ade, C. P., Karwen, T., Schmitz, W., Slotta, A., Erk, M., Janaki-Raman, S., Matesanz, N., Torres, J. L., Marcos, M., Sabio, G., Eilers, M., Schulze, A. & Sumara, G. Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. EMBO J 37, doi:10.15252/embj.201899182 (2018).
  9. Bartmann, C., Janaki Raman, S. R., Floter, J., Schulze, A., Bahlke, K., Willingstorfer, J., Strunz, M., Wockel, A., Klement, R. J., Kapp, M., Djuzenova, C. S., Otto, C. & Kammerer, U. Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation. Cancer Metab 6, 8, doi:10.1186/s40170-018-0180-9 (2018).
  10. Ros, S., Floter, J., Kaymak, I., Da Costa, C., Houddane, A., Dubuis, S., Griffiths, B., Mitter, R., Walz, S., Blake, S., Behrens, A., Brindle, K. M., Zamboni, N., Rider, M. H. & Schulze, A. 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells. Oncogene 36, 3287-3299, doi:10.1038/onc.2016.477 (2017).
  11. Klein-Hessling, S., Muhammad, K., Klein, M., Pusch, T., Rudolf, R., Floter, J., Qureischi, M., Beilhack, A., Vaeth, M., Kummerow, C., Backes, C., Schoppmeyer, R., Hahn, U., Hoth, M., Bopp, T., Berberich-Siebelt, F., Patra, A., Avots, A., Muller, N., Schulze, A. & Serfling, E. NFATc1 controls the cytotoxicity of CD8(+) T cells. Nat Commun 8, 511, doi:10.1038/s41467-017-00612-6 (2017).
  12. Dubuis, S., Baenke, F., Scherbichler, N., Alexander, L. T., Schulze, A. & Zamboni, N. Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics. Metab Eng 43, 173-186, doi:10.1016/j.ymben.2016.12.009 (2017).
  13. Peck, B., Schug, Z. T., Zhang, Q., Dankworth, B., Jones, D. T., Smethurst, E., Patel, R., Mason, S., Jiang, M., Saunders, R., Howell, M., Mitter, R., Spencer-Dene, B., Stamp, G., McGarry, L., James, D., Shanks, E., Aboagye, E. O., Critchlow, S. E., Leung, H. Y., Harris, A. L., Wakelam, M. J. O., Gottlieb, E. & Schulze, A. Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 4, 6, doi:10.1186/s40170-016-0146-8 (2016).
  14. Gatto, F., Schulze, A. & Nielsen, J. Systematic Analysis Reveals that Cancer Mutations Converge on Deregulated Metabolism of Arachidonate and Xenobiotics. Cell Rep 16, 878-895, doi:10.1016/j.celrep.2016.06.038 (2016).
  15. Schug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., McGarry, L., James, D., Shanks, E., Kalna, G., Saunders, R. E., Jiang, M., Howell, M., Lassailly, F., Thin, M. Z., Spencer-Dene, B., Stamp, G., van den Broek, N. J., Mackay, G., Bulusu, V., Kamphorst, J. J., Tardito, S., Strachan, D., Harris, A. L., Aboagye, E. O., Critchlow, S. E., Wakelam, M. J., Schulze, A. & Gottlieb, E. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27, 57-71, doi:10.1016/j.ccell.2014.12.002 (2015).
  16. Lewis, C. A., Brault, C., Peck, B., Bensaad, K., Griffiths, B., Mitter, R., Chakravarty, P., East, P., Dankworth, B., Alibhai, D., Harris, A. L. & Schulze, A. SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 34, 5128-5140, doi:10.1038/onc.2014.439 (2015).
  17. Gatto, F., Miess, H., Schulze, A. & Nielsen, J. Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism. Sci Rep 5, 10738, doi:10.1038/srep10738 (2015).
  18. Baenke, F., Dubuis, S., Brault, C., Weigelt, B., Dankworth, B., Griffiths, B., Jiang, M., Mackay, A., Saunders, B., Spencer-Dene, B., Ros, S., Stamp, G., Reis-Filho, J. S., Howell, M., Zamboni, N. & Schulze, A. Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival. J Pathol 237, 152-165, doi:10.1002/path.4562 (2015).
  19. Yizhak, K., Le Devedec, S. E., Rogkoti, V. M., Baenke, F., de Boer, V. C., Frezza, C., Schulze, A., van de Water, B. & Ruppin, E. A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration. Mol Syst Biol 10, 744, doi:10.15252/msb.20134993 (2014).
  20. Bensaad, K., Favaro, E., Lewis, C. A., Peck, B., Lord, S., Collins, J. M., Pinnick, K. E., Wigfield, S., Buffa, F. M., Li, J. L., Zhang, Q., Wakelam, M. J. O., Karpe, F., Schulze, A. & Harris, A. L. Fatty acid uptake and lipid storage induced by HIF-1alpha contribute to cell growth and survival after hypoxia-reoxygenation. Cell Rep 9, 349-365, doi:10.1016/j.celrep.2014.08.056 (2014).
  21. Griffiths, B., Lewis, C. A., Bensaad, K., Ros, S., Zhang, Q., Ferber, E. C., Konisti, S., Peck, B., Miess, H., East, P., Wakelam, M., Harris, A. L. & Schulze, A. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab 1, 3, doi:10.1186/2049-3002-1-3 (2013).
  22. Eijkelenboom, A., Mokry, M., de Wit, E., Smits, L. M., Polderman, P. E., van Triest, M. H., van Boxtel, R., Schulze, A., de Laat, W., Cuppen, E. & Burgering, B. M. Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling. Mol Syst Biol 9, 638, doi:10.1038/msb.2012.74 (2013).
  23. Ros, S., Santos, C. R., Moco, S., Baenke, F., Kelly, G., Howell, M., Zamboni, N. & Schulze, A. Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2, 328-343, doi:10.1158/2159-8290.CD-11-0234 (2012).
  24. Ferber, E. C., Peck, B., Delpuech, O., Bell, G. P., East, P. & Schulze, A. FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ 19, 968-979, doi:10.1038/cdd.2011.179 (2012).
  25. Lewis, C. A., Griffiths, B., Santos, C. R., Pende, M. & Schulze, A. Regulation of the SREBP transcription factors by mTORC1. Biochem Soc Trans 39, 495-499, doi:10.1042/BST0390495 (2011).
  26. Lewis, C. A., Griffiths, B., Santos, C. R., Pende, M. & Schulze, A. Genetic ablation of S6-kinase does not prevent processing of SREBP1. Adv Enzyme Regul 51, 280-290, doi:10.1016/j.advenzreg.2010.09.001 (2011).
  27. Alfano, D., Votta, G., Schulze, A., Downward, J., Caputi, M., Stoppelli, M. P. & Iaccarino, I. Modulation of cellular migration and survival by c-Myc through the downregulation of urokinase (uPA) and uPA receptor. Mol Cell Biol 30, 1838-1851, doi:10.1128/MCB.01442-09 (2010).
  28. Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y. L. & Schulze, A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8, 224-236, doi:10.1016/j.cmet.2008.07.007 (2008).
  29. Hui, R. C., Gomes, A. R., Constantinidou, D., Costa, J. R., Karadedou, C. T., Fernandez de Mattos, S., Wymann, M. P., Brosens, J. J., Schulze, A. & Lam, E. W. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol 28, 5886-5898, doi:10.1128/MCB.01265-07 (2008).
  30. Delpuech, O., Griffiths, B., East, P., Essafi, A., Lam, E. W., Burgering, B., Downward, J. & Schulze, A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol 27, 4917-4930, doi:10.1128/MCB.01789-06 (2007).
  31. van den Heuvel, A. P., Schulze, A. & Burgering, B. M. Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J 385, 795-802, doi:10.1042/BJ20041449 (2005).
  32. Porstmann, T., Griffiths, B., Chung, Y. L., Delpuech, O., Griffiths, J. R., Downward, J. & Schulze, A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24, 6465-6481, doi:10.1038/sj.onc.1208802 (2005).
  33. Nicke, B., Bastien, J., Khanna, S. J., Warne, P. H., Cowling, V., Cook, S. J., Peters, G., Delpuech, O., Schulze, A., Berns, K., Mullenders, J., Beijersbergen, R. L., Bernards, R., Ganesan, T. S., Downward, J. & Hancock, D. C. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell 20, 673-685, doi:10.1016/j.molcel.2005.10.038 (2005).
  34. Schulze, A., Nicke, B., Warne, P. H., Tomlinson, S. & Downward, J. The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component. Mol Biol Cell 15, 3450-3463, doi:10.1091/mbc.e03-11-0807 (2004).
  35. Schulze, A., Lehmann, K., Jefferies, H. B., McMahon, M. & Downward, J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev 15, 981-994, doi:10.1101/gad.191101 (2001).
  36. Lehmann, K., Janda, E., Pierreux, C. E., Rytomaa, M., Schulze, A., McMahon, M., Hill, C. S., Beug, H. & Downward, J. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Genes Dev 14, 2610-2622 (2000).
  37. Vogt, B., Zerfass-Thome, K., Schulze, A., Botz, J. W., Zwerschke, W. & Jansen-Durr, P. Regulation of cyclin E gene expression by the human papillomavirus type 16 E7 oncoprotein. J Gen Virol 80 ( Pt 8), 2103-2113, doi:10.1099/0022-1317-80-8-2103 (1999).
  38. Duro, D., Schulze, A., Vogt, B., Bartek, J., Mittnacht, S. & Jansen-Durr, P. Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8. J Gen Virol 80 ( Pt 3), 549-555, doi:10.1099/0022-1317-80-3-549 (1999).
  39. Schulze, A., Mannhardt, B., Zerfass-Thome, K., Zwerschke, W. & Jansen-Durr, P. Anchorage-independent transcription of the cyclin A gene induced by the E7 oncoprotein of human papillomavirus type 16. J Virol 72, 2323-2334 (1998).
  40. Zerfass-Thome, K., Schulze, A., Zwerschke, W., Vogt, B., Helin, K., Bartek, J., Henglein, B. & Jansen-Durr, P. p27KIP1 blocks cyclin E-dependent transactivation of cyclin A gene expression. Mol Cell Biol 17, 407-415 (1997).
  41. Spitkovsky, D., Schulze, A., Boye, B. & Jansen-Durr, P. Down-regulation of cyclin A gene expression upon genotoxic stress correlates with reduced binding of free E2F to the promoter. Cell Growth Differ 8, 699-710 (1997).
  42. Hermanns, J., Schulze, A., Jansen-Db1urr, P., Kleinschmidt, J. A., Schmidt, R. & zur Hausen, H. Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins. J Virol 71, 6020-6027 (1997).
  43. Zerfass, K., Spitkovsky, D., Schulze, A., Joswig, S., Henglein, B. & Jansen-Durr, P. Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J Virol 70, 2637-2642 (1996).
  44. Schulze, A., Zerfass-Thome, K., Berges, J., Middendorp, S., Jansen-Durr, P. & Henglein, B. Anchorage-dependent transcription of the cyclin A gene. Mol Cell Biol 16, 4632-4638 (1996).
  45. Zerfass, K., Schulze, A., Spitkovsky, D., Friedman, V., Henglein, B. & Jansen-Durr, P. Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J Virol 69, 6389-6399 (1995).
  46. Schulze, A., Zerfass, K., Spitkovsky, D., Middendorp, S., Berges, J., Helin, K., Jansen-Durr, P. & Henglein, B. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci U S A 92, 11264-11268 (1995).
  47. Spitkovsky, D., Steiner, P., Lukas, J., Lees, E., Pagano, M., Schulze, A., Joswig, S., Picard, D., Tommasino, M., Eilers, M. & et al. Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation. J Virol 68, 2206-2214 (1994).
  48. Schulze, A., Zerfass, K., Spitkovsky, D., Henglein, B. & Jansen-Durr, P. Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9, 3475-3482 (1994).

Review articles:

  1. Snaebjornsson, MT, Janaki-Raman, S, Schulze, A. Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer. Cell Metab (2019), doi: 10.1016/j.cmet.2019.11.010.
  2. Peck, B. & Schulze, A. Lipid Metabolism at the Nexus of Diet andTumor Microenvironment. Trends in Cancer (2019), doi:doi.org/10.1016/j.trecan.2019.09.007 (2019).
  3. Snaebjornsson, M. T. & Schulze, A. Tumours use a metabolic twist to make lipids. Nature 566, 333-334, doi:10.1038/d41586-019-00352-1 (2019).
  4. Friedmann Angeli, J. P., Miyamoto, S. & Schulze, A. Ferroptosis: The Greasy Side of Cell Death. Chem Res Toxicol 32, 362-369, doi:10.1021/acs.chemrestox.8b00349 (2019).
  5. Snaebjornsson, M. T. & Schulze, A. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med 50, 34, doi:10.1038/s12276-018-0065-6 (2018).
  6. Floter, J., Kaymak, I. & Schulze, A. Regulation of Metabolic Activity by p53. Metabolites 7, doi:10.3390/metabo7020021 (2017).
  7. Rohrig, F. & Schulze, A. The multifaceted roles of fatty acid synthesis in cancer. Nat Rev Cancer 16, 732-749, doi:10.1038/nrc.2016.89 (2016).
  8. Peck, B. & Schulze, A. Lipid desaturation - the next step in targeting lipogenesis in cancer? FEBS J 283, 2767-2778, doi:10.1111/febs.13681 (2016).
  9. Peck, B. & Schulze, A. Cholesteryl esters: fueling the fury of prostate cancer. Cell Metab 19, 350-352, doi:10.1016/j.cmet.2014.02.012 (2014).
  10. Ros, S. & Schulze, A. Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism. Cancer Metab 1, 8, doi:10.1186/2049-3002-1-8 (2013).
  11. Ros, S. & Schulze, A. Glycolysis back in the limelight: systemic targeting of HK2 blocks tumor growth. Cancer Discov 3, 1105-1107, doi:10.1158/2159-8290.CD-13-0565 (2013).
  12. Peck, B., Ferber, E. C. & Schulze, A. Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Front Oncol 3, 96, doi:10.3389/fonc.2013.00096 (2013).
  13. Currie, E., Schulze, A., Zechner, R., Walther, T. C. & Farese, R. V., Jr. Cellular fatty acid metabolism and cancer. Cell Metab 18, 153-161, doi:10.1016/j.cmet.2013.05.017 (2013).
  14. Baenke, F., Peck, B., Miess, H. & Schulze, A. Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis Model Mech 6, 1353-1363, doi:10.1242/dmm.011338 (2013).
  15. Schulze, A. & Harris, A. L. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 491, 364-373, doi:10.1038/nature11706 (2012).
  16. Santos, C. R. & Schulze, A. Lipid metabolism in cancer. FEBS J 279, 2610-2623, doi:10.1111/j.1742-4658.2012.08644.x (2012).
  17. Ros, S. & Schulze, A. Linking glycogen and senescence in cancer cells. Cell Metab 16, 687-688, doi:10.1016/j.cmet.2012.11.010 (2012).
  18. Jones, N. P. & Schulze, A. Targeting cancer metabolism--aiming at a tumour's sweet-spot. Drug Discov Today 17, 232-241, doi:10.1016/j.drudis.2011.12.017 (2012).
  19. Schulze, A. & Downward, J. Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells. Mol Cell 44, 846-848, doi:10.1016/j.molcel.2011.12.004 (2011).
  20. Peck, B. & Schulze, A. A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells. Aging (Albany NY) 3, 329-331, doi:10.18632/aging.100302 (2011).
  21. Porstmann, T., Santos, C. R., Lewis, C., Griffiths, B. & Schulze, A. A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochem Soc Trans 37, 278-283, doi:10.1042/BST0370278 (2009).
  22. Schulze, A. & Downward, J. Navigating gene expression using microarrays--a technology review. Nat Cell Biol 3, E190-195, doi:10.1038/35087138 (2001).
  23. Schulze, A. & Downward, J. Analysis of gene expression by microarrays: cell biologist's gold mine or minefield? J Cell Sci 113 Pt 23, 4151-4156 (2000).

Book chapters:

  1. Schulze, A., Bensaad, K. & Harris, A. L. Cancer Metabolism. Oxford Textbook of Cancer Biology (2019).
  2. Brault, C. & Schulze, A. The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells. Recent Results Cancer Res 207, 1-22, doi:10.1007/978-3-319-42118-6_1

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