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Publications Prof. Dr. Ingrid Hoffmann

Selection of Recent Publications

Krause A and Hoffmann I. (2010)
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication.
PLoS One 24;5(3):e9849.

Timofeev, O., Cizmecioglu, O., Settele F., Kempf, T. and Hoffmann I. (2010)
Cdc25 phosphatases are required for timely assembly of Cdk1/CyclinB complex at G2/M transition.
J. Biol. Chem. 285(22):16978-90.

Chang, J., Cizmecioglu, O., Hoffmann, I. and Rhee, K. (2010)
Plk2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.
EMBO J. 29(14):2395-406.

Guernsey, D., Jiang, H, Hussin, J., Arnold, M., Bouyakdan, K., Perry, S., Babineau-Sturk,T., Beis, J, Dumas, D., Evans, S, Ferguson, M., Matsuoka, M, Macgillivray, C., Nightingale, M, Patry, L., Rideout, A., Thomas, A., Orr, A., Hoffmann, I., Michaud, J., Awadalla, P. Meek, D., Ludman, M. and Samuels, M. (2010)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Amer J Hum Genet 87(1):40-51.

Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiß U, Antony C, Hoffmann I (2010)
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
J Cell Biol. 2010 Nov 15;191(4):731-739. Epub 2010 Nov 8.

Commented in:

Tumurbaatar, I., Cizmecioglu, O., Hoffmann, I., Grummt, I, and Voit, R. (2011)
Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/CyclinB activity.
Plos One 6, e14711.

Puklowski, A., Homsi, Y., Chauhan, S., Keller, D., Grünwald, V., Kubicka, S., Pich, A., Mann, M., Hoffmann, I., Gönczy, P. and Malek, N. (2011)
The activity of the SCFFbw5 E3-ubiquitin ligase is regulated by the APC/C and Plk4 to control centrosome duplication.
Nat. Cell Biol, 13, 1004-9.

Bahtz, R., Seidler, J., Arnold, M., Haselmann-Weiss, U., Antony, C., Lehmann, W and Hoffmann, I., (2012)
GCP6 is a substrate of Plk4 and required for centriole duplication.
J Cell Sci. 2012 Feb 15;125(Pt 4):981-92. Epub 2012 Mar 7.

Cizmecioglu, O, Krause, A., Bahtz, R., Ehret, L., Malek, N. and Hoffmann, I. (2012)

Phosphorylation of Fbxw7/hCdc4 regulated by Plk2 promotes cyclin E stabilization.
J Cell Sci. 2012 Jan 15;125(Pt 2):486-96. Epub 2012 Feb 2.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2012)
RhoD participates in the regulation of cell-cycle progression and centrosome duplication.
Oncogene. 2012 Jun 4. doi: 10.1038/onc.2012.195.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2013)
The RhoD to centrosomal duplication.
Small GTPases. 2013 Feb 19;4(2).

Zhu M, Settele F, Kotak S, Sanchez-Pulido L, Ehret L, Ponting CP, Gönczy P, Hoffmann I. (2013)
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
J Cell Biol. 2013 Mar 18;200(6):773-787.
Audio file concerning this article

Bärenz, F. and Hoffmann, I. (2013)
DUBing CP110 controls centrosomes numbers, Curr. Biol. 23, 459-460.

Martin, C.A., Ahmad, I., Klingeisen, A., Hussain, M., Bicknell, L., Leitch, A., Nürnberg, G., Toliat, M., Murray, J., Hunt, D., Khan, F., Ali, z., Tinschert, S., Ding, J., Keith, C., Harley, M., Heyn, P., Müller, R., Hoffmann, I., Daire, V., Dollfus, H., Dupuis, L., McElreavey, K., Kariminejad, A., Mendoza-Londono, R., Moore, A., Saggar, A., Schlechter, C., Weleber, R., Thiele, H., Altmüller, J., Höhne, W., Hurles, M., Noegel, A., Baig, S., Nürnberg, P. and Jackson, A., (2014)
Mutations in Plk4, a master regulator of centriole biogenesis cause microcephaly, growth failure and retinopathy.
Nat. Genet. 46,1283–1292.

Kratz, A., Bärenz, F., Richter, K. and Hoffmann, I. (2015)
Plk4-dependent phosphorylation of STIL is required for centriole duplication.
Biology Open 4, 370-377.

Brunk, K., Zhu, M., Bärenz, F., Kratz, AS., Haselmann-Weiss, U., Antony, C. and Hoffmann, I., (2016)
Cep78 is a novel centriolar protein involved in PLK4-induced centriole overduplication.
J Cell Sci 129, 2713-2718.

Kratz, AS., Richter, K., Schlosser, Y., Schmitt, M., Shumilov, A., Delecluse HJ and Hoffmann, I. (2016)
Fbxo28 regulates topoisomerase IIα-dependent DNA decatenation.
Cell Cycle 18:1-13.

Shumilov, A., Tsai, M.H., Schlosser, Y.T., Kratz, AS, Bernhard, K., Fink, S. Tuba, M., Jauch, A., Mautner, J., Kopp-Schneider, A., Feederle, R., Lin, X, Hoffmann, I. and Delecluse HJ. (2017) 
Epstein-Barr virus particles induce centrosome amplification and chromosomal instability.
Nat Comm 8:14257

Vodicska B, Cerikan B, Schiebel E, and Hoffmann I. (2018)
MISP regulates the IQGAP1/Cdc42 complex to collectively orchestrate spindle orientation and mitotic progression. Sci Rep. 8(1):6330.
doi: 10.1038/s41598-018-24682-8. PMID:29679050

Kschonsak YT and Hoffmann I. (2018)
Activated Ezrin controls MISP levels to ensure correct NuMA polarization and spindle orientation.
J. Cell Sci. in press doi: 10.1242/jcs.214544. [Epub ahead of print] PMID:29669740

Bärenz F, Kschonsak YT, Meyer A, Jafarpour A, Lorenz H, Hoffmann I. (2018)
Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
Mol Biol Cell. Oct 24 doi: 10.1091/mbc.E18-02-0115. [Epub ahead of print]
PMID: 30354798J

Richter, K., Kschonsak, Y., Vodicska, B., and Hoffmann, I. (2020)
FBXO45- MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation, Cell Death and Differentiation, 27, 758–772.
doi: 10.1038/s41418-019-0385-7
Hoffmann, I. (2021)
Centrosomes in mitotic spindle assembly and orientation. Current opinion in structural biology. 66:193-198.
doi: 10.1016/
Li Z, Baccianti F, Delecluse S, Tsai MH, Shumilov A, Cheng X, Ma S, Hoffmann I, Poirey R, Delecluse HJ. (2021)
The Epstein-Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth. Proc Natl Acad Sci U S A 118(43):e2115508118 doi: 10.1073/pnas.2115508118.
The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of Histone 3 Lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.>
J. Biol. Chem. 298(12):102703
doi: 10.1016/j.jbc.2022.102703.

Hoffmann, I. (2022)
Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication-Impact on Cancer
Cells 11(5):786
doi: 10.3390/cells11050786.

Grossmann J, Kratz AS, Kordonsky A, Prag G, Hoffmann I. (2024)
CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
Life Sci Alliance, 7(6):e202402668.
doi: 10.26508/lsa.202402668.

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