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Clinical Cooperation Unit Dermato-Oncology

Prof. Dr. Jochen Sven Utikal

Primary malignant melanoma
© dkfz.de

The Clinical Cooperation Unit Dermato-Oncology is engaged in the diagnosis and therapy of skin tumors. Research results obtained are transferred directly into clinical practice. The main focus is on malignant melanoma, a tumor that originates from the pigment cells of the skin. The Clinical Cooperation Unit Dermato-Oncology conducts several translational research projects, including different Phase I-IV clinical trials, with innovative melanoma therapies. (LINK: clinical trials)

Translational research focuses on stem cell features of melanoma cells, target identification to overcome resistance mechanisms, immunosuppression in melanoma, and prognostic and predictive melanoma biomarker.

Contact

Prof. Dr. Jochen Sven Utikal
Dermato-Oncology (A370)
Deutsches Krebsforschungszentrum
Im Neuenheimer Feld 280
69120 Heidelberg
Tel: +49 621 383 4461

Selected Publications

  • Sahin U. et al. (2017). Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer. Nature, 547(7662):222-226.
  • Bernhardt M. et al. (2017). Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response. Stem Cell Reports, 8(5):1379-1391.
  • Blattner C. et al. (2018). CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions. Cancer Res. 78:157-167.
  • Fleming V. et al. (2019). Melanoma Extracellular Vesicles Generate Immunosuppressive Myeloid Cells by Upregulating PD-L1 via TLR4 Signaling. Cancer Res. 79:4715-4728.
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