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Publications (selected)

Jahn A#, Rump A#, Widmann TJ#, Heining C, Horak P, Hutter B, Paramasivam N, Uhrig S, Gieldon L, Drukewitz S, Kübler A, Bermudez M, Hackmann K, Porrmann J, Wagner J, Arlt M, Franke M, Fischer J, Kowalzyk Z, William D, Weth V, Oster S, Fröhlich M, Hüllein J, Valle González C, Kreutzfeldt S, Mock A, Heilig CE, Lipka DB, Möhrmann L, Hanf D, Teleanu V, Allgäuer M, Ruhnke L, Kutz O, Knurr A, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Metzeler KH, Bitzer M, Schulze-Osthoff K, von Kalle C, Brors B, Stenzinger A, Weichert W, Hübschmann D, Fröhling S§, Glimm H§, Schröck E§,* & Klink B§. (2022). Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers. Ann Oncol, doi:10.1016/j.annonc.2022.07.008


Möhrmann L#, Werner M#, Oleś M#, Mock A#, Uhrig S#, Jahn A, Kreutzfeldt S, Fröhlich M, Hutter B, Paramasivam N, Richter D, Beck K, Winter U, Pfütze K, Heilig CE, Teleanu V, Lipka DB, Zapatka M, Hanf D, List C, Allgäuer M, Penzel R, Rüter G, Jelas I, Hamacher R, Falkenhorst J, Wagner S, Brandts CH, Boerries M, Illert AL, Metzeler KH, Westphalen CB, Desuki A, Kindler T, Folprecht G, Weichert W, Brors B, Stenzinger A, Schröck E, Hübschmann D, Horak P, Heining C§, Fröhling S§ & Glimm H§,*. (2022). Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity. Nat Commun, 13(1), 4485. doi:10.1038/s41467-022-31866-4


Dieter SM*, Lovecchio D, Pataskar A, Zowada MK, Körner PR, Khalizieva A, van Tellingen O, Jäger D, Glimm H & Agami R*. (2022). Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors. Oncogene, 41(32), 3953-3968. doi:10.1038/s41388-022-02400-z


Dieter SM*, Siegl C, Codó PL, Huerta M, Ostermann-Parucha AL, Schulz E, Zowada MK, Martin S, Laaber K, Nowrouzi A, Blatter M, Kreth S, Westermann F, Benner A, Uhrig U, Putzker K, Lewis J, Haegebarth A, Mumberg D, Holton SJ, Weiske J, Toepper LM, Scheib U, Siemeister G, Ball CR, Kuster B, Stoehr G, Hahne H, Johannes S, Lange M, Herbst F & Glimm H*. (2021). Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Rep, 36(3), 109394. doi:10.1016/j.celrep.2021.109394


Horak P#, Heining C#, Kreutzfeldt S#, Hutter B#, Mock A, Hüllein J, Fröhlich M, Uhrig S, Jahn A, Rump A, Gieldon L, Möhrmann L, Hanf D, Teleanu V, Heilig CE, Lipka DB, Allgäuer M, Ruhnke L, Laßmann A, Endris V, Neumann O, Penzel R, Beck K, Richter D, Winter U, Wolf S, Pfütze K, Geörg C, Meißburger B, Buchhalter I, Augustin M, Aulitzky WE, Hohenberger P, Kroiss M, Schirmacher P, Schlenk RF, Keilholz U, Klauschen F, Folprecht G, Bauer S, Siveke JT, Brandts CH, Kindler T, Boerries M, Illert AL, von Bubnoff N, Jost PJ, Spiekermann K, Bitzer M, Schulze-Osthoff K, von Kalle C, Klink B, Brors B, Stenzinger A, Schröck E, Hübschmann D, Weichert W, Glimm H§,* & Fröhling S§,*. (2021). Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers. Cancer Discov, 11(11), 2780-2795. doi:10.1158/2159-8290.Cd-21-0126


Li L#, Ugalde AP#, Scheele C, Dieter SM, Nagel R, Ma J, Pataskar A, Korkmaz G, Elkon R, Chien MP, You L, Su PR, Bleijerveld OB, Altelaar M, Momchev L, Manber Z, Han R, van Breugel PC, Lopes R, Ten Dijke P, van Rheenen J & Agami R*. (2021). A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis. Genome Biol, 22(1), 54. doi:10.1186/s13059-021-02272-8


Horak P*, Uhrig S, Witzel M, Gil-Farina I, Hutter B, Rath T, Gieldon L, Balasubramanian GP, Pastor X, Heilig CE, Richter D, Schröck E, Ball CR, Brors B, Braun CJ, Albert MH, Scholl C, von Kalle C, Schmidt M, Fröhling S, Klein C & Glimm H*. (2020). Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia. Leukemia, 34(10), 2785-2789. doi:10.1038/s41375-020-0779-z


Möhrmann L#, Zowada MK#, Strakerjahn H, Siegl C, Kopp-Schneider A, Krunic D, Strunk D, Schneider M, Kriegsmann M, Kriegsmann K, Herbst F, Ball CR, Glimm H* & Dieter SM*. (2020). A perivascular niche in the bone marrow hosts quiescent and proliferating tumorigenic colorectal cancer cells. Int J Cancer, 147(2), 519-531. doi:10.1002/ijc.32933


Ronellenfitsch MW*, Harter PN, Kirchner M, Heining C, Hutter B, Gieldon L, Schittenhelm J, Schuhmann MU, Tatagiba M, Marquardt G, Wagner M, Endris V, Brandts CH, Mautner VF, Schröck E, Weichert W, Brors B, von Deimling A, Mittelbronn M, Steinbach JP§, Reuss DE§, Glimm H§, Stenzinger A§ & Fröhling S§. (2020). Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors. J Clin Invest, 130(5), 2488-2495. doi:10.1172/jci130787


Wünsche P#, Eckert ESP#, Holland-Letz T, Paruzynski A, Hotz-Wagenblatt A, Fronza R, Rath T, Gil-Farina I, Schmidt M, von Kalle C, Klein C, Ball CR, Herbst F§ & Glimm H§,*. (2018). Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs. Cell Stem Cell, 23(1), 132-146.e139. doi:10.1016/j.stem.2018.06.003


Bormann F, Rodríguez-Paredes M, Lasitschka F, Edelmann D, Musch T, Benner A, Bergman Y, Dieter SM, Ball CR, Glimm H, Linhart HG & Lyko F*. (2018). Cell-of-Origin DNA Methylation Signatures Are Maintained during Colorectal Carcinogenesis. Cell Rep, 23(11), 3407-3418. doi:10.1016/j.celrep.2018.05.045


Heining C#, Horak P#, Uhrig S#, Codo PL, Klink B, Hutter B, Fröhlich M, Bonekamp D, Richter D, Steiger K, Penzel R, Endris V, Ehrenberg KR, Frank S, Kleinheinz K, Toprak UH, Schlesner M, Mandal R, Schulz L, Lambertz H, Fetscher S, Bitzer M, Malek NP, Horger M, Giese NA, Strobel O, Hackert T, Springfeld C, Feuerbach L, Bergmann F, Schröck E, von Kalle C, Weichert W, Scholl C, Ball CR, Stenzinger A, Brors B, Fröhling S§,* & Glimm H§,*. (2018). NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer. Cancer Discov, 8(9), 1087-1095. doi:10.1158/2159-8290.Cd-18-0036


Giessler KM#, Kleinheinz K#, Huebschmann D, Balasubramanian GP, Dubash TD, Dieter SM, Siegl C, Herbst F, Weber S, Hoffmann CM, Fronza R, Buchhalter I, Paramasivam N, Eils R, Schmidt M, von Kalle C, Schneider M, Ulrich A, Scholl C, Fröhling S, Weichert W, Brors B, Schlesner M, Ball CR§ & Glimm H§,*. (2017). Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer. J Exp Med, 214(7), 2073-2088. doi:10.1084/jem.20162017


Dieter SM, Glimm H* & Ball CR. (2017). Colorectal cancer-initiating cells caught in the act. EMBO Mol Med, 9(7), 856-858. doi:10.15252/emmm.201707858


Ball CR, Oppel F, Ehrenberg KR, Dubash TD, Dieter SM, Hoffmann CM, Abel U, Herbst F, Koch M, Werner J, Bergmann F, Ishaque N, Schmidt M, von Kalle C, Scholl C, Fröhling S, Brors B, Weichert W, Weitz J & Glimm H*. (2017). Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts. EMBO Mol Med, 9(7), 918-932. doi:10.15252/emmm.201607354


Dieter SM#, Giessler KM#, Kriegsmann M, Dubash TD, Möhrmann L, Schulz ER, Siegl C, Weber S, Strakerjahn H, Oberlack A, Heger U, Gao J, Hartinger EM, Oppel F, Hoffmann CM, Ha N, Brors B, Lasitschka F, Ulrich A, Strobel O, Schmidt M, von Kalle C, Schneider M, Weichert W, Ehrenberg KR, Glimm H§ & Ball CR§,*. (2017). Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation. Int J Cancer, 140(6), 1356-1363. doi:10.1002/ijc.30561


Weischenfeldt J#, Dubash T#, Drainas AP#, Mardin BR, Chen Y, Stütz AM, Waszak SM, Bosco G, Halvorsen AR, Raeder B, Efthymiopoulos T, Erkek S, Siegl C, Brenner H, Brustugun OT, Dieter SM, Northcott PA, Petersen I, Pfister SM, Schneider M, Solberg SK, Thunissen E, Weichert W, Zichner T, Thomas R, Peifer M, Helland A, Ball CR, Jechlinger M, Sotillo R, Glimm H* & Korbel JO*. (2017). Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking. Nat Genet, 49(1), 65-74. doi:10.1038/ng.3722


Dieter SM#, Heining C#, Agaimy A, Huebschmann D, Bonekamp D, Hutter B, Ehrenberg KR, Fröhlich M, Schlesner M, Scholl C, Schlemmer HP, Wolf S, Mavratzas A, Jung CS, Gröschel S, von Kalle C, Eils R, Brors B, Penzel R, Kriegsmann M, Reuss DE, Schirmacher P, Stenzinger A, Federspil PA, Weichert W§, Glimm H§ & Fröhling S§,*. (2017). Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma. Ann Oncol, 28(1), 142-148. doi:10.1093/annonc/mdw446


Kaeppel C#, Beattie SG#, Fronza R#, van Logtenstein R, Salmon F, Schmidt S, Wolf S, Nowrouzi A, Glimm H, von Kalle C, Petry H, Gaudet D & Schmidt M*. (2013). A largely random AAV integration profile after LPLD gene therapy. Nat Med, 19(7), 889-891. doi:10.1038/nm.3230


Dietrich S#, Glimm H#, Andrulis M, von Kalle C, Ho AD & Zenz T*. (2012). BRAF inhibition in refractory hairy-cell leukemia. N Engl J Med, 366(21), 2038-2040. doi:10.1056/NEJMc1202124


Dieter SM#, Ball CR#, Hoffmann CM#, Nowrouzi A, Herbst F, Zavidij O, Abel U, Arens A, Weichert W, Brand K, Koch M, Weitz J, Schmidt M, von Kalle C* & Glimm H*. (2011). Distinct types of tumor-initiating cells form human colon cancer tumors and metastases. Cell Stem Cell, 9(4), 357-365. doi:10.1016/j.stem.2011.08.010


Boztug K, Schmidt M, Schwarzer A, Banerjee PP, Díez IA, Dewey RA, Böhm M, Nowrouzi A, Ball CR, Glimm H, Naundorf S, Kühlcke K, Blasczyk R, Kondratenko I, Maródi L, Orange JS, von Kalle C & Klein C*. (2010). Stem-cell gene therapy for the Wiskott-Aldrich syndrome. N Engl J Med, 363(20), 1918-1927. doi:10.1056/NEJMoa1003548


Paruzynski A#, Arens A#, Gabriel R#, Bartholomae CC#, Scholz S, Wang W, Wolf S, Glimm H, Schmidt M* & von Kalle C. (2010). Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc, 5(8), 1379-1395. doi:10.1038/nprot.2010.87


Gabriel R#, Eckenberg R#, Paruzynski A#, Bartholomae CC#, Nowrouzi A, Arens A, Howe SJ, Recchia A, Cattoglio C, Wang W, Faber K, Schwarzwaelder K, Kirsten R, Deichmann A, Ball CR, Balaggan KS, Yáñez-Muñoz RJ, Ali RR, Gaspar HB, Biasco L, Aiuti A, Cesana D, Montini E, Naldini L, Cohen-Haguenauer O, Mavilio F, Thrasher AJ, Glimm H, von Kalle C*, Saurin W§ & Schmidt M§. (2009). Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med, 15(12), 1431-1436. doi:10.1038/nm.2057


# Shared first authorship.
Shared second authorship.
§ Shared senior authorship.
* Corresponding authorship.

 

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