Research group on bone marrow

Dynamic MRI of multiple myelom

The research group hemato-oncological imaging deals with the possibilities of non-invasive imaging of the blood forming tissues and the lymphatic system. In particular magnetic resonance imaging (MRI) and computed tomography (CT) are used. The obtained data are correlated with serological, genetic and clinical parameters. We examine whether dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted imaging (DWI) of patients with newly diagnosed multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS) help to predict the course of disease. In addition, we are analyzing large patient populations who have been examined with standard imaging methods such as whole-body MRI and whole-body CT in clinical routine. In particular, the transition from early stages of disease - not requiring treatment - to advanced stages will be investigated. In addition, findings of residual disease after therapy are explored for their prognostic significance.
Due to the large amount of data collected we are conducting projects in cooperation with partners from the departments of medical software development to support the analysis of imaging data.
Furthermore, we are currently broadening the spectrum of the studied hemato-oncological diseases and examine for example patients with malignant lymphoma, myelodysplastic syndrome and acute leukemia.

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