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Awakening Stem Cells with Vitamins/Cell, May 4, 2017 (Vol. 169, Issue 5)
Cell Paper Video Abstract
Billions of blood cells die every day and need to be replaced by new ones. In this Cell video abstract, Andreas Trumpp, head of the division "Stem Cells and Cancer" at German Cancer Research Center, shows that Vitamin A is a key signal that controls both the transition of hematopoietic stem cells from a "sleep-mode" state called dormancy to an active state and how Vitamin A metabolites may help to improve treatment of blood disorders and leukemias.
Read the paper at http://www.cell.com/cell/fulltext/S0092-8674(17)30464-6
Cabezas-Wallscheid N., Buettner F., Sommerkamp P., Klimmeck D., Ladel L., Thalheimer F.B., Pastor-Flores D., Roma L.P., Renders S., Zeisberger P., Przybylla A., Schönberger K., Scognamiglio R., Altamura S., Florian C.M., Fawaz M., Vonficht D., Tesio M., Collier P., Pavlinic D., Geiger H., Schroeder T., Benes V., Dick T.P., Rieger M.A., Stegle O., Trumpp A. (2017). Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy. Cell, https://doi.org/10.1016/j.cell.2017.04.018
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