Selected Publications

CUP - Carcinoma of Unknown Primary

Bochtler, Tilmann; Reiling, Anna; Endris, Volker; Hielscher, Thomas; Volckmar, Anna-Lena; Neumann, Olaf et al. (2020): Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary. In: International journal of cancer 146 (11), S. 3053–3064. DOI: 10.1002/ijc.32882.

Bochtler, Tilmann; Endris, Volker; Leichsenring, Jonas; Reiling, Anna; Neumann, Olaf; Volckmar, Anna-Lena et al. (2019): Comparative genetic profiling aids diagnosis and clinical decision making in challenging cases of CUP syndrome. In: International journal of cancer 145 (11), S. 2963–2973. DOI: 10.1002/ijc.32316.

Kirchner, Martina; Neumann, Olaf; Volckmar, Anna-Lena; Stögbauer, Fabian; Allgäuer, Michael; Kazdal, Daniel et al. (2019): RNA-Based Detection of Gene Fusions in Formalin-Fixed and Paraffin-Embedded Solid Cancer Samples. In: Cancers 11 (9). DOI: 10.3390/cancers11091309.

Bochtler, Tilmann; Endris, Volker; Reiling, Anna; Leichsenring, Jonas; Schweiger, Michal R.; Klein, Sebastian et al. (2018): Integrated Histogenetic Analysis Reveals BAP1-Mutated Epithelioid Mesothelioma in a Patient With Cancer of Unknown Primary. In: Journal of the National Comprehensive Cancer Network: JNCCN 16 (6), S. 677–682. DOI: 10.6004/jnccn.2018.7012.

Hemminki, Kari; Chen, Bowang; Kumar, Abhishek; Melander, Olle; Manjer, Jonas; Hallmans, Göran et al. (2016): Germline genetics of cancer of unknown primary (CUP) and its specific subtypes. In: Oncotarget 7 (16), S. 22140–22149. DOI: 10.18632/oncotarget.7903.

Löffler, Harald; Pfarr, Nicole; Kriegsmann, Mark; Endris, Volker; Hielscher, Thomas; Lohneis, Philipp et al. (2016): Molecular driver alterations and their clinical relevance in cancer of unknown primary site. In: Oncotarget 7 (28), S. 44322–44329. DOI: 10.18632/oncotarget.10035.

CIN - Chromosomal Instability

Cazzola, Anna; Schlegel, Christin; Jansen, Ilka; Bochtler, Tilmann; Jauch, Anna; Krämer, Alwin (2019): TP53 deficiency permits chromosome abnormalities and karyotype heterogeneity in acute myeloid leukemia. In: Leukemia 33 (11), S. 2619–2627. DOI: 10.1038/s41375-019-0550-5.

Kraft, Bianca; Lombard, Jan; Kirsch, Michael; Wuchter, Patrick; Bugert, Peter; Hielscher, Thomas et al. (2019): SMC3 protein levels impact on karyotype and outcome in acute myeloid leukemia. In: Leukemia 33 (3), S. 795–799. DOI: 10.1038/s41375-018-0287-6.

Bochtler, Tilmann; Kartal-Kaess, Mutlu; Granzow, Martin; Hielscher, Thomas; Cosenza, Marco R.; Herold-Mende, Christel et al. (2019): Micronucleus formation in human cancer cells is biased by chromosome size. In: Genes, chromosomes & cancer 58 (6), S. 392–395. DOI: 10.1002/gcc.22707.

Bochtler, Tilmann; Merz, Maximilian; Hielscher, Thomas; Granzow, Martin; Hoffmann, Korbinian; Krämer, Alwin et al. (2018b): Cytogenetic intraclonal heterogeneity of plasma cell dyscrasia in AL amyloidosis as compared with multiple myeloma. In: Blood advances 2 (20), S. 2607–2618. DOI: 10.1182/bloodadvances.2018023200.

Cosenza, Marco R.; Cazzola, Anna; Rossberg, Annik; Schieber, Nicole L.; Konotop, Gleb; Bausch, Elena et al. (2017): Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer. In: Cell reports 20 (8), S. 1906–1920. DOI: 10.1016/j.celrep.2017.08.005.

Bochtler, Tilmann; Granzow, Martin; Stölzel, Friedrich; Kunz, Christina; Mohr, Brigitte; Kartal-Kaess, Mutlu et al. (2017): Marker chromosomes can arise from chromothripsis and predict adverse prognosis in acute myeloid leukemia. In: Blood 129 (10), S. 1333–1342. DOI: 10.1182/blood-2016-09-738161.

Konotop, Gleb; Bausch, Elena; Nagai, Tomoaki; Turchinovich, Andrey; Becker, Natalia; Benner, Axel et al. (2016): Pharmacological Inhibition of Centrosome Clustering by Slingshot-Mediated Cofilin Activation and Actin Cortex Destabilization. In: Cancer research 76 (22), S. 6690–6700. DOI: 10.1158/0008-5472.CAN-16-1144.


Daly, Owen M.; Gaboriau, David; Karakaya, Kadin; King, Sinéad; Dantas, Tiago J.; Lalor, Pierce et al. (2016): CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity. In: Journal of cell science 129 (9), S. 1769–1774. DOI: 10.1242/jcs.186221.

Stölzel, F.; Mohr, B.; Kramer, M.; Oelschlägel, U.; Bochtler, T.; Berdel, W. E. et al. (2016): Karyotype complexity and prognosis in acute myeloid leukemia. In: Blood cancer journal 6, e386. DOI: 10.1038/bcj.2015.114.

Alsara, Mohammad; Löffler, Harald; Fechter, Anne; Bartek, Jiri; Krämer, Alwin (2015): Cep63 recruits cdk1 to the centrosome-letter. In: Cancer research 75 (4), S. 777–778. DOI: 10.1158/0008-5472.CAN-14-3431.

Bochtler, T.; Fröhling, S.; Krämer, A. (2015): Role of chromosomal aberrations in clonal diversity and progression of acute myeloid leukemia. In: Leukemia 29 (6), S. 1243–1252. DOI: 10.1038/leu.2015.32.

Bochtler, Tilmann; Stölzel, Friedrich; Heilig, Christoph E.; Kunz, Christina; Mohr, Brigitte; Jauch, Anna et al. (2013): Clonal heterogeneity as detected by metaphase karyotyping is an indicator of poor prognosis in acute myeloid leukemia. In: Journal of clinical oncology: official journal of the American Society of Clinical Oncology 31 (31), S. 3898–3905. DOI: 10.1200/JCO.2013.50.7921.

Mardin, Balca R.; Isokane, Mayumi; Cosenza, Marco R.; Krämer, Alwin; Ellenberg, Jan; Fry, Andrew M.; Schiebel, Elmar (2013): EGF-induced centrosome separation promotes mitotic progression and cell survival. In: Developmental cell 25 (3), S. 229–240. DOI: 10.1016/j.devcel.2013.03.012.

Löffler, H.; Fechter, A.; Liu, F. Y.; Poppelreuther, S.; Krämer, A. (2013): DNA damage-induced centrosome amplification occurs via excessive formation of centriolar satellites. In: Oncogene 32 (24), S. 2963–2972. DOI: 10.1038/onc.2012.310.

Vulprecht, Julia; David, Ahuvit; Tibelius, Alexandra; Castiel, Asher; Konotop, Gleb; Liu, Fengying et al. (2012): STIL is required for centriole duplication in human cells. In: Journal of cell science 125 (Pt 5), S. 1353–1362. DOI: 10.1242/jcs.104109.

Raab, Marc S.; Breitkreutz, Iris; Anderhub, Simon; Rønnest, Mads H.; Leber, Blanka; Larsen, Thomas O. et al. (2012): GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo. In: Cancer research 72 (20), S. 5374–5385. DOI: 10.1158/0008-5472.CAN-12-2026.

Stein, Stefan; Ott, Marion G.; Schultze-Strasser, Stephan; Jauch, Anna; Burwinkel, Barbara; Kinner, Andrea et al. (2010): Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. In: Nature medicine 16 (2), S. 198–204. DOI: 10.1038/nm.2088.

Leber, Blanka; Maier, Bettina; Fuchs, Florian; Chi, Jing; Riffel, Phillip; Anderhub, Simon et al. (2010): Proteins required for centrosome clustering in cancer cells. In: Science translational medicine 2 (33), 33ra38. DOI: 10.1126/scitranslmed.3000915.

Tibelius, Alexandra; Marhold, Joachim; Zentgraf, Hanswalter; Heilig, Christoph E.; Neitzel, Heidemarie; Ducommun, Bernard et al. (2009): Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. In: The Journal of cell biology 185 (7), S. 1149–1157. DOI: 10.1083/jcb.200810159.

Rebacz, Blanka; Larsen, Thomas O.; Clausen, Mads H.; Rønnest, Mads H.; Löffler, Harald; Ho, Anthony D.; Krämer, Alwin (2007): Identification of griseofulvin as an inhibitor of centrosomal clustering in a phenotype-based screen. In: Cancer research 67 (13), S. 6342–6350. DOI: 10.1158/0008-5472.CAN-07-0663.

Bartkova, Jirina; Horejsí, Zuzana; Koed, Karen; Krämer, Alwin; Tort, Frederic; Zieger, Karsten et al. (2005): DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. In: Nature 434 (7035), S. 864–870. DOI: 10.1038/nature03482.

Krämer, Alwin; Mailand, Niels; Lukas, Claudia; Syljuåsen, Randi G.; Wilkinson, Christopher J.; Nigg, Erich A. et al. (2004): Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. In: Nature cell biology 6 (9), S. 884–891. DOI: 10.1038/ncb1165.

Neben, Kai; Giesecke, Christian; Schweizer, Silja; Ho, Anthony D.; Krämer, Alwin (2003): Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile. In: Blood 101 (1), S. 289–291. DOI: 10.1182/blood-2002-04-1188.

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